| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Se-Hoon Shim, Young Hwangbo, Young-Joon Kwon, Hee-Yeon Jeong, Bun-Hee Lee, Jung-A Hwang, Yong-Ku Ki. A case-control association study of serotonin 1A receptor gene and tryptophan hydroxylase 2 gene in attention deficit hyperactivity disorder. Progress in neuro-psychopharmacology & biological psychiatry. vol 34. issue 6. 2010-11-02. PMID:20470849. |
we investigated the association of serotonin the 1a receptor c-1019g single nucleotide polymorphism (htr1a c-1019g snp) and tryptophan hydroxylase 2 gene -703g/t (tph2 -703g/t) snp with adhd. |
2010-11-02 |
2023-08-12 |
human |
| S F Tee, T J Chow, P Y Tang, H C Lo. Linkage of schizophrenia with TPH2 and 5-HTR2A gene polymorphisms in the Malay population. Genetics and molecular research : GMR. vol 9. issue 3. 2010-10-19. PMID:20623453. |
association studies have focused on the tryptophan hydroxylase 2 gene (tph2) and the 5-hydroxytryptamine receptor 2a gene (5-htr2a). |
2010-10-19 |
2023-08-12 |
Not clear |
| S Kloiber, M A Kohli, T Brueckl, S Ripke, M Ising, M Uhr, A Menke, P G Unschuld, S Horstmann, D Salyakina, B Muller-Myhsok, E B Binder, F Holsboer, S Luca. Variations in tryptophan hydroxylase 2 linked to decreased serotonergic activity are associated with elevated risk for metabolic syndrome in depression. Molecular psychiatry. vol 15. issue 7. 2010-10-18. PMID:19125159. |
this led us to investigate whether variants in the gene coding for tryptophan hydroxylase 2 (tph2), the brain-specific and rate-limiting enzyme for serotonin biosynthesis, might be predictive for an increased liability for the development of mets in depressed patients. |
2010-10-18 |
2023-08-12 |
Not clear |
| Susann Matthes, Valentina Mosienko, Saleh Bashammakh, Natalia Alenina, Michael Bade. Tryptophan hydroxylase as novel target for the treatment of depressive disorders. Pharmacology. vol 85. issue 2. 2010-10-04. PMID:20130443. |
the peripheral and cerebral biosynthesis of 5-ht is initiated by two distinct tryptophan hydroxylases: tph1 and tph2. |
2010-10-04 |
2023-08-12 |
Not clear |
| Stefan Johansson, Anne Halmøy, Thegna Mavroconstanti, Kaya K Jacobsen, Elisabeth T Landaas, Andreas Reif, Christian Jacob, Andrea Boreatti-Hümmer, Susanne Kreiker, Klaus-Peter Lesch, Cornelis C Kan, J J Sandra Kooij, Lambertus A Kiemeney, Jan K Buitelaar, Barbara Franke, Marta Ribasés, Rosa Bosch, Mònica Bayés, Miguel Casas, Josep Antoni Ramos-Quiroga, Bru Cormand, Per Knappskog, Jan Haavi. Common variants in the TPH1 and TPH2 regions are not associated with persistent ADHD in a combined sample of 1,636 adult cases and 1,923 controls from four European populations. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 153B. issue 5. 2010-09-29. PMID:20213726. |
the tryptophan hydroxylase 1 and 2 (tph1 and tph2) genes encode the rate-limiting enzymes in the serotonin biosynthesis. |
2010-09-29 |
2023-08-12 |
Not clear |
| Christian P Jacob, Thuy Trang Nguyen, Astrid Dempfle, Monika Heine, Christine Windemuth-Kieselbach, Katarina Baumann, Florian Jacob, Julian Prechtl, Maike Wittlich, Martin J Herrmann, Silke Gross-Lesch, Klaus-Peter Lesch, Andreas Rei. A gene-environment investigation on personality traits in two independent clinical sets of adult patients with personality disorder and attention deficit/hyperactive disorder. European archives of psychiatry and clinical neuroscience. vol 260. issue 4. 2010-08-24. PMID:19894072. |
the present study therefore aimed to detect main effects as well as interactions of serotonergic candidate genes (coding for the serotonin transporter, 5-htt; the serotonin autoreceptor, htr1a; and the enzyme which synthesizes serotonin in the brain, tph2) with the burden of life events (#le) in two independent samples consisting of 183 patients suffering from personality disorders and 123 patients suffering from adult attention deficit/hyperactivity disorder (aadhd). |
