| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haas. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The EMBO journal. 2022-01-12. PMID:35019161. |
trem2 deficiency in grn ko mice reduced microglia hyperactivation. |
2022-01-12 |
2023-08-13 |
mouse |
| Anika Reifschneider, Sophie Robinson, Bettina van Lengerich, Johannes Gnörich, Todd Logan, Steffanie Heindl, Miriam A Vogt, Endy Weidinger, Lina Riedl, Karin Wind, Artem Zatcepin, Ida Pesämaa, Sophie Haberl, Brigitte Nuscher, Gernot Kleinberger, Julien Klimmt, Julia K Götzl, Arthur Liesz, Katharina Bürger, Matthias Brendel, Johannes Levin, Janine Diehl-Schmid, Jung Suh, Gilbert Di Paolo, Joseph W Lewcock, Kathryn M Monroe, Dominik Paquet, Anja Capell, Christian Haas. Loss of TREM2 rescues hyperactivation of microglia, but not lysosomal deficits and neurotoxicity in models of progranulin deficiency. The EMBO journal. 2022-01-12. PMID:35019161. |
furthermore, trem2 antibody-treated pgrn-deficient microglia derived from human-induced pluripotent stem cells showed reduced microglial hyperactivation, trem2 signaling, and phagocytic activity, but lysosomal dysfunction was not rescued. |
2022-01-12 |
2023-08-13 |
mouse |
| Pengzhen Wang, Peng Yang, Kang Qian, Yixian Li, Shuting Xu, Ran Meng, Qian Guo, Yunlong Cheng, Jinxu Cao, Minjun Xu, Wei Lu, Qizhi Zhan. Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease. Biomaterials. vol 281. 2022-01-06. PMID:34991033. |
precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by trem2 for treatment of alzheimer's disease. |
2022-01-06 |
2023-08-13 |
mouse |
| Pengzhen Wang, Peng Yang, Kang Qian, Yixian Li, Shuting Xu, Ran Meng, Qian Guo, Yunlong Cheng, Jinxu Cao, Minjun Xu, Wei Lu, Qizhi Zhan. Precise gene delivery systems with detachable albumin shell remodeling dysfunctional microglia by TREM2 for treatment of Alzheimer's disease. Biomaterials. vol 281. 2022-01-06. PMID:34991033. |
upregulation of triggering receptor expressed on myeloid cells-2 (trem2) attenuates the neuroinflammatory processes and normalizes the dysfunctional microglia. |
2022-01-06 |
2023-08-13 |
mouse |
| Fabia Filipello, Shih-Feng You, Rita Martinez, Olena Korvatska, Wendy H Raskind, Sidhartha Mahali, Laura Ghezzi, Beatty Wandy, Marina Cella, Laura Piccio, Celeste M Karc. Functional characterization of hiPSCs-derived glial cells and neurons from patients harboring a TREM2 loss of function mutation. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971160. |
triggering receptor expressed on myeloid cells 2 (trem2) is an innate immune receptor expressed by microglia in the adult brain. |
2021-12-31 |
2023-08-13 |
Not clear |
| Peter Bor-Chian Lin, Andy Po-Yi Tsai, Kwangsik Nho, Bruce T Lamb, Adrian L Obla. INPP5D regulates the amyloid pathology in Alzheimer's disease. Alzheimer's & dementia : the journal of the Alzheimer's Association. vol 17 Suppl 2. 2021-12-31. PMID:34971187. |
inpp5d is linked to the triggering receptor expressed on myeloid cells 2 (trem2) signaling, but little is known about the function of inpp5d in microglia and how inpp5d regulates trem2-related ad pathogenesis. |
2021-12-31 |
2023-08-13 |
Not clear |
| Qi Wang, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhang, Rui L. Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia. Bioengineered. vol 13. issue 1. 2021-12-29. PMID:34964706. |
