| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang, Weina Yan. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway. Experimental neurology. vol 336. 2021-08-30. PMID:33065077. |
triggering receptor expressed on myeloid cells-2 (trem2), a type i transmembrane receptor, expressed uniquely by microglia in the brain, is involved in the neuroinflammatory responses of ad. |
2021-08-30 |
2023-08-13 |
mouse |
| John Bosco Ruganzu, Quzhao Zheng, Xiangyuan Wu, Yingying He, Xiaoqian Peng, Hui Jin, Jinsong Zhou, Ruiyang Ma, Shengfeng Ji, Yanbing Ma, Yihua Qian, Yang Wang, Weina Yan. TREM2 overexpression rescues cognitive deficits in APP/PS1 transgenic mice by reducing neuroinflammation via the JAK/STAT/SOCS signaling pathway. Experimental neurology. vol 336. 2021-08-30. PMID:33065077. |
similarly, overexpression of trem2 in bv2 cells also promoted m2 polarization and led to the alleviation of m1 microglial inflammatory responses through jak/stat/socs signaling pathway, suggesting that trem2 is an important factor in shifting the microglia from m1 to m2 phenotype. |
2021-08-30 |
2023-08-13 |
mouse |
| Vaishnavi S Jadhav, Peter B C Lin, Taylor Pennington, Gonzalo Viana Di Prisco, Asha Jacob Jannu, Guixiang Xu, Miguel Moutinho, Jie Zhang, Brady K Atwood, Shweta S Puntambekar, Stephanie J Bissel, Adrian L Oblak, Gary E Landreth, Bruce T Lam. Trem2 Y38C mutation and loss of Trem2 impairs neuronal synapses in adult mice. Molecular neurodegeneration. vol 15. issue 1. 2021-08-26. PMID:33115519. |
triggering receptor expressed on myeloid cells 2 (trem2) is expressed in the brain exclusively on microglia and genetic variants are linked to neurodegenerative diseases including alzheimer's disease (ad), frontotemporal dementia (ftd) and nasu hakola disease (nhd). |
2021-08-26 |
2023-08-13 |
mouse |
| Jason Schapansky, Yelena Y Grinberg, David M Osiecki, Emily A Freeman, Stephen G Walker, Eric Karran, Sujatha M Gopalakrishnan, Robert V Talania. MEK1/2 activity modulates TREM2 cell surface recruitment. The Journal of biological chemistry. vol 296. 2021-08-25. PMID:33839686. |
rare sequence variants in the microglial cell surface receptor trem2 have been shown to increase the risk for alzheimer's disease (ad). |
2021-08-25 |
2023-08-13 |
human |
| Jason Schapansky, Yelena Y Grinberg, David M Osiecki, Emily A Freeman, Stephen G Walker, Eric Karran, Sujatha M Gopalakrishnan, Robert V Talania. MEK1/2 activity modulates TREM2 cell surface recruitment. The Journal of biological chemistry. vol 296. 2021-08-25. PMID:33839686. |
in ipsc-derived microglia, mek inhibition increased cell surface trem2 only modestly, so various cytokines were used to alter ipsc microglia phenotype, making cells more sensitive to mek inhibitor-induced trem2 recruitment. |
2021-08-25 |
2023-08-13 |
human |
| Anna Vilalta, Ye Zhou, Jean Sevalle, Jennifer K Griffin, Kanayo Satoh, David H Allendorf, Suman De, Mar Puigdellívol, Arturas Bruzas, Miguel A Burguillos, Roger B Dodd, Fusheng Chen, Yalun Zhang, Patrick Flagmeier, Lisa-Maria Needham, Masahiro Enomoto, Seema Qamar, James Henderson, Jochen Walter, Paul E Fraser, David Klenerman, Steven F Lee, Peter St George-Hyslop, Guy C Brow. Wild-type sTREM2 blocks Aβ aggregation and neurotoxicity, but the Alzheimer's R47H mutant increases Aβ aggregation. The Journal of biological chemistry. vol 296. 2021-08-20. PMID:33823153. |
trem2 is a pattern recognition receptor, expressed on microglia and myeloid cells, detecting lipids and aβ and inducing an innate immune response. |
2021-08-20 |
2023-08-13 |
Not clear |
