| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yi-Mei J Lin, Huei-Chen Ko, Fong-Ming Chang, Tzung-Lieh Yeh, H Sunny Su. Population-specific functional variant of the TPH2 gene 2755C>A polymorphism contributes risk association to major depression and anxiety in Chinese peripartum women. Archives of women's mental health. vol 12. issue 6. 2010-01-22. PMID:19588223. |
the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase 2 (tph2), is one of the most promising candidate genes for psychiatric disorders. |
2010-01-22 |
2023-08-12 |
Not clear |
| Alexandra Schosser, Siegfried Kaspe. The role of pharmacogenetics in the treatment of depression and anxiety disorders. International clinical psychopharmacology. vol 24. issue 6. 2010-01-07. PMID:19738481. |
two functional polymorphisms of the serotonin transporter gene, 5-httlpr and stin2 have been investigated in a large number of pharmacogenetic studies of depression; other candidate genes include serotonin receptor genes, brain-derived neurotrophic factor, p-glycoprotein (located in the blood-brain barrier), g-proteins, tph1 and tph2, maoa, the noradrenaline transporter gene, fkbp5, or cytochrome p450 (cyp450) genes. |
2010-01-07 |
2023-08-12 |
Not clear |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
all 5-ht neurons express tryptophan hydroxylase-2 (tph2), the brain specific, rate-limiting enzyme for 5-ht synthesis. |
2009-12-14 |
2023-08-12 |
rat |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
therefore, we tested the hypothesis that er beta may contribute to the regulation of gene expression in 5-ht neurons of the dorsal raphe nuclei (drn) by examining the effects of systemic and local application of the selective er beta agonist diarylpropionitrile (dpn) on tph2 mrna expression. |
2009-12-14 |
2023-08-12 |
rat |
| N Donner, R J Hand. Estrogen receptor beta regulates the expression of tryptophan-hydroxylase 2 mRNA within serotonergic neurons of the rat dorsal raphe nuclei. Neuroscience. vol 163. issue 2. 2009-12-14. PMID:19559077. |
these data indicate that er beta acts at the level of the rat drn to modulate tph2 mrna expression and thereby influence 5-ht synthesis in drn subregions. |
2009-12-14 |
2023-08-12 |
rat |
| Cory D Rice, James H Lois, Ilan A Kerman, Bill J Yate. Localization of serotoninergic neurons that participate in regulating diaphragm activity in the cat. Brain research. vol 1279. 2009-09-30. PMID:19433074. |
the present study identified these neurons in cats by combining the transneuronal retrograde transport of rabies virus from the diaphragm with the immunohistochemical detection of the n-terminal region of tryptophan hydroxylase-2 (tph2), the brain-specific isoform of the enzyme responsible for the initial and rate-limiting step in serotonin synthesis. |
2009-09-30 |
2023-08-12 |
cat |
| Ari Illi, Eija Setälä-Soikkeli, Merja Viikki, Outi Poutanen, Heini Huhtala, Nina Mononen, Terho Lehtimäki, Esa Leinonen, Olli Kampma. 5-HTR1A, 5-HTR2A, 5-HTR6, TPH1 and TPH2 polymorphisms and major depression. Neuroreport. vol 20. issue 12. 2009-09-29. PMID:19590397. |
in this study, we evaluated the association of seven serotonin signal transduction-linked single nucleotide polymorphisms [htr1a (rs6295), htr2a (rs6313, rs6311 and rs7997012), htr6 (rs1805054), tph1 (rs1800532) and tph2 (rs1386494)] with major depressive disorder and/or treatment outcome with serotonin reuptake inhibitors. |
2009-09-29 |
2023-08-12 |
Not clear |
| John Jacob, Robert Storm, Diogo S Castro, Christopher Milton, Patrick Pla, François Guillemot, Carmen Birchmeier, James Brisco. Insm1 (IA-1) is an essential component of the regulatory network that specifies monoaminergic neuronal phenotypes in the vertebrate hindbrain. Development (Cambridge, England). vol 136. issue 14. 2009-09-24. PMID:19542360. |
nevertheless, serotonergic precursors begin to differentiate in insm1 mutants, but fail to produce serotonin because of a failure to activate expression of tryptophan hydroxylase 2 (tph2), the key enzyme of serotonin biosynthesis. |
2009-09-24 |
2023-08-12 |
mouse |
| Martin Marziniak, Claudia Kienzler, Gregor Kuhlenbäumer, Claudia Sommer, Rainald Mössne. Functional gene variants of the serotonin-synthesizing enzyme tryptophan hydroxylase 2 in migraine. Journal of neural transmission (Vienna, Austria : 1996). vol 116. issue 7. 2009-09-08. PMID:19434366. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in the biosynthesis of 5-ht in the brain and is therefore a major factor in the availability of 5-ht and its rate of production. |
2009-09-08 |
2023-08-12 |
human |
