| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Nicole Scott-Hewitt, Fabio Perrucci, Raffaella Morini, Marco Erreni, Matthew Mahoney, Agata Witkowska, Alanna Carey, Elisa Faggiani, Lisa Theresia Schuetz, Sydney Mason, Matteo Tamborini, Matteo Bizzotto, Lorena Passoni, Fabia Filipello, Reinhard Jahn, Beth Stevens, Michela Matteol. Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia. The EMBO journal. vol 39. issue 16. 2021-04-06. PMID:32657463. |
in hippocampal neuron and microglia co-cultures, synapse elimination can be partially prevented by blocking accessibility of exposed ps using annexin v or through microglial loss of trem2. |
2021-04-06 |
2023-08-13 |
mouse |
| Yaping Wang, Yan Lin, Linhan Wang, Hongrui Zhan, Xiaoting Luo, Yanyan Zeng, Wen Wu, Xingmei Zhang, Fang Wan. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice. Aging. vol 12. issue 20. 2021-03-29. PMID:33065553. |
on the contrary, overexpression of trem2 alleviated the lps-induced inflammatory response and induced m2 phenotype microglia in vitro. |
2021-03-29 |
2023-08-13 |
mouse |
| Yaping Wang, Yan Lin, Linhan Wang, Hongrui Zhan, Xiaoting Luo, Yanyan Zeng, Wen Wu, Xingmei Zhang, Fang Wan. TREM2 ameliorates neuroinflammatory response and cognitive impairment via PI3K/AKT/FoxO3a signaling pathway in Alzheimer's disease mice. Aging. vol 12. issue 20. 2021-03-29. PMID:33065553. |
taken together, our results show that the protective functions of trem2, both in inflammatory response and cognitive impairment as well as in the decrease of m1 phenotype microglia, are related to pi3k/akt/foxo3a signaling pathway in ad mice. |
2021-03-29 |
2023-08-13 |
mouse |
| Zhaoji Liu, Jinhuan Ning, Xiaoyuan Zheng, Jian Meng, Linkun Han, Honghua Zheng, Li Zhong, Xiao-Fen Chen, Xian Zhang, Hong Luo, Dan Can, Huaxi Xu, Yun-Wu Zhan. TMEM59 interacts with TREM2 and modulates TREM2-dependent microglial activities. Cell death & disease. vol 11. issue 8. 2021-03-25. PMID:32826884. |
importantly, we found that overexpression of trem2 reduced tmem59 protein levels through promoting its degradation, whereas tmem59 levels were elevated in trem2-deficient microglia. |
2021-03-25 |
2023-08-13 |
Not clear |
| Ling-Zhi Ma, Lan Tan, Yan-Lin Bi, Xue-Ning Shen, Wei Xu, Ya-Hui Ma, Hong-Qi Li, Qiang Dong, Jin-Tai Y. Dynamic changes of CSF sTREM2 in preclinical Alzheimer's disease: the CABLE study. Molecular neurodegeneration. vol 15. issue 1. 2021-03-19. PMID:32276587. |
loss of function of triggering receptor expressed on myeloid cell 2 (trem2), a key receptor selectively expressed by microglia in the brain, contributes to the development of alzheimer's disease (ad). |
2021-03-19 |
2023-08-13 |
Not clear |
| Mar Bosch-Queralt, Ludovico Cantuti-Castelvetri, Alkmini Damkou, Martina Schifferer, Kai Schlepckow, Ioannis Alexopoulos, Dieter Lütjohann, Christian Klose, Lenka Vaculčiaková, Takahiro Masuda, Marco Prinz, Kathryn M Monroe, Gilbert Di Paolo, Joseph W Lewcock, Christian Haass, Mikael Simon. Diet-dependent regulation of TGFβ impairs reparative innate immune responses after demyelination. Nature metabolism. vol 3. issue 2. 2021-03-15. PMID:33619376. |
blocking tgfβ or promoting triggering receptor expressed on myeloid cells 2 (trem2) activity restores microglia responsiveness and myelin-debris clearance after demyelinating injury. |
2021-03-15 |
2023-08-13 |
mouse |
| Yvette Zarb, Sucheta Sridhar, Sina Nassiri, Sebastian Guido Utz, Johanna Schaffenrath, Upasana Maheshwari, Elisabeth J Rushing, K Peter R Nilsson, Mauro Delorenzi, Marco Colonna, Melanie Greter, Annika Kelle. Microglia control small vessel calcification via TREM2. Science advances. vol 7. issue 9. 2021-03-12. PMID:33637522. |
