| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
surprisingly, deletion of tryptophan hydroxylase-1 (tph1), upon which 5-ht biosynthesis in ec cells depends, does not alter constitutive gi motility, whereas deletion of tph2, upon which biosynthesis of neuronal 5-ht depends, slows intestinal transit and accelerates gastric emptying. |
2013-07-01 |
2023-08-12 |
mouse |
| Michael D Gersho. Serotonin is a sword and a shield of the bowel: serotonin plays offense and defense. Transactions of the American Clinical and Climatological Association. vol 123. 2013-07-01. PMID:23303993. |
tph1 deletion, however, protects mice from experimental inflammation; 5-ht potentiation and tph2 deletion each make inflammation more severe. |
2013-07-01 |
2023-08-12 |
mouse |
| Guo-Lin Chen, Gregory M Mille. Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders. Biochemical pharmacology. vol 85. issue 9. 2013-05-21. PMID:23435356. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in 5-ht synthesis, and the recent identification of a second, neuron-specific tph isoform (tph2) opened up a new area of research. |
2013-05-21 |
2023-08-12 |
Not clear |
| Guo-Lin Chen, Gregory M Mille. Tryptophan hydroxylase-2: an emerging therapeutic target for stress disorders. Biochemical pharmacology. vol 85. issue 9. 2013-05-21. PMID:23435356. |
as a major modulator of 5-ht neurotransmission and the stress response, tph2 is of both pathophysiological and pharmacological significance, and is emerging as a new therapeutic target for the treatment of stress disorders. |
2013-05-21 |
2023-08-12 |
Not clear |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
impacts of brain serotonin deficiency following tph2 inactivation on development and raphe neuron serotonergic specification. |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
to further analyze the importance of brain 5-ht in somatic and brain development and function, and more specifically differentiation and specification of the serotonergic system itself, we generated a mouse model with brain-specific 5-ht deficiency resulting from a genetically driven constitutive inactivation of neuronal tryptophan hydroxylase-2 (tph2). |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
tph2 inactivation (tph2-/-) resulted in brain 5-ht deficiency leading to growth retardation and persistent leanness, whereas a sex- and age-dependent increase in body weight was observed in tph2+/- mice. |
2013-05-01 |
2023-08-12 |
mouse |
| Lise Gutknecht, Naozumi Araragi, Sören Merker, Jonas Waider, Frank M J Sommerlandt, Boris Mlinar, Gilda Baccini, Ute Mayer, Florian Proft, Michel Hamon, Angelika G Schmitt, Renato Corradetti, Laurence Lanfumey, Klaus-Peter Lesc. Impacts of brain serotonin deficiency following Tph2 inactivation on development and raphe neuron serotonergic specification. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912815. |
the conserved expression pattern of the 5-ht neuron-specific markers (except tph2 and 5-ht) demonstrates that brain 5-ht synthesis is not a prerequisite for the proliferation, differentiation and survival of raphe neurons subjected to the developmental program of serotonergic specification. |
2013-05-01 |
2023-08-12 |
mouse |
| Wenjun Zhou, Ligong Chen, Jodi Paul, Sufen Yang, Fuzeng Li, Karen Sampson, Jim R Woodgett, Jean Martin Beaulieu, Karen L Gamble, Xiaohua L. The effects of glycogen synthase kinase-3beta in serotonin neurons. PloS one. vol 7. issue 8. 2013-05-01. PMID:22912839. |
these mice had normal growth and physiological characteristics, similar numbers of tryptophan hydroxylase-2 (tph2)-expressing serotonin neurons, and the same brain serotonin content as in littermate wild type mice. |
2013-05-01 |
2023-08-12 |
mouse |
| Kafui Dzirasa, Sunil Kumar, Benjamin D Sachs, Marc G Caron, Miguel A L Nicoleli. Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 33. issue 10. 2013-04-26. PMID:23467366. |
although the majority of first-line antidepressants increase brain serotonin and rare polymorphisms in tryptophan hydroxlase-2 (tph2), the rate-limiting enzyme in the brain serotonin synthesis pathway, have been identified in cohorts of subjects with major depressive disorder, the circuit level alterations that results from serotonergic hypofunction remain poorly understood. |
2013-04-26 |
2023-08-12 |
mouse |
| Michael J Kane, Mariana Angoa-Peréz, Denise I Briggs, Catherine E Sykes, Dina M Francescutti, David R Rosenberg, Donald M Kuh. Mice genetically depleted of brain serotonin display social impairments, communication deficits and repetitive behaviors: possible relevance to autism. PloS one. vol 7. issue 11. 2013-04-23. PMID:23139830. |