| Ian R Gizer, Courtney Ficks, Irwin D Waldma. Candidate gene studies of ADHD: a meta-analytic review. Human genetics. vol 126. issue 1. 2009-08-25. PMID:19506906. |
further, significant heterogeneity was observed for the associations between adhd and dat1, drd4, drd5, dbh, adra2a, 5htt, tph2, maoa, and snap25, suggesting that future studies should explore potential moderators of these associations (e.g., adhd subtype diagnoses, gender, exposure to environmental risk factors). |
2009-08-25 |
2023-08-12 |
Not clear |
| Yong-Ku Kim, Heon-Jeong Lee, Jong-Chul Yang, Jung-A Hwang, Ho-Kyoung Yoo. A tryptophan hydroxylase 2 gene polymorphism is associated with panic disorder. Behavior genetics. vol 39. issue 2. 2009-08-13. PMID:19132526. |
the novel brain-specific serotonin synthesizing enzyme, tryptophan hydroxylase 2 (tph2), which represents the rate-limiting enzyme of serotonin production in the brain, may therefore be of particular importance in pd. |
2009-08-13 |
2023-08-12 |
human |
| Shih-Jen Tsai, Chen-Jee Hong, Ying-Jay Liou, Younger W-Y Yu, Tai-Jui Chen, Sheue-Jane Hou, Feng-Chang Ye. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19272410. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and has been implicated in the pathogenesis of major depressive disorder (mdd) and in the mechanism of antidepressant action. |
2009-08-10 |
2023-08-12 |
Not clear |
| Shih-Jen Tsai, Chen-Jee Hong, Ying-Jay Liou, Younger W-Y Yu, Tai-Jui Chen, Sheue-Jane Hou, Feng-Chang Ye. Tryptophan hydroxylase 2 gene is associated with major depression and antidepressant treatment response. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 4. 2009-08-10. PMID:19272410. |
our findings show that tph2 genetic variants may play a role in mdd susceptibility and in acute therapeutic response to selective serotonin reuptake inhibitors. |
2009-08-10 |
2023-08-12 |
Not clear |
| Jeffrey A McKinney, Banu Turel, Ingeborg Winge, Per M Knappskog, Jan Haavi. Functional properties of missense variants of human tryptophan hydroxylase 2. Human mutation. vol 30. issue 5. 2009-07-30. PMID:19319927. |
tryptophan hydroxylase 2 (tph2) catalyzes the rate-limiting step in serotonin biosynthesis in the nervous system. |
2009-07-30 |
2023-08-12 |
human |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
serotonin synthesis in mammals is initiated by 2 distinct tryptophan hydroxylases (tph), tph1 and tph2. |
2009-07-17 |
2023-08-12 |
mouse |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
by genetically ablating tph2, we created mice (tph2(-/-)) that lack serotonin in the central nervous system. |
2009-07-17 |
2023-08-12 |
mouse |
| Natalia Alenina, Dana Kikic, Mihail Todiras, Valentina Mosienko, Fatimunnisa Qadri, Ralph Plehm, Philipp Boyé, Larissa Vilianovitch, Reinhard Sohr, Katja Tenner, Heide Hörtnagl, Michael Bade. Growth retardation and altered autonomic control in mice lacking brain serotonin. Proceedings of the National Academy of Sciences of the United States of America. vol 106. issue 25. 2009-07-17. PMID:19520831. |
these data confirm that the majority of central serotonin is generated by tph2. |
2009-07-17 |
2023-08-12 |
mouse |
| Siobhan Roche, Patrick McKeo. Support for tryptophan hydroxylase-2 as a susceptibility gene for bipolar affective disorder. Psychiatric genetics. vol 19. issue 3. 2009-06-26. PMID:19352219. |
we investigated whether variants within the tryptophan hydroxylase-2 (tph2) gene, which is required for the synthesis of serotonin (5-ht), are associated with susceptibility to developing bpad. |
2009-06-26 |
2023-08-12 |
Not clear |
| M A Tikhonova, E L Al'perina, T G Tolstikova, D V Bazovkina, V Iu Di, G V Idova, A V Kulikov, N K Popov. [Effects of chronic fluoxetine treatment on catalepsy and immune response in mice genetically predisposed to freezing reaction: the role of 5-HT1A and 5-HT2A receptors and tph2 and SERT genes]. Zhurnal vysshei nervnoi deiatelnosti imeni I P Pavlova. vol 59. issue 2. 2009-06-19. PMID:19445393. |
no effect on cortical 5-ht1a and 5-ht2a receptor mrna levels and on 5-ht1a receptor, tph2 (tryptophan hydroxylase-2) and sert (serotonin transporter) mesencephalic gene expression was observed in asc mice. |
2009-06-19 |
2023-08-12 |
mouse |
| Guo-Lin Chen, Gregory M Mille. 5'-Untranslated region of the tryptophan hydroxylase-2 gene harbors an asymmetric bidirectional promoter but not internal ribosome entry site in vitro. Gene. vol 435. issue 1-2. 2009-06-18. PMID:19344641. |
tryptophan hydroxylase-2 (tph2) catalyzes the synthesis of neuronal serotonin, a major neurotransmitter involved in many brain functions and psychiatric disorders. |
2009-06-18 |
2023-08-12 |
human |