| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
using appswe/ps1de9 mice, a transgenic model of ad, we showed that trem2 was upregulated in microglia during disease progression. |
2015-07-07 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
by knockdown and overexpression of trem2 in cultured primary microglia, we revealed that trem2 modulated microglial functions under ad context, as it facilitated aβ(1-42) phagocytosis and inhibited aβ(1-42)-triggered proinflammatory responses. |
2015-07-07 |
2023-08-13 |
mouse |
| Teng Jiang, Lan Tan, Xi-Chen Zhu, Qiao-Quan Zhang, Lei Cao, Meng-Shan Tan, Li-Ze Gu, Hui-Fu Wang, Zheng-Zheng Ding, Ying-Dong Zhang, Jin-Tai Y. Upregulation of TREM2 ameliorates neuropathology and rescues spatial cognitive impairment in a transgenic mouse model of Alzheimer's disease. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 13. 2015-07-07. PMID:25047746. |
taken together, our data suggest that the upregulation of trem2 serves as a compensatory response to aβ(1-42) and subsequently protects against ad progression by modulation of microglia functions. |
2015-07-07 |
2023-08-13 |
mouse |
| Serge Rives. TREM2 enables amyloid β clearance by microglia. Cell research. vol 25. issue 5. 2015-07-02. PMID:25828532. |
trem2 enables amyloid β clearance by microglia. |
2015-07-02 |
2023-08-13 |
mouse |
| Serge Rives. TREM2 enables amyloid β clearance by microglia. Cell research. vol 25. issue 5. 2015-07-02. PMID:25828532. |
trem2 acts as a signaling receptor involved in innate immunity for the natural clearance of this toxic protein by microglia. |
2015-07-02 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
triggering receptor expressed on myeloid cells 2 (trem2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
triggering receptor expressed on myeloid cells-2 (trem2) is a newly identified receptor expressed on microglia and is thought to phagocytose damaged brain cells. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
trem2 knockdown in microglia reduced microglial activation to an amoeboid phenotype and decreased the phagocytosis of injured neurons. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
the numbers of activated microglia and phagocytes in trem2 ko mice were decreased compared with wt mice, and foamy macrophages were nearly absent in the trem2 ko mice. |
2015-06-29 |
2023-08-13 |
mouse |
| Masahito Kawabori, Rachid Kacimi, Tiina Kauppinen, Cyrus Calosing, Jong Youl Kim, Christine L Hsieh, Mary C Nakamura, Midori A Yenar. Triggering receptor expressed on myeloid cells 2 (TREM2) deficiency attenuates phagocytic activities of microglia and exacerbates ischemic damage in experimental stroke. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 35. issue 8. 2015-06-29. PMID:25716838. |
postischemia, trem2 was highly expressed on microglia and trem2-fc fusion protein (used as a probe to identify potential trem2 binding partners) bound to an unknown trem2 ligand that colocalized to neurons. |
2015-06-29 |
2023-08-13 |
mouse |
| Taylor R Jay, Crystal M Miller, Paul J Cheng, Leah C Graham, Shane Bemiller, Margaret L Broihier, Guixiang Xu, Daniel Margevicius, J Colleen Karlo, Gregory L Sousa, Anne C Cotleur, Oleg Butovsky, Lynn Bekris, Susan M Staugaitis, James B Leverenz, Sanjay W Pimplikar, Gary E Landreth, Gareth R Howell, Richard M Ransohoff, Bruce T Lam. TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models. The Journal of experimental medicine. vol 212. issue 3. 2015-06-23. PMID:25732305. |
trem2 was detected on cd45(hi)ly6c(+) myeloid cells, but not on p2ry12(+) parenchymal microglia. |
2015-06-23 |
2023-08-13 |
mouse |
| Sheng Chih Jin, Bruno A Benitez, Celeste M Karch, Breanna Cooper, Tara Skorupa, David Carrell, Joanne B Norton, Simon Hsu, Oscar Harari, Yefei Cai, Sarah Bertelsen, Alison M Goate, Carlos Cruchag. Coding variants in TREM2 increase risk for Alzheimer's disease. Human molecular genetics. vol 23. issue 21. 2015-06-10. PMID:24899047. |
the triggering receptor expressed on myeloid 2 (trem2) is an immune phagocytic receptor expressed on brain microglia known to trigger phagocytosis and regulate the inflammatory response. |
2015-06-10 |
2023-08-13 |
human |
