| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Marvin Reich, Iñaki Paris, Martin Ebeling, Nadine Dahm, Christophe Schweitzer, Dieter Reinhardt, Roland Schmucki, Megana Prasad, Fabian Köchl, Marcel Leist, Sally A Cowley, Jitao David Zhang, Christoph Patsch, Simon Gutbier, Markus Britschg. Alzheimer's Risk Gene TREM2 Determines Functional Properties of New Type of Human iPSC-Derived Microglia. Frontiers in immunology. vol 11. 2021-06-21. PMID:33613545. |
alzheimer's risk gene trem2 determines functional properties of new type of human ipsc-derived microglia. |
2021-06-21 |
2023-08-13 |
human |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
apoe and trem2 are major genetic risk factors for alzheimer's disease (ad), but how they affect microglia response to aβ remains unclear. |
2021-06-15 |
2023-08-13 |
mouse |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
bulk and single-cell rna-seq demonstrate that, compared to apoe4, cortical infusion of apoe3 lipoproteins upregulates a higher proportion of genes linked to an activated microglia response, and this trend is augmented by trem2 deficiency. |
2021-06-15 |
2023-08-13 |
mouse |
| Nicholas F Fitz, Kyong Nyon Nam, Cody M Wolfe, Florent Letronne, Brittany E Playso, Bistra E Iordanova, Takashi D Y Kozai, Richard J Biedrzycki, Valerian E Kagan, Yulia Y Tyurina, Xianlin Han, Iliya Lefterov, Radosveta Koldamov. Phospholipids of APOE lipoproteins activate microglia in an isoform-specific manner in preclinical models of Alzheimer's disease. Nature communications. vol 12. issue 1. 2021-06-15. PMID:34099706. |
in vitro, lack of trem2 decreases aβ uptake by apoe4-treated microglia only, suggesting trem2-apoe interaction. |
2021-06-15 |
2023-08-13 |
mouse |
| Milan Stoiljkovic, Karel Otero Gutierrez, Craig Kelley, Tamas L Horvath, Mihály Hajó. TREM2 Deficiency Disrupts Network Oscillations Leading to Epileptic Activity and Aggravates Amyloid-β-Related Hippocampal Pathophysiology in Mice. Journal of Alzheimer's disease : JAD. 2021-06-14. PMID:34120899. |
in the brain, trem2 protein is specifically expressed on microglia suggesting their active involvement in driving disease pathology. |
2021-06-14 |
2023-08-13 |
mouse |
| Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi, Laura Picci. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32772264. |
trem2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. |
2021-05-31 |
2023-08-13 |
human |
| Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi, Laura Picci. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32772264. |
trem2 is expressed by microglia and promotes microglial survival, proliferation, and phagocytic activity. |
2021-05-31 |
2023-08-13 |
human |
| Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi, Laura Picci. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32772264. |
most importantly, antibody-dependent trem2 activation on microglia increased density of oligodendrocyte precursors in areas of demyelination, as well as the formation of mature oligodendrocytes thus enhancing remyelination and axonal integrity. |
2021-05-31 |
2023-08-13 |
human |
| Francesca Cignarella, Fabia Filipello, Bryan Bollman, Claudia Cantoni, Alberto Locca, Robert Mikesell, Melissa Manis, Adiljan Ibrahim, Li Deng, Bruno A Benitez, Carlos Cruchaga, Danilo Licastro, Kathie Mihindukulasuriya, Oscar Harari, Michael Buckland, David M Holtzman, Arnon Rosenthal, Tina Schwabe, Ilaria Tassi, Laura Picci. TREM2 activation on microglia promotes myelin debris clearance and remyelination in a model of multiple sclerosis. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32772264. |
these results are relevant as they propose trem2 on microglia as a potential new target to promote remyelination. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
apoe and trem2 regulate amyloid-responsive microglia in alzheimer's disease. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
using single-nucleus rna sequencing of postmortem human brain with varied apoe and trem2 genotypes and neuropathology, we identified distinct microglia subpopulations, including a subpopulation of cd163-positive amyloid-responsive microglia (arm) that are depleted in cases with apoe and trem2 risk variants. |
2021-05-31 |
2023-08-13 |
human |
| Aivi T Nguyen, Kui Wang, Gang Hu, Xuran Wang, Zhen Miao, Joshua A Azevedo, EunRan Suh, Vivianna M Van Deerlin, David Choi, Kathryn Roeder, Mingyao Li, Edward B Le. APOE and TREM2 regulate amyloid-responsive microglia in Alzheimer's disease. Acta neuropathologica. vol 140. issue 4. 2021-05-31. PMID:32840654. |
