| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Lih-Fen Lue, Christopher T Schmitz, Geidy Serrano, Lucia I Sue, Thomas G Beach, Douglas G Walke. TREM2 Protein Expression Changes Correlate with Alzheimer's Disease Neurodegenerative Pathologies in Post-Mortem Temporal Cortices. Brain pathology (Zurich, Switzerland). vol 25. issue 4. 2016-03-15. PMID:25186950. |
strong intensities of trem2 immunoreactivity were observed in the microglia associated with amyloid plaques and in neuritic pathology-enriched areas. |
2016-03-15 |
2023-08-13 |
human |
| Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzz. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of aging. vol 36. issue 5. 2016-02-29. PMID:25816748. |
we report that trem2 expression by microglia is significantly up-regulated upon prion infection. |
2016-02-29 |
2023-08-13 |
mouse |
| Caihong Zhu, Uli S Herrmann, Bei Li, Irina Abakumova, Rita Moos, Petra Schwarz, Elisabeth J Rushing, Marco Colonna, Adriano Aguzz. Triggering receptor expressed on myeloid cells-2 is involved in prion-induced microglial activation but does not contribute to prion pathogenesis in mouse brains. Neurobiology of aging. vol 36. issue 5. 2016-02-29. PMID:25816748. |
further phenotype profiling of microglia revealed that trem2 deficiency did not change microglial phenotypes. |
2016-02-29 |
2023-08-13 |
mouse |
| Yuka Atagi, Chia-Chen Liu, Meghan M Painter, Xiao-Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, Rosa Rademakers, Silvia S Kang, Huaxi Xu, Steven Younkin, Pritam Das, John D Fryer, Guojun B. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of biological chemistry. vol 290. issue 43. 2016-02-16. PMID:26374899. |
trem2 is highly expressed in microglia, the resident immune cells of the central nervous system. |
2016-02-16 |
2023-08-13 |
human |
| Yuka Atagi, Chia-Chen Liu, Meghan M Painter, Xiao-Fen Chen, Christophe Verbeeck, Honghua Zheng, Xia Li, Rosa Rademakers, Silvia S Kang, Huaxi Xu, Steven Younkin, Pritam Das, John D Fryer, Guojun B. Apolipoprotein E Is a Ligand for Triggering Receptor Expressed on Myeloid Cells 2 (TREM2). The Journal of biological chemistry. vol 290. issue 43. 2016-02-16. PMID:26374899. |
the functional significance of this binding was highlighted by increased phagocytosis of apoe-bound apoptotic n2a cells by primary microglia in a manner that depends on trem2 expression. |
2016-02-16 |
2023-08-13 |
human |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
trem2 regulates microglial cell activation in response to demyelination in vivo. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
however, it is unknown how trem2 contributes to microglia function in vivo. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
here, we identify a critical role for trem2 in the activation and function of microglia during cuprizone (cpz)-induced demyelination. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
trem2(-/-) microglia proliferated less in areas of demyelination and were less activated, displaying a more resting morphology and decreased expression of the activation markers mhc ii and inducible nitric oxide synthase as compared to wt. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
mechanistically, gene expression and ultrastructural analysis of microglia suggested a defect in myelin degradation and phagosome processing during cpz intoxication in trem2(-/-) microglia. |
2015-12-01 |
2023-08-13 |
mouse |
| Claudia Cantoni, Bryan Bollman, Danilo Licastro, Mingqiang Xie, Robert Mikesell, Robert Schmidt, Carla M Yuede, Daniela Galimberti, Gunilla Olivecrona, Robyn S Klein, Anne H Cross, Karel Otero, Laura Picci. TREM2 regulates microglial cell activation in response to demyelination in vivo. Acta neuropathologica. vol 129. issue 3. 2015-12-01. PMID:25631124. |
these findings place trem2 as a key regulator of microglia activation in vivo in response to tissue damage. |
2015-12-01 |
2023-08-13 |
mouse |
