| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Thomas Del'Guidice, Francis Lemay, Morgane Lemasson, Jean Levasseur-Moreau, Stella Manta, Adeline Etievant, Guy Escoffier, François Y Doré, François S Roman, Jean-Martin Beaulie. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24196946. |
furthermore, identification of a role for a 5-ht(2) receptor agonist as a cognition-enhancing agent in mutant mice suggests a potential avenue to explore for the personalized treatment of cognitive symptoms in humans with reduced 5-ht synthesis and tph2 polymorphisms. |
2014-12-01 |
2023-08-12 |
mouse |
| Sören Enge, Monika Fleischhauer, Klaus-Peter Lesch, Andreas Reif, Alexander Strobe. Variation in key genes of serotonin and norepinephrine function predicts gamma-band activity during goal-directed attention. Cerebral cortex (New York, N.Y. : 1991). vol 24. issue 5. 2014-11-28. PMID:23258345. |
to investigate this link, 130 volunteers were genotyped for the 5-ht transporter gene-linked polymorphic region (5-httlpr) and for a variation (tph2-703 g/t) of the tph2 gene coding for the rate-limiting enzyme of 5-ht synthesis in the brain. |
2014-11-28 |
2023-08-12 |
human |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
in the present study, we investigated mrna expression and immunohistochemical localization of the 5-ht synthetic enzyme isoforms, tryptophan hydroxylase 1 (tph1) and tph2, and the 5-ht plasma membrane transport protein, 5-ht transporter (sert), in the cb of the rat. |
2014-11-24 |
2023-08-12 |
rat |
| X M Xu, M Ding, H Pang, B J Wan. TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668623. |
the rate-limiting enzyme of 5-ht synthesis is tryptophan hydroxylase 2 (tph2). |
2014-11-04 |
2023-08-12 |
Not clear |
| X M Xu, M Ding, H Pang, B J Wan. TPH2 gene polymorphisms in the regulatory region are associated with paranoid schizophrenia in Northern Han Chinese. Genetics and molecular research : GMR. vol 13. issue 1. 2014-11-04. PMID:24668623. |
single nucleotide polymorphisms (snps) in the regulatory regions of tph2 gene may affect gene expression and biosynthesis of 5-ht triggering to various neuropsychiatric disorders related to 5-ht dysfunction. |
2014-11-04 |
2023-08-12 |
Not clear |
| Nurgul Carkaci-Salli, Ugur Salli, Izel Tekin, Jeremy A Hengst, Moe K Zhao, T Lee Gilman, Anne M Andrews, Kent E Vran. Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2. Journal of neurochemistry. vol 130. issue 6. 2014-10-30. PMID:24899127. |
human tph2 (htph2) catalyzes the rate-limiting step in cns serotonin biosynthesis. |
2014-10-30 |
2023-08-13 |
human |
| Stephen Hickner, Najaah Hussain, Mariana Angoa-Perez, Dina M Francescutti, Donald M Kuhn, Jason H Mateik. Ventilatory long-term facilitation is evident after initial and repeated exposure to intermittent hypoxia in mice genetically depleted of brain serotonin. Journal of applied physiology (Bethesda, Md. : 1985). vol 116. issue 3. 2014-10-18. PMID:24336886. |
nineteen tryptophan hydroxylase 2-deficient (tph2(-/-)) mice, devoid of serotonin in the cns, and their wild-type counterparts (tph2(+/+)) were exposed to intermittent hypoxia each day for 10 consecutive days. |
2014-10-18 |
2023-08-12 |
mouse |
| Yun-Fang Jia, Ning-Ning Song, Rong-Rong Mao, Jin-Nan Li, Qiong Zhang, Ying Huang, Lei Zhang, Hui-Li Han, Yu-Qiang Ding, Lin X. Abnormal anxiety- and depression-like behaviors in mice lacking both central serotonergic neurons and pancreatic islet cells. Frontiers in behavioral neuroscience. vol 8. 2014-10-08. PMID:25294992. |
mice lacking either 5-ht or central serotonergic neurons were generated by conditional deletion of tph2 or lmx1b respectively. |
2014-10-08 |
2023-08-13 |
mouse |
| Joon W Shim, Todd R Dodge, Max A Hammond, Joseph M Wallace, Feng C Zhou, Hiroki Yokot. Physical weight loading induces expression of tryptophan hydroxylase 2 in the brain stem. PloS one. vol 9. issue 1. 2014-09-02. PMID:24416346. |
focusing on serotonergic signaling, we addressed a question: does local mechanical loading to the skeleton elevate expression of tryptophan hydroxylase 2 (tph2) that is a rate-limiting enzyme for brain serotonin? |
2014-09-02 |
2023-08-12 |
mouse |
| C M Ragan, J S Lonstei. Differential postpartum sensitivity to the anxiety-modulating effects of offspring contact is associated with innate anxiety and brainstem levels of dopamine beta-hydroxylase in female laboratory rats. Neuroscience. vol 256. 2014-08-27. PMID:24161285. |
levels of dopamine β-hydroxylase (dbh, norepinephrine synthesizing enzyme) and tryptophan hydroxylase-2 (tph2, serotonin synthesizing enzyme) were measured in the brainstem and dorsal raphe, respectively. |
2014-08-27 |
2023-08-12 |
rat |
