| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Suzanne E Hickman, Joseph El Khour. TREM2 and the neuroimmunology of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24355566. |
using a novel technology called direct rna sequencing wedetermined the quantitative transcriptome of microglia, the principal innate neuroimmune cells and confirmed that trem2 is a major microglia-specific gene in the central nervous system. |
2014-05-19 |
2023-08-12 |
Not clear |
| Suzanne E Hickman, Joseph El Khour. TREM2 and the neuroimmunology of Alzheimer's disease. Biochemical pharmacology. vol 88. issue 4. 2014-05-19. PMID:24355566. |
here we propose that the mechanism(s) by which trem2 variants cause alzheimer's disease are via down regulation of the aβ phagocytic ability of microglia and by dysregulation of the pro-inflammatory response of these cells. |
2014-05-19 |
2023-08-12 |
Not clear |
| Mariela Chertoff, Kalpana Shrivastava, Berta Gonzalez, Laia Acarin, Lydia Giménez-Llor. Differential modulation of TREM2 protein during postnatal brain development in mice. PloS one. vol 8. issue 8. 2014-04-08. PMID:23977213. |
furthermore, the spatiotemporal expression pattern and characterization of trem2 indicate towards its other plausible roles in phagocytosis, progenitor's fate determination or microglia phenotype modulation during postnatal development. |
2014-04-08 |
2023-08-12 |
mouse |
| Paola Forabosco, Adaikalavan Ramasamy, Daniah Trabzuni, Robert Walker, Colin Smith, Jose Bras, Adam P Levine, John Hardy, Jennifer M Pocock, Rita Guerreiro, Michael E Weale, Mina Ryte. Insights into TREM2 biology by network analysis of human brain gene expression data. Neurobiology of aging. vol 34. issue 12. 2014-04-02. PMID:23855984. |
using network analysis, we detect a highly preserved trem2-containing module in human brain, show that it relates to microglia, and demonstrate that trem2 is a hub gene in 5 brain regions, including the hippocampus, suggesting that it can drive module function. |
2014-04-02 |
2023-08-12 |
human |
| Patrick Wunderlich, Konstantin Glebov, Nadja Kemmerling, Nguyen T Tien, Harald Neumann, Jochen Walte. Sequential proteolytic processing of the triggering receptor expressed on myeloid cells-2 (TREM2) protein by ectodomain shedding and γ-secretase-dependent intramembranous cleavage. The Journal of biological chemistry. vol 288. issue 46. 2014-01-23. PMID:24078628. |
triggering receptor expressed on myeloid cells-2 (trem2) and its signaling adaptor protein tyrobp/dap12 play important roles in signal transduction in dendritic cells, osteoclasts, tissue macrophages, and microglia. |
2014-01-23 |
2023-08-12 |
Not clear |
| Margarita Giraldo, Francisco Lopera, Ashley L Siniard, Jason J Corneveaux, Isabelle Schrauwen, Julian Carvajal, Claudia Muñoz, Manuel Ramirez-Restrepo, Chris Gaiteri, Amanda J Myers, Richard J Caselli, Kenneth S Kosik, Eric M Reiman, Matthew J Huentelma. Variants in triggering receptor expressed on myeloid cells 2 are associated with both behavioral variant frontotemporal lobar degeneration and Alzheimer's disease. Neurobiology of aging. vol 34. issue 8. 2013-11-04. PMID:23582655. |
trem2 is important in the phagocytosis of apoptotic neuronal cells by microglia in the brain. |
2013-11-04 |
2023-08-12 |
Not clear |
