| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ho-Kyoung Yoon, Yong-Ku Ki. TPH2 -703G/T SNP may have important effect on susceptibility to suicidal behavior in major depression. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 3. 2009-06-16. PMID:19162119. |
in this study, we aimed to investigate the association of serotonin 2a receptor gene -1438a/g snp (htr2a -1438a/g), tryptophan hydroxylase 2 gene -703g/t snp (tph2 -703g/t) and serotonin 1a receptor c-1019g (htr1a c-1019g) with suicidal behavior. |
2009-06-16 |
2023-08-12 |
Not clear |
| Anne Must, Gunnar Tasa, Aavo Lang, Eero Vasar, Sulev Kõks, Eduard Maron, Marika Väl. Variation in tryptophan hydroxylase-2 gene is not associated to male completed suicide in Estonian population. Neuroscience letters. vol 453. issue 2. 2009-06-12. PMID:19356604. |
tryptophan hydroxylase isoform 2 (tph2) is the rate-limiting enzyme in the biosynthetic pathway of serotonin, being expressed in serotonergic neurons of raphe nuclei. |
2009-06-12 |
2023-08-12 |
human |
| Daria V Osipova, Alexander V Kulikov, Nina K Popov. C1473G polymorphism in mouse tph2 gene is linked to tryptophan hydroxylase-2 activity in the brain, intermale aggression, and depressive-like behavior in the forced swim test. Journal of neuroscience research. vol 87. issue 5. 2009-06-01. PMID:19006079. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme of brain serotonin synthesis. |
2009-06-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Claudia Kriegebaum, Jonas Waider, Angelika Schmitt, Klaus-Peter Lesc. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19181488. |
in support of tph2 specificity in brain 5-ht synthesis, raphe neurons of tph2 knockout mice were completely devoid of 5-ht, with no compensatory activation of tph1 expression. |
2009-05-20 |
2023-08-12 |
mouse |
| Lise Gutknecht, Claudia Kriegebaum, Jonas Waider, Angelika Schmitt, Klaus-Peter Lesc. Spatio-temporal expression of tryptophan hydroxylase isoforms in murine and human brain: convergent data from Tph2 knockout mice. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 19. issue 4. 2009-05-20. PMID:19181488. |
in conclusion, our findings indicate that brain 5-ht synthesis across the lifespan is exclusively maintained by tph2. |
2009-05-20 |
2023-08-12 |
mouse |
| Geza Nagy, Zsolt Ronai, Aniko Somogyi, Maria Sasvari-Szekely, Omar Abdul Rahman, Attila Mate, Timea Varga, Zsofia Nemod. P2RX7 Gln460Arg polymorphism is associated with depression among diabetic patients. Progress in neuro-psychopharmacology & biological psychiatry. vol 32. issue 8. 2009-04-15. PMID:18801407. |
in the present study, candidate polymorphisms of the serotonin transporter, the tryptophan hydroxylase 2 (tph2) genes, as well as of the brain-derived neurotrophic factor bdnf, and the p2rx7 purinergic receptor genes were analyzed in hungarian diabetic population. |
2009-04-15 |
2023-08-12 |
Not clear |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
we have recently shown that estrogen decreases anxiety and increases expression of tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme for 5-ht synthesis. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
therefore, we examined the effects of estrogen on 5-ht(1b) mrna in the rat drn, focusing on specific subregions, and whether 5-ht(1b) mrna levels correlated with tph2 mrna levels and with anxiety-like behavior. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
in contrast, estrogen selectively decreased 5-ht(1b) mrna in the mid-ventromedial subregion of the drn, where 5-ht(1b) mrna was associated with higher anxiety-like behavior and inversely correlated with tph2 mrna levels. |
2009-04-15 |
2023-08-12 |
rat |
| R Hiroi, J F Neumaie. Estrogen decreases 5-HT1B autoreceptor mRNA in selective subregion of rat dorsal raphe nucleus: inverse association between gene expression and anxiety behavior in the open field. Neuroscience. vol 158. issue 2. 2009-04-15. PMID:19049819. |
these results suggest that estrogen may reduce 5-ht(1b) autoreceptor and increase tph2 synthesis in a coordinated fashion, thereby increasing the capacity for 5-ht synthesis and release in distinct forebrain regions that modulate specific components of anxiety behavior. |
2009-04-15 |
2023-08-12 |
rat |
| Tomas Furmark, Susanne Henningsson, Lieuwe Appel, Fredrik Ahs, Clas Linnman, Anna Pissiota, Vanda Faria, Lars Oreland, Massimo Bani, Emilio Merlo Pich, Elias Eriksson, Mats Fredrikso. Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. Journal of psychiatry & neuroscience : JPN. vol 34. issue 1. 2009-03-12. PMID:19125211. |
the short (s) allele of the 5-ht transporter linked polymorphic region (5-httlpr) and the t variant of the g-703t polymorphism in the tryptophan hydroxylase-2 (tph2) gene have previously been associated with amygdala hyperresponsivity to negative faces in healthy controls. |
2009-03-12 |
2023-08-12 |
Not clear |
