| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. |
consistent with this in vivo result, lps or oligomeric amyloid-β treatment down regulated trem2 but up-regulated treml2 expression in primary microglia. |
2017-09-19 |
2023-08-13 |
mouse |
| Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. |
in addition, the proliferation of primary microglia was significantly decreased when trem2 was down regulated, whereas it was increased on treml2 knockdown. |
2017-09-19 |
2023-08-13 |
mouse |
| Honghua Zheng, Chia-Chen Liu, Yuka Atagi, Xiao-Fen Chen, Lin Jia, Longyu Yang, Wencan He, Xilin Zhang, Silvia S Kang, Terrone L Rosenberry, John D Fryer, Yun-Wu Zhang, Huaxi Xu, Guojun B. Opposing roles of the triggering receptor expressed on myeloid cells 2 and triggering receptor expressed on myeloid cells-like transcript 2 in microglia activation. Neurobiology of aging. vol 42. 2017-09-19. PMID:27143430. |
our findings provide novel mechanistic insights into the functions of trem2 and treml2 in microglia and have implications on designing new therapeutic strategies to treat ad. |
2017-09-19 |
2023-08-13 |
mouse |
| Marc Suárez-Calvet, Gernot Kleinberger, Miguel Ángel Araque Caballero, Matthias Brendel, Axel Rominger, Daniel Alcolea, Juan Fortea, Alberto Lleó, Rafael Blesa, Juan Domingo Gispert, Raquel Sánchez-Valle, Anna Antonell, Lorena Rami, José L Molinuevo, Frederic Brosseron, Andreas Traschütz, Michael T Heneka, Hanne Struyfs, Sebastiaan Engelborghs, Kristel Sleegers, Christine Van Broeckhoven, Henrik Zetterberg, Bengt Nellgård, Kaj Blennow, Alexander Crispin, Michael Ewers, Christian Haas. sTREM2 cerebrospinal fluid levels are a potential biomarker for microglia activity in early-stage Alzheimer's disease and associate with neuronal injury markers. EMBO molecular medicine. vol 8. issue 5. 2017-09-13. PMID:26941262. |
trem2 is an innate immune receptor expressed on the surface of microglia. |
2017-09-13 |
2023-08-13 |
Not clear |
| Jie Yin, Xiaocui Liu, Qing He, Lujun Zhou, Zengqiang Yuan, Siqi Zha. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). vol 17. issue 12. 2017-09-04. PMID:27717139. |
triggering receptor expressed on myeloid cells 2 (trem2), an immune-modulatory receptor, is preferentially expressed in microglia of central nervous system. |
2017-09-04 |
2023-08-13 |
Not clear |
| Jie Yin, Xiaocui Liu, Qing He, Lujun Zhou, Zengqiang Yuan, Siqi Zha. Vps35-dependent recycling of Trem2 regulates microglial function. Traffic (Copenhagen, Denmark). vol 17. issue 12. 2017-09-04. PMID:27717139. |
trem2 might be involved in the development of alzheimer's disease (ad) through regulating the inflammatory responses and phagocytosis of microglia. |
2017-09-04 |
2023-08-13 |
Not clear |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
trem2 binds to apolipoproteins, including apoe and clu/apoj, and thereby facilitates uptake of amyloid-beta by microglia. |
2017-08-22 |
2023-08-13 |
human |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
genetic variants of trem2, a protein expressed selectively by microglia in the brain, are associated with alzheimer's disease (ad). |
2017-08-22 |
2023-08-13 |
human |
| Felix L Yeh, Yuanyuan Wang, Irene Tom, Lino C Gonzalez, Morgan Shen. TREM2 Binds to Apolipoproteins, Including APOE and CLU/APOJ, and Thereby Facilitates Uptake of Amyloid-Beta by Microglia. Neuron. vol 91. issue 2. 2017-08-22. PMID:27477018. |
trem2 knockout microglia showed reduced internalization of ldl and clu. |
2017-08-22 |
2023-08-13 |
human |
| Honghua Zheng, Lin Jia, Chia-Chen Liu, Zhouyi Rong, Li Zhong, Longyu Yang, Xiao-Fen Chen, John D Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guojun B. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28077724. |
triggering receptor expressed on myeloid cells 2 (trem2), which is expressed on myeloid cells including microglia in the cns, has recently been identified as a risk factor for alzheimer's disease (ad). |
2017-08-18 |
2023-08-13 |
Not clear |