microglia control small vessel calcification via trem2. |
2021-03-12 |
2023-08-13 |
mouse |
| Sujin Kim, Hyunju Chung, Han Ngoc Mai, Yunkwon Nam, Soo Jung Shin, Yong Ho Park, Mi Joo Chung, Jong Kil Lee, Hak Young Rhee, Geon-Ho Jahng, Youngkyong Kim, Yu Jin Lim, Moonkyoo Kong, Minho Moon, Weon Kuu Chun. Low-Dose Ionizing Radiation Modulates Microglia Phenotypes in the Models of Alzheimer's Disease. International journal of molecular sciences. vol 21. issue 12. 2021-03-09. PMID:32630597. |
the activation of triggering receptor expressed on myeloid cells 2 (trem2) may result in microglia phenotype switching from m1 to m2, which finally attenuated aβ deposition and memory loss in ad. |
2021-03-09 |
2023-08-13 |
mouse |
| José A Rodríguez-Gómez, Edel Kavanagh, Pinelopi Engskog-Vlachos, Mikael K R Engskog, Antonio J Herrera, Ana M Espinosa-Oliva, Bertrand Joseph, Nabil Hajji, José L Venero, Miguel A Burguillo. Microglia: Agents of the CNS Pro-Inflammatory Response. Cells. vol 9. issue 7. 2021-03-04. PMID:32709045. |
here, we discuss the phenotypic transformation from homeostatic microglia towards reactive microglia, initiated by specific ligand binding to pattern recognition receptors including toll-like receptor-4 (tlr4) or triggering receptors expressed on myeloid cells-2 (trem2), as well as pro-inflammatory signaling pathways triggered such as the caspase-mediated immune response. |
2021-03-04 |
2023-08-13 |
human |
| Wenhui Qu, Ling L. Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 40. issue 50. 2021-03-04. PMID:33139402. |
triggering receptor expressed on myeloid cells 2 (trem2), a receptor exclusively expressed by microglia in the brain, modulates microglial immune homeostasis. |
2021-03-04 |
2023-08-13 |
mouse |
| Shoutang Wang, Meer Mustafa, Carla M Yuede, Santiago Viveros Salazar, Philip Kong, Hua Long, Michael Ward, Omer Siddiqui, Robert Paul, Susan Gilfillan, Adiljan Ibrahim, Hervé Rhinn, Ilaria Tassi, Arnon Rosenthal, Tina Schwabe, Marco Colonn. Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. The Journal of experimental medicine. vol 217. issue 9. 2021-03-02. PMID:32579671. |
anti-human trem2 induces microglia proliferation and reduces pathology in an alzheimer's disease model. |
2021-03-02 |
2023-08-13 |
mouse |
| Shoutang Wang, Meer Mustafa, Carla M Yuede, Santiago Viveros Salazar, Philip Kong, Hua Long, Michael Ward, Omer Siddiqui, Robert Paul, Susan Gilfillan, Adiljan Ibrahim, Hervé Rhinn, Ilaria Tassi, Arnon Rosenthal, Tina Schwabe, Marco Colonn. Anti-human TREM2 induces microglia proliferation and reduces pathology in an Alzheimer's disease model. The Journal of experimental medicine. vol 217. issue 9. 2021-03-02. PMID:32579671. |
trem2 is a receptor for lipids expressed in microglia. |
2021-03-02 |
2023-08-13 |
mouse |
| Zhouyi Rong, Baoying Cheng, Li Zhong, Xiaowen Ye, Xin Li, Lin Jia, Yanfang Li, Francis Shue, Na Wang, Yiyun Cheng, Xiaohua Huang, Chia-Chen Liu, John D Fryer, Xin Wang, Yun-Wu Zhang, Honghua Zhen. Activation of FAK/Rac1/Cdc42-GTPase signaling ameliorates impaired microglial migration response to Aβ FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 34. issue 8. 2021-02-25. PMID:32613609. |
activation of fak/rac1/cdc42-gtpase signaling ameliorates impaired microglial migration response to aβ mutation of triggering receptor expressed on myeloid cells 2 (trem2) impairs the response of microglia to amyloid-β (aβ) pathology in alzheimer's disease (ad), although the mechanism governing trem2-regulated microglia recruitment to aβ plaques remains unresolved. |
2021-02-25 |
2023-08-13 |
