| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
this study evaluated the effects of polysaccharides from spirulina platensis (psp) on endurance during treadmill exercise; levels of some biochemical indicators including hemoglobin (hb), lactic acid (la), creatine kinase (ck), and blood urea nitrogen (bun); concentrations of 5-hydroxytryptamine (5-ht); and expressions of second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptor (5-ht1b) in the caudate putamen of exercising rats. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
the results demonstrated that psp prolonged the time to exhaustion during the treadmill exercise; increased hb levels; decreased la, bun, and ck levels in the blood; suppressed the exercise-induced increase of 5-ht concentrations and tph2 expression; and prevented the exercise-induced decrease of 5-ht1b expression in the caudate putamen. |
2020-10-19 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Xiaomin Ding, Shaosheng Liu, Yuanhua Zo. Analysis of the anti-fatigue activity of polysaccharides from Spirulina platensis: role of central 5-hydroxytryptamine mechanisms. Food & function. vol 11. issue 2. 2020-10-19. PMID:32057057. |
these results suggest that the mechanism of promotion of physical performance by psp might be related to increase in hb levels; decrease in la, bun, and ck levels in the blood; inhibition of the exercise-induced 5-ht and tph2 expressions; and the increase in the 5-ht1b expression in the caudate putamen of exercised rats. |
2020-10-19 |
2023-08-13 |
rat |
| Feng Wang, Nana Li, Xixi Wei, Xiaojian Jia, Huanhuan Liu, Yongling Wang, Yu Shi, Min Pan, Yue Wang, Yaling Yin, Fei Yan, Yun Che. MRI-Guided Focused Ultrasound-Induced Blood Brain Barrier Disruption to Deliver Glial Cell Line Derived Neurotropic Factor Proteins into Brain to Treat Rat Depression. Journal of biomedical nanotechnology. vol 16. issue 5. 2020-10-19. PMID:32919483. |
behavioral tests demonstrated the increased gdnf could reverse the depressive-like behaviors induced by chronic mild stress, improve the expression of 5-ht 1b receptor and the protein p11, and increase the number of 5-ht or tph2 immunoreactive neurons. |
2020-10-19 |
2023-08-13 |
rat |
| Emiliano Tesoro-Cruz, Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Suárez, Miguel Pérez de la Mora, Gloria Martínez-Pérez, Francisco Xavier Guerra-Castillo, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Ménde. Ophthalmic Administration of a DNA Plasmid Harboring the Murine Tph2 Gene: Evidence of Recombinant Tph2-FLAG in Brain Structures. Molecular biotechnology. vol 62. issue 3. 2020-10-08. PMID:32030628. |
tryptophan hydroxylase-type 2 (tph2) is the first rate-limiting step in the biosynthesis of serotonin (5-ht) in the brain. |
2020-10-08 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Norma Oviedo, Leticia Manuel-Apolinar, Sandra Orozco-Suárez, Miguel Pérez de la Mora, Gloria Martínez-Pérez, Francisco Xavier Guerra-Castillo, Charmina Aguirre-Alvarado, Vilma Carolina Bekker-Ménde. Ophthalmic Administration of a DNA Plasmid Harboring the Murine Tph2 Gene: Evidence of Recombinant Tph2-FLAG in Brain Structures. Molecular biotechnology. vol 62. issue 3. 2020-10-08. PMID:32030628. |
in conclusion, this study showed the feasibility of delivering therapeutic genes, such as the tph2, the first enzyme, rate-limiting step in the 5-ht biosynthesis. |
2020-10-08 |
2023-08-13 |
mouse |
| Ryoko Hiroi, Giulia Weyrich, Stephanie V Koebele, Sarah E Mennenga, Joshua S Talboom, Lauren T Hewitt, Courtney N Lavery, Perla Mendoza, Ambra Jordan, Heather A Bimonte-Nelso. Benefits of Hormone Therapy Estrogens Depend on Estrogen Type: 17β-Estradiol and Conjugated Equine Estrogens Have Differential Effects on Cognitive, Anxiety-Like, and Depressive-Like Behaviors and Increase Tryptophan Hydroxylase-2 mRNA Levels in Dorsal Raphe Nucleus Subregions. Frontiers in neuroscience. vol 10. 2020-10-01. PMID:28008302. |