| Sruti Rayaprolu, Bianca Mullen, Matt Baker, Timothy Lynch, Elizabeth Finger, William W Seeley, Kimmo J Hatanpaa, Catherine Lomen-Hoerth, Andrew Kertesz, Eileen H Bigio, Carol Lippa, Keith A Josephs, David S Knopman, Charles L White, Richard Caselli, Ian R Mackenzie, Bruce L Miller, Magdalena Boczarska-Jedynak, Grzegorz Opala, Anna Krygowska-Wajs, Maria Barcikowska, Steven G Younkin, Ronald C Petersen, Nilüfer Ertekin-Taner, Ryan J Uitti, James F Meschia, Kevin B Boylan, Bradley F Boeve, Neill R Graff-Radford, Zbigniew K Wszolek, Dennis W Dickson, Rosa Rademakers, Owen A Ros. TREM2 in neurodegeneration: evidence for association of the p.R47H variant with frontotemporal dementia and Parkinson's disease. Molecular neurodegeneration. vol 8. 2013-09-20. PMID:23800361. |
given the key role of trem2 in the effective phagocytosis of apoptotic neuronal cells by microglia, we hypothesized that dysfunction of trem2 may play a more generalized role in neurodegeneration. |
2013-09-20 |
2023-08-12 |
Not clear |
| Jun-Ichi Satoh, Yoshihiro Shimamura, Hiroko Tabunok. Gene expression profile of THP-1 monocytes following knockdown of DAP12, a causative gene for Nasu-Hakola disease. Cellular and molecular neurobiology. vol 32. issue 3. 2012-12-20. PMID:22080356. |
trem2 and dap12 constitute a receptor/adaptor complex expressed on osteoclasts, dendritic cells, macrophages, monocytes, and microglia. |
2012-12-20 |
2023-08-12 |
human |
| Karel Otero, Masahiro Shinohara, Haibo Zhao, Marina Cella, Susan Gilfillan, Angela Colucci, Roberta Faccio, F Patrick Ross, Steve L Teitelbaum, Hiroshi Takayanagi, Marco Colonn. TREM2 and β-catenin regulate bone homeostasis by controlling the rate of osteoclastogenesis. Journal of immunology (Baltimore, Md. : 1950). vol 188. issue 6. 2012-04-19. PMID:22312126. |
trem2 is an immunoreceptor expressed on osteoclasts (oc) and microglia that transmits intracellular signals through the adaptor dap12. |
2012-04-19 |
2023-08-12 |
mouse |
| Y Numasawa, C Yamaura, S Ishihara, S Shintani, M Yamazaki, H Tabunoki, J-I Sato. Nasu-Hakola disease with a splicing mutation of TREM2 in a Japanese family. European journal of neurology. vol 18. issue 9. 2012-04-03. PMID:21834902. |
nasu-hakola disease (nhd) is a rare autosomal recessive disorder, characterized by a combination of progressive presenile dementia and formation of multifocal bone cysts, caused by genetic mutations of dap12 and trem2, which constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells, macrophages, and microglia. |
2012-04-03 |
2023-08-12 |
Not clear |
| Jun-Ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Naonobu Futamura, Michio Kobayashi, Itaru Toyoshima, Toshiaki Yoshioka, Katsuhiko Enomoto, Nobutaka Arai, Kunimasa Arim. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 4. 2011-12-12. PMID:21118401. |
trem2 and dap12 constitute a receptor/adapter signaling complex expressed on osteoclasts, dendritic cells (dc), macrophages and microglia. |
2011-12-12 |
2023-08-12 |
mouse |
| Jun-Ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Naonobu Futamura, Michio Kobayashi, Itaru Toyoshima, Toshiaki Yoshioka, Katsuhiko Enomoto, Nobutaka Arai, Kunimasa Arim. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 4. 2011-12-12. PMID:21118401. |
unexpectedly, trem2 was not expressed on microglia but expressed on a small subset of intravascular monocytes/macrophages in control and nhd brains. |
2011-12-12 |
2023-08-12 |
mouse |
| Jun-Ichi Satoh, Hiroko Tabunoki, Tsuyoshi Ishida, Saburo Yagishita, Kenji Jinnai, Naonobu Futamura, Michio Kobayashi, Itaru Toyoshima, Toshiaki Yoshioka, Katsuhiko Enomoto, Nobutaka Arai, Kunimasa Arim. Immunohistochemical characterization of microglia in Nasu-Hakola disease brains. Neuropathology : official journal of the Japanese Society of Neuropathology. vol 31. issue 4. 2011-12-12. PMID:21118401. |
these observations indicate that human microglia in brain tissues do not express trem2 and dap12-deficient microglia are preserved in nhd brains, suggesting that the loss of dap2/trem2 function in microglia might not be primarily responsible for the neuropathological phenotype of nhd. |
