| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Matthew W Hale, Anantha Shekhar, Christopher A Lowr. Development by environment interactions controlling tryptophan hydroxylase expression. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21640184. |
recent studies suggest that tph2 expression and brain serotonin turnover are upregulated in depressed suicide patients, and drug-free depressed patients, respectively. |
2012-02-22 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Fernanda B Lima, Maria L Centeno, Karin V Weissheimer, Olga Senashova, Arubala P Reddy, Judy L Camero. Effects of citalopram on serotonin and CRF systems in the midbrain of primates with differences in stress sensitivity. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21683135. |
examination of the serotonin system revealed that ss monkeys had significantly lower fev (fifth ewing variant, rodent pet1), tph2 (tryptophan hydroxylase 2), 5ht1a autoreceptor and sert (serotonin reuptake transporter) expression in the dorsal raphe than sr monkeys. |
2012-02-22 |
2023-08-12 |
monkey |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
the expression, turnover and distribution of tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in 5-ht biosynthesis in the drn and mrn are complex, in keeping with the existence of different subpopulations of 5-ht neurons in this area. |
2012-02-22 |
2023-08-12 |
mouse |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
thus, there were significant decreases in tph2 transcript levels in 5-ht transporter (5-htt)-/- mutant mice, whereas increases were observed in the vesicular glutamate transporter 1 hemi knock out (vglut1+/-) and cannabinoid receptor 1 mutant (cb1r-/-) mice. |
2012-02-22 |
2023-08-12 |
mouse |
| Ali Jahanshahi, Erwan Le Maitre, Yasin Temel, Laurence Lanfumey, Michel Hamon, Klaus-Peter Lesch, Rosa M Tordera, Joaquín Del Río, Ester Aso, Rafael Maldonado, Tomas Hökfelt, Harry W M Steinbusc. Altered expression of neuronal tryptophan hydroxylase-2 mRNA in the dorsal and median raphe nuclei of three genetically modified mouse models relevant to depression and anxiety. Journal of chemical neuroanatomy. vol 41. issue 4. 2012-02-22. PMID:21704153. |
based on these findings, we suggest that tph2 mrna expression is under the influence of multiple messenger systems in relation to presynaptic and/or postsynaptic feedback control of serotonin synthesis that, 5-htt, vglut1 and cb1r seem to be involved in these feedback mechanisms. |
2012-02-22 |
2023-08-12 |
mouse |
| Jukka M Leppänen, Mikko J Peltola, Kaija Puura, Mirjami Mäntymaa, Nina Mononen, Terho Lehtimäk. Serotonin and early cognitive development: variation in the tryptophan hydroxylase 2 gene is associated with visual attention in 7-month-old infants. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 11. 2012-02-01. PMID:21418063. |
allelic variation in the promoter region of a gene that encodes tryptophan hydroxylase isoform 2 (tph2), a rate-limiting enzyme of serotonin synthesis in the central nervous system, has been associated with variations in cognitive function and vulnerability to affective spectrum disorders. |
2012-02-01 |
2023-08-12 |
Not clear |
| C L Bethea, A W Smith, M L Centeno, A P Redd. Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques. Neuroscience. vol 192. 2012-01-18. PMID:21763405. |
in macaques, ovarian steroid administration to ovariectomized (ovx) individuals improves serotonin neural function through actions on pivotal serotonin-related genes and proteins, such as tph2 (tryptophan hydroxylase 2), sert (serotonin reuptake transporter), and the 5ht1a autoreceptor. |
2012-01-18 |
2023-08-12 |
Not clear |
| C L Bethea, A W Smith, M L Centeno, A P Redd. Long-term ovariectomy decreases serotonin neuron number and gene expression in free ranging macaques. Neuroscience. vol 192. 2012-01-18. PMID:21763405. |
in summary, long-term ovarian steroid loss resulted in fewer serotonin neurons and overall lower fev, tph2, sert, and 5ht1a gene expression. |
2012-01-18 |
2023-08-12 |
Not clear |
| Sara Trowbridge, Nicolas Narboux-Nême, Patricia Gaspa. Genetic models of serotonin (5-HT) depletion: what do they tell us about the developmental role of 5-HT? Anatomical record (Hoboken, N.J. : 2007). vol 294. issue 10. 2012-01-17. PMID:20818612. |
serotonin (5-ht) depletion has been obtained via targeting of genes involved in 5-ht synthesis (tph1 and tph2), specification and determination of the 5-ht phenotype during development (gata3, pet1, and lmx1b), and 5-ht storage or clearance (vmat2 and sert). |
2012-01-17 |
2023-08-12 |
Not clear |
| Julia C Lemos, Guojun Zhang, Teresa Walsh, Lynn G Kirby, Adaure Akanwa, Amy Brooks-Kayal, Sheryl G Bec. Stress-hyperresponsive WKY rats demonstrate depressed dorsal raphe neuronal excitability and dysregulated CRF-mediated responses. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 36. issue 4. 2011-12-12. PMID:21160465. |