2010-08-24 |
2023-08-12 |
human |
| G-L Chen, M A Novak, J S Meyer, B J Kelly, E J Vallender, G M Mille. TPH2 5'- and 3'-regulatory polymorphisms are differentially associated with HPA axis function and self-injurious behavior in rhesus monkeys. Genes, brain, and behavior. vol 9. issue 3. 2010-08-20. PMID:20059554. |
tryptophan hydroxylase-2 (tph2) synthesizes neuronal serotonin and is linked to numerous behavioral traits. |
2010-08-20 |
2023-08-12 |
monkey |
| Gabriella Juhasz, Darragh Downey, Neal Hinvest, Emma Thomas, Diana Chase, Zoltan G Toth, Kathryn Lloyd-Williams, Krisztina Mekli, Hazel Platt, Antony Payton, Gyorgy Bagdy, Rebecca Elliott, J F William Deakin, Ian M Anderso. Risk-taking behavior in a gambling task associated with variations in the tryptophan hydroxylase 2 gene: relevance to psychiatric disorders. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 35. issue 5. 2010-06-21. PMID:20043001. |
we tested the hypothesis that variations in serotonergic genes (tph2, tph1, slc6a4, htr1a), which influence serotonin availability, affect choice behavior in a probabilistic gambling task. |
2010-06-21 |
2023-08-12 |
human |
| Kyoichi Shiroiwa, Akitoyo Hishimoto, Kentaro Mouri, Masaaki Fukutake, Irwan Supriyanto, Naoki Nishiguchi, Osamu Shirakaw. Common genetic variations in TPH1/TPH2 genes are not associated with schizophrenia in Japanese population. Neuroscience letters. vol 472. issue 3. 2010-06-11. PMID:20144688. |
although a genetic association of tryptophan hydroxylase isoform 1 (tph1), the rate-limiting enzyme in serotonin synthesis, with schizophrenia has been suggested by recent systematic meta-analyses, the newly identified neuronal isoform tph2 is more relevant to the central nervous system and the association of tph2 gene with schizophrenia has been much less explored. |
2010-06-11 |
2023-08-12 |
Not clear |
| Simone Becho Campos, Débora Marques Miranda, Bruno Rezende Souza, Patricia Araújo Pereira, Fernando Silva Neves, Maria Aparecida Camargos Bicalho, Paulo Henrique Casadei Melillo, Juliana Tramontina, Flávio Kapczinski, Marco Aurélio Romano-Silva, Humberto Corre. Association of polymorphisms of the tryptophan hydroxylase 2 gene with risk for bipolar disorder or suicidal behavior. Journal of psychiatric research. vol 44. issue 5. 2010-06-04. PMID:19800079. |
tryptophan hydroxylase 2 (tph2) which is a rate limiting enzyme in the serotonin synthesis is considered an important candidate gene associated with psychiatric disorders. |
2010-06-04 |
2023-08-12 |
human |
| Diana Armbruster, Anett Mueller, Alexander Strobel, Clemens Kirschbaum, Klaus-Peter Lesch, Burkhard Brock. Influence of functional tryptophan hydroxylase 2 gene variation and sex on the startle response in children, young adults, and older adults. Biological psychology. vol 83. issue 3. 2010-06-02. PMID:20064585. |
allelic variation of tph2 gene expression influences serotonin synthesis in the brain and therefore may modulate emotional processing. |
2010-06-02 |
2023-08-12 |
human |
| Maik Grohmann, Paul Hammer, Maria Walther, Nils Paulmann, Andreas Büttner, Wolfgang Eisenmenger, Thomas C Baghai, Cornelius Schüle, Rainer Rupprecht, Michael Bader, Brigitta Bondy, Peter Zill, Josef Priller, Diego J Walthe. Alternative splicing and extensive RNA editing of human TPH2 transcripts. PloS one. vol 5. issue 1. 2010-05-20. PMID:20126463. |
therefore, our results strongly suggest a complex fine-tuning of central nervous system 5-ht biosynthesis by tph2 alternative splicing and rna editing. |
2010-05-20 |
2023-08-12 |
human |
| Scott F Stoltenberg, Joanna M Vandeve. Gender moderates the association between 5-HTTLPR and decision-making under ambiguity but not under risk. Neuropharmacology. vol 58. issue 2. 2010-04-13. PMID:19781560. |
