| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victoria E von Saucken, Taylor R Jay, Gary E Landret. The effect of amyloid on microglia-neuron interactions before plaque onset occurs independently of TREM2 in a mouse model of Alzheimer's disease. Neurobiology of disease. vol 145. 2021-10-12. PMID:32890775. |
however, trem2 was still required for early morphological changes exhibited by microglia. |
2021-10-12 |
2023-08-13 |
mouse |
| Pranav Joshi, Florian Riffel, Kanayo Satoh, Masahiro Enomoto, Seema Qamar, Hannah Scheiblich, Nàdia Villacampa, Sathish Kumar, Sandra Theil, Samira Parhizkar, Christian Haass, Michael T Heneka, Paul E Fraser, Peter St George-Hyslop, Jochen Walte. Differential interaction with TREM2 modulates microglial uptake of modified Aβ species. Glia. vol 69. issue 12. 2021-10-11. PMID:34427354. |
phosphorylation of aβ also affected the trem2 dependent interaction and phagocytosis by primary microglia and in app transgenic mouse models. |
2021-10-11 |
2023-08-13 |
mouse |
| Bhargavi Kulkarni, Dileep Kumar, Natália Cruz-Martins, Satheeshkumar Sellamuth. Role of TREM2 in Alzheimer's Disease: A Long Road Ahead. Molecular neurobiology. vol 58. issue 10. 2021-10-08. PMID:34275100. |
genetic variations in trem2 gene disturb the neuroinflammatory action of microglia in reducing the progression of the disease.trem2 is a transmembrane receptor present on the microglia, which has an important function in neuroinflammation. |
2021-10-08 |
2023-08-13 |
mouse |
| Muhammad Irfan, Kirsten S Evonuk, Tara M DeSilv. Microglia phagocytose oligodendrocyte progenitor cells and synapses during early postnatal development: implications for white versus gray matter maturation. The FEBS journal. 2021-09-29. PMID:34496137. |
at least three innate immune receptors expressed on microglia-fractalkine, complement, and triggering receptor expressed on microglia (trem2)-modulate developmental synaptic pruning to refine brain circuitry. |
2021-09-29 |
2023-08-13 |
Not clear |
| Zhi-Jie Zhao, Dong-Po Wei, Rui-Zhe Zheng, Tinghua Peng, Xiang Xiao, Fu-Sheng L. The Gene Coexpression Analysis Identifies Functional Modules Dynamically Changed After Traumatic Brain Injury. Computational and mathematical methods in medicine. vol 2021. 2021-09-24. PMID:33953790. |
the green yellow module highlighted genes involved in microglial cell activation such as tyrobp, cx3cr1, grn, trem2, c1qa, and aif1, suggesting that these genes were responsible for the inflammatory response caused by tbi. |
2021-09-24 |
2023-08-13 |
Not clear |
| Yue Wei, Menghui Ma, Sheng Lin, Xin Li, Yue Shu, Ziwei Wang, Yuhang Zhou, Banglian Hu, Baoying Cheng, Shengshun Duan, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zhen. Proteolytic Shedding of Human Colony-Stimulating Factor 1 Receptor and its implication. Journal of cellular and molecular medicine. vol 25. issue 9. 2021-09-22. PMID:33783963. |
both colony-stimulating factor 1 receptor (csf1r) and triggering receptor expressed on myeloid cells-2 (trem2) are trans-membrane receptors and are expressed in the brain primarily by microglia. |
2021-09-22 |
2023-08-13 |
human |
| Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily Meymand, Modupe F Olufemi, Pyry Koivula, Shaniya Maimaiti, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunde. Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice. Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34503586. |
microglia are also in proximity to these plaques and microglial gene variants are known risk factors in ad, including loss-of-function variants of trem2. |
2021-09-22 |
2023-08-13 |
mouse |
| Argyro Thalia Delizannis, Annelies Nonneman, Wangchen Tsering, An De Bondt, Ilse Van den Wyngaert, Bin Zhang, Emily Meymand, Modupe F Olufemi, Pyry Koivula, Shaniya Maimaiti, John Q Trojanowski, Virginia M-Y Lee, Kurt R Brunde. Effects of microglial depletion and TREM2 deficiency on Aβ plaque burden and neuritic plaque tau pathology in 5XFAD mice. Acta neuropathologica communications. vol 9. issue 1. 2021-09-22. PMID:34503586. |
we have further investigated the role of aβ plaque-associated microglia in 5xfad mice in which np tau pathology forms after intracerebral injection of ad brain-derived pathologic tau (ad-tau), focusing on the consequences of reduced trem2 expression and microglial depletion after treatment with the colony-stimulating factor 1 (csfr1) inhibitor, plx3397. |
2021-09-22 |
2023-08-13 |
mouse |
| Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Prasada R S Kodavanti, Joyce L Royland, Urmila P Kodavanti, Michelle L Bloc. Diesel exhaust impairs TREM2 to dysregulate neuroinflammation. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33222683. |
trem2 is a myeloid cell membrane receptor that is a key regulator of disease-associated microglia (dam) cells, where loss-of-function trem2 mutations are associated with an increased risk of ad. |