Not clear |
| Siqiang Ren, Wen Yao, Marc D Tambini, Tao Yin, Kelly A Norris, Luciano D'Adami. Microglia eLife. vol 9. 2021-02-22. PMID:32579116. |
microglia to study the mechanisms by which the p.r47h variant of the microglia gene and alzheimer's disease (ad) risk factor trem2 increases dementia risk, we created |
2021-02-22 |
2023-08-13 |
Not clear |
| Juan Kong, Zhigang Du, Li Don. Pinitol Prevents Lipopolysaccharide (LPS)-Induced Inflammatory Responses in BV2 Microglia Mediated by TREM2. Neurotoxicity research. vol 38. issue 1. 2021-02-18. PMID:32198705. |
pinitol prevents lipopolysaccharide (lps)-induced inflammatory responses in bv2 microglia mediated by trem2. |
2021-02-18 |
2023-08-13 |
Not clear |
| Xiao-Yan Li, Hong-Mei Wang, Ya Zhao, Chen Li, Jun Lu, Ji-Hong Wu, Ya T. [Effect of acupuncture on microglia activation in prefrontal cortex of chronic stress-induced depression rats]. Zhen ci yan jiu = Acupuncture research. vol 46. issue 1. 2021-02-10. PMID:33559426. |
to observe the effect of acupuncture on the expression of proinflammatory cytokines interleukin-1β (il-1β), interleukin-6 (il-6), microglia marker ion calcium adaptor protein (iba-1) and triggering receptor expressed on myeloid cells 2 (trem2) in the prefrontal cortex of chronic stress-induced depression rats, so as to explore its antidepressant mechanism. |
2021-02-10 |
2023-08-13 |
rat |
| Maud Gratuze, Cheryl Eg Leyns, Andrew D Sauerbeck, Marie-Kim St-Pierre, Monica Xiong, Nayeon Kim, Javier Remolina Serrano, Marie-Ève Tremblay, Terrance T Kummer, Marco Colonna, Jason D Ulrich, David M Holtzma. Impact of TREM2R47H variant on tau pathology-induced gliosis and neurodegeneration. The Journal of clinical investigation. vol 130. issue 9. 2021-02-08. PMID:32544086. |
it is likely that these trem2 variants increase ad risk by decreasing the response of microglia to aβ and its local toxicity. |
2021-02-08 |
2023-08-13 |
mouse |
| Mar Puigdellívol, David H Allendorf, Guy C Brow. Sialylation and Galectin-3 in Microglia-Mediated Neuroinflammation and Neurodegeneration. Frontiers in cellular neuroscience. vol 14. 2021-02-03. PMID:32581723. |
activated microglia also release galectin-3 (gal-3), which: (i) further activates microglia via binding to tlr4 and trem2, (ii) binds to desialylated neurons opsonizing them for phagocytosis via mer tyrosine kinase, and (iii) promotes aβ aggregation and toxicity |
2021-02-03 |
2023-08-13 |
Not clear |
| Anne-Brita Knapskog, Kristi Henjum, Ane-Victoria Idland, Rannveig Sakshaug Eldholm, Karin Persson, Ingvild Saltvedt, Leiv Otto Watne, Knut Engedal, Lars N G Nilsso. Cerebrospinal fluid sTREM2 in Alzheimer's disease: comparisons between clinical presentation and AT classification. Scientific reports. vol 10. issue 1. 2020-12-24. PMID:32985583. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor expressed by microglia. |
2020-12-24 |
2023-08-13 |
Not clear |
| Gemma Manich, Ariadna Regina Gómez-López, Beatriz Almolda, Nàdia Villacampa, Mireia Recasens, Kalpana Shrivastava, Berta González, Bernardo Castellan. Differential Roles of TREM2+ Microglia in Anterograde and Retrograde Axonal Injury Models. Frontiers in cellular neuroscience. vol 14. 2020-12-18. PMID:33328887. |
in the last years, the microglial receptor triggering receptor expressed on myeloid cells-2 (trem2) has been defined to mediate several microglial functions, including phagocytosis, survival, proliferation, and migration, and to be a key regulator of a new common microglial signature induced under neurodegenerative conditions and aging, also known as disease-associated microglia (dam). |
2020-12-18 |
2023-08-13 |
Not clear |