| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
these results suggest that trem2 expression is important for post-stroke recovery, and that trem2 expression on brain resident microglia is more essential to this recovery, than that of circulating macrophages. |
2020-05-18 |
2023-08-13 |
mouse |
| Christel Claes, Johanna Van Den Daele, Ruben Boon, Sarah Schouteden, Alessio Colombo, Laura Sebastian Monasor, Mark Fiers, Laura Ordovás, FatemehArefeh Nami, Bernd Bohrmann, Sabina Tahirovic, Bart De Strooper, Catherine M Verfailli. Human stem cell-derived monocytes and microglia-like cells reveal impaired amyloid plaque clearance upon heterozygous or homozygous loss of TREM2. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 15. issue 3. 2020-05-05. PMID:30442540. |
murine microglia expressing the alzheimer's disease-linked trem2 |
2020-05-05 |
2023-08-13 |
human |
| Yingyue Zhou, Wilbur M Song, Prabhakar S Andhey, Amanda Swain, Tyler Levy, Kelly R Miller, Pietro L Poliani, Manuela Cominelli, Shikha Grover, Susan Gilfillan, Marina Cella, Tyler K Ulland, Konstantin Zaitsev, Akinori Miyashita, Takeshi Ikeuchi, Makoto Sainouchi, Akiyoshi Kakita, David A Bennett, Julie A Schneider, Michael R Nichols, Sean A Beausoleil, Jason D Ulrich, David M Holtzman, Maxim N Artyomov, Marco Colonn. Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease. Nature medicine. vol 26. issue 1. 2020-04-13. PMID:31932797. |
variants of the microglia receptor triggering receptor expressed on myeloid cells 2 (trem2) increase ad risk, and activation of disease-associated microglia (dam) is dependent on trem2 in mouse models of ad. |
2020-04-13 |
2023-08-13 |
mouse |
| Taylor R Jay, Victoria E von Saucken, Braulio Muñoz, Juan F Codocedo, Brady K Atwood, Bruce T Lamb, Gary E Landret. TREM2 is required for microglial instruction of astrocytic synaptic engulfment in neurodevelopment. Glia. vol 67. issue 10. 2020-03-16. PMID:31265185. |
to understand the role of trem2 on microglia more generally, we investigated changes in microglial function in trem2 |
2020-03-16 |
2023-08-13 |
Not clear |
| Gregory A Elder, Michelle E Ehrlich, Sam Gand. Relationship of traumatic brain injury to chronic mental health problems and dementia in military veterans. Neuroscience letters. vol 707. 2020-03-11. PMID:31141716. |
at the molecular level, recent studies have identified trem2 and tyrobp/dap12 as components of a key molecular hub linking inflammation and microglia to the pathophysiology of ad and possibly tbi. |
2020-03-11 |
2023-08-13 |
Not clear |
| Huiping Long, Gang Zhong, Chengzhi Wang, Jian Zhang, Yueling Zhang, Jinglian Luo, Shengliang Sh. TREM2 Attenuates Aβ1-42-Mediated Neuroinflammation in BV-2 Cells by Downregulating TLR Signaling. Neurochemical research. vol 44. issue 8. 2020-01-06. PMID:31134514. |
the triggering receptor expressed on myeloid cells 2 (trem2) gene is associated with the pathogenesis of load and plays important roles in mediating the phagocytosis of aβ by microglia and regulating inflammation in central nervous system. |
2020-01-06 |
2023-08-13 |
Not clear |
| Boris-Stephan Rauchmann, Thomas Schneider-Axmann, Panagiotis Alexopoulos, Robert Perneczk. CSF soluble TREM2 as a measure of immune response along the Alzheimer's disease continuum. Neurobiology of aging. vol 74. 2019-11-26. PMID:30458365. |
trem2 was suggested to be an important regulator of microglia during neurodegeneration, but previous studies report conflicting results in relation to soluble trem2 (strem2) in cerebrospinal fluid (csf) when using clinical criteria to classify alzheimer's disease (ad). |
2019-11-26 |
2023-08-13 |
human |
| Beata Peplonska, Mariusz Berdynski, Monika Mandecka, Anna Barczak, Magdalena Kuzma-Kozakiewicz, Maria Barcikowska, Cezary Zekanowsk. TREM2 variants in neurodegenerative disorders in the Polish population. Homozygosity and compound heterozygosity in FTD patients. Amyotrophic lateral sclerosis & frontotemporal degeneration. vol 19. issue 5-6. 2019-10-21. PMID:29557178. |
activation of the trem2 receptor on microglia stimulates phagocytosis and decreases the microglial proinflammatory response. |
2019-10-21 |
2023-08-13 |
human |
| Jerel Adam Fields, Brian Spencer, Mary Swinton, Emma Martine Qvale, María J Marquine, Arina Alexeeva, Sarah Gough, Benchawanna Soontornniyomkij, Elvira Valera, Eliezer Masliah, Cristian L Achim, Paula Desplat. Alterations in brain TREM2 and Amyloid-β levels are associated with neurocognitive impairment in HIV-infected persons on antiretroviral therapy. Journal of neurochemistry. vol 147. issue 6. 2019-09-27. PMID:30152135. |
in this retrospective study, we investigated trem2 expression levels and localization to microglia, aβ protein levels, and tumor necrosis factor (tnf)-α transcript levels in the frontal cortices of 52 hiv+ decedents. |
