| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gemma Manich, Ariadna Regina Gómez-López, Beatriz Almolda, Nàdia Villacampa, Mireia Recasens, Kalpana Shrivastava, Berta González, Bernardo Castellan. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328887. |
our results indicate the appearance of a subpopulation of microglia expressing trem2 after both anterograde and retrograde axonal injury. |
2020-12-18 |
2023-08-13 |
Not clear |
| Jing Li, Runtian Zhao, Yuhan Jiang, Yi Xu, Huan Zhao, Xiaoling Lyu, Tao W. Bilberry anthocyanins improve neuroinflammation and cognitive dysfunction in APP/PSEN1 mice via the CD33/TREM2/TYROBP signaling pathway in microglia. Food & function. vol 11. issue 2. 2020-11-23. PMID:32003387. |
immunofluorescence and rt-pcr analysis results showed that ba fully activates the microglia and astrocytes, downregulates the expression of inflammatory factors (tnf-α, nf-kβ, il-1β, il-6, cox-2, inos and cd33) and chemokine receptor cx3cr1, and upregulates the expression of microglia homeostatic factors (trem2 and tyrobp) and toll-like receptors (tlr2 and tlr4). |
2020-11-23 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
the discovery of trem2 as a myeloid-specific alzheimer's disease (ad) risk gene has accelerated research into the role of microglia in ad. |
2020-11-09 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
while trem2 mouse models have provided critical insight, the normal and disease-associated functions of trem2 in human microglia remain unclear. |
2020-11-09 |
2023-08-13 |
mouse |
| Amanda McQuade, You Jung Kang, Jonathan Hasselmann, Amit Jairaman, Alexandra Sotelo, Morgan Coburn, Sepideh Kiani Shabestari, Jean Paul Chadarevian, Gianna Fote, Christina H Tu, Emma Danhash, Jorge Silva, Eric Martinez, Carl Cotman, G Aleph Prieto, Leslie M Thompson, Joan S Steffan, Ian Smith, Hayk Davtyan, Michael Cahalan, Hansang Cho, Mathew Blurton-Jone. Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease. Nature communications. vol 11. issue 1. 2020-11-09. PMID:33097708. |
single-cell sequencing of xenotransplanted human microglia further highlights a loss of disease-associated microglial (dam) responses in human trem2 knockout microglia that we validate by flow cytometry and immunohistochemistry. |
2020-11-09 |
2023-08-13 |
mouse |
| Benjamin J Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcoc. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature neuroscience. vol 23. issue 8. 2020-11-05. PMID:32514138. |
alzheimer's-associated plcγ2 is a signaling node required for both trem2 function and the inflammatory response in human microglia. |
2020-11-05 |
2023-08-13 |
mouse |
| Benjamin J Andreone, Laralynne Przybyla, Ceyda Llapashtica, Anil Rana, Sonnet S Davis, Bettina van Lengerich, Karin Lin, Ju Shi, Yuan Mei, Giuseppe Astarita, Gilbert Di Paolo, Thomas Sandmann, Kathryn M Monroe, Joseph W Lewcoc. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature neuroscience. vol 23. issue 8. 2020-11-05. PMID:32514138. |
human genetic data indicate that microglial dysfunction contributes to the pathology of alzheimer's disease (ad), exemplified by the identification of coding variants in triggering receptor expressed on myeloid cells 2 (trem2) and, more recently, in plcg2, a phospholipase-encoding gene expressed in microglia. |
2020-11-05 |
2023-08-13 |
mouse |
| Anurag K Singh, Gaurav Mishra, Anand Maurya, Rajendra Awasthi, Komal Kumari, Abhimanyu Thakur, Arati Rai, Gopal Kumar Rai, Bhupesh Sharma, Giriraj T Kulkarni, Santosh Kumar Sing. Role of TREM2 in Alzheimer's Disease and its Consequences on β- Amyloid, Tau and Neurofibrillary Tangles. Current Alzheimer research. vol 16. issue 13. 2020-10-06. PMID:31481003. |
however, whether decrease level of trem2 assists pathology of tau through changed clearance and pathological escalation of tau or through direct contact between microglia and neuron and any alternative possible mechanisms need to examine. |
2020-10-06 |
2023-08-13 |
Not clear |
| Yingyue Zhou, Tyler K Ulland, Marco Colonn. TREM2-Dependent Effects on Microglia in Alzheimer's Disease. Frontiers in aging neuroscience. vol 10. 2020-10-01. PMID:30038567. |
trem2 is an immunoreceptor primarily present on microglia in the cns that binds to polyanionic molecules. |
2020-10-01 |
2023-08-13 |
mouse |
| Alejandro Carrillo-Jimenez, Mar Puigdellívol, Anna Vilalta, Jose Luis Venero, Guy Charles Brown, Peter StGeorge-Hyslop, Miguel Angel Burguillo. Effective Knockdown of Gene Expression in Primary Microglia With siRNA and Magnetic Nanoparticles Without Cell Death or Inflammation. Frontiers in cellular neuroscience. vol 12. 2020-10-01. PMID:30297984. |
