| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| C Y Daniel Lee, Anthony Daggett, Xiaofeng Gu, Lu-Lin Jiang, Peter Langfelder, Xiaoguang Li, Nan Wang, Yingjun Zhao, Chang Sin Park, Yonatan Cooper, Isabella Ferando, Istvan Mody, Giovanni Coppola, Huaxi Xu, X William Yan. Elevated TREM2 Gene Dosage Reprograms Microglia Responsivity and Ameliorates Pathological Phenotypes in Alzheimer's Disease Models. Neuron. vol 97. issue 5. 2019-07-15. PMID:29518357. |
in summary, our study shows that a genomic transgene-driven increase in trem2 expression reprograms microglia responsivity and ameliorates neuropathological and behavioral deficits in ad mouse models. |
2019-07-15 |
2023-08-13 |
mouse |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
trem2 inhibits inflammatory responses in mouse microglia by suppressing the pi3k/nf-κb signaling. |
2019-07-15 |
2023-08-13 |
mouse |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
this study aimed to investigate the effects of triggering receptor expressed on myeloid cell-2 (trem2) on the production of pro-inflammatory mediators and cytokines induced by lipopolysaccharide (lps) in bv2 microglia. |
2019-07-15 |
2023-08-13 |
mouse |
| Caixia Li, Bing Zhao, Caizhao Lin, Zhiping Gong, Xiaoxia A. TREM2 inhibits inflammatory responses in mouse microglia by suppressing the PI3K/NF-κB signaling. Cell biology international. vol 43. issue 4. 2019-07-15. PMID:29663649. |
thus, we concluded that trem2 inhibited neuroinflammation by down-regulating pi3 k/akt and nf-kb signaling in bv2 microglia. |
2019-07-15 |
2023-08-13 |
mouse |
| Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30630532. |
trem2 is a transmembrane receptor that is predominantly expressed by microglia in the central nervous system. |
2019-07-05 |
2023-08-13 |
Not clear |
| Marc Suárez-Calvet, Estrella Morenas-Rodríguez, Gernot Kleinberger, Kai Schlepckow, Miguel Ángel Araque Caballero, Nicolai Franzmeier, Anja Capell, Katrin Fellerer, Brigitte Nuscher, Erden Eren, Johannes Levin, Yuetiva Deming, Laura Piccio, Celeste M Karch, Carlos Cruchaga, Leslie M Shaw, John Q Trojanowski, Michael Weiner, Michael Ewers, Christian Haas. Early increase of CSF sTREM2 in Alzheimer's disease is associated with tau related-neurodegeneration but not with amyloid-β pathology. Molecular neurodegeneration. vol 14. issue 1. 2019-07-05. PMID:30630532. |
soluble trem2 (strem2) resulting from shedding of the trem2 ectodomain can be detected in the cerebrospinal fluid (csf) and is a surrogate measure of trem2-mediated microglia function. |
2019-07-05 |
2023-08-13 |
Not clear |
| C Gussago, M Casati, E Ferri, B Arosi. The Triggering Receptor Expressed on Myeloid Cells-2 (TREM-2) as Expression of the Relationship between Microglia and Alzheimer's Disease: A Novel Marker for a Promising Pathway to Explore. The Journal of frailty & aging. vol 8. issue 2. 2019-06-27. PMID:30997915. |
it has been reported that genetic variants of the triggering receptor expressed on myeloid cells-2 (trem2), a cell-surface receptor expressed in microglial cells, greatly increase the risk of ad, thus suggesting an involvement of the microglia in the ad pathogenesis. |
2019-06-27 |
2023-08-13 |
Not clear |
| Bettina Linnartz-Gerlach, Liviu-Gabriel Bodea, Christine Klaus, Aurélien Ginolhac, Rashi Halder, Lasse Sinkkonen, Jochen Walter, Marco Colonna, Harald Neuman. TREM2 triggers microglial density and age-related neuronal loss. Glia. vol 67. issue 3. 2019-06-13. PMID:30548312. |
cultured microglia of trem2 knock-out mice showed reduced phagocytosis and oxidative burst. |
2019-06-13 |
2023-08-13 |
mouse |
| Melanie Hüttenrauch, Isabella Ogorek, Hans Klafki, Markus Otto, Christine Stadelmann, Sascha Weggen, Jens Wiltfang, Oliver Wirth. Glycoprotein NMB: a novel Alzheimer's disease associated marker expressed in a subset of activated microglia. Acta neuropathologica communications. vol 6. issue 1. 2019-06-12. PMID:30340518. |
our data further indicate that gpnmb is part of a microglia activation state that is only present under neurodegenerative conditions and that is characterized by the up-regulation of a subset of genes including trem2, apoe and cst7. |
