| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Victor A Lopez, Sevilla Detera-Wadleigh, Imer Cardona, Layla Kassem, Francis J McMaho. Nested association between genetic variation in tryptophan hydroxylase II, bipolar affective disorder, and suicide attempts. Biological psychiatry. vol 61. issue 2. 2007-03-15. PMID:16806105. |
serotonin signaling has long been implicated in both bpad and suicide, and the gene encoding the brain-expressed isoform of tryptophan hydroxlyase (tph2) has been described. |
2007-03-15 |
2023-08-12 |
human |
| Michael D Gershon, Jan Tac. The serotonin signaling system: from basic understanding to drug development for functional GI disorders. Gastroenterology. vol 132. issue 1. 2007-03-14. PMID:17241888. |
serotonin is synthesized through the actions of 2 different tryptophan hydroxylases, tph1 and tph2, which are found, respectively, in ec cells and neurons. |
2007-03-14 |
2023-08-12 |
Not clear |
| N N Dygalo, G T Shishkina, T S Kalinina, A M Yudina, E S Ovchinnikov. Effect of repeated treatment with fluoxetine on tryptophan hydroxylase-2 gene expression in the rat brainstem. Pharmacology, biochemistry, and behavior. vol 85. issue 1. 2007-02-23. PMID:16982082. |
two-week fluoxetine treatment also significantly reduced expression of tryptophan hydroxylase-2 (tph2) and 5-ht transporter mrnas as determined by rt-pcr in the brainstem. |
2007-02-23 |
2023-08-12 |
human |
| Ilan A Kerman, Cyrus Shabrang, Larry Taylor, Huda Akil, Stanley J Watso. Relationship of presympathetic-premotor neurons to the serotonergic transmitter system in the rat brainstem. The Journal of comparative neurology. vol 499. issue 6. 2007-02-23. PMID:17072838. |
to test this hypothesis we first produced an antibody against tph2, a brain-specific isoform of tryptophan hydroxylase (serotonin synthetic enzyme). |
2007-02-23 |
2023-08-12 |
rat |
| Nicolas Ramoz, Guiqing Cai, Jennifer G Reichert, Thomas E Corwin, Lauren A Kryzak, Christopher J Smith, Jeremy M Silverman, Eric Hollander, Joseph D Buxbau. Family-based association study of TPH1 and TPH2 polymorphisms in autism. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 141B. issue 8. 2007-02-13. PMID:16958027. |
the tph1 and tph2 genes encode the rate-limiting enzymes that control serotonin biosynthesis, and serotonin is clearly altered in autism. |
2007-02-13 |
2023-08-12 |
Not clear |
| Li Ke, Zhang Yu Qi, Yu Ping, Cheng Yi Re. Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide. Brain research. vol 1122. issue 1. 2007-01-30. PMID:17011525. |
the novel tryptophan hydroxylase isoform (tph2), being the rate-limiting enzyme in the biosynthesis of serotonin, has many biological functions and plays an important role as candidate gene in several psychiatric disorders. |
2007-01-30 |
2023-08-12 |
Not clear |
| Zhong-Qiu Zhao, Michael Scott, Santina Chiechio, Jin-Shan Wang, Kenneth J Renner, Robert W Gereau, Randy L Johnson, Evan S Deneris, Zhou-Feng Che. Lmx1b is required for maintenance of central serotonergic neurons and mice lacking central serotonergic system exhibit normal locomotor activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 26. issue 49. 2006-12-29. PMID:17151281. |
the loss of gene expression is concomitant with downregulation of lmx1b expression, with the exception of serotonin transporter sert and tryptophan hydroxylase tph2, whose expression appears to be most sensitive to lmx1b. |
2006-12-29 |
2023-08-12 |
mouse |
| John P Dahl, Joseph F Cubells, Riju Ray, Andrew E Weller, Falk W Lohoff, Thomas N Ferraro, David W Oslin, Kyle M Kampman, Charles Dackis, Yilang Tang, Joel Gelernter, Henry R Kranzler, Charles P O'Brien, Wade H Berrettin. Analysis of variations in the tryptophan hydroxylase-2 (TPH2) gene in cocaine dependence. Addiction biology. vol 11. issue 1. 2006-11-09. PMID:16759340. |