| Honghua Zheng, Lin Jia, Chia-Chen Liu, Zhouyi Rong, Li Zhong, Longyu Yang, Xiao-Fen Chen, John D Fryer, Xin Wang, Yun-Wu Zhang, Huaxi Xu, Guojun B. TREM2 Promotes Microglial Survival by Activating Wnt/β-Catenin Pathway. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 37. issue 7. 2017-08-18. PMID:28077724. |
to elucidate the signaling pathways underlying reduced trem2 expression or loss of function in microglia, we respectively knocked down and knocked out the expression of trem2 in |
2017-08-18 |
2023-08-13 |
Not clear |
| Tyler K Ulland, Wilbur M Song, Stanley Ching-Cheng Huang, Jason D Ulrich, Alexey Sergushichev, Wandy L Beatty, Alexander A Loboda, Yingyue Zhou, Nigel J Cairns, Amal Kambal, Ekaterina Loginicheva, Susan Gilfillan, Marina Cella, Herbert W Virgin, Emil R Unanue, Yaming Wang, Maxim N Artyomov, David M Holtzman, Marco Colonn. TREM2 Maintains Microglial Metabolic Fitness in Alzheimer's Disease. Cell. vol 170. issue 4. 2017-08-16. PMID:28802038. |
here, we find that microglia in ad patients carrying trem2 risk variants and trem2-deficient mice with ad-like pathology have abundant autophagic vesicles, as do trem2-deficient macrophages under growth-factor limitation or endoplasmic reticulum (er) stress. combined metabolomics and rna sequencing (rna-seq) linked this anomalous autophagy to defective mammalian target of rapamycin (mtor) signaling, which affects atp levels and biosynthetic pathways. |
2017-08-16 |
2023-08-13 |
mouse |
| Li Zhong, Xiao-Fen Chen, Tingting Wang, Zhe Wang, Chunyan Liao, Zongqi Wang, Ruizhi Huang, Daxin Wang, Xinxiu Li, Linbei Wu, Lin Jia, Honghua Zheng, Meghan Painter, Yuka Atagi, Chia-Chen Liu, Yun-Wu Zhang, John D Fryer, Huaxi Xu, Guojun B. Soluble TREM2 induces inflammatory responses and enhances microglial survival. The Journal of experimental medicine. vol 214. issue 3. 2017-08-14. PMID:28209725. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor expressed in microglia in the brain. |
2017-08-14 |
2023-08-13 |
Not clear |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
trem2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
haplodeficiency of the microglia gene trem2 increases risk for late-onset alzheimer's disease (ad) but the mechanisms remain uncertain. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
we found that microglia processes, rich in trem2, tightly surround early amyloid fibrils and plaques promoting their compaction and insulation. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
in trem2- or dap12-haplodeficient mice and in humans with r47h trem2 mutations, microglia had a markedly reduced ability to envelop amyloid deposits. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 90. issue 4. 2017-08-03. PMID:27196974. |
thus, trem2 deficiency may disrupt the formation of a neuroprotective microglia barrier that regulates amyloid compaction and insulation. |
2017-08-03 |
2023-08-13 |
mouse |
| Peng Yuan, Carlo Condello, C Dirk Keene, Yaming Wang, Thomas D Bird, Steven M Paul, Wenjie Luo, Marco Colonna, David Baddeley, Jaime Grutzendle. TREM2 Haplodeficiency in Mice and Humans Impairs the Microglia Barrier Function Leading to Decreased Amyloid Compaction and Severe Axonal Dystrophy. Neuron. vol 92. issue 1. 2017-07-24. PMID:27710785. |
trem2 haplodeficiency in mice and humans impairs the microglia barrier function leading to decreased amyloid compaction and severe axonal dystrophy. |
2017-07-24 |
2023-08-13 |
mouse |
| Yaming Wang, Tyler K Ulland, Jason D Ulrich, Wilbur Song, John A Tzaferis, Justin T Hole, Peng Yuan, Thomas E Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B DeMattos, John R Cirrito, David M Holtzman, Marco Colonn. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of experimental medicine. vol 213. issue 5. 2017-07-21. PMID:27091843. |
however, in the absence of trem2, aβ plaques were not fully enclosed by microglia; they were more diffuse, less dense, and were associated with significantly greater neuritic damage. |
2017-07-21 |
2023-08-13 |
mouse |