| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Alexander Strobel, Gesine Dreisbach, Johannes Müller, Thomas Goschke, Burkhard Brocke, Klaus-Peter Lesc. Genetic variation of serotonin function and cognitive control. Journal of cognitive neuroscience. vol 19. issue 12. 2008-06-20. PMID:17892388. |
eighty-five healthy participants performed a cued continuous performance task (the ax continuous performance task [axcpt]) and were genotyped for polymorphisms in the transcriptional control regions of the tryptophan hydroxylase 2 gene (tph2 g-703t; rs4570625) and the serotonin transporter gene (5-httlpr). |
2008-06-20 |
2023-08-12 |
human |
| Karen L Murphy, Xiaodong Zhang, Raul R Gainetdinov, Jean-Martin Beaulieu, Marc G Caro. A regulatory domain in the N terminus of tryptophan hydroxylase 2 controls enzyme expression. The Journal of biological chemistry. vol 283. issue 19. 2008-06-17. PMID:18339632. |
because this domain is unique to tph2, these data provide evidence for selective regulation of brain serotonin synthesis. |
2008-06-17 |
2023-08-12 |
Not clear |
| Basudha Basu, Radha Desai, J Balaji, Raghothama Chaerkady, V Sriram, Sudipta Maiti, Mitradas M Panicke. Serotonin in pre-implantation mouse embryos is localized to the mitochondria and can modulate mitochondrial potential. Reproduction (Cambridge, England). vol 135. issue 5. 2008-06-11. PMID:18304982. |
pre-implantation mouse embryos were also examined at various developmental stages for the presence of transcripts of the peripheral and neuronal forms of tryptophan hydroxylase (tph1 and tph2 respectively) and the classical serotonin transporter (slc6a4). |
2008-06-11 |
2023-08-12 |
mouse |
| J John Mann, Dianne Currier, Lauren Murphy, Yung-yu Huang, Hanga Galfalvy, David Brent, Laurence Greenhill, Maria Oquend. No association between a TPH2 promoter polymorphism and mood disorders or monoamine turnover. Journal of affective disorders. vol 106. issue 1-2. 2008-05-14. PMID:17604842. |
tph2 is a recently discovered isoform that is expressed predominantly in serotonin neurons. |
2008-05-14 |
2023-08-12 |
Not clear |
| Alicia K Smith, Irina Dimulescu, Virginia R Falkenberg, Supraja Narasimhan, Christine Heim, Suzanne D Vernon, Mangalathu S Rajeeva. Genetic evaluation of the serotonergic system in chronic fatigue syndrome. Psychoneuroendocrinology. vol 33. issue 2. 2008-05-06. PMID:18079067. |
a total of 77 polymorphisms in genes related to serotonin synthesis (tph2), signaling (htr1a, htr1e, htr2a, htr2b, htr2c, htr3a, htr3b, htr4, htr5a, htr6, and htr7), transport (slc6a4), and catabolism (maoa) were examined in 137 clinically evaluated subjects (40 cfs, 55 with insufficient fatigue, and 42 non-fatigued, nf, controls) derived from a population-based cfs surveillance study in wichita, kansas. |
2008-05-06 |
2023-08-12 |
human |
| Katja Tenner, Fatimunnisa Qadri, Bettina Bert, Jörg-Peter Voigt, Michael Bade. The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neuroscience letters. vol 431. issue 1. 2008-05-01. PMID:18082956. |
tryptophan hydroxylase 2 (tph2) is the rate limiting enzyme of serotonin synthesis in the brain. |
2008-05-01 |
2023-08-12 |
mouse |
| Katja Tenner, Fatimunnisa Qadri, Bettina Bert, Jörg-Peter Voigt, Michael Bade. The mTPH2 C1473G single nucleotide polymorphism is not responsible for behavioural differences between mouse strains. Neuroscience letters. vol 431. issue 1. 2008-05-01. PMID:18082956. |
a recently described functional (c1473g) single nucleotide polymorphism in mouse tph2 resulting in vitro in a strongly decreased enzymatic activity was suspected to be responsible for the observed differences in 5-ht levels and behaviour between mice strains. |
2008-05-01 |
2023-08-12 |
mouse |
| Guo-Lin Chen, Eric J Vallender, Gregory M Mille. Functional characterization of the human TPH2 5' regulatory region: untranslated region and polymorphisms modulate gene expression in vitro. Human genetics. vol 122. issue 6. 2008-04-30. PMID:17972101. |
tryptophan hydroxylase-2 (tph2) is a recently identified tph isoform responsible for neuronal serotonin (5-ht) synthesis, and tph2 polymorphisms are associated with a range of behavioral traits and psychiatric disorders. |
2008-04-30 |
2023-08-12 |
human |
| G T Shishkina, T S Kalinina, N N Dygal. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17950541. |
tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme in 5-ht synthesis in the brain, is a candidate for participation in a mechanism mediating the antidepressant effect of selective 5-ht reuptake inhibitors such as fluoxetine. |
2008-04-03 |
2023-08-12 |
rat |
| G T Shishkina, T S Kalinina, N N Dygal. Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. Neuroscience. vol 150. issue 2. 2008-04-03. PMID:17950541. |
a significant induction of tph2 and 5-ht transporter (5-htt) mrnas was detected in the midbrain of untreated rats 24 h after the swim test. |
