| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Chao-Jin Xu, Jun-Ling Wang, Jing-Pan, Min-Lia. Tph2 Genetic Ablation Contributes to Senile Plaque Load and Astrogliosis in APP/PS1 Mice. Current Alzheimer research. vol 16. issue 3. 2020-06-16. PMID:30827242. |
in addition, tryptophan hydroxylase-2 (tph2), a second tryptophan hydroxylase isoform, controls brain serotonin synthesis. |
2020-06-16 |
2023-08-13 |
mouse |
| Susann Matthes, Valentina Mosienko, Elena Popova, Marion Rivalan, Michael Bader, Natalia Alenin. Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30977636. |
tph1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-ht biosynthesis in non-neuronal tissues, while tph2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-ht in the brain. |
2020-06-11 |
2023-08-13 |
rat |
| Qinglan Chen, Fafa Tian, Qiang Yue, Qiong Zhan, Mian Wang, Bo Xiao, Chang Zen. Decreased serotonin synthesis is involved in seizure-induced respiratory arrest in DBA/1 mice. Neuroreport. vol 30. issue 12. 2020-04-16. PMID:31283708. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme of central serotonin (5-hydroxytryptamine) synthesis which converts l-tryptophan to 5-hydroxytryptophan. |
2020-04-16 |
2023-08-13 |
mouse |
| Mitchell R Knisely, Yvette P Conley, Kord M Kober, Betty Smoot, Steven M Paul, Jon D Levine, Christine Miaskowsk. Associations Between Catecholaminergic and Serotonergic Genes and Persistent Breast Pain Phenotypes After Breast Cancer Surgery. The journal of pain. vol 19. issue 10. 2020-04-06. PMID:29723560. |
polymorphisms in 5 genes were associated with membership in the mild pain class: ** beta-2-adrenergic receptor (adrb2) rs2400707, beta adrenergic receptor kinase 2 (adrbk2) hapa04, 5-hydroxytryptamine receptor 3a (htr3a) rs10160548, solute-like carrier (slc) family 6 member 2-noradrenaline transporter (slc6a2) rs1566652, and tryptophan hydroxylase 2 (tph2) rs11179000. |
2020-04-06 |
2023-08-13 |
Not clear |
| Lili Wang, Deping Han, Peng Yin, Kedao Teng, Jianqin Xu, Yunfei M. Decreased tryptophan hydroxylase 2 mRNA and protein expression, decreased brain serotonin concentrations, and anxiety-like behavioral changes in a rat model of simulated transport stress. Stress (Amsterdam, Netherlands). vol 22. issue 6. 2020-03-17. PMID:31184239. |
this study aimed to explore changes in concentrations of 5-hydroxytryptamine (serotonin), and the expression changes of tryptophan hydroxylase 2 (tph2) mrna and protein associated with anxiety-related behavioral responses under transport stress. |
2020-03-17 |
2023-08-13 |
rat |
| Seong W Kang, Karen D Christensen, Douglas Aldridge, Wayne J Kuenze. Effects of light intensity and dual light intensity choice on plasma corticosterone, central serotonergic and dopaminergic activities in birds, Gallus gallus. General and comparative endocrinology. vol 285. 2020-03-13. PMID:31557469. |
this study aims to investigate the effects of different light intensity and dual light intensity choice (dlic) lighting program on plasma corticosterone (cort), and tryptophan hydroxylase 2 (tph2, the rate-limiting enzyme of serotonin biosynthesis) and tyrosine hydroxylase (th, the rate-limiting enzyme of dopamine biosynthesis) gene expression in the brainstem of male chickens. |
2020-03-13 |
2023-08-13 |
Not clear |
| Yiqiong Liu, Yunong Sun, Xiaoyan Zhao, Ji-Young Kim, Lu Luo, Qian Wang, Xiaolu Meng, Yonghui Li, Nan Sui, Zhou-Feng Chen, Chuxiong Pan, Liang Li, Yan Zhan. Enhancement of Aggression Induced by Isolation Rearing is Associated with a Lack of Central Serotonin. Neuroscience bulletin. vol 35. issue 5. 2020-03-03. PMID:30977041. |
