| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yaming Wang, Tyler K Ulland, Jason D Ulrich, Wilbur Song, John A Tzaferis, Justin T Hole, Peng Yuan, Thomas E Mahan, Yang Shi, Susan Gilfillan, Marina Cella, Jaime Grutzendler, Ronald B DeMattos, John R Cirrito, David M Holtzman, Marco Colonn. TREM2-mediated early microglial response limits diffusion and toxicity of amyloid plaques. The Journal of experimental medicine. vol 213. issue 5. 2017-07-21. PMID:27091843. |
thus, trem2 protects from ad by enabling microglia to surround and alter aβ plaque structure, thereby limiting neuritic damage. |
2017-07-21 |
2023-08-13 |
mouse |
| Masaaki Kobayashi, Hiroyuki Konishi, Akira Sayo, Toshiyuki Takai, Hiroshi Kiyam. TREM2/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 43. 2017-07-14. PMID:27798193. |
the present study showed that the dnax-activating protein of 12 kda (dap12) and its associated "triggering receptor expressed on myeloid cells 2" (trem2) were predominantly expressed by microglia in the dorsal horn after spinal nerve injury, revealing a role for trem2/dap12 signaling in neuropathic pain. |
2017-07-14 |
2023-08-13 |
mouse |
| Gernot Kleinberger, Matthias Brendel, Eva Mracsko, Benedikt Wefers, Linda Groeneweg, Xianyuan Xiang, Carola Focke, Maximilian Deußing, Marc Suárez-Calvet, Fargol Mazaheri, Samira Parhizkar, Nadine Pettkus, Wolfgang Wurst, Regina Feederle, Peter Bartenstein, Thomas Mueggler, Thomas Arzberger, Irene Knuesel, Axel Rominger, Christian Haas. The FTD-like syndrome causing TREM2 T66M mutation impairs microglia function, brain perfusion, and glucose metabolism. The EMBO journal. vol 36. issue 13. 2017-07-14. PMID:28559417. |
the ftd-like syndrome causing trem2 t66m mutation impairs microglia function, brain perfusion, and glucose metabolism. |
2017-07-14 |
2023-08-13 |
mouse |
| Megan M Varnum, Kevin A Clayton, Asuka Yoshii-Kitahara, Grant Yonemoto, Lacin Koro, Seiko Ikezu, Tsuneya Ikez. A split-luciferase complementation, real-time reporting assay enables monitoring of the disease-associated transmembrane protein TREM2 in live cells. The Journal of biological chemistry. vol 292. issue 25. 2017-07-05. PMID:28490631. |
triggering receptor expressed on myeloid cells 2 (trem2) is a single transmembrane molecule uniquely expressed in microglia. |
2017-07-05 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of trem2 signaling, and the cytokine paradox in alzheimer's disease are further contributions to this article. |
2017-06-14 |
2023-08-13 |
Not clear |
| Katrin I Andreasson, Adam D Bachstetter, Marco Colonna, Florent Ginhoux, Clive Holmes, Bruce Lamb, Gary Landreth, Daniel C Lee, Donovan Low, Marina A Lynch, Alon Monsonego, M Kerry O'Banion, Milos Pekny, Till Puschmann, Niva Russek-Blum, Leslie A Sandusky, Maj-Linda B Selenica, Kazuyuki Takata, Jessica Teeling, Terrence Town, Linda J Van Eldi. Targeting innate immunity for neurodegenerative disorders of the central nervous system. Journal of neurochemistry. vol 138. issue 5. 2017-06-14. PMID:27248001. |
microglial ontogeny and induced pluripotent stem cell-derived microglia, advances of trem2 signaling, and the cytokine paradox in alzheimer's disease are further contributions to this article. |
2017-06-14 |
2023-08-13 |
Not clear |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
as a novel risk gene for alzheimer's disease (ad), triggering receptor expressed on myeloid cells 2 (trem2) gene encodes a type i transmembrane receptor that is uniquely expressed by the microglia in the brain. |
2017-06-13 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
in the present study, to test this hypothesis, a lentiviral-mediated strategy was employed to selectively overexpress trem2 on microglia in the brain of p301s mice. |
2017-06-13 |
2023-08-13 |
mouse |
| Teng Jiang, Ying-Dong Zhang, Qi Chen, Qing Gao, Xi-Chen Zhu, Jun-Shan Zhou, Jian-Quan Shi, Huan Lu, Lan Tan, Jin-Tai Y. TREM2 modifies microglial phenotype and provides neuroprotection in P301S tau transgenic mice. Neuropharmacology. vol 105. 2017-06-13. PMID:26802771. |
additionally, the suppressed neuroinflammation might be ascribed to the m2 activation of microglia induced by trem2, as the expression of m2 phenotype makers including arg1, retnla, il4 and il10 was markedly increased. |
2017-06-13 |
2023-08-13 |
mouse |
| Jun-ichi Satoh, Yoshihiro Kino, Nobutaka Motohashi, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Nobutaka Arai, Kiyotaka Nakamagoe, Akira Tamaoka, Yuko Saito, Kunimasa Arim. Immunohistochemical characterization of CD33 expression on microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 35. issue 6. 2016-12-13. PMID:26087043. |