to test the hypothesis that serotonin dysfunction can contribute to the core symptoms of autism, we analyzed mice lacking brain serotonin (via a null mutation in the gene for tryptophan hydroxylase 2 (tph2)) for behaviors that are relevant to this disorder. |
2013-04-23 |
2023-08-12 |
mouse |
| Lei Li, Sachio Morimoto, Sachiko Take, Dong-Yun Zhan, Cheng-Kun Du, Yuan-Yuan Wang, Xue-Li Fan, Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Toshihiko Katafuchi, Toshiyuki Sasagur. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. Journal of molecular and cellular cardiology. vol 53. issue 6. 2013-04-19. PMID:22921782. |
balb/c mice have brain serotonin dysfunction due to a single nucleotide polymorphism (snp) in tryptophan hydroxylase 2 (tph2). |
2013-04-19 |
2023-08-12 |
mouse |
| Lei Li, Sachio Morimoto, Sachiko Take, Dong-Yun Zhan, Cheng-Kun Du, Yuan-Yuan Wang, Xue-Li Fan, Tatsuya Yoshihara, Fumi Takahashi-Yanaga, Toshihiko Katafuchi, Toshiyuki Sasagur. Role of brain serotonin dysfunction in the pathophysiology of congestive heart failure. Journal of molecular and cellular cardiology. vol 53. issue 6. 2013-04-19. PMID:22921782. |
these results strongly suggest that genetic backgrounds involving brain serotonin dysfunction, such as tph2 gene snp, may play an important role in the development of congestive hf in dcm. |
2013-04-19 |
2023-08-12 |
mouse |
| Ashley P Kennedy, Elisabeth B Binder, Dubois Bowman, Keith Harenski, Timothy Ely, Josh M Cisler, Shanti P Tripathi, Sidney VanNess, Clinton D Kilt. A common TPH2 haplotype regulates the neural processing of a cognitive control demand. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 7. 2013-04-04. PMID:22915309. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the synthesis of serotonin with the neuron-specific tph2 isoform present exclusively in the brain and encoded by the tph2 gene on chromosome 12q21. |
2013-04-04 |
2023-08-12 |
human |
| Stefan M Berger, Tillmann Weber, Stephanie Perreau-Lenz, Miriam A Vogt, Sarah E Gartside, Christiane Maser-Gluth, Laurence Lanfumey, Peter Gass, Rainer Spanagel, Dusan Bartsc. A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 9. 2013-03-17. PMID:22491354. |
the arg(447) substitution in the tph2 enzyme resulted in a significant reduction of the brain serotonin (5-ht) in vivo synthesis rate. |
2013-03-17 |
2023-08-12 |
mouse |
| Stefan M Berger, Tillmann Weber, Stephanie Perreau-Lenz, Miriam A Vogt, Sarah E Gartside, Christiane Maser-Gluth, Laurence Lanfumey, Peter Gass, Rainer Spanagel, Dusan Bartsc. A functional Tph2 C1473G polymorphism causes an anxiety phenotype via compensatory changes in the serotonergic system. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 37. issue 9. 2013-03-17. PMID:22491354. |
these findings provide evidence for an involvement of functional tph2 polymorphisms in anxiety-related behaviors, which are likely not caused directly by alterations in 5-ht content or release but are rather due to compensatory changes during development involving functional desensitization of 5-ht(1a) autoreceptors. |
2013-03-17 |
2023-08-12 |
mouse |
| V Mosienko, B Bert, D Beis, S Matthes, H Fink, M Bader, N Alenin. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Translational psychiatry. vol 2. 2013-03-04. PMID:22832966. |
biosynthesis of serotonin in the cns is initiated by tryptophan hydroxylase 2 (tph2). |
2013-03-04 |
2023-08-12 |
mouse |
| V Mosienko, B Bert, D Beis, S Matthes, H Fink, M Bader, N Alenin. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Translational psychiatry. vol 2. 2013-03-04. PMID:22832966. |
in this study, we used tph2-deficient (tph2(-/-)) mice to evaluate the impact of serotonin depletion in the brain on mouse behavior. |
2013-03-04 |
2023-08-12 |
mouse |
| V Mosienko, B Bert, D Beis, S Matthes, H Fink, M Bader, N Alenin. Exaggerated aggression and decreased anxiety in mice deficient in brain serotonin. Translational psychiatry. vol 2. 2013-03-04. PMID:22832966. |
despite carrying only one copy of the gene, heterozygous tph2(+/-) mice showed only 10% reduction in brain serotonin, which was not sufficient to modulate behavior in the tested paradigms. |
2013-03-04 |
2023-08-12 |
mouse |
| Gabriel Manjarrez-Gutiérrez, Karina Martínez-Radilla, Alfonso Boyzo-Montes de Oca, Sandra Orozco-Suárez, Jorge Hernández-Rodrígue. Increased expression of tryptophan-5-hydroxylase 1, but not 2, in brainstem as a result of intrauterine malnutrition. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 30. issue 6. 2013-02-05. PMID:22819790. |
it was confirmed that ium produces an increase in 5-ht in the brainstem and also showed increased expression of tph1 at birth, with decreased expression of tph2. |
2013-02-05 |
2023-08-12 |
Not clear |