| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
however, whether trem2 is related to the stimulus-dependent phagocytic activity of microglia is unclear. |
2021-08-02 |
2023-08-13 |
Not clear |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
trem2 of microglia was detected by qpcr and western blotting. |
2021-08-02 |
2023-08-13 |
Not clear |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
the trem2 signal was blocked in microglia using the sirna technique. |
2021-08-02 |
2023-08-13 |
Not clear |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
the trem2 expression was up-regulated in il-4- or il-10- treated microglia. |
2021-08-02 |
2023-08-13 |
Not clear |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
trem2 sirna treatment blocked the phagocytic activity of il-4- or il-10-treated microglia. |
2021-08-02 |
2023-08-13 |
Not clear |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
in conclusion, these results indicated that il-4 and il-10 promote the phagocytic activity of microglia by the up-regulation of trem2, which suggested a new potential therapeutic target for neurodegenerative disease. |
2021-08-02 |
2023-08-13 |
Not clear |
| Daniela Diaz-Lucena, Niels Kruse, Katrin Thüne, Matthias Schmitz, Anna Villar-Piqué, Jose Eriton Gomes da Cunha, Peter Hermann, Óscar López-Pérez, Pol Andrés-Benito, Anna Ladogana, Miguel Calero, Enric Vidal, Joachim Riggert, Hailey Pineau, Valerie Sim, Henrik Zetterberg, Kaj Blennow, Jose Antonio Del Río, Alba Marín-Moreno, Juan Carlos Espinosa, Juan María Torres, Raquel Sánchez-Valle, Brit Mollenhauer, Isidre Ferrer, Inga Zerr, Franc Lloren. TREM2 expression in the brain and biological fluids in prion diseases. Acta neuropathologica. vol 141. issue 6. 2021-07-30. PMID:33881612. |
our data indicate that, compared to controls, trem2 is increased in scjd patient brains at the mrna and protein levels in a regional and subtype dependent fashion, and expressed in a subpopulation of microglia. |
2021-07-30 |
2023-08-13 |
human |
| Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haas. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO molecular medicine. vol 12. issue 4. 2021-07-28. PMID:32154671. |
triggering receptor expressed on myeloid cells 2 (trem2) is essential for the transition of homeostatic microglia to a disease-associated microglial state. |
2021-07-28 |
2023-08-13 |
mouse |
| Kai Schlepckow, Kathryn M Monroe, Gernot Kleinberger, Ludovico Cantuti-Castelvetri, Samira Parhizkar, Dan Xia, Michael Willem, Georg Werner, Nadine Pettkus, Bettina Brunner, Alice Sülzen, Brigitte Nuscher, Heike Hampel, Xianyuan Xiang, Regina Feederle, Sabina Tahirovic, Joshua I Park, Rachel Prorok, Cathal Mahon, Chun-Chi Liang, Ju Shi, Do Jin Kim, Hanna Sabelström, Fen Huang, Gilbert Di Paolo, Mikael Simons, Joseph W Lewcock, Christian Haas. Enhancing protective microglial activities with a dual function TREM2 antibody to the stalk region. EMBO molecular medicine. vol 12. issue 4. 2021-07-28. PMID:32154671. |
moreover, in a mouse model for alzheimer's disease-related pathology, 4d9 reduced amyloidogenesis, enhanced microglial trem2 expression, and reduced a homeostatic marker, suggesting a protective function by driving microglia toward a disease-associated state. |
2021-07-28 |
2023-08-13 |
mouse |
| Audrey C Knight, Samuel A Brill, Clarisse V Solis, Morgan R Richardson, Megan E McCarron, Suzanne E Queen, Charles C Bailey, Joseph L Mankowsk. Differential regulation of TREM2 and CSF1R in CNS macrophages in an SIV/macaque model of HIV CNS disease. Journal of neurovirology. vol 26. issue 4. 2021-07-06. PMID:32488843. |
using the siv/macaque model of hiv, we evaluated cns expression of triggering receptor expressed on myeloid cells 2 (trem2) which is constitutively expressed by microglia and contributes to cell survival, proliferation, and differentiation. |
2021-07-06 |
2023-08-13 |
Not clear |
| Qian Wang, Weixia Yang, Jingmei Zhang, Yueran Zhao, Yuzhen X. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia. Neural plasticity. vol 2020. 2021-06-30. PMID:32617097. |
triggering receptor expressed on myeloid cells 2 (trem2) is a transmembrane receptor mainly expressed on microglia and has been known for its anti-inflammatory properties during immune response. |
