| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jiao Chen, Zhen-Zhen Wang, Shuai Zhang, Shi-Feng Chu, Zheng Mou, Nai-Hong Che. The effects of glucocorticoids on depressive and anxiety-like behaviors, mineralocorticoid receptor-dependent cell proliferation regulates anxiety-like behaviors. Behavioural brain research. vol 362. 2019-07-11. PMID:30654121. |
it was interesting to find that the level of serotonin (5-ht) and the expression of tryptophan hydroxylase-2 (tph2) were decreased after cus in the hippocampus in sham rats, while adrenalectomy (adx) prevented such decreases. |
2019-07-11 |
2023-08-13 |
rat |
| Marta Pratelli, Massimo Pasqualett. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models. Biochimie. vol 161. 2019-07-08. PMID:30513372. |
in 2003 it became evident that two distinct isoforms of tryptophan hydroxylase (tph), the rate-limiting enzyme for the synthesis of serotonin, are selectively expressed in peripheral tissues and in the cns, with tph2 as the brain specific isoform. |
2019-07-08 |
2023-08-13 |
human |
| Marta Pratelli, Massimo Pasqualett. Serotonergic neurotransmission manipulation for the understanding of brain development and function: Learning from Tph2 genetic models. Biochimie. vol 161. 2019-07-08. PMID:30513372. |
we mainly focus on the analysis of animal models generated by genetic manipulation of tph2, in which the synthesis of brain serotonin was either reduced or disrupted. |
2019-07-08 |
2023-08-13 |
human |
| Jianying Yu, Zaiquan Dong, Tao Yu, Xirong Li, Xueli Su. [Association of TPH2 gene polymorphism with response to antidepressant treatment among ethnic Han Chinese population]. Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics. vol 35. issue 4. 2019-06-24. PMID:30098258. |
to assess the association of tph2 gene polymorphisms with the response or remission to selective serotonin reuptake inhibitors (ssris) drugs during treatment of major depressive disorder. |
2019-06-24 |
2023-08-13 |
Not clear |
| Charlotte S Auth, Magdalena T Weidner, Sandy Popp, Tatyana Strekalova, Angelika G Schmitt-Böhrer, Daniel LA van den Hove, Klaus-Peter Lesch, Jonas Waide. Differential anxiety-related behaviours and brain activation in Tph2-deficient female mice exposed to adverse early environment. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 28. issue 11. 2019-05-29. PMID:30146458. |
in order to further elucidate the interaction of genetic predisposition and adversity in early, developmental stages on anxiety-related behaviours, the current study employed tryptophan hydroxylase 2 (tph2)-deficient female mice, as a model for lifelong brain 5-ht synthesis deficiency. |
2019-05-29 |
2023-08-13 |
mouse |
| b' Guillemette Fouquet, Tereza Coman, Olivier Hermine, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin, hematopoiesis and stem cells. Pharmacological research. vol 140. 2019-05-13. PMID:30107202.' |
since the generation of tryptophan hydroxylase (tph1 and tph2) knockout mice, unsuspected roles have been identified for serotonin synthesized outside the brain. |
2019-05-13 |
2023-08-13 |
mouse |
| Huan Liu, Qingyi Huang, Hanzhi Sun, Jieming Li, Qianwen Lin, Haoming Wu, Chunhong Li. Effects of separate or combined exposure of nonylphenol and octylphenol on central 5-HT system and related learning and memory in the rats. Ecotoxicology and environmental safety. vol 172. 2019-04-29. PMID:30743168. |
levels of estrogen receptor β (erβ), 5-ht, tryptophan hydroxylase 2 (tph2), monoamine oxidase (maoa) enzyme, serotonin transporter (sert), the vesicular monoamine transporter 2 (vmat2), 5-hydroxytryptamine 1 a (5-ht |
2019-04-29 |
2023-08-13 |
rat |
| Anoosha Attaran, Arash Salahinejad, Adam L Crane, Som Niyogi, Douglas P Chiver. Chronic exposure to dietary selenomethionine dysregulates the genes involved in serotonergic neurotransmission and alters social and antipredator behaviours in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). vol 246. 2019-04-09. PMID:30623840. |
in the zebrafish brain, we found significant upregulation in the mrna expression of serotonin receptors (htr1aa and htr1b), a transporter (slc6a4a), and tryptophan hydroxylase-2 (tph2), whereas there was a downregulation of the monoamine oxidase (mao) gene. |
2019-04-09 |
2023-08-13 |
zebrafish |
| Adrian M Russo, Adam J Lawther, Benjamin M Prior, Luke Isbel, W Gregory Somers, John A Lesku, Amanda L Richdale, Cheryl Dissanayake, Stephen Kent, Christopher A Lowry, Matthew W Hal. Social approach, anxiety, and altered tryptophan hydroxylase 2 activity in juvenile BALB/c and C57BL/6J mice. Behavioural brain research. vol 359. 2019-04-03. PMID:29935278. |
for example, balb/c mice carry a loss-of-function single nucleotide polymorphism (snp; c1473 g) in tryptophan hydroxylase 2 (tph2), which encodes the brain-specific isoform of the rate-limiting enzyme for serotonin synthesis, and these mice frequently have been used to model symptoms of asd. |
2019-04-03 |
2023-08-13 |
mouse |