| Yuwei Wu, Qisheng Tu, Paloma Valverde, Jin Zhang, Dana Murray, Lily Q Dong, Jessica Cheng, Hua Jiang, Maribel Rios, Elise Morgan, Zhihui Tang, Jake Che. Central adiponectin administration reveals new regulatory mechanisms of bone metabolism in mice. American journal of physiology. Endocrinology and metabolism. vol 306. issue 12. 2014-08-20. PMID:24780611. |
in addition, centrally administered apn increased hypothalamic tryptophan hydroxylase 2 (tph2), cocaine- and amphetamine-regulated transcript (cart), and 5-hydroxytryptamine (serotonin) receptor 2c (htr2c) expressions but decreased hypothalamic cannabinoid receptor-1 expression. |
2014-08-20 |
2023-08-13 |
mouse |
| Farida Islahudin, Sarah M Tindall, Ian R Mellor, Karen Swift, Hans E M Christensen, Kevin C F Fone, Richard J Pleass, Kang-Nee Ting, Simon V Aver. The antimalarial drug quinine interferes with serotonin biosynthesis and action. Scientific reports. vol 4. 2014-08-19. PMID:24402577. |
by assaying activity and kinetics of the rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase (tph2), we showed that quinine competitively inhibits tph2 in the presence of the substrate tryptophan. |
2014-08-19 |
2023-08-12 |
human |
| Sang-Eun Jun, Ruth Kohen, Kevin C Cain, Monica E Jarrett, Margaret M Heitkempe. TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome. Biological research for nursing. vol 16. issue 1. 2014-07-30. PMID:23172723. |
tph is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms, tph1 and tph2. |
2014-07-30 |
2023-08-12 |
human |
| Evelyn Andersson, Christian Rück, Catharina Lavebratt, Erik Hedman, Martin Schalling, Nils Lindefors, Elias Eriksson, Per Carlbring, Gerhard Andersson, Tomas Furmar. Genetic polymorphisms in monoamine systems and outcome of cognitive behavior therapy for social anxiety disorder. PloS one. vol 8. issue 11. 2014-07-07. PMID:24260145. |
the serotonin transporter (5-httlpr), the catechol-o-methyltransferase (comt) val158met, and the tryptophan hydroxylase-2 (tph2) g-703t polymorphisms are implicated in the regulation of amygdala reactivity and fear extinction and therefore might be of relevance for cbt outcome. |
2014-07-07 |
2023-08-12 |
Not clear |
| Aki Takahashi, Toshihiko Shiroishi, Tsuyoshi Koid. Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes. Frontiers in neuroscience. vol 8. 2014-06-26. PMID:24966813. |
expression analysis of mrnas of serotonin receptors, serotonin transporter and tph2, an enzyme involved in serotonin synthesis in seven brain areas, indicated several differences among msm, c57bl/6j, and their consomic strains. |
2014-06-26 |
2023-08-13 |
mouse |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| François Reichardt, Charlotte Baudry, Lisa Gruber, Gemma Mazzuoli, Raphaël Moriez, Christian Scherling, Patrick Kollmann, Hannelore Daniel, Sigrid Kisling, Dirk Haller, Michel Neunlist, Michael Scheman. Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice. The Journal of physiology. vol 591. issue 20. 2014-06-20. PMID:23940384. |
this was associated with increased tissue acetylcholine and 5-hydroxytryptamine (5-ht) content, and increased expression of tph1 and tph2. |
2014-06-20 |
2023-08-12 |
mouse |
| Vladimir S Naumenko, Daria V Bazovkina, Alina A Semenova, Anton S Tsybko, Tatyana V Il'chibaeva, Elena M Kondaurova, Nina K Popov. Effect of glial cell line-derived neurotrophic factor on behavior and key members of the brain serotonin system in mouse strains genetically predisposed to behavioral disorders. Journal of neuroscience research. vol 91. issue 12. 2014-06-17. PMID:24105724. |
gdnf failed to change tph2, 5-ht1a , or 5-ht2a receptor mrna levels in cba mice as well as 5-ht transporter gene expression and 5-ht1a and 5-ht2a receptor functional activity in both investigated mouse strains. |
2014-06-17 |
2023-08-12 |
mouse |
| S Migliarini, G Pacini, B Pelosi, G Lunardi, M Pasqualett. Lack of brain serotonin affects postnatal development and serotonergic neuronal circuitry formation. Molecular psychiatry. vol 18. issue 10. 2014-05-29. PMID:23007167. |
in this study we address the consequences of 5-ht synthesis abrogation on cns development using a knock-in mouse line in which the tryptophan hydroxylase 2 (tph2) gene is replaced by the egfp reporter. |
2014-05-29 |
2023-08-12 |
mouse |
| Jianping Chen, Jennifer Magnusson, Gerard Karsenty, Kevin J Cumming. Time- and age-dependent effects of serotonin on gasping and autoresuscitation in neonatal mice. Journal of applied physiology (Bethesda, Md. : 1985). vol 114. issue 12. 2014-04-28. PMID:23558391. |
we also tested p8-9 tph2(-/-) mice after restoring 5-ht with a single injection of 5-hydroxytryptophan (5-htp) 1-2 h before testing or with multiple injections beginning 24 h before testing. |
2014-04-28 |
2023-08-12 |
mouse |