because gender moderates the effect of genetic polymorphisms on serotonin function and because there are gender differences in decision-making, the present study examined potential gender moderation of associations between polymorphisms in important serotonin system candidate genes (serotonin transporter [slc6a4] and tryptophan hydroxylase-2 [tph2]) and performance on a decision-making task (iowa gambling task, igt) in healthy, adults (n = 188; 62% women). |
2010-04-13 |
2023-08-12 |
human |
| Guo-Lin Chen, Melinda A Novak, Jerrold S Meyer, Brian J Kelly, Eric J Vallender, Gregory M Mille. The effect of rearing experience and TPH2 genotype on HPA axis function and aggression in rhesus monkeys: a retrospective analysis. Hormones and behavior. vol 57. issue 2. 2010-04-12. PMID:19900455. |
tryptophan hydroxylase-2 (tph2) synthesizes neuronal serotonin and is closely related to the hypothalamic-pituitary-adrenal (hpa) axis, while early life experience is a critical environmental factor programming the hpa axis response to stress. |
2010-04-12 |
2023-08-12 |
human |
| Kathrin Scheuch, Markus Höltje, Holger Budde, Marion Lautenschlager, Andreas Heinz, Gudrun Ahnert-Hilger, Josef Prille. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain research. vol 1307. 2010-03-08. PMID:19840776. |
using real-time reverse transcriptase polymerase chain reaction and western blotting, we examined the effect of lithium on tryptophan hydroxylase 2 (tph2) expression, the rate-limiting enzyme in brain 5-ht biosynthesis. |
2010-03-08 |
2023-08-12 |
rat |
| Kathrin Scheuch, Markus Höltje, Holger Budde, Marion Lautenschlager, Andreas Heinz, Gudrun Ahnert-Hilger, Josef Prille. Lithium modulates tryptophan hydroxylase 2 gene expression and serotonin release in primary cultures of serotonergic raphe neurons. Brain research. vol 1307. 2010-03-08. PMID:19840776. |
our results suggest that lithium can modify tph2 gene expression and 5-ht release in raphe neurons, providing new insight into the serotonergic mechanisms of action of lithium. |
2010-03-08 |
2023-08-12 |
rat |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
fev (fifth ewing variant) ets transcription factor, tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor were determined at 7-8 levels of the dorsal raphe nucleus with in situ hybridization (ish) using radiolabeled- and digoxygenin-incorporated riboprobes. |
2010-02-12 |
2023-08-12 |
monkey |
| F B Lima, M L Centeno, M E Costa, A P Reddy, J L Cameron, C L Bethe. Stress sensitive female macaques have decreased fifth Ewing variant (Fev) and serotonin-related gene expression that is not reversed by citalopram. Neuroscience. vol 164. issue 2. 2010-02-12. PMID:19671441. |
these data suggest that ss monkeys have fewer serotonin (5-ht) neurons than hsr monkeys, and that they have deficient fev expression, which in turn, leads to deficient tph2, sert and 5ht1a expression. |
2010-02-12 |
2023-08-12 |
monkey |
| C G Baehne, A-C Ehlis, M M Plichta, A Conzelmann, P Pauli, C Jacob, L Gutknecht, K-P Lesch, A J Fallgatte. Tph2 gene variants modulate response control processes in adult ADHD patients and healthy individuals. Molecular psychiatry. vol 14. issue 11. 2010-01-25. PMID:18427560. |
in that respect, several variants of the tryptophan hydroxylase gene (tph2), which codes for the rate-limiting enzyme in the biosynthesis of serotonin (5-ht), have been associated with adhd. |
2010-01-25 |
2023-08-12 |
Not clear |
| Kentaro Mouri, Akitoyo Hishimoto, Masaaki Fukutake, Kyoichi Shiroiwa, Migiwa Asano, Yasushi Nagasaki, Yasuhiro Ueno, Osamu Shirakawa, Naoki Nishiguchi, Kiyoshi Maed. TPH2 is not a susceptibility gene for suicide in Japanese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 33. issue 8. 2010-01-25. PMID:19748542. |
the newly identified neuronal tryptophan hydroxylase isoform 2 (tph2), the rate-limiting enzyme in serotonin synthesis, represents a prime candidate in numerous genetic association analyses of suicidal behavior; however, the results are still inconclusive. |
2010-01-25 |
2023-08-12 |
human |