| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
the biosynthesis of serotonin is regulated by two rate-limiting enzymes, tryptophan hydroxylase-1 and -2 (tph1 and tph2). |
2008-12-18 |
2023-08-12 |
mouse |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
this resulted in dramatically reduced central 5-ht levels in tph2 knockout (tph2ko) and tph1/tph2 double knockout (dko) mice; and substantially reduced peripheral 5-ht levels in dko, but not tph2ko mice. |
2008-12-18 |
2023-08-12 |
mouse |
| Katerina V Savelieva, Shulei Zhao, Vladimir M Pogorelov, Indrani Rajan, Qi Yang, Emily Cullinan, Thomas H Lanthor. Genetic disruption of both tryptophan hydroxylase genes dramatically reduces serotonin and affects behavior in models sensitive to antidepressants. PloS one. vol 3. issue 10. 2008-12-18. PMID:18923670. |
the behavioral effects observed in the tph2 ko and dko mice strongly confirm the role of 5-ht and its synthetic enzymes in the etiology and treatment of affective disorders. |
2008-12-18 |
2023-08-12 |
mouse |
| G-L Chen, G M Mille. Rhesus monkey tryptophan hydroxylase-2 coding region haplotypes affect mRNA stability. Neuroscience. vol 155. issue 2. 2008-12-03. PMID:18593594. |
tryptophan hydroxylase-2 (tph2) synthesizes neuronal 5-ht and its genetic variance is associated with numerous behavioral traits and psychiatric disorders. |
2008-12-03 |
2023-08-12 |
monkey |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
the present study was designed to assess the effect of mdma on the rate-limiting enzyme in 5-ht biosynthesis, tryptophan hydroxylase (tph), by measuring tph2 protein and mrna levels in rat dorsal raphe (dr) nucleus. |
2008-11-05 |
2023-08-12 |
rat |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
in contrast, tph2 mrna levels were significantly increased by 24% in the mid dr and by 12% in the caudal dr. mdma treatment significantly decreased (125)i-rti-55 labeled sert binding sites in the striatum, nucleus accumbens and cingulate cortex demonstrating a loss of 5-ht terminals. |
2008-11-05 |
2023-08-12 |
rat |
| W L Bonkale, M C Austi. 3,4-Methylenedioxymethamphetamine induces differential regulation of tryptophan hydroxylase 2 protein and mRNA levels in the rat dorsal raphe nucleus. Neuroscience. vol 155. issue 1. 2008-11-05. PMID:18515011. |
the increase in tph2 mrna levels in both the mid dr and caudal dr of mdma-treated rats may reflect a compensatory mechanism in the injured 5-ht neurons to increase tph2 protein synthesis. |
2008-11-05 |
2023-08-12 |
rat |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
deficiency of brain 5-ht synthesis but serotonergic neuron formation in tph2 knockout mice. |
2008-10-24 |
2023-08-12 |
mouse |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
to investigate the respective role of tph2 in neuron serotonin (5-ht) synthesis and the role of 5-ht in brain development, mice with a targeted disruption of tph2 were generated. |
2008-10-24 |
2023-08-12 |
mouse |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
the preliminary results indicate that in tph2 knockout mice raphe neurons are completely devoid of 5-ht, whereas no obvious alteration in morphology and fiber distribution are observed. |
2008-10-24 |
2023-08-12 |
mouse |
| Lise Gutknecht, Jonas Waider, Stefanie Kraft, Claudia Kriegebaum, Bettina Holtmann, Andreas Reif, Angelika Schmitt, Klaus-Peter Lesc. Deficiency of brain 5-HT synthesis but serotonergic neuron formation in Tph2 knockout mice. Journal of neural transmission (Vienna, Austria : 1996). vol 115. issue 8. 2008-10-24. PMID:18665319. |
the findings confirm the exclusive specificity of tph2 in brain 5-ht synthesis and suggest that tph2-synthesized 5-ht is not required for serotonergic neuron formation. |
2008-10-24 |
2023-08-12 |
mouse |
| M Reuter, C Esslinger, C Montag, S Lis, B Gallhofer, P Kirsc. A functional variant of the tryptophan hydroxylase 2 gene impacts working memory: a genetic imaging study. Biological psychology. vol 79. issue 1. 2008-10-23. PMID:18234415. |
recently some molecular genetic studies reported associations between a functional promoter polymorphism of the tryptophan hydroxylase 2 gene (tph2), that regulates the synthesis of serotonin, and attention. |