| Yaming Wang, Marina Cella, Kaitlin Mallinson, Jason D Ulrich, Katherine L Young, Michelle L Robinette, Susan Gilfillan, Gokul M Krishnan, Shwetha Sudhakar, Bernd H Zinselmeyer, David M Holtzman, John R Cirrito, Marco Colonn. TREM2 lipid sensing sustains the microglial response in an Alzheimer's disease model. Cell. vol 160. issue 6. 2015-05-12. PMID:25728668. |
we found that trem2 deficiency and haploinsufficiency augment β-amyloid (aβ) accumulation due to a dysfunctional response of microglia, which fail to cluster around aβ plaques and become apoptotic. |
2015-05-12 |
2023-08-13 |
mouse |
| Gernot Kleinberger, Yoshinori Yamanishi, Marc Suárez-Calvet, Eva Czirr, Ebba Lohmann, Elise Cuyvers, Hanne Struyfs, Nadine Pettkus, Andrea Wenninger-Weinzierl, Fargol Mazaheri, Sabina Tahirovic, Alberto Lleó, Daniel Alcolea, Juan Fortea, Michael Willem, Sven Lammich, José L Molinuevo, Raquel Sánchez-Valle, Anna Antonell, Alfredo Ramirez, Michael T Heneka, Kristel Sleegers, Julie van der Zee, Jean-Jacques Martin, Sebastiaan Engelborghs, Asli Demirtas-Tatlidede, Henrik Zetterberg, Christine Van Broeckhoven, Hakan Gurvit, Tony Wyss-Coray, John Hardy, Marco Colonna, Christian Haas. TREM2 mutations implicated in neurodegeneration impair cell surface transport and phagocytosis. Science translational medicine. vol 6. issue 243. 2015-02-23. PMID:24990881. |
trem2 is an innate immune receptor preferentially expressed by microglia and is involved in inflammation and phagocytosis. |
2015-02-23 |
2023-08-13 |
Not clear |
| Jun-Ichi Satoh, Nobutaka Motohashi, Yoshihiro Kino, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Nobutaka Arai, Kiyotaka Nakamagoe, Akira Tamaoka, Yuko Saito, Kunimasa Arim. LC3, an autophagosome marker, is expressed on oligodendrocytes in Nasu-Hakola disease brains. Orphanet journal of rare diseases. vol 9. 2014-11-12. PMID:24886140. |
trem2 and dap12 constitute a receptor/adaptor signaling complex expressed exclusively on osteoclasts, dendritic cells, macrophages, and microglia. |
2014-11-12 |
2023-08-13 |
Not clear |
| Jason D Ulrich, Mary Beth Finn, Yaming Wang, Alice Shen, Thomas E Mahan, Hong Jiang, Floy R Stewart, Laura Piccio, Marco Colonna, David M Holtzma. Altered microglial response to Aβ plaques in APPPS1-21 mice heterozygous for TREM2. Molecular neurodegeneration. vol 9. 2014-09-12. PMID:24893973. |
trem2 is expressed by microglia and is thought to regulate phagocytic and inflammatory microglial responses to brain pathology. |
2014-09-12 |
2023-08-13 |
mouse |
| Allal Boutajangout, Thomas Wisniewsk. The innate immune system in Alzheimer's disease. International journal of cell biology. vol 2013. 2014-06-24. PMID:24223593. |
trem2 is expressed on myeloid cells including microglia, macrophages, and dendritic cells, as well as osteoclasts. |
2014-06-24 |
2023-08-12 |
Not clear |
| Todd E Golde, Wolfgang J Streit, Paramita Chakrabart. Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Alzheimer's research & therapy. vol 5. issue 3. 2014-06-19. PMID:23692967. |
trem2 is a type 1 membrane receptor protein primarily expressed on microglia in the central nervous system that has been shown to regulate phagocytosis and activation of monocytes. |
2014-06-19 |
2023-08-12 |
Not clear |
| Peter N Alexandrov, Yuhai Zhao, Brandon M Jones, Surjyadipta Bhattacharjee, Walter J Luki. Expression of the phagocytosis-essential protein TREM2 is down-regulated by an aluminum-induced miRNA-34a in a murine microglial cell line. Journal of inorganic biochemistry. vol 128. 2014-06-07. PMID:23778113. |
expression of the phagocytosis-essential protein trem2 is down-regulated by an aluminum-induced mirna-34a in a murine microglial cell line. |
2014-06-07 |
2023-08-12 |
Not clear |
| Dorit Trudler, Orly Weinreb, Silvia A Mandel, Moussa B H Youdim, Dan Frenke. DJ-1 deficiency triggers microglia sensitivity to dopamine toward a pro-inflammatory phenotype that is attenuated by rasagiline. Journal of neurochemistry. vol 129. issue 3. 2014-06-04. PMID:24355073. |
moreover, we discovered that dj-1-deficient microglia have reduced expression of triggering receptor expressed on myeloid cells 2 (trem2), previously suggested as a risk factor for pro-inflammation in neurodegenerative diseases. |
2014-06-04 |
2023-08-12 |
Not clear |