| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Federico Remes Lenicov, Sylvie Lemonde, Margaret Czesak, Tera M Mosher, Paul R Alber. Cell-type specific induction of tryptophan hydroxylase-2 transcription by calcium mobilization. Journal of neurochemistry. vol 103. issue 5. 2008-01-03. PMID:17868301. |
alterations in brain serotonin levels are implicated in major depression and are regulated by tryptophan hydroxylase-2 (tph2). |
2008-01-03 |
2023-08-12 |
rat |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
serotonin [5-hydroxytryptamine (5-ht)] biosynthesis depends on two rate-limiting tryptophan hydroxylases (tph): tph1, which is expressed in peripheral organs, and tph2, which is expressed in neurons. |
2007-11-27 |
2023-08-12 |
mouse |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
because 5-ht is involved in pulmonary hypertension (ph), we investigated whether genetic variations in tph1 and/or tph2 affected ph development in mice. |
2007-11-27 |
2023-08-12 |
mouse |
| M Izikki, N Hanoun, E Marcos, L Savale, A M Barlier-Mur, F Saurini, S Eddahibi, M Hamon, S Adno. Tryptophan hydroxylase 1 knockout and tryptophan hydroxylase 2 polymorphism: effects on hypoxic pulmonary hypertension in mice. American journal of physiology. Lung cellular and molecular physiology. vol 293. issue 4. 2007-11-27. PMID:17675372. |
these results provide evidence that dysregulation of 5-ht synthesis is closely linked to the hypoxic ph phenotype in mice and that tph1 and tph2 may contribute to ph development. |
2007-11-27 |
2023-08-12 |
mouse |
| M S Clark, R A McDevitt, B J Hoplight, J F Neumaie. Chronic low dose ovine corticotropin releasing factor or urocortin II into the rostral dorsal raphe alters exploratory behavior and serotonergic gene expression in specific subregions of the dorsal raphe. Neuroscience. vol 146. issue 4. 2007-10-25. PMID:17467184. |
following behavioral testing, 5-ht1a, 5-ht1b, 5-ht transporter (sert), and tryptophan hydroxylase-2 (tph2) expression was examined through the drn by in situ hybridization. |
2007-10-25 |
2023-08-12 |
human |
| Paresh D Patel, Daniel A Bochar, David L Turner, Fan Meng, Helena M Mueller, Crystal G Pontrell. Regulation of tryptophan hydroxylase-2 gene expression by a bipartite RE-1 silencer of transcription/neuron restrictive silencing factor (REST/NRSF) binding motif. The Journal of biological chemistry. vol 282. issue 37. 2007-10-19. PMID:17613521. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme in raphe serotonin biosynthesis, and polymorphisms of tph2 are implicated in vulnerability to psychiatric disorders. |
2007-10-19 |
2023-08-12 |
mouse |
| Yi-Mei J Lin, Shin-Chih Chao, Tsung-Ming Chen, Te-Jen Lai, Jia-Shing Chen, H Sunny Su. Association of functional polymorphisms of the human tryptophan hydroxylase 2 gene with risk for bipolar disorder in Han Chinese. Archives of general psychiatry. vol 64. issue 9. 2007-09-28. PMID:17768266. |
the tryptophan hydroxylase 2 (tph2) gene encodes the first (also the rate-limiting) enzyme in the serotonin biosynthetic pathway. |
2007-09-28 |
2023-08-12 |
human |
| Margaret Czesak, Ariel M Burns, Federico Remes Lenicov, Paul R Alber. Characterization of rat rostral raphe primary cultures: multiplex quantification of serotonergic markers. Journal of neuroscience methods. vol 164. issue 1. 2007-09-27. PMID:17498810. |
the standard error of tph2 rna levels between cultures was <20%, indicating a consistent purity of 5-ht neurons. |
2007-09-27 |
2023-08-12 |
rat |
| Peter Zill, Ulrich W Preuss, Gabrielle Koller, Brigitta Bondy, Michael Soyk. SNP- and haplotype analysis of the tryptophan hydroxylase 2 gene in alcohol-dependent patients and alcohol-related suicide. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 32. issue 8. 2007-09-26. PMID:17251907. |
recent studies have indicated that a newly identified second isoform of the tryptophan hydroxylase gene (tph2) is preferentially involved in the rate limiting synthesis of neuronal serotonin. |
2007-09-26 |
2023-08-12 |
Not clear |
| Lise Gutknecht, Christian Jacob, Alexander Strobel, Claudia Kriegebaum, Johannes Müller, Yong Zeng, Christoph Markert, Andrea Escher, Jens Wendland, Andreas Reif, Rainald Mössner, Cornelius Gross, Burkhard Brocke, Klaus-Peter Lesc. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. The international journal of neuropsychopharmacology. vol 10. issue 3. 2007-07-20. PMID:17176492. |
variation in the tryptophan hydroxylase-2 gene (tph2) coding for the rate-limiting enzyme of serotonin (5-ht) synthesis in the brain modulates responses of limbic circuits to emotional stimuli and has been linked to a spectrum of clinical populations characterized by emotional dysregulation. |
2007-07-20 |
2023-08-12 |
Not clear |
| Lise Gutknecht, Christian Jacob, Alexander Strobel, Claudia Kriegebaum, Johannes Müller, Yong Zeng, Christoph Markert, Andrea Escher, Jens Wendland, Andreas Reif, Rainald Mössner, Cornelius Gross, Burkhard Brocke, Klaus-Peter Lesc. Tryptophan hydroxylase-2 gene variation influences personality traits and disorders related to emotional dysregulation. The international journal of neuropsychopharmacology. vol 10. issue 3. 2007-07-20. PMID:17176492. |