in the present study, using mice deficient in central serotonin tph2 |
2020-03-03 |
2023-08-13 |
mouse |
| Deborah G A Peeters, Sietse F de Boer, Anneke Terneusen, Adrian Newman-Tancredi, Mark A Varney, Robbert-Jan Verkes, Judith R Homber. Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT Neuropharmacology. vol 153. 2020-03-03. PMID:31078489. |
enhanced aggressive phenotype of tph2 knockout rats is associated with diminished 5-ht brain serotonin (5-ht) plays a key role in aggressive behaviours and related psychopathologies, but its precise mechanism of action remains elusive. |
2020-03-03 |
2023-08-13 |
rat |
| Deborah G A Peeters, Sietse F de Boer, Anneke Terneusen, Adrian Newman-Tancredi, Mark A Varney, Robbert-Jan Verkes, Judith R Homber. Enhanced aggressive phenotype of Tph2 knockout rats is associated with diminished 5-HT Neuropharmacology. vol 153. 2020-03-03. PMID:31078489. |
the present study showed that tryptophan hydroxylase 2 (tph2) knockout (ko) rats, which exhibit profoundly diminished extracellular serotonin levels, display increased aggressiveness compared to their tph2 wildtype (wt) counterparts. |
2020-03-03 |
2023-08-13 |
rat |
| Erik Höglund, Øyvind Øverli, Svante Winber. Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31024440. |
the rate of 5-ht biosynthesis is limited by trp availability, but only in neurons of the hindbrain raphe area predominantly expressing the isoform tph2 of the enzyme tryptophan hydroxylase (tph). |
2020-02-25 |
2023-08-13 |
Not clear |
| Megan M Haney, Joseph Sinnott, Kate L Osman, Ian Deninger, Ellyn Andel, Victoria Caywood, Alexis Mok, Brayton Ballenger, Kevin Cummings, Lori Thombs, Teresa E Leve. Mice Lacking Brain-Derived Serotonin Have Altered Swallowing Function. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery. vol 161. issue 3. 2020-01-30. PMID:31035861. |
we investigated this using mice deficient in tryptophan-hydroxylase-2 (tph2), the enzyme catalyzing the rate-limiting step in 5-ht synthesis. |
2020-01-30 |
2023-08-13 |
mouse |
| Roberto Laureano-Melo, Janaina Sena de Souza, Rodrigo Rodrigues da Conceição, Josie Marcelle Lira Albuquerque, Nayana Coutinho Rodrigues, Bruno Guimarães Marinho, Emerson Lopes Olivares, Gisele Giannocco, Wellington da Silva Côrte. Prenatal thyroxine treatment promotes anxiolysis in male Swiss mice offspring. Hormones and behavior. vol 108. 2020-01-22. PMID:30576638. |
in the hippocampus, t4 offspring had a higher expression of tryptophan hydroxylase 2 (tph2), serotonin transporter (sert) and glutamate decarboxylase 67 (gad 67) in comparison to controls. |
2020-01-22 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Dariya V Fursenko, Elizabeth A Kulikova, Nikita V Khotskin, Nadezhda A Sinyakova, Alexander A Kuliko. Effect of photoperiodic alterations on depression-like behavior and the brain serotonin system in mice genetically different in tryptophan hydroxylase 2 activity. Neuroscience letters. vol 699. 2019-12-17. PMID:30685409. |
tryptophan hydroxylase-2 (tph2) is the key enzyme of 5-ht synthesis in the brain. |
2019-12-17 |
2023-08-13 |
mouse |
| Kasper D Tidemand, Hans E M Christensen, Niclas Hoeck, Pernille Harris, Jane Boesen, Günther H Peter. Stabilization of tryptophan hydroxylase 2 by l-phenylalanine-induced dimerization. FEBS open bio. vol 6. issue 10. 2019-11-20. PMID:27761358. |
tryptophan hydroxylase 2 (tph2) catalyses the initial and rate-limiting step in the biosynthesis of serotonin, which is associated with a variety of disorders such as depression, obsessive compulsive disorder, and schizophrenia. |
2019-11-20 |
2023-08-13 |
human |