| Claudia Schoenichen, Christoph Bode, Daniel Duerschmie. Role of platelet serotonin in innate immune cell recruitment. Frontiers in bioscience (Landmark edition). vol 24. 2019-04-01. PMID:30468670. |
peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (tph), which exists in two different isoforms: tph2 being responsible for serotonin synthesis in neurons and tph1 for generation of serotonin in peripheral organs. |
2019-04-01 |
2023-08-13 |
Not clear |
| Hailong Shi, Yaya Cui, Yifei Qi. Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug. Chemical biology & drug design. vol 91. issue 1. 2019-02-20. PMID:28719094. |
two distinct tryptophan hydroxylases (tph), tph1 and tph2, are the rate-limiting enzymes in the 5-ht biosynthesis process. |
2019-02-20 |
2023-08-13 |
rat |
| A G Galyamina, I L Kovalenko, D A Smagin, N N Kudryavtsev. [Altered Expression of Neurotransmitters Systems' Genes in the Ventral Tegmental Area of Depressive Male Mice: Data of RNA-Seq]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 67. issue 1. 2019-02-19. PMID:30695556. |
'we found that genes, related with serotonin (tph2, maob, sic6a4, htr4, htr1a) were upregulated but expression of htr3a gene was downregulated in the ventral tegmental area of depressive mice in comparison with the control. |
2019-02-19 |
2023-08-13 |
mouse |
| Mihye Ko, Smi Choi-Kwon, Sang-Eun Jun, Ju Han Kim, Kyung-Hee Cho, Hyun-Wook Nah, Hasup Song, Jong S Ki. Poststroke emotional disturbances and a tryptophan hydroxylase 2 gene polymorphism. Brain and behavior. vol 8. issue 2. 2019-02-11. PMID:29484259. |
despite reports on serotonergic involvement in the etiology of poststroke emotional dysfunction (psed), the role of serotonin synthesizing tryptophan hydroxylase 2 (tph2) genes in the development of psed remains unclear. |
2019-02-11 |
2023-08-13 |
Not clear |
| Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booi. TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 92. 2019-02-11. PMID:29775696. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in brain serotonin synthesis. |
2019-02-11 |
2023-08-13 |
Not clear |
| Koen Willem Ottenhof, Mari Sild, Mélissa Luce Lévesque, Henricus Gerardus Ruhé, Linda Booi. TPH2 polymorphisms across the spectrum of psychiatric morbidity: A systematic review and meta-analysis. Neuroscience and biobehavioral reviews. vol 92. 2019-02-11. PMID:29775696. |
characterizing how exactly the different tph2 variants influence the serotonergic neurotransmission is a next necessary step in understanding the psychiatric disorders where serotonin is implicated. |
2019-02-11 |
2023-08-13 |
Not clear |
| Yi Zhang, Cuiyuan Jin, Xiaoyu Wang, Manlu Shen, Jiajie Zhou, Sisheng Wu, Zhengwei Fu, Yuanxiang Ji. Propamocarb exposure decreases the secretion of neurotransmitters and causes behavioral impairments in mice. Environmental toxicology. vol 34. issue 1. 2019-01-28. PMID:30251769. |
it was observed that acute or chronic exposure to pm changed the levels of serotonin (5-ht) and dopamine in the serum and colon and the transcription of tph2 and drd2 in the colons of mice. |
2019-01-28 |
2023-08-13 |
mouse |
| Alexander V Kulikov, Raul R Gainetdinov, Evgeni Ponimaskin, Allan V Kalueff, Vladimir S Naumenko, Nina K Popov. Interplay between the key proteins of serotonin system in SSRI antidepressants efficacy. Expert opinion on therapeutic targets. vol 22. issue 4. 2019-01-03. PMID:29542343. |
specifically, it discusses: (1) the data on the association between antidepressant drug efficacy and genetically defined characteristics of key proteins in the 5-ht signaling (tph2, maoa, sert and 5-ht |
2019-01-03 |
2023-08-13 |
Not clear |
| Melanie Y Vincent, Nina C Donner, David G Smith, Christopher A Lowry, Lauren Jacobso. Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice. Neuroscience letters. vol 665. 2018-11-13. PMID:29174640. |
drn gr deletion increased tph2 mrna levels in the dorsal, lateral wing, and caudal parts of the drn without altering tissue concentrations of 5-ht, 5-hiaa, or the 5-hiaa/5-ht ratio in limbic forebrain regions. |
2018-11-13 |
2023-08-13 |
mouse |
| Melanie Y Vincent, Nina C Donner, David G Smith, Christopher A Lowry, Lauren Jacobso. Dorsal raphé nucleus glucocorticoid receptors inhibit tph2 gene expression in male C57BL/6J mice. Neuroscience letters. vol 665. 2018-11-13. PMID:29174640. |
we conclude that drn gr inhibit drn tph2 gene expression in mice without marked effects on serotonin metabolism, at least under basal conditions at the circadian nadir. |
2018-11-13 |
2023-08-13 |
mouse |
| Michelle A Patriquin, Sara C Hamon, Mark J Harding, Ellen M Nielsen, Thomas F Newton, Richard De La Garza, David A Nielse. Genetic moderation of cocaine subjective effects by variation in the TPH1, TPH2, and SLC6A4 serotonin genes. Psychiatric genetics. vol 27. issue 5. 2018-07-27. PMID:28590957. |
genetic moderation of cocaine subjective effects by variation in the tph1, tph2, and slc6a4 serotonin genes. |
2018-07-27 |
2023-08-13 |
Not clear |