| Yaping Wang, Yu Shi, Yongquan Huang, Wei Liu, Guiyuan Cai, Shimin Huang, Yanyan Zeng, Siqiang Ren, Hongrui Zhan, Wen W. Resveratrol mediates mechanical allodynia through modulating inflammatory response via the TREM2-autophagy axis in SNI rat model. Journal of neuroinflammation. vol 17. issue 1. 2021-08-19. PMID:33081801. |
recently, the triggering receptor expressed on myeloid cells 2 (trem2) expressed by microglia was identified as a critical factor of inflammation in nervous system diseases. |
2021-08-19 |
2023-08-13 |
rat |
| Michael Ewers, Gloria Biechele, Marc Suárez-Calvet, Christian Sacher, Tanja Blume, Estrella Morenas-Rodriguez, Yuetiva Deming, Laura Piccio, Carlos Cruchaga, Gernot Kleinberger, Leslie Shaw, John Q Trojanowski, Jochen Herms, Martin Dichgans, Matthias Brendel, Christian Haass, Nicolai Franzmeie. Higher CSF sTREM2 and microglia activation are associated with slower rates of beta-amyloid accumulation. EMBO molecular medicine. vol 12. issue 9. 2021-08-18. PMID:32790063. |
both cerebrospinal fluid (csf) levels of soluble trem2 (strem2), a biomarker of microglia activation, and microglia pet are increased in ad; however, whether an increase in these biomarkers is associated with reduced amyloid-beta (aβ) accumulation remains unclear. |
2021-08-18 |
2023-08-13 |
Not clear |
| Skylar J Ferrara, Priya Chaudhary, Margaret J DeBell, Gail Marracci, Hannah Miller, Evan Calkins, Edvinas Pocius, Brooke A Napier, Ben Emery, Dennis Bourdette, Thomas S Scanla. bioRxiv : the preprint server for biology. 2021-08-18. PMID:33532772. |
triggering receptor expressed on myeloid cells-2 (trem2) is a cell surface receptor on macrophages and microglia that senses and responds to disease associated signals to regulate the phenotype of these innate immune cells. |
2021-08-18 |
2023-08-13 |
Not clear |
| Skylar J Ferrara, Priya Chaudhary, Margaret J DeBell, Gail Marracci, Hannah Miller, Evan Calkins, Edvinas Pocius, Brooke A Napier, Ben Emery, Dennis Bourdette, Thomas S Scanla. TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor. Cell chemical biology. 2021-08-18. PMID:34375614. |
triggering receptor expressed on myeloid cells-2 (trem2) is a cell surface receptor on macrophages and microglia that senses and responds to disease-associated signals to regulate the phenotype of these innate immune cells. |
2021-08-18 |
2023-08-13 |
Not clear |
| Skylar J Ferrara, Priya Chaudhary, Margaret J DeBell, Gail Marracci, Hannah Miller, Evan Calkins, Edvinas Pocius, Brooke A Napier, Ben Emery, Dennis Bourdette, Thomas S Scanla. TREM2 is thyroid hormone regulated making the TREM2 pathway druggable with ligands for thyroid hormone receptor. Cell chemical biology. 2021-08-18. PMID:34375614. |
here, we report that trem2 is a thyroid hormone-regulated gene and its expression in macrophages and microglia is stimulated by thyroid hormone and synthetic thyroid hormone agonists (thyromimetics). |
2021-08-18 |
2023-08-13 |
Not clear |
| Emma L van der Ende, Estrella Morenas-Rodriguez, Corey McMillan, Murray Grossman, David Irwin, Raquel Sanchez-Valle, Caroline Graff, Rik Vandenberghe, Yolande A L Pijnenburg, Robert Laforce, Isabelle Le Ber, Alberto Lleo, Christian Haass, Marc Suarez-Calvet, John C van Swieten, Harro Seelaa. CSF sTREM2 is elevated in a subset in GRN-related frontotemporal dementia. Neurobiology of aging. vol 103. 2021-08-16. PMID:33896652. |
we measured soluble triggering receptor expressed on myeloid cells 2 (strem2), which is shed from disease-associated microglia following cleavage of trem2, in cerebrospinal fluid of 34 presymptomatic and 35 symptomatic grn mutation carriers, 6 presymptomatic and 32 symptomatic c9orf72 mutation carriers and 67 healthy noncarriers by elisa. |
2021-08-16 |
2023-08-13 |
Not clear |