2021-06-30 |
2023-08-13 |
mouse |
| Qian Wang, Weixia Yang, Jingmei Zhang, Yueran Zhao, Yuzhen X. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia. Neural plasticity. vol 2020. 2021-06-30. PMID:32617097. |
further mechanistic study revealed that overexpression of trem2 significantly inhibited microglia m1 polarization by decreasing inducible nitric oxide synthase (inos) and proinflammatory cytokines expression levels and conversely enhanced microglia m2 polarization by increasing arginase-1 (arg-1) and anti-inflammatory cytokine expression levels. |
2021-06-30 |
2023-08-13 |
mouse |
| Qian Wang, Weixia Yang, Jingmei Zhang, Yueran Zhao, Yuzhen X. TREM2 Overexpression Attenuates Cognitive Deficits in Experimental Models of Vascular Dementia. Neural plasticity. vol 2020. 2021-06-30. PMID:32617097. |
these results strongly suggest that trem2 provides a protective effect in vd via modulating the phenotype of activated microglia and may serve as a novel potential therapeutic target for vd. |
2021-06-30 |
2023-08-13 |
mouse |
| S Liu, X-M Li, J-B Yuan, L-L Li, C Wang, X-M Lin, X Miao, Z-C Sh. MiR-665 inhibits inflammatory response in microglia following spinal cord injury by targeting TREM2. European review for medical and pharmacological sciences. vol 25. issue 1. 2021-06-29. PMID:33506893. |
mir-665 inhibits inflammatory response in microglia following spinal cord injury by targeting trem2. |
2021-06-29 |
2023-08-13 |
Not clear |
| Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S James, Emma Mead, John B Davis, Sally A Cowle. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33198789. |
trem2 is a microglial cell surface receptor, with risk mutations linked to alzheimer's disease (ad), including r47h. |
2021-06-24 |
2023-08-13 |
mouse |
| Hazel Hall-Roberts, Devika Agarwal, Juliane Obst, Thomas B Smith, Jimena Monzón-Sandoval, Elena Di Daniel, Caleb Webber, William S James, Emma Mead, John B Davis, Sally A Cowle. TREM2 Alzheimer's variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages. Alzheimer's research & therapy. vol 12. issue 1. 2021-06-24. PMID:33198789. |
we investigated cell phenotypes of the r47h mutant and trem2 ko in a model of human microglia, and compared their transcriptional signatures, to determine the mechanism by which r47h trem2 disrupts function. |
2021-06-24 |
2023-08-13 |
mouse |
| Qiuju Yuan, Xiaodong Liu, Yi Zhang, Yan-Fang Xian, Juntao Zou, Xie Zhang, Pengyun Huang, You-Qiang Song, Zhi-Xiu Li. Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model. Molecules (Basel, Switzerland). vol 26. issue 9. 2021-06-24. PMID:34064330. |
established beta amyloid pathology is unaffected by trem2 elevation in reactive microglia in an alzheimer's disease mouse model. |
2021-06-24 |
2023-08-13 |
mouse |
| Qiuju Yuan, Xiaodong Liu, Yi Zhang, Yan-Fang Xian, Juntao Zou, Xie Zhang, Pengyun Huang, You-Qiang Song, Zhi-Xiu Li. Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model. Molecules (Basel, Switzerland). vol 26. issue 9. 2021-06-24. PMID:34064330. |
we found that peripheral nerve injury resulted in a robust elevation of trem2 exclusively in reactive microglia in the ipsilateral spinal cord of aged tgcrnd8 mice at the age of 20 months. |
2021-06-24 |
2023-08-13 |
mouse |
| Qiuju Yuan, Xiaodong Liu, Yi Zhang, Yan-Fang Xian, Juntao Zou, Xie Zhang, Pengyun Huang, You-Qiang Song, Zhi-Xiu Li. Established Beta Amyloid Pathology Is Unaffected by TREM2 Elevation in Reactive Microglia in an Alzheimer's Disease Mouse Model. Molecules (Basel, Switzerland). vol 26. issue 9. 2021-06-24. PMID:34064330. |
we further showed direct evidence that trem2 elevation in reactive microglia did not affect amyloid-β pathology in plaque-bearing tgcrnd8 mice by applying anti-trem2 neutralizing antibody to selectively block trem2. |
2021-06-24 |
2023-08-13 |
mouse |
| Qiankun Lv, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Wei Huan. MicroRNA-3473b regulates the expression of TREM2/ULK1 and inhibits autophagy in inflammatory pathogenesis of Parkinson disease. Journal of neurochemistry. vol 157. issue 3. 2021-06-21. PMID:33448372. |
deletion of trem2, one of the most highly expressed receptors in microglia, leads to the occurrence and development of pd. |
2021-06-21 |
2023-08-13 |
mouse |