| Yukino Nawa, Hanae Kaneko, Masayuki Oda, Masaaki Tsubonoya, Tomoko Hiroi, Maria Teresa Gentile, Luca Colucci-D'Amato, Ryoya Takahashi, Hiroaki Matsu. Functional characterization of the neuron-restrictive silencer element in the human tryptophan hydroxylase 2 gene expression. Journal of neurochemistry. vol 142. issue 6. 2019-11-20. PMID:28464229. |
tryptophan hydroxylase 2 (tph2) is the key enzyme in the synthesis of neuronal serotonin. |
2019-11-20 |
2023-08-13 |
human |
| Giacomo Maddaloni, Sara Migliarini, Francesco Napolitano, Andrea Giorgi, Serena Nazzi, Daniele Biasci, Alessia De Felice, Marta Gritti, Anna Cavaccini, Alberto Galbusera, Sara Franceschi, Francesca Lessi, Marco La Ferla, Paolo Aretini, Chiara Maria Mazzanti, Raffaella Tonini, Alessandro Gozzi, Alessandro Usiello, Massimo Pasqualett. Serotonin depletion causes valproate-responsive manic-like condition and increased hippocampal neuroplasticity that are reversed by stress. Scientific reports. vol 8. issue 1. 2019-11-18. PMID:30087403. |
depletion of brain 5-ht in tph2 mutant mice resulted in reduced behavioural despair, reduced anxiety, marked aggression and lower habituation in novel environments, reminiscent of bipolar-associated manic behaviour. |
2019-11-18 |
2023-08-13 |
mouse |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
role of the allelic variation in the 5-hydroxytryptamine receptor 1a (htr1a) and the tryptophan hydroxylase 2 (tph2) genes in the development of ptsd. |
2019-09-16 |
2023-08-13 |
Not clear |
| Afërdita Goçi Uka, Ferid Agani, Afrim Blyta, Blerina Hoxha, Shpend Haxhibeqiri, Valdete Haxhibeqiri, Emina Sabic Dzananovic, Sabina Kucukalic, Alma Bravo Mehmedbasic, Abdulah Kucukalic, Alma Dzubur-Kulenovic, Elma Feric Bojic, Damir Marjanovic, Nermina Kravic, Esmina Avdibegovic, Mirnesa Muminovic Umihanic, Nenad Jaksic, Ana Cima Franc, Dusko Rudan, Miro Jakovljevic, Romana Babic, Marko Pavlovic, Dragan Babic, Branka Aukst Margetic, Nada Bozina, Osman Sinanovic, Christiane Ziegler, Bodo Warrings, Katharina Domschke, Jürgen Deckert, Christiane Wol. Role of the Allelic Variation in the 5-Hydroxytryptamine Receptor 1A (HTR1A) and the Tryptophan Hydroxylase 2 (TPH2) Genes in the Development of PTSD. Psychiatria Danubina. vol 31. issue 2. 2019-09-16. PMID:31291234. |
the aim of this study was to investigate the potential role of single nucleotide polymorphisms (snps) of the two serotonergic candidate genes 5-hydroxytryptamine receptor 1a (htr1a) and tryptophan hydroxylase 2 (tph2) in the pathogenesis of ptsd and comorbid psychopathology. |
2019-09-16 |
2023-08-13 |
Not clear |
| Narek Israelyan, Andrew Del Colle, Zhishan Li, Yeji Park, Albert Xing, Jacob P R Jacobsen, Ruth Ann Luna, Dane D Jensen, Moneek Madra, Virginia Saurman, Ray Rahim, Rocco Latorre, Kimberly Law, William Carson, Nigel W Bunnett, Marc G Caron, Kara G Margoli. Effects of Serotonin and Slow-Release 5-Hydroxytryptophan on Gastrointestinal Motility in a Mouse Model of Depression. Gastroenterology. vol 157. issue 2. 2019-08-26. PMID:31071306. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in 5-ht biosynthesis. |
2019-08-26 |
2023-08-13 |
mouse |
| V M Pokrovskii, Yu V Kashina, O V Kiek, O V Gumerova, V Yu Gorbunova, V G Abushkevich, A G Penzhoyan, N V Zabolotskik. Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism. Bulletin of experimental biology and medicine. vol 166. issue 4. 2019-07-15. PMID:30783842. |
we performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase tph1 (a218c polymorphism) and tph2 (g703t polymorphism), and serotonin receptors (htr2c and htr2a genes). |
2019-07-15 |
2023-08-13 |
human |