in particular, polymorphisms of tryptophan hydroxylase-2 (tph2, the brain-specific, rate-limiting enzyme for 5-ht biosynthesis) are implicated in cognitive and affective disorders. |
2020-10-01 |
2023-08-13 |
rat |
| Nina C Donner, Kenneth H Kubala, James E Hassell, Margaret W Lieb, Kadi T Nguyen, Jared D Heinze, Robert C Drugan, Steven F Maier, Christopher A Lowr. Two models of inescapable stress increase Neurobiology of stress. vol 8. 2020-10-01. PMID:29520369. |
two models of inescapable stress increase expression of tph2, the rate-limiting enzyme for brain serotonin synthesis, is elevated in the dorsal raphe nucleus (dr) of depressed suicide victims. |
2020-10-01 |
2023-08-13 |
Not clear |
| Magdalena T Weidner, Roy Lardenoije, Lars Eijssen, Floriana Mogavero, Lilian P M T De Groodt, Sandy Popp, Rupert Palme, Konrad U Förstner, Tatyana Strekalova, Harry W M Steinbusch, Angelika G Schmitt-Böhrer, Jeffrey C Glennon, Jonas Waider, Daniel L A van den Hove, Klaus-Peter Lesc. Identification of Cholecystokinin by Genome-Wide Profiling as Potential Mediator of Serotonin-Dependent Behavioral Effects of Maternal Separation in the Amygdala. Frontiers in neuroscience. vol 13. 2020-10-01. PMID:31133792. |
converging evidence suggests a role of serotonin (5-hydroxytryptamine, 5-ht) and tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of 5-ht synthesis in the brain, in modulating long-term, neurobiological effects of early-life adversity. |
2020-10-01 |
2023-08-13 |
Not clear |
| Paola Brivio, Giulia Sbrini, Polina Peeva, Mihail Todiras, Michael Bader, Natalia Alenina, Francesca Calabres. TPH2 Deficiency Influences Neuroplastic Mechanisms and Alters the Response to an Acute Stress in a Sex Specific Manner. Frontiers in molecular neuroscience. vol 11. 2020-09-30. PMID:30425618. |
we took advantage of tryptophan hydroxylase 2 (tph2) deficient rats, lacking serotonin specifically in the brain, to investigate whether a vulnerable genotype can be associated with alterations of neuronal plasticity from the early stage of maturation of the brain until adulthood. |
2020-09-30 |
2023-08-13 |
rat |
| Hong-Ru Pan, Miao Tian, Jian-Bo Xue, Song-Min Li, Xiao-Cui Luo, Xiao Huang, Zhen-Huang Chen, Liquan Huan. Mammalian Taste Bud Cells Utilize Extragemmal 5-Hydroxy-L-Tryptophan to Biosynthesize the Neurotransmitter Serotonin. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30534058. |
first, we verified that the rate-limiting enzyme tryptophan hydroxylase (tph2) responsible for converting l-tryptophan into the intermediate 5-hydroxy-l-tryptophan (5-htp) is expressed in a subset of type ii taste bud cells (tbcs) whereas the enzyme aromatic l-aromatic amino acid decarboxylase (aadc) capable of converting 5-htp into 5-ht is found in type iii tbcs. |
2020-09-30 |
2023-08-13 |
mouse |
| Hong-Ru Pan, Miao Tian, Jian-Bo Xue, Song-Min Li, Xiao-Cui Luo, Xiao Huang, Zhen-Huang Chen, Liquan Huan. Mammalian Taste Bud Cells Utilize Extragemmal 5-Hydroxy-L-Tryptophan to Biosynthesize the Neurotransmitter Serotonin. Frontiers in cellular neuroscience. vol 12. 2020-09-30. PMID:30534058. |
and abolishment of tph2 did not affect the production of intragemmal 5-ht or alter tbcs; the mutant mice did not show any changes in behavioral responses to all five primary taste qualities: sweet, umami, bitter, salty, and sour. |
2020-09-30 |
2023-08-13 |
mouse |