the focus of the present study is to determine whether genetic variation in the tryptophan hydroxylase-2 (tph2) gene, which encodes the enzyme responsible for synthesis of the majority of the serotonin contained in neurons of the central nervous system, contributes to the pathophysiology of cocaine dependence. |
2006-11-09 |
2023-08-12 |
human |
| Rafael Ortíz-Alvarado, Omar Guzmán-Quevedo, Rosalio Mercado-Camargo, Thomas Haertle, Caroline Vignes, Francisco Bolaños-Jiméne. Expression of tryptophan hydroxylase in developing mouse taste papillae. FEBS letters. vol 580. issue 22. 2006-11-09. PMID:16989820. |
here, we show by quantitative real time rt-pcr that both isoforms of tryptophan hydroxylase (tph1 and tph2), the first and rate limiting enzyme of serotonin (5-ht) synthesis, are expressed in developing circumvallate papillae. |
2006-11-09 |
2023-08-12 |
mouse |
| G-L Chen, M A Novak, S Hakim, Z Xie, G M Mille. Tryptophan hydroxylase-2 gene polymorphisms in rhesus monkeys: association with hypothalamic-pituitary-adrenal axis function and in vitro gene expression. Molecular psychiatry. vol 11. issue 10. 2006-11-08. PMID:16847459. |
tryptophan hydroxylase-2 (tph2) is a newly identified second form of tph responsible for serotonin synthesis in the brain and has been increasingly implicated as a contributor to the etiology of various psychiatric disorders. |
2006-11-08 |
2023-08-12 |
monkey |
| Michael S Clark, Ross A McDevitt, John F Neumaie. Quantitative mapping of tryptophan hydroxylase-2, 5-HT1A, 5-HT1B, and serotonin transporter expression across the anteroposterior axis of the rat dorsal and median raphe nuclei. The Journal of comparative neurology. vol 498. issue 5. 2006-10-18. PMID:16917826. |
to foster uniform definitions of locations within these nuclei, we have quantitatively mapped gene expression in drn and mrn for tryptophan hydroxylase-2 (tph2), the serotonin transporter, as well as 5-ht1a and 5-ht1b receptors. |
2006-10-18 |
2023-08-12 |
rat |
| Rainald Mössner, Susanne Walitza, Frank Geller, André Scherag, Lise Gutknecht, Christian Jacob, Lisa Bogusch, Helmut Remschmidt, Michael Simons, Beate Herpertz-Dahlmann, Christian Fleischhaker, Eberhard Schulz, Andreas Warnke, Anke Hinney, Christoph Wewetzer, Klaus-Peter Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. The international journal of neuropsychopharmacology. vol 9. issue 4. 2006-10-10. PMID:16146581. |
the aim of this study was to investigate the effect of polymorphic variants in the gene of the novel brain-specific tryptophan hydroxylase-2 (tph2), the rate-limiting enzyme of serotonin (5-ht) synthesis in the brain, in ocd with disease onset in childhood and adolescence. |
2006-10-10 |
2023-08-12 |
Not clear |
| Rainald Mössner, Susanne Walitza, Frank Geller, André Scherag, Lise Gutknecht, Christian Jacob, Lisa Bogusch, Helmut Remschmidt, Michael Simons, Beate Herpertz-Dahlmann, Christian Fleischhaker, Eberhard Schulz, Andreas Warnke, Anke Hinney, Christoph Wewetzer, Klaus-Peter Lesc. Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in children and adolescents with obsessive-compulsive disorder. The international journal of neuropsychopharmacology. vol 9. issue 4. 2006-10-10. PMID:16146581. |
in conclusion, the results link tph2 variations to the pathogenesis of early-onset ocd and further support the aetiological relevance of 5-ht signalling in ocd. |
2006-10-10 |
2023-08-12 |
Not clear |