we validated our single-nucleus rna sequencing findings in an expanded cohort of ad cases, demonstrating that apoe and trem2 risk variants are associated with a significant reduction in cd163-positive amyloid-responsive microglia. |
2021-05-31 |
2023-08-13 |
human |
| Yu-Ling Xu, Xiao-Yu Liu, Sai-Bo Cheng, Pei-Kun He, Mu-Keng Hong, Yu-Yao Chen, Feng-Hua Zhou, Yu-Hua Ji. Geniposide Enhances Macrophage Autophagy through Downregulation of TREM2 in Atherosclerosis. The American journal of Chinese medicine. vol 48. issue 8. 2021-05-28. PMID:33308094. |
trem2 is a key factor in the development of alzheimer's disease (ad), the deficiency of which leads to anomalous autophagy in microglia. |
2021-05-28 |
2023-08-13 |
Not clear |
| Jiaolong Yang, Zhihui Fu, Xingyu Zhang, Min Xiong, Lanxia Meng, Zhentao Zhan. TREM2 ectodomain and its soluble form in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32635934. |
triggering receptor expressed on myeloid cells 2 (trem2) is a receptor mainly expressed on the surface of microglia. |
2021-05-24 |
2023-08-13 |
Not clear |
| Jiaolong Yang, Zhihui Fu, Xingyu Zhang, Min Xiong, Lanxia Meng, Zhentao Zhan. TREM2 ectodomain and its soluble form in Alzheimer's disease. Journal of neuroinflammation. vol 17. issue 1. 2021-05-24. PMID:32635934. |
trem2 is a transmembrane protein that is specifically expressed on microglia in the brain. |
2021-05-24 |
2023-08-13 |
Not clear |
| Daniel C Ellwanger, Shoutang Wang, Simone Brioschi, Zhifei Shao, Lydia Green, Ryan Case, Daniel Yoo, Dawn Weishuhn, Palaniswami Rathanaswami, Jodi Bradley, Sara Rao, Diana Cha, Peng Luan, Shilpa Sambashivan, Susan Gilfillan, Samuel A Hasson, Ian N Foltz, Menno van Lookeren Campagne, Marco Colonn. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 3. 2021-05-12. PMID:33446504. |
prior activation state shapes the microglia response to antihuman trem2 in a mouse model of alzheimer's disease. |
2021-05-12 |
2023-08-13 |
mouse |
| Daniel C Ellwanger, Shoutang Wang, Simone Brioschi, Zhifei Shao, Lydia Green, Ryan Case, Daniel Yoo, Dawn Weishuhn, Palaniswami Rathanaswami, Jodi Bradley, Sara Rao, Diana Cha, Peng Luan, Shilpa Sambashivan, Susan Gilfillan, Samuel A Hasson, Ian N Foltz, Menno van Lookeren Campagne, Marco Colonn. Prior activation state shapes the microglia response to antihuman TREM2 in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. vol 118. issue 3. 2021-05-12. PMID:33446504. |
triggering receptor expressed on myeloid cells 2 (trem2) sustains microglia response to brain injury stimuli including apoptotic cells, myelin damage, and amyloid β (aβ). |
2021-05-12 |
2023-08-13 |
mouse |
| Lorenza Magno, Tom D Bunney, Emma Mead, Fredrik Svensson, Magda N Bictas. TREM2/PLCγ2 signalling in immune cells: function, structural insight, and potential therapeutic modulation. Molecular neurodegeneration. vol 16. issue 1. 2021-04-11. PMID:33823896. |
that is now beginning to change, as exemplified by a number of recent exciting and important reports that provide insight into the function of two key gene products - trem2 (triggering receptor expressed on myeloid cells 2) and plcγ2 (phospholipase c gamma2) - in microglia, and their role in neurodegenerative disorders. |
2021-04-11 |
2023-08-13 |
Not clear |
| Daniel L Kober, Melissa D Stuchell-Brereton, Colin E Kluender, Hunter B Dean, Michael R Strickland, Deborah F Steinberg, Samantha S Nelson, Berevan Baban, David M Holtzman, Carl Frieden, Jennifer Alexander-Brett, Erik D Roberson, Yuhua Song, Tom J Bret. Functional insights from biophysical study of TREM2 interactions with apoE and Aβ Alzheimer's & dementia : the journal of the Alzheimer's Association. 2021-04-10. PMID:33090700. |
functional insights from biophysical study of trem2 interactions with apoe and aβ triggering receptor expressed on myeloid cells-2 (trem2) is an immune receptor expressed on microglia that also can become soluble (strem2). |
2021-04-10 |
2023-08-13 |
Not clear |
| Yan-Fei Guan, Guo-Bin Huang, Min-Dong Xu, Feng Gao, Song Lin, Jie Huang, Jin Wang, Yuan-Quan Li, Cui-Hong Wu, Shan Yao, Ying Wang, Yun-Long Zhang, Jian-Peng Teoh, Aiguo Xuan, Xiang-Dong Su. Anti-depression effects of ketogenic diet are mediated via the restoration of microglial activation and neuronal excitability in the lateral habenula. Brain, behavior, and immunity. vol 88. 2021-04-06. PMID:32413556. |
specific knockdown of trem2 in lhb microglia induced depressive-like behaviors, increased neuronal excitability as well as robust microglial inflammatory activation. |
2021-04-06 |
2023-08-13 |
mouse |