2019-06-12 |
2023-08-13 |
mouse |
| Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. |
trem2 promotes aβ phagocytosis by upregulating c/ebpα-dependent cd36 expression in microglia. |
2019-06-11 |
2023-08-13 |
mouse |
| Su-Man Kim, Bo-Ram Mun, Sun-Jun Lee, Yechan Joh, Hwa-Youn Lee, Kon-Young Ji, Ha-Rim Choi, Eun-Hee Lee, Eun-Mi Kim, Ji-Hye Jang, Hyeong-Woo Song, Inhee Mook-Jung, Won-Seok Choi, Hyung-Sik Kan. TREM2 promotes Aβ phagocytosis by upregulating C/EBPα-dependent CD36 expression in microglia. Scientific reports. vol 7. issue 1. 2019-06-11. PMID:28894284. |
trem2 plays a critical role in the alleviation of alzheimer's disease by promoting aβ phagocytosis by microglia, but the detailed molecular mechanism underlying trem2-induced direct phagocytic activity of aβ remains to be revealed. |
2019-06-11 |
2023-08-13 |
mouse |
| Guillermo Carbajosa, Karim Malki, Nathan Lawless, Hong Wang, John W Ryder, Eva Wozniak, Kristie Wood, Charles A Mein, Richard J B Dobson, David A Collier, Michael J O'Neill, Angela K Hodges, Stephen J Newhous. Loss of Trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain. Neurobiology of aging. vol 69. 2019-05-21. PMID:29906661. |
loss of trem2 in microglia leads to widespread disruption of cell coexpression networks in mouse brain. |
2019-05-21 |
2023-08-13 |
mouse |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
functional studies of missense trem2 mutations in human stem cell-derived microglia. |
2019-04-23 |
2023-08-13 |
human |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
we used stem cell-derived microglia to study the consequences of missense mutations in the microglial-expressed protein triggering receptor expressed on myeloid cells 2 (trem2), which are causal for frontotemporal dementia-like syndrome and nasu-hakola disease. |
2019-04-23 |
2023-08-13 |
human |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
however, in the absence of plasma membrane trem2, microglia differentiate normally, respond to stimulation with lipopolysaccharide, and are phagocytically competent. |
2019-04-23 |
2023-08-13 |
human |
| Philip W Brownjohn, James Smith, Ravi Solanki, Ebba Lohmann, Henry Houlden, John Hardy, Sabine Dietmann, Frederick J Livese. Functional Studies of Missense TREM2 Mutations in Human Stem Cell-Derived Microglia. Stem cell reports. vol 10. issue 4. 2019-04-23. PMID:29606617. |
these data indicate that dementia-associated trem2 mutations have subtle effects on microglia biology, consistent with the adult onset of disease in individuals with these mutations. |
2019-04-23 |
2023-08-13 |
human |
| Maud Gratuze, Cheryl E G Leyns, David M Holtzma. New insights into the role of TREM2 in Alzheimer's disease. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30572908. |
genetic factors such as rare variants of trem2 (triggering receptor expressed on myeloid cells-2) strongly increase the risk of developing ad, confirming the role of microglia in ad pathogenesis. |
2019-04-12 |
2023-08-13 |
human |
| Maud Gratuze, Cheryl E G Leyns, David M Holtzma. New insights into the role of TREM2 in Alzheimer's disease. Molecular neurodegeneration. vol 13. issue 1. 2019-04-12. PMID:30572908. |
in this review, we summarize increases in our understanding of the involvement of trem2 and microglia in ad development that may open new therapeutic strategies targeting the immune system to influence ad pathogenesis. |
2019-04-12 |
2023-08-13 |
human |
| Jiang-Tao Li, Ying Zhan. TREM2 regulates innate immunity in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29655369. |
recent research has shown that the triggering receptor expressed on myeloid cells 2 (trem2) in microglia is closely related to the pathogenesis of alzheimer's disease (ad). |
2019-04-08 |
2023-08-13 |
Not clear |
| Jiang-Tao Li, Ying Zhan. TREM2 regulates innate immunity in Alzheimer's disease. Journal of neuroinflammation. vol 15. issue 1. 2019-04-08. PMID:29655369. |
trem2 is part of the trem family of receptors, which are expressed primarily in myeloid cells, including monocytes, dendritic cells, and microglia. |
2019-04-08 |
2023-08-13 |
Not clear |