| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S Walitza, T J Renner, A Dempfle, K Konrad, Ch Wewetzer, A Halbach, B Herpertz-Dahlmann, H Remschmidt, J Smidt, M Linder, L Flierl, U Knölker, S Friedel, H Schäfer, C Gross, J Hebebrand, A Warnke, K P Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Molecular psychiatry. vol 10. issue 12. 2006-03-01. PMID:16116490. |
here, we investigated the effect of polymorphic variants in the gene of the tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme of serotonin (5-ht) synthesis in the brain, in children and adolescents with adhd. |
2006-03-01 |
2023-08-12 |
Not clear |
| S Walitza, T J Renner, A Dempfle, K Konrad, Ch Wewetzer, A Halbach, B Herpertz-Dahlmann, H Remschmidt, J Smidt, M Linder, L Flierl, U Knölker, S Friedel, H Schäfer, C Gross, J Hebebrand, A Warnke, K P Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder. Molecular psychiatry. vol 10. issue 12. 2006-03-01. PMID:16116490. |
our results link potentially functional tph2 variations to the pathophysiology of adhd, and further support the relevance of 5-ht in disorders related to altered motor activity and cognitive processes. |
2006-03-01 |
2023-08-12 |
Not clear |
| X Zhang, J-M Beaulieu, R R Gainetdinov, M G Caro. Functional polymorphisms of the brain serotonin synthesizing enzyme tryptophan hydroxylase-2. Cellular and molecular life sciences : CMLS. vol 63. issue 1. 2006-02-21. PMID:16378243. |
tryptophan hydroxylase-2 (tph2) is the neuronal-specific enzyme that controls brain serotonin synthesis. |
2006-02-21 |
2023-08-12 |
Not clear |
| A V Kulikov, D V Osipova, V S Naumenko, N K Popov. Association between Tph2 gene polymorphism, brain tryptophan hydroxylase activity and aggressiveness in mouse strains. Genes, brain, and behavior. vol 4. issue 8. 2006-01-23. PMID:16268992. |
the main factor determining the brain serotonin level is the activity of the rate-limiting enzyme in the biosynthesis of the neurotransmitter--tryptophan hydroxylase isoform (tph) 2 encoded by the tph2 gene. |
2006-01-23 |
2023-08-12 |
mouse |
| S M Brown, E Peet, S B Manuck, D E Williamson, R E Dahl, R E Ferrell, A R Harir. A regulatory variant of the human tryptophan hydroxylase-2 gene biases amygdala reactivity. Molecular psychiatry. vol 10. issue 9. 2005-11-08. PMID:16044172. |
recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (tph2) is preferentially involved in the rate-limiting synthesis of neuronal serotonin. |
2005-11-08 |
2023-08-12 |
human |
| Zhifeng Zhou, Alec Roy, Robert Lipsky, Kavi Kuchipudi, Guanshan Zhu, Julie Taubman, Mary-Anne Enoch, Matti Virkkunen, David Goldma. Haplotype-based linkage of tryptophan hydroxylase 2 to suicide attempt, major depression, and cerebrospinal fluid 5-hydroxyindoleacetic acid in 4 populations. Archives of general psychiatry. vol 62. issue 10. 2005-10-24. PMID:16203956. |
tryptophan hydroxylase 2 (tph2) encodes the rate-limiting enzyme for brain serotonin biosynthesis. |
2005-10-24 |
2023-08-12 |
Not clear |
| Zeina S Malek, Hugues Dardente, Paul Pevet, Sylvie Raiso. Tissue-specific expression of tryptophan hydroxylase mRNAs in the rat midbrain: anatomical evidence and daily profiles. The European journal of neuroscience. vol 22. issue 4. 2005-10-18. PMID:16115212. |
these data show that the circadian 5-ht synthesis within the serotonergic neurons projecting to the circadian system might be explained by the rhythmic transcription of the tph2 gene in raphe nuclei. |
2005-10-18 |
2023-08-12 |
rat |
| Jeffrey McKinney, Per M Knappskog, Jan Haavi. Different properties of the central and peripheral forms of human tryptophan hydroxylase. Journal of neurochemistry. vol 92. issue 2. 2005-05-26. PMID:15663479. |
the differences between tph1 and tph2 have important implications for the regulation of serotonin production in the brain and the periphery and may provide an explanation for some of the diverging results reported for tph from different sources in the past. |
2005-05-26 |
2023-08-12 |
human |
| Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (New York, N.Y.). vol 305. issue 5681. 2004-08-02. PMID:15247473. |
we report a functional (c1473g) single-nucleotide polymorphism in mouse tph2 that results in the substitution of pro447 with arg447 and leads to decreased serotonin levels in pc12 cells. |
2004-08-02 |
2023-08-12 |
mouse |
| Xiaodong Zhang, Jean-Martin Beaulieu, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase-2 controls brain serotonin synthesis. Science (New York, N.Y.). vol 305. issue 5681. 2004-08-02. PMID:15247473. |
our data provide direct evidence for a fundamental role of tph2 in brain serotonin synthesis. |
2004-08-02 |
2023-08-12 |
mouse |
| Francine Côté, Cécile Fligny, Jacques Mallet, Guilan Vodjdan. [Abnormal cardiac activity in mice in the absence of peripheral serotonin synthesis]. Journal de la Societe de biologie. vol 198. issue 1. 2004-07-19. PMID:15146950. |
the rate limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes: the well characterized tph1 gene and a recently identified tph2 gene. |
2004-07-19 |
2023-08-12 |
mouse |
| Francine Côté, Etienne Thévenot, Cécile Fligny, Yves Fromes, Michèle Darmon, Marie-Anne Ripoche, Elisa Bayard, Naima Hanoun, Francoise Saurini, Philippe Lechat, Luisa Dandolo, Michel Hamon, Jacques Mallet, Guilan Vodjdan. Disruption of the nonneuronal tph1 gene demonstrates the importance of peripheral serotonin in cardiac function. Proceedings of the National Academy of Sciences of the United States of America. vol 100. issue 23. 2004-01-05. PMID:14597720. |
the rate-limiting enzyme of 5-ht synthesis, tryptophan hydroxylase (tph), is encoded by two genes, the well characterized tph1 gene and a recently identified tph2 gene. |
2004-01-05 |
2023-08-12 |
mouse |