| Ze Li, Hai-Yuan Yang, Ying Wang, Man-Ling Zhang, Xiao-Rui Liu, Qiang Xiong, Li-Ning Zhang, Yong Jin, Li-Sha Mou, Yan Liu, Rong-Feng Li, Yi Rao, Yi-Fan Da. Generation of tryptophan hydroxylase 2 gene knockout pigs by CRISPR/Cas9-mediated gene targeting. Journal of biomedical research. vol 31. issue 5. 2020-09-29. PMID:28866660. |
the biosynthesis of neuronal 5-ht is regulated by the rate-limiting enzyme, tryptophan hydroxylase-2 (tph2). |
2020-09-29 |
2023-08-13 |
Not clear |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
evidence suggests that mice deficient in tph2, the rate-limiting enzyme for brain serotonin synthesis, display disruptions in behavioral phenotypes relevant to stress-related psychiatric disorders. |
2020-09-14 |
2023-08-13 |
mouse |
| Margaret W Lieb, Magdalena Weidner, Mathew R Arnold, Kelsey M Loupy, Kadi T Nguyen, James E Hassell, K'Loni S Schnabel, Raphael Kern, Heidi E W Day, Klaus-Peter Lesch, Jonas Waider, Christopher A Lowr. Effects of maternal separation on serotonergic systems in the dorsal and median raphe nuclei of adult male Tph2-deficient mice. Behavioural brain research. vol 373. 2020-09-14. PMID:31319134. |
serotonergic genes studied included tph2, the high-affinity, low-capacity, sodium-dependent serotonin transporter (slc6a4), the serotonin type 1a receptor (htr1a), and the corticosterone-sensitive, low-affinity, high-capacity sodium-independent serotonin transporter, organic cation transporter 3 (slc22a3). |
2020-09-14 |
2023-08-13 |
mouse |
| Hisatsugu Koshimizu, Nao Hirata, Keizo Takao, Keiko Toyama, Takashi Ichinose, Shigeki Furuya, Tsuyoshi Miyakaw. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology reports. vol 39. issue 1. 2020-08-20. PMID:30472790. |
tryptophan hydroxylase 2 (tph2) is a rate-limiting enzyme for the biosynthesis of 5-hydroxytryptamine (5-ht, serotonin). |
2020-08-20 |
2023-08-13 |
mouse |
| Hisatsugu Koshimizu, Nao Hirata, Keizo Takao, Keiko Toyama, Takashi Ichinose, Shigeki Furuya, Tsuyoshi Miyakaw. Comprehensive behavioral analysis and quantification of brain free amino acids of C57BL/6J congenic mice carrying the 1473G allele in tryptophan hydroxylase-2. Neuropsychopharmacology reports. vol 39. issue 1. 2020-08-20. PMID:30472790. |
previous studies have reported that c1473g polymorphism of the murine tph2 gene leads to decreased 5-ht levels in the brain and abnormal behavioral phenotypes, such as impaired anxiety- and depression-like behaviors. |
2020-08-20 |
2023-08-13 |
mouse |
| Niklas Kästner, S Helene Richter, Sarah Urbanik, Joachim Kunert, Jonas Waider, Klaus-Peter Lesch, Sylvia Kaiser, Norbert Sachse. Brain serotonin deficiency affects female aggression. Scientific reports. vol 9. issue 1. 2020-08-18. PMID:30718564. |
while so far most studies have investigated variation in serotonin levels, a recently created tryptophan hydroxylase 2 (tph2) knockout mouse model allows studying effects of complete brain serotonin deficiency. |
2020-08-18 |
2023-08-13 |
mouse |
| Gabriel Rodrigues Coutinho Pereira, Gustavo Duarte Bocayuva Tavares, Marta Costa de Freitas, Joelma Freire De Mesquit. In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders. PloS one. vol 15. issue 3. 2020-06-17. PMID:32119710. |
the tryptophan hydroxylase 2 (tph2) enzyme catalyzes the first step of serotonin biosynthesis. |
2020-06-17 |
2023-08-13 |
human |
| Gabriel Rodrigues Coutinho Pereira, Gustavo Duarte Bocayuva Tavares, Marta Costa de Freitas, Joelma Freire De Mesquit. In silico analysis of the tryptophan hydroxylase 2 (TPH2) protein variants related to psychiatric disorders. PloS one. vol 15. issue 3. 2020-06-17. PMID:32119710. |
as the reaction catalyzed by tph2 is the rate-limiting step of serotonin biosynthesis, mutations in tph2 have been associated with several psychiatric disorders (pd). |
2020-06-17 |
2023-08-13 |
human |