trem2, by transmitting signals via the immunoreceptor tyrosine-based activation motif (itam) of dap12, stimulates phagocytic activity of microglia, and itam signaling is counterbalanced by sialic acid-binding immunoglobulin (ig)-like lectins (siglecs)-mediated immunoreceptor tyrosine-based inhibitory motif (itim) signaling. |
2016-12-13 |
2023-08-13 |
Not clear |
| Amanda Heslegrave, Wendy Heywood, Ross Paterson, Nadia Magdalinou, Johan Svensson, Per Johansson, Annika Öhrfelt, Kaj Blennow, John Hardy, Jonathan Schott, Kevin Mills, Henrik Zetterber. Increased cerebrospinal fluid soluble TREM2 concentration in Alzheimer's disease. Molecular neurodegeneration. vol 11. 2016-11-08. PMID:26754172. |
trem2 is expressed on microglia, the resident immune cells of the brain and has been linked to phagocytotic clearance of amyloid β (aβ) plaques. |
2016-11-08 |
2023-08-13 |
Not clear |
| Romain Fol, Jerome Braudeau, Susann Ludewig, Tobias Abel, Sascha W Weyer, Jan-Peter Roederer, Florian Brod, Mickael Audrain, Alexis-Pierre Bemelmans, Christian J Buchholz, Martin Korte, Nathalie Cartier, Ulrike C Mülle. Viral gene transfer of APPsα rescues synaptic failure in an Alzheimer's disease mouse model. Acta neuropathologica. vol 131. issue 2. 2016-10-17. PMID:26538149. |
in addition, appsα induced the recruitment of microglia with a ramified morphology into the vicinity of plaques and upregulated ide and trem2 expression suggesting enhanced plaque clearance. |
2016-10-17 |
2023-08-13 |
mouse |
| Konstantin Glebov, Patrick Wunderlich, Ilker Karaca, Jochen Walte. Functional involvement of γ-secretase in signaling of the triggering receptor expressed on myeloid cells-2 (TREM2). Journal of neuroinflammation. vol 13. 2016-10-06. PMID:26792193. |
triggering receptor expressed on myeloid cells-2 (trem2) exerts important functions in the regulation of monocytes, like dendritic cells, osteoclasts, tissue macrophages, and microglia. |
2016-10-06 |
2023-08-13 |
Not clear |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
as a novel susceptibility gene for these 2 diseases, triggering receptor expressed on myeloid cells 2 (trem2) gene encodes an immune receptor that is uniquely expressed by microglia. |
2016-08-15 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Jun-Shan Zhou, Lei Cao, Meng-Shan Tan, Hui-Fu Wang, Qi Chen, Ying-Dong Zhang, Jin-Tai Y. Silencing of TREM2 exacerbates tau pathology, neurodegenerative changes, and spatial learning deficits in P301S tau transgenic mice. Neurobiology of aging. vol 36. issue 12. 2016-08-15. PMID:26364736. |
herein, using p301s mice, we showed that trem2 was upregulated in microglia during disease progression. |
2016-08-15 |
2023-08-13 |
mouse |
| Marco Colonna, Yaming Wan. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nature reviews. Neuroscience. vol 17. issue 4. 2016-07-21. PMID:26911435. |
genome-wide association studies have identified rare variants of the gene that encodes triggering receptor expressed on myeloid cells 2 (trem2) - an immune receptor that is found in brain microglia - as risk factors for non-familial alzheimer disease (ad). |
2016-07-21 |
2023-08-13 |
Not clear |
| Marco Colonna, Yaming Wan. TREM2 variants: new keys to decipher Alzheimer disease pathogenesis. Nature reviews. Neuroscience. vol 17. issue 4. 2016-07-21. PMID:26911435. |
furthermore, animal studies have indicated that microglia have an important role in the brain response to amyloid-β (aβ) plaques and that trem2 variants may have an impact on such a function. |
2016-07-21 |
2023-08-13 |
Not clear |
| L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. |
although ligands for trem2 are largely unknown, the mitochondrial heat shock protein 60, expressed on cell surface of apoptotic neurons, is a specific ligand that activates trem2-mediated phagocytosis by microglia. |
2016-04-26 |
2023-08-13 |
human |
| L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. |
the association of trem2 mutations with neurodegenerative disease also calls for the understanding of the biology and pathological role of non-mutated trem2 on human brains and microglia. |
2016-04-26 |
2023-08-13 |
human |
| L-F Lue, C Schmitz, D G Walke. What happens to microglial TREM2 in Alzheimer's disease: Immunoregulatory turned into immunopathogenic? Neuroscience. vol 302. 2016-04-26. PMID:25281879. |
this review provides a summary of current literature in trem2 and dap12 from several aspects, and proposes a theory that loss of trem2 functions might contribute to the immunopathogenic role of microglia in alzheimer's disease. |
2016-04-26 |
2023-08-13 |
human |