| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Li Yang, Peiyu Jin, Xiaoyan Wang, Qing Zhou, Xiaoli Lin, Shuhua X. Fluoride activates microglia, secretes inflammatory factors and influences synaptic neuron plasticity in the hippocampus of rats. Neurotoxicology. vol 69. 2019-03-15. PMID:30273629. |
we found that fluoride exposure activated microglia and increased the expression of dap12 and trem2, as well as promoted pro-inflammatory cytokines secretion via erk/mapk and p38/mapk signal pathways. |
2019-03-15 |
2023-08-13 |
rat |
| Lang-Yue Hu, Yang Zhou, Wen-Qiang Cui, Xue-Ming Hu, Li-Xia Du, Wen-Li Mi, Yu-Xia Chu, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Yin. Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29051087. |
furthermore, cisplatin enhanced triggering receptor expressed on myeloid cells 2 (trem2) /dnax-activating protein of 12 kda (dap12) signaling in the spinal cord microglia. |
2019-03-12 |
2023-08-13 |
mouse |
| Lang-Yue Hu, Yang Zhou, Wen-Qiang Cui, Xue-Ming Hu, Li-Xia Du, Wen-Li Mi, Yu-Xia Chu, Gen-Cheng Wu, Yan-Qing Wang, Qi-Liang Mao-Yin. Triggering receptor expressed on myeloid cells 2 (TREM2) dependent microglial activation promotes cisplatin-induced peripheral neuropathy in mice. Brain, behavior, and immunity. vol 68. 2019-03-12. PMID:29051087. |
functional blockage of trem2 or inhibition of microglia both benefited for cisplatin-induced peripheral neuropathy. |
2019-03-12 |
2023-08-13 |
mouse |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
as part of investigations of microglia using post-mortem resources provided by the medical research council cognitive function and ageing studies (mrc-cfas), we immunostained the cerebral cortex of 299 participants for trem2 using the sigma antibody hpa010917 and compared with the macrophage/microglial markers iba1 and cd68. |
2019-03-05 |
2023-08-13 |
human |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
however, in most cases (284/299), the trem2 antibody labelled monocytes within vascular lumens, but not microglia or perivascular macrophages. |
2019-03-05 |
2023-08-13 |
human |
| Marie Fahrenhold, Sonja Rakic, John Classey, Carol Brayne, Paul G Ince, James A R Nicoll, Delphine Boch. TREM2 expression in the human brain: a marker of monocyte recruitment? Brain pathology (Zurich, Switzerland). vol 28. issue 5. 2019-03-05. PMID:28987033. |
our observations, using the hpa010917 anti-trem2 antibody, suggest that trem2 is not expressed by microglia but instead seems to be a marker of recruited monocytes in the human brain. |
2019-03-05 |
2023-08-13 |
human |
| Aleksandra Deczkowska, Hadas Keren-Shaul, Assaf Weiner, Marco Colonna, Michal Schwartz, Ido Ami. Disease-Associated Microglia: A Universal Immune Sensor of Neurodegeneration. Cell. vol 173. issue 5. 2019-02-27. PMID:29775591. |
here, we propose that microglia are endowed with a dedicated sensory mechanism, which includes the trem2 signaling pathway, to detect damage within the cns in the form of neurodegeneration-associated molecular patterns (namps). |
2019-02-27 |
2023-08-13 |
human |
| Qingwen Cheng, Jean Danao, Santosh Talreja, Paul Wen, Jun Yin, Ning Sun, Chi-Ming Li, Danny Chui, David Tran, Samir Koirala, Hang Chen, Ian N Foltz, Songli Wang, Shilpa Sambashiva. TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant The Journal of biological chemistry. vol 293. issue 32. 2019-02-15. PMID:29599291. |
trem2-activating antibodies abrogate the negative pleiotropic effects of the alzheimer's disease variant triggering receptor expressed on myeloid cells 2 (trem2) is an orphan immune receptor expressed on cells of myeloid lineage such as macrophages and microglia. |
2019-02-15 |
2023-08-13 |
Not clear |
| Athena Sudom, Santosh Talreja, Jean Danao, Eric Bragg, Rob Kegel, Xiaoshan Min, Jason Richardson, Zhongqi Zhang, Nikolai Sharkov, Edoardo Marcora, Steve Thibault, Jodi Bradley, Steve Wood, Ai-Ching Lim, Hang Chen, Songli Wang, Ian N Foltz, Shilpa Sambashivan, Zhulun Wan. Molecular basis for the loss-of-function effects of the Alzheimer's disease-associated R47H variant of the immune receptor TREM2. The Journal of biological chemistry. vol 293. issue 32. 2019-02-07. PMID:29794134. |