2008-10-23 |
2023-08-12 |
human |
| Turhan Canli, Eliza Congdon, R Todd Constable, Klaus Peter Lesc. Additive effects of serotonin transporter and tryptophan hydroxylase-2 gene variation on neural correlates of affective processing. Biological psychology. vol 79. issue 1. 2008-10-23. PMID:18314252. |
individual differences in brain response to emotional stimuli have previously been associated with gene variations within the serotonin transporter (5-htt) and tryptophan hydroxylase-2 (tph2) genes. |
2008-10-23 |
2023-08-12 |
Not clear |
| F Haghighi, H Bach-Mizrachi, Y Y Huang, V Arango, S Shi, A J Dwork, G Rosoklija, H T Sheng, I Morozova, J Ju, J J Russo, J J Man. Genetic architecture of the human tryptophan hydroxylase 2 Gene: existence of neural isoforms and relevance for major depression. Molecular psychiatry. vol 13. issue 8. 2008-10-08. PMID:18180764. |
tryptophan hydroxylase-2 (tph2), is the rate limiting biosynthetic isoenzyme for serotonin that is preferentially expressed in the brain and a cause of impaired serotonin transmission. |
2008-10-08 |
2023-08-12 |
human |
| Nashat Abumaria, Adema Ribic, Christoph Anacker, Eberhard Fuchs, Gabriele Flügg. Stress upregulates TPH1 but not TPH2 mRNA in the rat dorsal raphe nucleus: identification of two TPH2 mRNA splice variants. Cellular and molecular neurobiology. vol 28. issue 3. 2008-08-11. PMID:18197473. |
two isoforms of the rate-limiting enzyme of serotonin biosynthesis, tryptophan hydroxylase, tph1 and tph2, are known. |
2008-08-11 |
2023-08-12 |
rat |
| Francesco Nonnis Marzano, Milena Maldini, Laura Filonzi, Anna Maria Lavezzi, Stefano Parmigiani, Cinzia Magnani, Giulio Bevilacqua, Luigi Matturr. Genes regulating the serotonin metabolic pathway in the brain stem and their role in the etiopathogenesis of the sudden infant death syndrome. Genomics. vol 91. issue 6. 2008-07-07. PMID:18387780. |
molecular polymorphisms are discussed considering their functional role in regulating serotonin synthesis (tph2), neuronal reuptake (5-httlpr and 5-htt intron 2), and catabolism (maoa) in the nervous system of italian sids infants. |
2008-07-07 |
2023-08-12 |
Not clear |
| J A Clark, R B Flick, L-Y Pai, I Szalayova, S Key, R K Conley, A Y Deutch, P H Hutson, E Meze. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:17622221. |
moreover, the glucocorticoid-elicited inhibition of tph2 was functionally significant: serotonin synthesis was significantly reduced in the frontal cortex of glucocorticoid-treated mice, an effect that was blocked by mifepristone co-administration. |
2008-07-03 |
2023-08-12 |
mouse |
| J A Clark, R B Flick, L-Y Pai, I Szalayova, S Key, R K Conley, A Y Deutch, P H Hutson, E Meze. Glucocorticoid modulation of tryptophan hydroxylase-2 protein in raphe nuclei and 5-hydroxytryptophan concentrations in frontal cortex of C57/Bl6 mice. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:17622221. |
this study provides further evidence for the glucocorticoid regulation of serotonin biosynthesis via inhibition of tph2 expression, and suggest that elevated glucocorticoid levels may be relevant to the etiology of psychiatric diseases, such as depression, where hypothalamic-pituitary-adrenal axis dysregulation has been documented. |
2008-07-03 |
2023-08-12 |
mouse |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
paradoxically, in the dorsal raphe nucleus (drn) there are more serotonin neurons and more neuronal tryptophan hydroxylase-2 (tph2) expression postmortem in depressed suicides. |
2008-07-03 |
2023-08-12 |
Not clear |
| H Bach-Mizrachi, M D Underwood, A Tin, S P Ellis, J J Mann, V Arang. Elevated expression of tryptophan hydroxylase-2 mRNA at the neuronal level in the dorsal and median raphe nuclei of depressed suicides. Molecular psychiatry. vol 13. issue 5. 2008-07-03. PMID:18180753. |
higher tph2 expression in depressed suicides may explain more tph2 protein and reflect a homeostatic response to deficient serotonin levels in the brains of depressed suicides. |
2008-07-03 |
2023-08-12 |
Not clear |