2021-09-16 |
2023-08-13 |
Not clear |
| Hendrik J Greve, Christen L Mumaw, Evan J Messenger, Prasada R S Kodavanti, Joyce L Royland, Urmila P Kodavanti, Michelle L Bloc. Diesel exhaust impairs TREM2 to dysregulate neuroinflammation. Journal of neuroinflammation. vol 17. issue 1. 2021-09-16. PMID:33222683. |
using diesel exhaust (de) as a model of urban air pollution exposure, we sought to address its impact on trem2 expression, the dam phenotype, the association of microglia with the neurovasculature, and the role of trem2 in de-induced neuroinflammation. |
2021-09-16 |
2023-08-13 |
Not clear |
| Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zhen. Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival. Frontiers in immunology. vol 12. 2021-09-16. PMID:33841415. |
triggering receptor expressed on myeloid cells-2 (trem2) and colony-stimulating factor 1 receptor (csf1r) are crucial molecules for microgliopathy, which is characterized by microglia dysfunction and has recently been proposed as the neuropathological hallmark of neurological disorders. |
2021-09-16 |
2023-08-13 |
Not clear |
| Baoying Cheng, Xin Li, Kai Dai, Shengshun Duan, Zhouyi Rong, Yingmin Chen, Liangcheng Lü, Zhaoji Liu, Xiaohua Huang, Huaxi Xu, Yun-Wu Zhang, Honghua Zhen. Triggering Receptor Expressed on Myeloid Cells-2 (TREM2) Interacts With Colony-Stimulating Factor 1 Receptor (CSF1R) but Is Not Necessary for CSF1/CSF1R-Mediated Microglial Survival. Frontiers in immunology. vol 12. 2021-09-16. PMID:33841415. |
trem2 and csf1r are receptors expressed primarily in microglia in the brain and modulate microglial activation and survival. |
2021-09-16 |
2023-08-13 |
Not clear |
| Michael Fassler, Maya Saban Rappaport, Clara Benaim Cuño, Jacob Georg. Engagement of TREM2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in Alzheimer's disease models. Journal of neuroinflammation. vol 18. issue 1. 2021-09-07. PMID:33422057. |
engagement of trem2 by a novel monoclonal antibody induces activation of microglia and improves cognitive function in alzheimer's disease models. |
2021-09-07 |
2023-08-13 |
Not clear |
| Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelman. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency. Neurobiology of disease. vol 155. 2021-09-03. PMID:34019997. |
thy-tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through trem2 deficiency. |
2021-09-03 |
2023-08-13 |
mouse |
| Audrey Vautheny, Charlotte Duwat, Gwennaëlle Aurégan, Charlène Joséphine, Anne-Sophie Hérard, Caroline Jan, Julien Mitja, Pauline Gipchtein, Marie-Claude Gaillard, Luc Buée, David Blum, Philippe Hantraye, Gilles Bonvento, Emmanuel Brouillet, Karine Cambon, Alexis-Pierre Bemelman. THY-Tau22 mouse model accumulates more tauopathy at late stage of the disease in response to microglia deactivation through TREM2 deficiency. Neurobiology of disease. vol 155. 2021-09-03. PMID:34019997. |
among these genes trem2, a cell surface receptor expressed by microglia, arouses strong interest because its r47h variant confers a risk of developing ad comparable to the ε4 allele of the apoe gene. |
2021-09-03 |
2023-08-13 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. |
2021-08-30 |
2023-08-13 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
the prevailing phenotype of trem2 r47h knock-in mice was decreased expression levels of trem2 in microglia, which resulted in decreased density of microglia in the hippocampus. |
2021-08-30 |
2023-08-13 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
overall, primary microglia with reduced trem2 expression, either by sirna or from the r47h knock-in mice, displayed a similar phenotype. |
2021-08-30 |
2023-08-13 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
rna-seq analysis showed that il-4 induced the expression of a program of genes including arg1 and ap1b1 in microglia, which showed an attenuated response to il-4 when trem2 expression was decreased. |
2021-08-30 |
2023-08-13 |
mouse |
| Wenfei Liu, Orjona Taso, Rui Wang, Sevinc Bayram, Andrew C Graham, Pablo Garcia-Reitboeck, Anna Mallach, William D Andrews, Thomas M Piers, Juan A Botia, Jennifer M Pocock, Damian M Cummings, John Hardy, Frances A Edwards, Dervis A Sali. Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions. Human molecular genetics. vol 29. issue 19. 2021-08-30. PMID:32959884. |
given that anti-inflammatory signaling is associated with tissue repair, understanding the signaling mechanisms downstream of trem2 in coordinating the pro- and anti-inflammatory balance of microglia, particularly mediating effects of the il-4-regulated anti-inflammatory pathway, has important implications for fighting neurodegenerative disease. |
2021-08-30 |
2023-08-13 |
mouse |