2019-09-27 |
2023-08-13 |
Not clear |
| Lihang Zhang, Juan Xu, Jinchao Gao, Yuncheng Wu, Ming Yin, Wenjuan Zha. CD200-, CX3CL1-, and TREM2-mediated neuron-microglia interactions and their involvements in Alzheimer's disease. Reviews in the neurosciences. vol 29. issue 8. 2019-08-29. PMID:29729150. |
accumulating studies have revealed that in the cns, cluster of differentiation-200 (cd200) and fractalkine (cx3cl1) expressed mainly on neurons and triggering receptor expressed on myeloid cells 2 (trem2) expressed mainly on microglia. |
2019-08-29 |
2023-08-13 |
Not clear |
| Tyler K Ulland, Marco Colonn. TREM2 - a key player in microglial biology and Alzheimer disease. Nature reviews. Neurology. vol 14. issue 11. 2019-08-29. PMID:30266932. |
variations in triggering receptor expressed on myeloid cells 2 (trem2), one of several genes for which expression is restricted to microglia in the brain, have now been shown to increase the risk of developing late-onset ad. |
2019-08-29 |
2023-08-13 |
mouse |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
this function of apoe is likely linked to triggering receptor expressed on myeloid cells 2 (trem2), which is expressed by microglia in the cns. |
2019-08-15 |
2023-08-13 |
Not clear |
| Yang Shi, David M Holtzma. Interplay between innate immunity and Alzheimer disease: APOE and TREM2 in the spotlight. Nature reviews. Immunology. vol 18. issue 12. 2019-08-15. PMID:30140051. |
here, we review the rapidly growing literature on the role of disease-associated microglia, trem2 and apoe in the pathogenesis of alzheimer disease and present an integrated view of innate immune function in alzheimer disease. |
2019-08-15 |
2023-08-13 |
Not clear |
| Min Wang, Xiaoping Gao, Kai Zhao, Hemu Chen, Mei Xu, Kai Wan. Effect of TREM2 on Release of Inflammatory Factor from LPS-stimulated Microglia and Its Possible Mechanism. Annals of clinical and laboratory science. vol 49. issue 2. 2019-08-13. PMID:31028072. |
effect of trem2 on release of inflammatory factor from lps-stimulated microglia and its possible mechanism. |
2019-08-13 |
2023-08-13 |
Not clear |
| Min Wang, Xiaoping Gao, Kai Zhao, Hemu Chen, Mei Xu, Kai Wan. Effect of TREM2 on Release of Inflammatory Factor from LPS-stimulated Microglia and Its Possible Mechanism. Annals of clinical and laboratory science. vol 49. issue 2. 2019-08-13. PMID:31028072. |
this study aims to explore the effect of triggering a receptor expressed on myeloid cells 2 (trem2) in lipopolysaccharide (lps)-stimulated primary microglia cells and its mechanisms. |
2019-08-13 |
2023-08-13 |
Not clear |
| Sho Takatori, Wenbo Wang, Akihiro Iguchi, Taisuke Tomit. Genetic Risk Factors for Alzheimer Disease: Emerging Roles of Microglia in Disease Pathomechanisms. Advances in experimental medicine and biology. vol 1118. 2019-08-02. PMID:30747419. |
interestingly, trem2 and many genes associated with disease risk are predominantly expressed in microglia, suggesting that these risk factors are involved in pathogenicity through common mechanisms involving microglia. |
2019-08-02 |
2023-08-13 |
Not clear |
| S Loppi, N Kolosowska, O Kärkkäinen, P Korhonen, M Huuskonen, A Grubman, H Dhungana, S Wojciechowski, Y Pomeshchik, M Giordano, H Kagechika, A White, S Auriola, J Koistinaho, G Landreth, K Hanhineva, K Kanninen, T Mal. HX600, a synthetic agonist for RXR-Nurr1 heterodimer complex, prevents ischemia-induced neuronal damage. Brain, behavior, and immunity. vol 73. 2019-07-31. PMID:30063972. |
along with the anti-inflammatory capacity of hx600 in vitro, treatment of ischemic mice with hx600 reduced ischemia induced iba-1, p38 and trem2 immunoreactivities, protected endogenous microglia from ischemia induced death and prevented leukocyte infiltration. |
2019-07-31 |
2023-08-13 |
mouse |
| Tomoko Sao, Yuta Yoshino, Kiyohiro Yamazaki, Yuki Ozaki, Yoko Mori, Shinichiro Ochi, Taku Yoshida, Takaaki Mori, Jun-Ichi Iga, Shu-Ichi Uen. TREM1 mRNA Expression in Leukocytes and Cognitive Function in Japanese Patients with Alzheimer's Disease. Journal of Alzheimer's disease : JAD. vol 64. issue 4. 2019-07-26. PMID:30010135. |
triggering receptor expressed on myeloid cells 2 (trem2) activates the innate immune system, promotes phagocytosis by microglia, and is associated with alzheimer's disease (ad). |
2019-07-26 |
2023-08-13 |
Not clear |
| C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. |
elevated trem2 gene dosage reprograms microglia responsivity and ameliorates pathological phenotypes in alzheimer's disease models. |
2019-07-15 |
2023-08-13 |
mouse |
| C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. |
to study whether increasing trem2 gene dosage could modify the disease pathogenesis, we developed bac transgenic mice expressing human trem2 (bac-trem2) in microglia. |
2019-07-15 |
2023-08-13 |
mouse |