these findings implicate alterations of 5-ht synthesis in emotion regulation and confirm tph2 as a susceptibility and/or modifier gene of affective spectrum disorders. |
2007-07-20 |
2023-08-12 |
Not clear |
| J-E Lim, J Pinsonneault, W Sadee, D Saffe. Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons. Molecular psychiatry. vol 12. issue 5. 2007-06-26. PMID:17453063. |
tryptophan hydroxylase isoform 2 (tph2) is expressed in serotonergic neurons in the raphe nuclei, where it catalyzes the rate-limiting step in the synthesis of the neurotransmitter serotonin. |
2007-06-26 |
2023-08-12 |
human |
| Antonio Di Lieto, Damiana Leo, Floriana Volpicelli, Umberto di Porzio, Luca Colucci-D'Amat. FLUOXETINE modifies the expression of serotonergic markers in a differentiation-dependent fashion in the mesencephalic neural cell line A1 mes c-myc. Brain research. vol 1143. 2007-06-13. PMID:17321503. |
here we show that a mesencephalic neural cell line, mes-c-myc a1 (a1) produces 5-ht and expresses sert and both peripheral (tph1) and cns-specific (tph2) form of tryptophan hydroxylase, the limiting enzyme in 5-ht biosynthesis. |
2007-06-13 |
2023-08-12 |
Not clear |
| Martin J Herrmann, Theresa Huter, Frauke Müller, Andreas Mühlberger, Paul Pauli, Andreas Reif, Tobias Renner, Turhan Canli, Andreas J Fallgatter, Klaus-Peter Lesc. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on emotional processing. Cerebral cortex (New York, N.Y. : 1991). vol 17. issue 5. 2007-05-31. PMID:16801378. |
prior studies reported that functional variants of both the serotonin transporter (5-htt) and tryptophan hydroxylase-2 genes (tph2), 2 key regulators of the serotonergic signaling pathway, modulate amygdala activation during emotional processing. |
2007-05-31 |
2023-08-12 |
Not clear |
| Ingeborg Winge, Jeffrey A McKinney, Per M Knappskog, Jan Haavi. Characterization of wild-type and mutant forms of human tryptophan hydroxylase 2. Journal of neurochemistry. vol 100. issue 6. 2007-05-01. PMID:17181551. |
variants of tph2 have recently reported to be associated with reduced serotonin production and behavioural alterations in man and mice. |
2007-05-01 |
2023-08-12 |
mouse |
| Roberto Sacco, Veruska Papaleo, Jorg Hager, Francis Rousseau, Rainald Moessner, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Cindy Schneider, Raun Melmed, Maurizio Elia, Paolo Curatolo, Barbara Manzi, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Antonio M Persic. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC medical genetics. vol 8. 2007-04-12. PMID:17346350. |
the tph2 gene encodes the enzyme responsible for serotonin (5-ht) synthesis in the central nervous system (cns). |
2007-04-12 |
2023-08-12 |
Not clear |
| Roberto Sacco, Veruska Papaleo, Jorg Hager, Francis Rousseau, Rainald Moessner, Roberto Militerni, Carmela Bravaccio, Simona Trillo, Cindy Schneider, Raun Melmed, Maurizio Elia, Paolo Curatolo, Barbara Manzi, Tiziana Pascucci, Stefano Puglisi-Allegra, Karl-Ludvig Reichelt, Antonio M Persic. Case-control and family-based association studies of candidate genes in autistic disorder and its endophenotypes: TPH2 and GLO1. BMC medical genetics. vol 8. 2007-04-12. PMID:17346350. |
stereotypic and repetitive behaviors are influenced by 5-ht, and initial studies report an association of tph2 alleles with childhood-onset obsessive-compulsive disorder (ocd) and with autism. |
2007-04-12 |
2023-08-12 |
Not clear |
| Kyung-Won Hong, Yuko Sugawara, Hiroyuki Hasegawa, Ikuo Hayasaka, Ryota Hashimoto, Shin'ichi Ito, Miho Inoue-Murayam. A new gain-of-function allele in chimpanzee tryptophan hydroxylase 2 and the comparison of its enzyme activity with that in humans and rats. Neuroscience letters. vol 412. issue 3. 2007-04-05. PMID:17123720. |
tryptophan hydroxylase 2 (tph2) is a rate-limiting enzyme of neuronal serotonin biosynthesis. |
2007-04-05 |
2023-08-12 |
mouse |
| Karen Sheehan, Ziarih Hawi, Michael Gill, Lindsey Ken. No association between TPH2 gene polymorphisms and ADHD in a UK sample. Neuroscience letters. vol 412. issue 2. 2007-04-03. PMID:17123708. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in the biosynthesis of serotonin which is exclusively expressed in the brain. |
2007-04-03 |
2023-08-12 |
Not clear |
| Eduard Maron, Innar Tõru, Anne Must, Gunnar Tasa, Egle Toover, Veiko Vasar, Aavo Lang, Jakov Shli. Association study of tryptophan hydroxylase 2 gene polymorphisms in panic disorder. Neuroscience letters. vol 411. issue 3. 2007-03-30. PMID:17123728. |
recently, it has been discovered that the tryptophan hydroxylase gene isoform 2 (tph2), rather than tph1, is preferentially expressed in the neuronal tissue and, therefore, is primarily responsible for the regulation of brain 5-ht synthesis. |
2007-03-30 |
2023-08-12 |
human |