| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas M Piers, Katharina Cosker, Anna Mallach, Gabriel Thomas Johnson, Rita Guerreiro, John Hardy, Jennifer M Pococ. A locked immunometabolic switch underlies TREM2 R47H loss of function in human iPSC-derived microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 2. 2020-09-28. PMID:31907987. |
we investigated the role of trem2 on the microglial metabolic function in human patient ipsc-derived microglia expressing loss of function variants in trem2. |
2020-09-28 |
2023-08-13 |
human |
| Gen-Lin He, Zhen Luo, Ting-Ting Shen, Ze-Ze Wang, Ping Li, Xue Luo, Ju Yang, Yu-Long Tan, Yuan Wang, Peng Gao, Xue-Sen Yan. TREM2 Regulates Heat Acclimation-Induced Microglial M2 Polarization Involving the PI3K-Akt Pathway Following EMF Exposure. Frontiers in cellular neuroscience. vol 13. 2020-09-28. PMID:32009907. |
the function of triggering receptor expressed on myeloid cells-2 (trem2) has been described within microglia with a beneficial activated phenotype. |
2020-09-28 |
2023-08-13 |
Not clear |
| Bailey A Loving, Kimberley D Bruc. Lipid and Lipoprotein Metabolism in Microglia. Frontiers in physiology. vol 11. 2020-09-28. PMID:32411016. |
increased expression of genes such as apolipoprotein e (apoe), triggering receptor expressed on myeloid cells 2 (trem2) and lipoprotein lipase (lpl) in microglia during development, damage, and disease, suggest that increased lipid metabolism is needed to fuel protective cellular functions such as phagocytosis. |
2020-09-28 |
2023-08-13 |
Not clear |
| Qiming Xu, Wei Xu, Hao Cheng, Hong Yuan, Xiangshi Ta. Efficacy and mechanism of cGAMP to suppress Alzheimer's disease by elevating TREM2. Brain, behavior, and immunity. vol 81. 2020-08-14. PMID:31283973. |
additionally, trem2 regulates microglia polarization from m1 towards m2 phenotype thereby achieves reduction of neuroinflammation in ad. |
2020-08-14 |
2023-08-13 |
mouse |
| Daria Bortolotti, Valentina Gentili, Antonella Rotola, Elisabetta Caselli, Roberta Rizz. HHV-6A infection induces amyloid-beta expression and activation of microglial cells. Alzheimer's research & therapy. vol 11. issue 1. 2020-08-06. PMID:31831060. |
we evaluated the effect of hhv-6a infection on microglial cell expression aβ and the activation status, determined by trem2, apoe, cytokines, and tau expression. |
2020-08-06 |
2023-08-13 |
Not clear |
| Stefan Prokop, Kelly R Miller, Sergio R Labra, Rose M Pitkin, Kevt'her Hoxha, Sneha Narasimhan, Lakshmi Changolkar, Alyssa Rosenbloom, Virginia M-Y Lee, John Q Trojanowsk. Impact of TREM2 risk variants on brain region-specific immune activation and plaque microenvironment in Alzheimer's disease patient brain samples. Acta neuropathologica. vol 138. issue 4. 2020-08-04. PMID:31350575. |
carriers of ad-associated risk variants in trem2 (triggering receptor expressed on myeloid cells 2) showed a reduction of plaque-associated microglia and a substantial increase in dystrophic neurites and overall pathological tau compared with age and disease stage matched ad patients without trem2 risk variants. |
2020-08-04 |
2023-08-13 |
human |
| Thomas Vogels, Adriana-Natalia Murgoci, Tomáš Hromádk. Intersection of pathological tau and microglia at the synapse. Acta neuropathologica communications. vol 7. issue 1. 2020-07-30. PMID:31277708. |
furthermore, ad risk genes such as triggering receptor expressed on myeloid cells 2 (trem2) and apolipoprotein e (apoe) are enriched in the innate immune system and modulate the neuroinflammatory response of microglia to tau pathology. |
2020-07-30 |
2023-08-13 |
Not clear |
| Michael Ewers, Nicolai Franzmeier, Marc Suárez-Calvet, Estrella Morenas-Rodriguez, Miguel Angel Araque Caballero, Gernot Kleinberger, Laura Piccio, Carlos Cruchaga, Yuetiva Deming, Martin Dichgans, John Q Trojanowski, Leslie M Shaw, Michael W Weiner, Christian Haas. Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer's disease. Science translational medicine. vol 11. issue 507. 2020-07-27. PMID:31462511. |
loss of function of trem2, a key receptor selectively expressed by microglia in the brain, contributes to the development of alzheimer's disease (ad). |
2020-07-27 |
2023-08-13 |
human |
| Francesca Grassivaro, Ramesh Menon, Massimo Acquaviva, Linda Ottoboni, Francesca Ruffini, Andrea Bergamaschi, Luca Muzio, Cinthia Farina, Gianvito Martin. Convergence between Microglia and Peripheral Macrophages Phenotype during Development and Neuroinflammation. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 4. 2020-07-23. PMID:31818979. |