isoflurane exposure reduced triggering receptor expressed on myeloid cells 2 (trem2) expression in bv2 microglia, which was restored by mirtazapine. |
2021-12-29 |
2023-08-13 |
Not clear |
| Qi Wang, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhang, Rui L. Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia. Bioengineered. vol 13. issue 1. 2021-12-29. PMID:34964706. |
moreover, silencing of trem2 abolished the inhibitory effects of mirtazapine on ionized calcium-binding adapter molecule 1 (iba1) expression and inflammation in bv2 microglia. |
2021-12-29 |
2023-08-13 |
Not clear |
| Qi Wang, Meina Ma, Hong Yu, Hongmei Yu, Shuai Zhang, Rui L. Mirtazapine prevents cell activation, inflammation, and oxidative stress against isoflurane exposure in microglia. Bioengineered. vol 13. issue 1. 2021-12-29. PMID:34964706. |
from these results, we could infer that mirtazapine exerted a protective effect on bv2 microglia against isoflurane exposure-caused microglia activation, neuroinflammation, and oxidative stress via inducing trem2 activation. |
2021-12-29 |
2023-08-13 |
Not clear |
| John Bosco Ruganzu, Xiaoqian Peng, Yingying He, Xiangyuan Wu, Quzhao Zheng, Bo Ding, Chengheng Lin, Hongsong Guo, Zikang Yang, Xiao Zhang, Weina Yan. Downregulation of TREM2 expression exacerbates neuroinflammatory responses through TLR4-mediated MAPK signaling pathway in a transgenic mouse model of Alzheimer's disease. Molecular immunology. vol 142. 2021-12-27. PMID:34959070. |
here, we employed a lentiviral-mediated strategy to downregulation of trem2 expression on microglia in the brain of appswe/ps1de9 (app/ps1) transgenic mice and bv2 cells. |
2021-12-27 |
2023-08-13 |
mouse |
| Whitaker Cohn, Mikhail Melnik, Calvin Huang, Bruce Teter, Sujyoti Chandra, Chunni Zhu, Laura Beth McIntire, Varghese John, Karen H Gylys, Tina Bilousov. Multi-Omics Analysis of Microglial Extracellular Vesicles From Human Alzheimer's Disease Brain Tissue Reveals Disease-Associated Signatures. Frontiers in pharmacology. vol 12. 2021-12-20. PMID:34925024. |
the results showed a significant reduction in the abundance of homeostatic microglia markers p2ry12 and tmem119, and increased levels of disease-associated microglia markers fth1 and trem2, in cd11b-positive evs from ad brain compared to nl cases. |
2021-12-20 |
2023-08-13 |
human |
| Manling Xie, Yong U Liu, Shunyi Zhao, Lingxin Zhang, Dale B Bosco, Yuan-Ping Pang, Jun Zhong, Udit Sheth, Yuka A Martens, Na Zhao, Chia-Chen Liu, Yongxian Zhuang, Liewei Wang, Dennis W Dickson, Mark P Mattson, Guojun Bu, Long-Jun W. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature neuroscience. 2021-12-17. PMID:34916658. |
we found that trem2 deficiency impaired phagocytic clearance of pathological tdp-43 by microglia and enhanced neuronal damage and motor impairments. |
2021-12-17 |
2023-08-13 |
mouse |
| Manling Xie, Yong U Liu, Shunyi Zhao, Lingxin Zhang, Dale B Bosco, Yuan-Ping Pang, Jun Zhong, Udit Sheth, Yuka A Martens, Na Zhao, Chia-Chen Liu, Yongxian Zhuang, Liewei Wang, Dennis W Dickson, Mark P Mattson, Guojun Bu, Long-Jun W. TREM2 interacts with TDP-43 and mediates microglial neuroprotection against TDP-43-related neurodegeneration. Nature neuroscience. 2021-12-17. PMID:34916658. |
our data highlight that tdp-43 is a possible ligand for microglial trem2 and that this interaction mediates neuroprotection of microglia in tdp-43-related neurodegeneration. |