| Rainald Mössner, Christine M Freitag, Lise Gutknecht, Andreas Reif, Ralf Tauber, Petra Franke, Jürgen Fritze, Gerd Wagner, Gregor Peikert, Berit Wenda, Philipp Sand, Marcella Rietschel, Henk Garritsen, Christian Jacob, K Peter Lesch, Jürgen Decker. The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. Journal of psychopharmacology (Oxford, England). vol 20. issue 4. 2006-08-18. PMID:16401665. |
the novel brain-specific 5-ht synthesizing enzyme, tryptophan hydroxylase-2 (tph2), which represents the rate-limiting enzyme of 5-ht production in the brain, may therefore be of particular importance in panic disorder. |
2006-08-18 |
2023-08-12 |
Not clear |
| Rainald Mössner, Christine M Freitag, Lise Gutknecht, Andreas Reif, Ralf Tauber, Petra Franke, Jürgen Fritze, Gerd Wagner, Gregor Peikert, Berit Wenda, Philipp Sand, Marcella Rietschel, Henk Garritsen, Christian Jacob, K Peter Lesch, Jürgen Decker. The novel brain-specific tryptophan hydroxylase-2 gene in panic disorder. Journal of psychopharmacology (Oxford, England). vol 20. issue 4. 2006-08-18. PMID:16401665. |
moreover, a recently described loss-of-function mutation of tph2 which results in an 80% reduction of serotonin production, was assessed. |
2006-08-18 |
2023-08-12 |
Not clear |
| T Canli, E Congdon, L Gutknecht, R T Constable, K P Lesc. Amygdala responsiveness is modulated by tryptophan hydroxylase-2 gene variation. Journal of neural transmission (Vienna, Austria : 1996). vol 112. issue 11. 2006-07-27. PMID:16245070. |
the tryptophan hydroxylase-2 gene (tph2) codes for the enzyme of serotonin (5-ht) synthesis in the brain and variation of tph2 has been implicated in disorders of emotion regulation. |
2006-07-27 |
2023-08-12 |
Not clear |
| Nina K Popov. From genes to aggressive behavior: the role of serotonergic system. BioEssays : news and reviews in molecular, cellular and developmental biology. vol 28. issue 5. 2006-06-23. PMID:16615082. |
specifically, it describes: (1) the effect of the knockout of mao a, the principal enzyme in 5-ht degradation, (2) the association of intermale aggression with the polymorphism in the tph2 gene encoding the key enzyme in 5-ht synthesis in the brain, tryptophan hydroxylase (tph), and (3) the effect of selective breeding for nonaggressive behavior on 5-ht metabolism, tph activity and 5-ht(1a) receptors in the brain. |
2006-06-23 |
2023-08-12 |
Not clear |
| V De Luca, D Hlousek, O Likhodi, H H M Van Tol, J L Kennedy, A H C Won. The interaction between TPH2 promoter haplotypes and clinical-demographic risk factors in suicide victims with major psychoses. Genes, brain, and behavior. vol 5. issue 1. 2006-05-03. PMID:16436194. |
tryptophan hydroxylase isoform 2 (tph2) is a rate-limiting enzyme in the biosynthesis of serotonin (5-ht) and is predominantly localized in the brain. |
2006-05-03 |
2023-08-12 |
human |
| Stacey A Sakowski, Timothy J Geddes, Donald M Kuh. Mouse tryptophan hydroxylase isoform 2 and the role of proline 447 in enzyme function. Journal of neurochemistry. vol 96. issue 3. 2006-03-30. PMID:16405505. |
in view of the importance of tph in determining brain 5-ht function, we cloned tph2 and produced the p447r mutant to assess the importance of this proline in enzyme function. |
2006-03-30 |
2023-08-12 |
mouse |
| Dong-Kyu Kim, Teresa J Tolliver, Su-Jan Huang, Bradley J Martin, Anne M Andrews, Christine Wichems, Andrew Holmes, Klaus-Peter Lesch, Dennis L Murph. Altered serotonin synthesis, turnover and dynamic regulation in multiple brain regions of mice lacking the serotonin transporter. Neuropharmacology. vol 49. issue 6. 2006-03-10. PMID:16183083. |
despite increased 5-ht synthesis, there was no change in either tph2 or tph1 mrna levels or in maximal in vitro tph activity in the brainstem of sert -/- mice. |
2006-03-10 |
2023-08-12 |
mouse |