this comprehensive approach demonstrated that the phenotypic differentiation between microglia and peripheral macrophages is age-dependent and that peripheral macrophages do express some of the most commonly described microglia-specific markers early during development, such as fcrls, p2ry12, tmem119, and trem2. |
2020-07-23 |
2023-08-13 |
mouse |
| Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Logan, Hilda O Solanoy, Hang Chen, Ankita Srivastava, Suresh B Poda, Pascal E Sanchez, Ryan J Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W Lewcock, Kathryn M Monroe, Gilbert Di Paol. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. vol 105. issue 5. 2020-07-07. PMID:31902528. |
loss-of-function (lof) variants of trem2, an immune receptor expressed in microglia, increase alzheimer's disease risk. |
2020-07-07 |
2023-08-13 |
human |
| Alicia A Nugent, Karin Lin, Bettina van Lengerich, Steve Lianoglou, Laralynne Przybyla, Sonnet S Davis, Ceyda Llapashtica, Junhua Wang, Do Jin Kim, Dan Xia, Anthony Lucas, Sulochanadevi Baskaran, Patrick C G Haddick, Melina Lenser, Timothy K Earr, Ju Shi, Jason C Dugas, Benjamin J Andreone, Todd Logan, Hilda O Solanoy, Hang Chen, Ankita Srivastava, Suresh B Poda, Pascal E Sanchez, Ryan J Watts, Thomas Sandmann, Giuseppe Astarita, Joseph W Lewcock, Kathryn M Monroe, Gilbert Di Paol. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. vol 105. issue 5. 2020-07-07. PMID:31902528. |
our studies identify trem2 as a key transcriptional regulator of cholesterol transport and metabolism under conditions of chronic myelin phagocytic activity, as trem2 lof causes pathogenic lipid accumulation in microglia. |
2020-07-07 |
2023-08-13 |
human |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
various immunohistochemical techniques and western blot analyses were applied to examine expressions of trem2, microglia, aβ, neuronal migration protein doublecortin (dcx) and bdnf in the hippocampus of mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
in the present study, we found the plaques-associated microglia lowly expressed trem2 and bdnf in aβ1-42 intra-hippocampal injected mice. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
this means that up-regulation of trem2 might induce the microglia to express the bdnf. |
2020-06-26 |
2023-08-13 |
mouse |
| Yubao Fan, Yuxin Ma, Weiling Huang, Xiaohui Cheng, Ningxin Gao, Guoying Li, Sumin Tia. Up-regulation of TREM2 accelerates the reduction of amyloid deposits and promotes neuronal regeneration in the hippocampus of amyloid beta1-42 injected mice. Journal of chemical neuroanatomy. vol 97. 2020-06-26. PMID:30790627. |
these findings further indicate that the level of trem2 may affect the microglia response to pathological process induced by aβ. |
2020-06-26 |
2023-08-13 |
mouse |
| Eyiyemisi C Damisah, Anupama Rai, Jaime Grutzendle. TREM2: Modulator of Lipid Metabolism in Microglia. Neuron. vol 105. issue 5. 2020-06-18. PMID:32135085. |
trem2: modulator of lipid metabolism in microglia. |
2020-06-18 |
2023-08-13 |
Not clear |
| Eyiyemisi C Damisah, Anupama Rai, Jaime Grutzendle. TREM2: Modulator of Lipid Metabolism in Microglia. Neuron. vol 105. issue 5. 2020-06-18. PMID:32135085. |
(2020) show by cell-specific lipidomics that trem2 deficiency leads to cholesterol ester (ce) overload in microglia. |
2020-06-18 |
2023-08-13 |
Not clear |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
triggering receptor expressed on myeloid cells-2 (trem2) is an innate immune receptor that promotes phagocytosis by myeloid cells such as microglia and macrophages. |
2020-05-18 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
we now clarify whether trem2 on brain microglia or circulating macrophages contribute to its beneficial role in ischemic stroke by generating bone marrow (bm) chimeric mice. |
2020-05-18 |
2023-08-13 |
mouse |
| Kota Kurisu, Zhen Zheng, Jong Youl Kim, Jian Shi, Atsushi Kanoke, Jialing Liu, Christine L Hsieh, Midori A Yenar. Triggering receptor expressed on myeloid cells-2 expression in the brain is required for maximal phagocytic activity and improved neurological outcomes following experimental stroke. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. vol 39. issue 10. 2020-05-18. PMID:30523715. |
mice with intact trem2 in brain microglia showed better neurological recovery and reduced infarct volumes, compared with mice lacking microglial trem2. |
2020-05-18 |
2023-08-13 |
mouse |