2011-12-12 |
2023-08-12 |
mouse |
| Benoit Melchior, Angie E Garcia, Bor-Kai Hsiung, Katherine M Lo, Jonathan M Doose, J Cameron Thrash, Anna K Stalder, Matthias Staufenbiel, Harald Neumann, Monica J Carso. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN neuro. vol 2. issue 3. 2011-12-06. PMID:20640189. |
transfection studies revealed that expression of trem2 correlated negatively with motility, but correlated positively with the ability of microglia to stimulate cd4(+) t-cell proliferation, tnf (tumour necrosis factor) and ccl2 (chemokine ligand 2) production, but not ifngamma (interferon gamma) production. |
2011-12-06 |
2023-08-12 |
mouse |
| Benoit Melchior, Angie E Garcia, Bor-Kai Hsiung, Katherine M Lo, Jonathan M Doose, J Cameron Thrash, Anna K Stalder, Matthias Staufenbiel, Harald Neumann, Monica J Carso. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN neuro. vol 2. issue 3. 2011-12-06. PMID:20640189. |
conversely, the phagocytic trem2(+) microglia on the plaque outer zones are positioned to capture and present self-antigens to cns (central nervous system)-infiltrating lymphocytes without promoting pro-inflammatory lymphocyte responses. |
2011-12-06 |
2023-08-12 |
mouse |
| Benoit Melchior, Angie E Garcia, Bor-Kai Hsiung, Katherine M Lo, Jonathan M Doose, J Cameron Thrash, Anna K Stalder, Matthias Staufenbiel, Harald Neumann, Monica J Carso. Dual induction of TREM2 and tolerance-related transcript, Tmem176b, in amyloid transgenic mice: implications for vaccine-based therapies for Alzheimer's disease. ASN neuro. vol 2. issue 3. 2011-12-06. PMID:20640189. |
instead, plaque-associated trem2(+) microglia have the potential to evoke neuroprotective immune responses that may serve to support cns function during pro-inflammatory anti-amyloid immune therapies. |
2011-12-06 |
2023-08-12 |
mouse |
| Bettina Linnartz, Yiner Wang, Harald Neuman. Microglial immunoreceptor tyrosine-based activation and inhibition motif signaling in neuroinflammation. International journal of Alzheimer's disease. vol 2010. 2011-07-14. PMID:20721346. |
microglial triggering receptor expressed on myeloid cells-2 (trem2), signal regulatory protein-beta1, and complement receptor-3 (cd11b/cd18) signal via the adaptor protein dap12 and activate phagocytic activity of microglia. |
2011-07-14 |
2023-08-12 |
Not clear |
| Luisa Stefano, Gabriella Racchetti, Fabio Bianco, Nadia Passini, Radhey S Gupta, Paola Panina Bordignon, Jacopo Meldoles. The surface-exposed chaperone, Hsp60, is an agonist of the microglial TREM2 receptor. Journal of neurochemistry. vol 110. issue 1. 2009-08-21. PMID:19457124. |
it might in contrast be appropriate for the binding of trem2 to hsp60 exposed at the surface of cells closely interacting with microglia. |
2009-08-21 |
2023-08-12 |
Not clear |
| Christine L Hsieh, Maya Koike, Steve C Spusta, Erene C Niemi, Midori Yenari, Mary C Nakamura, William E Seama. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302484. |
a role for trem2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. |
2009-07-16 |
2023-08-12 |
Not clear |
| Christine L Hsieh, Maya Koike, Steve C Spusta, Erene C Niemi, Midori Yenari, Mary C Nakamura, William E Seama. A role for TREM2 ligands in the phagocytosis of apoptotic neuronal cells by microglia. Journal of neurochemistry. vol 109. issue 4. 2009-07-16. PMID:19302484. |
however, evidence that microglia and neurons directly interact through trem2 to orchestrate microglial function is lacking. |
2009-07-16 |
2023-08-12 |
Not clear |