2021-12-17 |
2023-08-13 |
mouse |
| Wei Huang, Qiankun Lv, Yunfei Xiao, Zhen Zhong, Binbin Hu, Si Yan, Yufang Yan, Junjun Zhang, Ting Shi, Lijuan Jiang, Wen Li, Guohui L. Triggering Receptor Expressed on Myeloid Cells 2 Protects Dopaminergic Neurons by Promoting Autophagy in the Inflammatory Pathogenesis of Parkinson's Disease. Frontiers in neuroscience. vol 15. 2021-12-07. PMID:34867158. |
previous human genetics findings support the view that the loss of trem2 function will aggravate neurodegeneration, and trem2 is one of the most highly expressed receptors in microglia. |
2021-12-07 |
2023-08-13 |
human |
| Manling Xie, Shunyi Zhao, Dale B Bosco, Aivi Nguyen, Long-Jun W. Microglial TREM2 in amyotrophic lateral sclerosis. Developmental neurobiology. 2021-12-07. PMID:34874625. |
triggering receptor expressed on myeloid cell 2 (trem2) is a surface receptor that, within the cns, is exclusively expressed on microglia and plays crucial roles in microglial proliferation, migration, activation, metabolism, and phagocytosis. |
2021-12-07 |
2023-08-13 |
Not clear |
| Xinyan Liang, Haijian Wu, Mark Colt, Xinying Guo, Brock Pluimer, Jianxiong Zeng, Shupeng Dong, Zhen Zha. Microglia and its genetics in Alzheimer's Disease. Current Alzheimer research. 2021-12-03. PMID:34749609. |
different microglia subtypes displaying distinct genetic profiles have been identified in ad, and these signatures often link to ad risk genes identified from the genome-wide association studies (gwas), such as apoe and trem2. |
2021-12-03 |
2023-08-13 |
Not clear |
| Eduard Murani, Nares Trakooljul, Frieder Hadlich, Siriluck Ponsuksili, Klaus Wimmer. Brain transcriptome responses to dexamethasone depending on dose and sex reveal factors contributing to sex-specific vulnerability to stress-induced disorders. Neuroendocrinology. 2021-12-01. PMID:33853082. |
several key marker genes of disease-associated microglia were regulated by dex depending on sex, such as trem2 and lpl. |
2021-12-01 |
2023-08-13 |
Not clear |
| Huan Du, Man Ying Wong, Tingting Zhang, Mariela Nunez Santos, Charlene Hsu, Junke Zhang, Haiyuan Yu, Wenjie Luo, Fenghua H. A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses. Life science alliance. vol 4. issue 7. 2021-11-30. PMID:34103390. |
pgrn-deficient microglia exhibit increased expression of markers associated with microglial activation, including cd68, galectin-3, trem2, and gpnmb, specifically near aβ plaques. |
2021-11-30 |
2023-08-13 |
mouse |
| Qi Qin, Zhaoqian Teng, Changmei Liu, Qian Li, Yunsi Yin, Yi Tan. TREM2, microglia, and Alzheimer's disease. Mechanisms of ageing and development. vol 195. 2021-11-19. PMID:33516818. |
trem2, microglia, and alzheimer's disease. |
2021-11-19 |
2023-08-13 |
Not clear |
| Qi Qin, Zhaoqian Teng, Changmei Liu, Qian Li, Yunsi Yin, Yi Tan. TREM2, microglia, and Alzheimer's disease. Mechanisms of ageing and development. vol 195. 2021-11-19. PMID:33516818. |
in this review, we summarize our understanding of trem2 biology, explore trem2 functions in microglia, address the multiple mechanisms of trem2 in ad, and raise key questions for further investigations to elucidate the detailed roles and molecular mechanisms of trem2 in microglial responses. |
2021-11-19 |
2023-08-13 |
Not clear |