we demonstrate that this protocol successfully decreases the expression of two key genes associated with ad, the triggering receptor expressed in myeloid cells 2 (trem2) and cd33, in primary microglia cell cultures. |
2020-10-01 |
2023-08-13 |
Not clear |
| Matthias Brendel, Gernot Kleinberger, Federico Probst, Anna Jaworska, Felix Overhoff, Tanja Blume, Nathalie L Albert, Janette Carlsen, Simon Lindner, Franz Josef Gildehaus, Laurence Ozmen, Marc Suárez-Calvet, Peter Bartenstein, Karlheinz Baumann, Michael Ewers, Jochen Herms, Christian Haass, Axel Rominge. Increase of TREM2 during Aging of an Alzheimer's Disease Mouse Model Is Paralleled by Microglial Activation and Amyloidosis. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28197095. |
since trem2 is specifically expressed by microglia in the brain, we hypothesized that soluble trem2 (strem2) levels may increase together with |
2020-09-30 |
2023-08-13 |
mouse |
| Li Zhong, Zhen-Lian Zhang, Xinxiu Li, Chunyan Liao, Pengfei Mou, Tingting Wang, Zongqi Wang, Zhe Wang, Min Wei, Huaxi Xu, Guojun Bu, Xiao-Fen Che. TREM2/DAP12 Complex Regulates Inflammatory Responses in Microglia via the JNK Signaling Pathway. Frontiers in aging neuroscience. vol 9. 2020-09-30. PMID:28680398. |
trem2 has also been shown to stimulate the phagocytosis of apoptotic neurons and define the barrier function in microglia. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hiroyuki Konishi, Hiroshi Kiyam. Microglial TREM2/DAP12 Signaling: A Double-Edged Sword in Neural Diseases. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30127720. |
plasma membrane receptors play primary roles as activators of microglia and in this review, we focus on a receptor complex involving triggering receptor expressed on myeloid cells 2 (trem2) and dnax-activating protein of 12 kda (dap12), both of which are causative genes for nasu-hakola disease, a dementia with bone cysts. |
2020-09-30 |
2023-08-13 |
Not clear |
| Honghua Zheng, Baoying Cheng, Yanfang Li, Xin Li, Xiaofen Chen, Yun-Wu Zhan. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30532704. |
trem2 is specifically expressed in brain microglia and modulates microglial functions in response to key ad pathologies such as amyloid-β (aβ) plaques and tau tangles. |
2020-09-30 |
2023-08-13 |
Not clear |
| Honghua Zheng, Baoying Cheng, Yanfang Li, Xin Li, Xiaofen Chen, Yun-Wu Zhan. TREM2 in Alzheimer's Disease: Microglial Survival and Energy Metabolism. Frontiers in aging neuroscience. vol 10. 2020-09-30. PMID:30532704. |
in this review article, we discuss recent research progress in our understanding on the role of trem2 in microglia and its relevance to ad pathologies. |
2020-09-30 |
2023-08-13 |
Not clear |
| Hailan Yao, Kyle Coppola, Jonas Elias Schweig, Fiona Crawford, Michael Mullan, Daniel Pari. Distinct Signaling Pathways Regulate TREM2 Phagocytic and NFκB Antagonistic Activities. Frontiers in cellular neuroscience. vol 13. 2020-09-30. PMID:31649511. |
several genetic variants of the triggering receptor expressed on myeloid cells-2 (trem2) have been shown to increase the risk of developing alzheimer's disease (ad) supporting a role of microglia and immune cells in the pathobiology of ad. |
2020-09-30 |
2023-08-13 |
Not clear |
| Pascal Gervois, Ivo Lambricht. The Emerging Role of Triggering Receptor Expressed on Myeloid Cells 2 as a Target for Immunomodulation in Ischemic Stroke. Frontiers in immunology. vol 10. 2020-09-28. PMID:31379859. |
triggering receptor expressed on myeloid cells 2 (trem2) is a cell surface receptor which in the central nervous system is mainly expressed on microglia. |
2020-09-28 |
2023-08-13 |
Not clear |
| Juan García-Revilla, Isabel M Alonso-Bellido, Miguel A Burguillos, Antonio J Herrera, Ana M Espinosa-Oliva, Rocío Ruiz, Luis Cruz-Hernández, Irene García-Domínguez, María A Roca-Ceballos, Marti Santiago, José A Rodríguez-Gómez, Manuel Sarmiento Soto, Rocío M de Pablos, José L Vener. Reformulating Pro-Oxidant Microglia in Neurodegeneration. Journal of clinical medicine. vol 8. issue 10. 2020-09-28. PMID:31627485. |
however, the recent identification of endogenous disease-related ligands, which bind to and activate both tlrs and trem2, anticipates the existence of rather complex microglia responses. |
2020-09-28 |
2023-08-13 |
Not clear |
| Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pococ. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-28. PMID:31907987. |
a locked immunometabolic switch underlies trem2 r47h loss of function in human ipsc-derived microglia. |
2020-09-28 |
2023-08-13 |
human |
| Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pococ. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-28. PMID:31907987. |
microglia, the resident immune cell of the brain, express trem2, and microglial responses are implicated in dementia pathways. |
2020-09-28 |
2023-08-13 |
human |