2008-04-03 |
2023-08-12 |
rat |
| Ingeborg Winge, Jeffrey A McKinney, Ming Ying, Clive S D'Santos, Rune Kleppe, Per M Knappskog, Jan Haavi. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. The Biochemical journal. vol 410. issue 1. 2008-04-01. PMID:17973628. |
tph (tryptophan hydroxylase) catalyses the rate-limiting step in the synthesis of serotonin, and exists in two isoforms: tph1, mainly found in peripheral tissues and the pineal body, and tph2, a neuronal form. |
2008-04-01 |
2023-08-12 |
human |
| Ingeborg Winge, Jeffrey A McKinney, Ming Ying, Clive S D'Santos, Rune Kleppe, Per M Knappskog, Jan Haavi. Activation and stabilization of human tryptophan hydroxylase 2 by phosphorylation and 14-3-3 binding. The Biochemical journal. vol 410. issue 1. 2008-04-01. PMID:17973628. |
this indicates that 14-3-3 proteins could play a role in consolidating and strengthening the effects of phosphorylation on tph2 and that they may be important for the regulation of serotonin function in the nervous system. |
2008-04-01 |
2023-08-12 |
human |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
here, we generated knockin mice expressing a mutant form of the brain 5-ht synthesis enzyme, tryptophan hydroxylase 2 (tph2). |
2008-02-25 |
2023-08-12 |
mouse |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
expression of mutant tph2 in mice results in markedly reduced ( approximately 80%) brain 5-ht production and leads to behavioral abnormalities in tests assessing 5-ht-mediated emotional states. |
2008-02-25 |
2023-08-12 |
mouse |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
importantly, inactivation of gsk3beta in tph2 knockin mice, using pharmacological or genetic approaches, alleviates the aberrant behaviors produced by 5-ht deficiency. |
2008-02-25 |
2023-08-12 |
mouse |
| Jean-Martin Beaulieu, Xiaodong Zhang, Ramona M Rodriguiz, Tatyana D Sotnikova, Michael J Cools, William C Wetsel, Raul R Gainetdinov, Marc G Caro. Role of GSK3 beta in behavioral abnormalities induced by serotonin deficiency. Proceedings of the National Academy of Sciences of the United States of America. vol 105. issue 4. 2008-02-25. PMID:18212115. |
these findings establish a critical role of tph2 in the maintenance of brain serotonin homeostasis and identify gsk3beta signaling as an important pathway through which brain 5-ht deficiency induces abnormal behaviors. |
2008-02-25 |
2023-08-12 |
mouse |
| Sven Cichon, Ingeborg Winge, Manuel Mattheisen, Alexander Georgi, Anna Karpushova, Jan Freudenberg, Yun Freudenberg-Hua, Gulia Babadjanova, Ann Van Den Bogaert, Lilia I Abramova, Sofia Kapiletti, Per M Knappskog, Jeffrey McKinney, Wolfgang Maier, Rami Abou Jamra, Thomas G Schulze, Johannes Schumacher, Peter Propping, Marcella Rietschel, Jan Haavik, Markus M Nöthe. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. Human molecular genetics. vol 17. issue 1. 2008-02-11. PMID:17905754. |
in the brain, 5-ht production is controlled by tryptophan hydroxylase 2 (tph2). |
2008-02-11 |
2023-08-12 |
Not clear |
| Sven Cichon, Ingeborg Winge, Manuel Mattheisen, Alexander Georgi, Anna Karpushova, Jan Freudenberg, Yun Freudenberg-Hua, Gulia Babadjanova, Ann Van Den Bogaert, Lilia I Abramova, Sofia Kapiletti, Per M Knappskog, Jeffrey McKinney, Wolfgang Maier, Rami Abou Jamra, Thomas G Schulze, Johannes Schumacher, Peter Propping, Marcella Rietschel, Jan Haavik, Markus M Nöthe. Brain-specific tryptophan hydroxylase 2 (TPH2): a functional Pro206Ser substitution and variation in the 5'-region are associated with bipolar affective disorder. Human molecular genetics. vol 17. issue 1. 2008-02-11. PMID:17905754. |
examination of the functional effects of tph2 pro206ser provided evidence for a reduced thermal stability and solubility of the mutated enzyme, suggesting reduced 5-ht production in the brain as a pathophysiological mechanism in bpad. |
2008-02-11 |
2023-08-12 |
Not clear |
| Kathrin Scheuch, Marion Lautenschlager, Maik Grohmann, Silke Stahlberg, Julia Kirchheiner, Peter Zill, Andreas Heinz, Diego J Walther, Josef Prille. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biological psychiatry. vol 62. issue 11. 2008-01-28. PMID:17568567. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in brain serotonin (5-ht) biosynthesis. |
2008-01-28 |
2023-08-12 |
human |
| Kathrin Scheuch, Marion Lautenschlager, Maik Grohmann, Silke Stahlberg, Julia Kirchheiner, Peter Zill, Andreas Heinz, Diego J Walther, Josef Prille. Characterization of a functional promoter polymorphism of the human tryptophan hydroxylase 2 gene in serotonergic raphe neurons. Biological psychiatry. vol 62. issue 11. 2008-01-28. PMID:17568567. |
although dysfunction of 5-ht neurotransmission has been implicated in a variety of neuropsychiatric conditions, the human tph2 promoter has not been characterized in vitro. |
2008-01-28 |
2023-08-12 |
human |