| Paul Gacek, Tamlin S Conner, Howard Tennen, Henry R Kranzler, Jonathan Covaul. Tryptophan hydroxylase 2 gene and alcohol use among college students. Addiction biology. vol 13. issue 3-4. 2009-03-05. PMID:18782386. |
tryptophan hydroxylase (tph2) plays an important role in serotonergic neurotransmission by serving as the rate-limiting enzyme for serotonin biosynthesis in the midbrain and serotonergic neurons. |
2009-03-05 |
2023-08-12 |
human |
| Eric J Peters, Susan L Slager, Greg D Jenkins, Megan S Reinalda, Holly A Garriock, Stanley I Shyn, Jeffrey B Kraft, Patrick J McGrath, Steven P Hamilto. Resequencing of serotonin-related genes and association of tagging SNPs to citalopram response. Pharmacogenetics and genomics. vol 19. issue 1. 2009-03-03. PMID:19077664. |
here, we attempt to expand upon and replicate these results by (i) resequencing the exonic and putatively regulatory regions of five serotonin-related candidate genes (htr1a, htr2a, tph1, tph2, and maoa) in our fluoxetine-treated sample to uncover novel variants; (ii) selecting tagging single nucleotide polymorphisms (snps) for these genes from the resequencing data; and (iii) evaluating these tagging snps for association with response to the selective serotonin reuptake inhibitor citalopram in an independent sample of participants who are enrolled in the sequenced treatment alternatives to relieve depression (star*d) clinical study (n=1953). |
2009-03-03 |
2023-08-12 |
human |
| B-T Lee, B-J Ha. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes, brain, and behavior. vol 7. issue 8. 2009-02-27. PMID:18826444. |
all participants were genotyped with regard to the following polymorphisms: the serotonin transporter-gene-linked polymorphic region (5-httlpr), tryptophan hydroxylase 2 (tph2) g(-703)t, 5-ht(1a) c(-1019)g and 5-ht(2a) single nucleotide polymorphism (snp) rs6311. |
2009-02-27 |
2023-08-12 |
human |
| B-T Lee, B-J Ha. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes, brain, and behavior. vol 7. issue 8. 2009-02-27. PMID:18826444. |
higher activations in response to sad facial stimuli were found in the bilateral amygdala of subjects with the t/t genotype of 5-ht(2a) snp rs6311, compared with c allele carriers, and in subjects with the g/g genotype of tph2 g(-703)t, compared with those with t/t and g/t genotypes. |
2009-02-27 |
2023-08-12 |
human |
| S W Kang, B Leclerc, L J Mauro, M E El Halawan. Serotonergic and catecholaminergic interactions with co-localised dopamine-melatonin neurones in the hypothalamus of the female turkey. Journal of neuroendocrinology. vol 21. issue 1. 2009-02-03. PMID:19094089. |
tph2 mrna expression in serotonin neurones was found in several nuclei, and its most abundant mrna expression was seen in the nucleus locus ceruleus of laying and incubating hens. |
2009-02-03 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
depressed suicide patients have elevated expression of neuronal tryptophan hydroxylase 2 (tph2) mrna and protein in midbrain serotonergic neurons, as well as increases in brain serotonin turnover. |
2009-01-23 |
2023-08-12 |
Not clear |
| Christopher A Lowry, Matthew W Hale, Andrew K Evans, Jasper Heerkens, Daniel R Staub, Paul J Gasser, Anantha Shekha. Serotonergic systems, anxiety, and affective disorder: focus on the dorsomedial part of the dorsal raphe nucleus. Annals of the New York Academy of Sciences. vol 1148. 2009-01-23. PMID:19120094. |
the mechanisms underlying these changes are uncertain, but increased tph2 expression and serotonin turnover could result from genetic influences, adverse early life experiences, or acute stressful life events, all of which can alter serotonergic neurotransmission and have been implicated in determining vulnerability to major depression. |
2009-01-23 |
2023-08-12 |
Not clear |
| Tomas Furmark, Lieuwe Appel, Susanne Henningsson, Fredrik Ahs, Vanda Faria, Clas Linnman, Anna Pissiota, Orjan Frans, Massimo Bani, Paolo Bettica, Emilio Merlo Pich, Eva Jacobsson, Kurt Wahlstedt, Lars Oreland, Bengt Långström, Elias Eriksson, Mats Fredrikso. A link between serotonin-related gene polymorphisms, amygdala activity, and placebo-induced relief from social anxiety. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 28. issue 49. 2009-01-12. PMID:19052197. |
patients were genotyped with respect to the serotonin transporter-linked polymorphic region (5-httlpr) and the g-703t polymorphism in the tryptophan hydroxylase-2 (tph2) gene promoter. |
2009-01-12 |
2023-08-12 |
human |
| Fumihiro Kaneko, Koji Masuda, Yukari Takeuchi, Yuji Mor. Identifying novel polymorphisms in the canine tryptophan hydroxylase 2 gene. The Journal of veterinary medical science. vol 70. issue 10. 2009-01-08. PMID:18981671. |
tryptophan hydroxylase (tph) serves as the rate-limiting enzyme in the biosynthesis of serotonin, and two forms of tph genes, tph1 and tph2, have been reported with specific nucleotide sequences and expression patterns. |
2009-01-08 |
2023-08-12 |
Not clear |