triggering receptor expressed on myeloid cells 2 (trem2) is an immune receptor expressed on the surface of microglia, macrophages, dendritic cells, and osteoclasts. |
2019-02-07 |
2023-08-13 |
Not clear |
| Hongbei Xu, Song Mu, Wenyi Qi. Microglia TREM2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia/reperfusion rats. Biochemical and biophysical research communications. vol 503. issue 4. 2019-01-15. PMID:30149915. |
microglia trem2 is required for electroacupuncture to attenuate neuroinflammation in focal cerebral ischemia/reperfusion rats. |
2019-01-15 |
2023-08-13 |
rat |
| Manru Ren, Ying Guo, Xinbing Wei, Shaoqi Yan, Yue Qin, Xiumei Zhang, Fan Jiang, Haiyan Lo. TREM2 overexpression attenuates neuroinflammation and protects dopaminergic neurons in experimental models of Parkinson's disease. Experimental neurology. vol 302. 2018-12-11. PMID:29407460. |
triggering receptor expressed on myeloid cells-2 (trem2) was a newly identified receptor expressed on microglia. |
2018-12-11 |
2023-08-13 |
mouse |
| Li Zhong, Zongqi Wang, Daxin Wang, Zhe Wang, Yuka A Martens, Linbei Wu, Ying Xu, Kai Wang, Jianguo Li, Ruizhi Huang, Dan Can, Huaxi Xu, Guojun Bu, Xiao-Fen Che. Amyloid-beta modulates microglial responses by binding to the triggering receptor expressed on myeloid cells 2 (TREM2). Molecular neurodegeneration. vol 13. issue 1. 2018-11-09. PMID:29587871. |
trem2 is an innate immune receptor specifically expressed in microglia. |
2018-11-09 |
2023-08-13 |
Not clear |
| Yingjun Zhao, Xiaoguang Li, Timothy Huang, Lu-Lin Jiang, Zhenqiu Tan, Muxian Zhang, Irene Han-Juo Cheng, Xin Wang, Guojun Bu, Yun-Wu Zhang, Qi Wang, Huaxi X. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & molecular medicine. vol 49. issue 12. 2018-10-26. PMID:29611543. |
in the brain, trem2 is highly expressed on the cell surface of microglia, where it can transduce signals to regulate microglial functions such as phagocytosis. |
2018-10-26 |
2023-08-13 |
Not clear |
| Yingjun Zhao, Xiaoguang Li, Timothy Huang, Lu-Lin Jiang, Zhenqiu Tan, Muxian Zhang, Irene Han-Juo Cheng, Xin Wang, Guojun Bu, Yun-Wu Zhang, Qi Wang, Huaxi X. Intracellular trafficking of TREM2 is regulated by presenilin 1. Experimental & molecular medicine. vol 49. issue 12. 2018-10-26. PMID:29611543. |
furthermore, ps1 overexpression results in attenuated phagocytic uptake of aβ by microglia, which is reversed by trem2 overexpression. |
2018-10-26 |
2023-08-13 |
Not clear |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
as a recently identified susceptibility gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) encodes an immune receptor that is uniquely expressed on microglia, functioning as a modulator of microglial functions including phagocytosis and inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qing Gao, Zhou Ou, Peng-Yu Gong, Jian-Quan Shi, Liang Wu, Jun-Shan Zho. TREM2 Ameliorates Neuronal Tau Pathology Through Suppression of Microglial Inflammatory Response. Inflammation. vol 41. issue 3. 2018-10-10. PMID:29362997. |
more importantly, by manipulating trem2 levels in microglia with a lentiviral-mediated strategy, we demonstrated that trem2 ameliorated the pathological effects of activated microglia on neuronal tau hyperphosphorylation via suppression of microglial inflammatory response. |
2018-10-10 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
trem2 modulates microglia phenotypes in the neuroinflammation of parkinson's disease. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
triggering receptor expressed on myeloid cells-2 (trem2) is a recently identified immune receptor expressed by the microglia in the brain. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
emerging evidence indicates that trem2 enhances the phagocytosis function of microglia and suppress inflammation. |
2018-10-09 |
2023-08-13 |
mouse |
| Youwen Zhang, Shujun Feng, Kun Nie, Yan Li, Yuyuan Gao, Rong Gan, Limin Wang, Bing Li, Xuegang Sun, Lijuan Wang, Yuhu Zhan. TREM2 modulates microglia phenotypes in the neuroinflammation of Parkinson's disease. Biochemical and biophysical research communications. vol 499. issue 4. 2018-10-09. PMID:29621548. |
based on these evidence, we hypothesized that trem2 might play a protective role through regulating microglia polarization. |
2018-10-09 |
2023-08-13 |
mouse |