in the wky rat, there was a decrease in the neuronal excitability of 5-ht neurons coupled with decreased tph2 production. |
2011-12-12 |
2023-08-12 |
rat |
| Alexander V Kulikov, Maria A Tikhonova, Daria V Osipova, Victor A Kulikov, Nina K Popov. Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21726574. |
tryptophan hydroxylase-2 (tph2) is the rate limiting enzyme of serotonin synthesis in the brain. |
2011-12-09 |
2023-08-12 |
mouse |
| Alexander V Kulikov, Maria A Tikhonova, Daria V Osipova, Victor A Kulikov, Nina K Popov. Association between tryptophan hydroxylase-2 genotype and the antidepressant effect of citalopram and paroxetine on immobility time in the forced swim test in mice. Pharmacology, biochemistry, and behavior. vol 99. issue 4. 2011-12-09. PMID:21726574. |
here, the influence of the 1473g allele on the antidepressant effect of selective serotonin reuptake inhibitors (ssris), citalopram (2.5 or 5.0mg/kg) and paroxetine (5.0 or 10.0mg/kg), in the forced swim test was studied using b6-1473g and b6-1473c congenic mouse lines with the 1473g (decreased tph2 activity) or 1473c (normal tph2 activity) alleles, respectively, transferred to the genome of c57bl/6 mouse strain. |
2011-12-09 |
2023-08-12 |
mouse |
| Hideaki Kobayashi, Hiroshi Ujike, Nakao Iwata, Toshiya Inada, Mitsuhiko Yamada, Yoshimoto Sekine, Naohisa Uchimura, Masaomi Iyo, Norio Ozaki, Masanari Itokawa, Ichiro Sor. Association analysis of the tryptophan hydroxylase 2 gene polymorphisms in patients with methamphetamine dependence/psychosis. Current neuropharmacology. vol 9. issue 1. 2011-11-10. PMID:21886586. |
we analyzed the association between the variations in the brain tryptophan hydroxylase 2 (tph2) gene, a rate limiting enzyme for serotonin biosynthesis, and methamphetamine (meth) dependence/psychosis in a japanese population. |
2011-11-10 |
2023-08-12 |
Not clear |
| Kyung-Won Hong, Alexander Weiss, Naruki Morimura, Toshifumi Udono, Ikuo Hayasaka, Tatyana Humle, Yuichi Murayama, Shin'ichi Ito, Miho Inoue-Murayam. Polymorphism of the tryptophan hydroxylase 2 (TPH2) gene is associated with chimpanzee neuroticism. PloS one. vol 6. issue 7. 2011-11-09. PMID:21765945. |
in the brain, serotonin production is controlled by tryptophan hydroxylase 2 (tph2), a genotype. |
2011-11-09 |
2023-08-12 |
mouse |
| Kyung Bong Koh, Eun Hee Choi, Young-Joon Lee, Mooyoung Ha. Serotonin-related gene pathways associated with undifferentiated somatoform disorder. Psychiatry research. vol 189. issue 2. 2011-11-08. PMID:21531467. |
the genotype and allele frequencies of tryptophan hydroxylase (tph)1 a218c, tph2 rs1386494, serotonin receptor 2a-t102c (5-htr 2a-t102c), 5-htr 2a-g1438a and serotonin transporter (5httlpr) gene were compared between the groups. |
2011-11-08 |
2023-08-12 |
human |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
balb/c is an inbred stress-sensitive mouse strain exhibiting low brain serotonin (5-ht) content and a 5-ht biosynthetic enzyme tryptophan hydroxylase (tph2) variant reported to have lower catalytic activity compared with other inbred base strains. |
2011-11-01 |
2023-08-12 |
mouse |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
to evaluate other mechanisms that may explain low 5-ht, we compared balb/cj mice and a control inbred strain c57bl/6j mice, for expression of tph2 mrna, tph2 protein and regional levels of 5-ht and its metabolite 5-hydroxyindoleacetic acid. |
2011-11-01 |
2023-08-12 |
mouse |
| Helene Bach, Victoria Arango, Yung-Yu Huang, Sharlene Leong, J John Mann, Mark D Underwoo. Neuronal tryptophan hydroxylase expression in BALB/cJ and C57Bl/6J mice. Journal of neurochemistry. vol 118. issue 6. 2011-11-01. PMID:21740442. |
the behavioral differences in balb/cj mice relative to the c57bl/6j strain may be due in part, to fewer 5-ht neurons and lower tph2 gene expression resulting in less 5-ht neurotransmission. |
2011-11-01 |
2023-08-12 |
mouse |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
here we examine both the spatial and temporal profile of 5-ht related gene expression, including 5ht1a, 2a, 2c receptors, the 5-ht transporter (5htt), and tryptophan hydroxylase 2 (tph2) during early development (postnatal day [p]14, p17, p21, p28) in mice challenged with lipopolysaccharide (lps) during the first postnatal week. |
2011-10-31 |
2023-08-12 |
mouse |
| M M Sidor, A Amath, G MacQueen, J A Foste. A developmental characterization of mesolimbocortical serotonergic gene expression changes following early immune challenge. Neuroscience. vol 171. issue 3. 2011-10-31. PMID:20816924. |
increased tph2 and 5htt expression in the ventrolateral region of the dr of lps-mice accompanied decreased expression of ventral dr 5ht1a and dorsal dr 5htt. |
2011-10-31 |
2023-08-12 |
mouse |