| Olena Korvatska, James B Leverenz, Suman Jayadev, Pamela McMillan, Irina Kurtz, Xindi Guo, Malia Rumbaugh, Mark Matsushita, Santhosh Girirajan, Michael O Dorschner, Kostantin Kiianitsa, Chang-En Yu, Zoran Brkanac, Gwenn A Garden, Wendy H Raskind, Thomas D Bir. R47H Variant of TREM2 Associated With Alzheimer Disease in a Large Late-Onset Family: Clinical, Genetic, and Neuropathological Study. JAMA neurology. vol 72. issue 8. 2015-11-05. PMID:26076170. |
the r47h variant in the triggering receptor expressed on myeloid cells 2 gene (trem2), a modulator of the immune response of microglia, is a strong genetic risk factor for alzheimer disease (ad) and possibly other neurodegenerative disorders. |
2015-11-05 |
2023-08-13 |
Not clear |
| Li Zhong, Xiao-Fen Chen, Zhen-Lian Zhang, Zhe Wang, Xin-Zhen Shi, Kai Xu, Yun-Wu Zhang, Huaxi Xu, Guojun B. DAP12 Stabilizes the C-terminal Fragment of the Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) and Protects against LPS-induced Pro-inflammatory Response. The Journal of biological chemistry. vol 290. issue 25. 2015-08-28. PMID:25957402. |
triggering receptor expressed on myeloid cells 2 (trem2) is a dap12-associated receptor expressed in microglia, macrophages, and other myeloid-derived cells. |
2015-08-28 |
2023-08-13 |
Not clear |
| Kazuya Takahash. [Neurodegenerative disease and TREM2]. Rinsho shinkeigaku = Clinical neurology. vol 54. issue 12. 2015-08-17. PMID:25519966. |
a murine in vitro study revealed that the absence of trem2 expression on microglia impaired phagocytosis for tissue debris clearance and increased pro-inflammatory cytokine production; these are necessary to maintain the microenvironmental homeostasis of the central nervous system. |
2015-08-17 |
2023-08-13 |
human |
| Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonn. TREM2 sustains microglial expansion during aging and response to demyelination. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893602. |
like other tissue-resident macrophage populations, microglia express the surface receptor triggering receptor expressed on myeloid cells 2 (trem2), which binds polyanions, such as dextran sulphate and bacterial lps, and activates downstream signaling cascades through the adapter dap12. |
2015-08-17 |
2023-08-13 |
mouse |
| Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonn. TREM2 sustains microglial expansion during aging and response to demyelination. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893602. |
in wt mice, microglia expanded in the corpus callosum with age, whereas aged trem2(-/-) mice had fewer microglia with an abnormal morphology. |
2015-08-17 |
2023-08-13 |
mouse |
| Pietro Luigi Poliani, Yaming Wang, Elena Fontana, Michelle L Robinette, Yoshinori Yamanishi, Susan Gilfillan, Marco Colonn. TREM2 sustains microglial expansion during aging and response to demyelination. The Journal of clinical investigation. vol 125. issue 5. 2015-08-17. PMID:25893602. |
in the cuprizone model of oligodendrocyte degeneration and demyelination, trem2(-/-) microglia failed to amplify transcripts indicative of activation, phagocytosis, and lipid catabolism in response to myelin damage. |
2015-08-17 |
2023-08-13 |
mouse |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
different mechanisms of apolipoprotein e isoform-dependent modulation of prostaglandin e2 production and triggering receptor expressed on myeloid cells 2 (trem2) expression after innate immune activation of microglia. |
2015-07-30 |
2023-08-13 |
mouse |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
we tested the hypothesis that apoe ε4 inheritance modulates both the pge2 pathway and trem2 expression using primary murine microglia from targeted replacement (tr) apoe3/3 and apoe4/4 mice. |
2015-07-30 |
2023-08-13 |
mouse |
| Xianwu Li, Kathleen S Montine, C Dirk Keene, Thomas J Montin. Different mechanisms of apolipoprotein E isoform-dependent modulation of prostaglandin E2 production and triggering receptor expressed on myeloid cells 2 (TREM2) expression after innate immune activation of microglia. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 5. 2015-07-30. PMID:25593125. |
microglial trem2 expression was reduced approximately 85% by all tlr activators; this reduction was approximately one-third greater in microglia from tr apoe4/4 mice. |
2015-07-30 |
2023-08-13 |
mouse |