| Liang He, Jose Davila-Velderrain, Tomokazu S Sumida, David A Hafler, Manolis Kellis, Alexander M Kulminsk. NEBULA is a fast negative binomial mixed model for differential or co-expression analysis of large-scale multi-subject single-cell data. Communications biology. vol 4. issue 1. 2021-08-16. PMID:34040149. |
using nebula in alzheimer's disease cohort data sets, we found that the cell-level expression of apoe correlated with that of other genetic risk factors (including clu, cst3, trem2, c1q, and itm2b) in a cell-type-specific pattern and an isoform-dependent manner in microglia. |
2021-08-16 |
2023-08-13 |
Not clear |
| Christel Claes, Emma Pascal Danhash, Jonathan Hasselmann, Jean Paul Chadarevian, Sepideh Kiani Shabestari, Whitney E England, Tau En Lim, Jorge Luis Silva Hidalgo, Robert C Spitale, Hayk Davtyan, Mathew Blurton-Jone. Plaque-associated human microglia accumulate lipid droplets in a chimeric model of Alzheimer's disease. Molecular neurodegeneration. vol 16. issue 1. 2021-08-13. PMID:34301296. |
interestingly, trem2 has also been identified as a microglial lipid-sensor, and recent data indicates lipid droplet accumulation in aged microglia, that is in turn associated with a dysfunctional proinflammatory phenotype. |
2021-08-13 |
2023-08-13 |
mouse |
| Xin Cui, Jun Qiao, Sha Liu, Ming Wu, Weiwei G. Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response. Brain research bulletin. vol 166. 2021-08-11. PMID:33053435. |
we measured escape latency and platform crossing time using the morris water maze image automatic acquisition and software analysis system in trem2 and dap12 microglia knockout ad model mouse. |
2021-08-11 |
2023-08-13 |
mouse |
| Xin Cui, Jun Qiao, Sha Liu, Ming Wu, Weiwei G. Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response. Brain research bulletin. vol 166. 2021-08-11. PMID:33053435. |
newborn mice with trem2 knockout were selected for primary microglia isolation and culture, and aged oligomer aβ1-42 was added to the microglial culture medium to simulate the ad environment in vivo. |
2021-08-11 |
2023-08-13 |
mouse |
| Xin Cui, Jun Qiao, Sha Liu, Ming Wu, Weiwei G. Mechanism of TREM2/DAP12 complex affecting β-amyloid plaque deposition in Alzheimer's disease modeled mice through mediating inflammatory response. Brain research bulletin. vol 166. 2021-08-11. PMID:33053435. |
co-immunoprecipitation assay was used to detect the interaction between dap12 and trem2, and measured the inflammatory response induced by lipopolysaccharide (lps) in mice with trem2 and dap12 knockdown through adeno-associated virus in bv2 microglia. |
2021-08-11 |
2023-08-13 |
mouse |
| Yujie Li, Jing Jiang, Qisheng Tang, Huiling Tian, Shun Wang, Zidong Wang, Hao Liu, Jiayi Yang, Jingyu Re. Microglia TREM2: A Potential Role in the Mechanism of Action of Electroacupuncture in an Alzheimer's Disease Animal Model. Neural plasticity. vol 2020. 2021-08-03. PMID:32952550. |
microglia trem2: a potential role in the mechanism of action of electroacupuncture in an alzheimer's disease animal model. |
2021-08-03 |
2023-08-13 |
mouse |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
il-4 and il-10 promotes phagocytic activity of microglia by up-regulation of trem2. |
2021-08-02 |
2023-08-13 |
Not clear |
| Saini Yi, Xue Jiang, Xiaofang Tang, Yahui Li, Chenghong Xiao, Jinqiang Zhang, Tao Zho. IL-4 and IL-10 promotes phagocytic activity of microglia by up-regulation of TREM2. Cytotechnology. vol 72. issue 4. 2021-08-02. PMID:32623621. |
triggering receptor expressed on myeloid cells-2 (trem2) is an innate immune receptor that promotes phagocytosis by microglia. |
2021-08-02 |
2023-08-13 |
Not clear |