| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Mark Pitzer, Jordan Lueras, Anna Warden, Sydney Weber, Jodi McBrid. Viral vector mediated expression of mutant huntingtin in the dorsal raphe produces disease-related neuropathology but not depressive-like behaviors in wildtype mice. Brain research. vol 1608. 2015-12-24. PMID:25732261. |
moreover, n171-82q injected mice showed a 75% reduction in cells that stained positive for the serotonin synthesis enzyme, tryptophan hydroxylase-2 (tph2) compared to controls (p<0.05). |
2015-12-24 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Nieves Herrera-Mundo, Michael J Kane, Catherine E Sykes, John H Anneken, Dina M Francescutti, Donald M Kuh. Brain serotonin signaling does not determine sexual preference in male mice. PloS one. vol 10. issue 2. 2015-12-03. PMID:25706994. |
presently, mice with a null mutation in the gene for tryptophan hydroxylase 2 (tph2), which are depleted of brain 5-ht, were tested for sexual preference. |
2015-12-03 |
2023-08-13 |
mouse |
| D A Nielsen, M J Harding, S C Hamon, W Huang, T R Koste. Modifying the role of serotonergic 5-HTTLPR and TPH2 variants on disulfiram treatment of cocaine addiction: a preliminary study. Genes, brain, and behavior. vol 11. issue 8. 2015-11-30. PMID:22925276. |
disulfiram is a cocaine pharmacotherapy that may act through increasing serotonin, benefiting patients with genetically low serotonin transporter levels (5-httlpr, s' allele carriers) and low serotonin synthesis (tph2, a allele carriers). |
2015-11-30 |
2023-08-12 |
Not clear |
| Barbara Pelosi, Sara Migliarini, Giulia Pacini, Marta Pratelli, Massimo Pasqualett. Generation of Pet1210-Cre transgenic mouse line reveals non-serotonergic expression domains of Pet1 both in CNS and periphery. PloS one. vol 9. issue 8. 2015-11-30. PMID:25098329. |
in the mouse, pet1 mrna expression appears between 10 and 11 days post coitum (dpc) in serotonergic post-mitotic precursors and persists in serotonergic neurons up to adulthood, where it promotes the expression of genes defining the mature serotonergic phenotype such as tryptophan hydroxylase 2 (tph2) and serotonin transporter (sert). |
2015-11-30 |
2023-08-13 |
mouse |
| Pei Jiang, Li-Hong Zhang, Hua-Lin Cai, Huan-De Li, Yi-Ping Liu, Mi-Mi Tang, Rui-Li Dang, Wen-Ye Zhu, Ying Xue, Xin H. Neurochemical effects of chronic administration of calcitriol in rats. Nutrients. vol 6. issue 12. 2015-11-25. PMID:25533012. |
additionally, calcitriol treatment promoted tyrosine hydroxylase (th) and tryptophan hydroxylase 2 (tph2) expression without changing dopamine and serotonin status. |
2015-11-25 |
2023-08-13 |
rat |
| Ichiro Kaneko, Marya S Sabir, Christopher M Dussik, G Kerr Whitfield, Amitis Karrys, Jui-Cheng Hsieh, Mark R Haussler, Mark B Meyer, J Wesley Pike, Peter W Jurutk. 1,25-Dihydroxyvitamin D regulates expression of the tryptophan hydroxylase 2 and leptin genes: implication for behavioral influences of vitamin D. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 9. 2015-11-25. PMID:26071405. |
brain tph2 mrna, encoding the rate-limiting enzyme in serotonin synthesis, was induced 2.2-fold by 10 nm 1,25d in human u87 glioblastoma cells and 47.8-fold in rat serotonergic rn46a-b14 cells. |
2015-11-25 |
2023-08-13 |
mouse |
| D Beis, K Holzwarth, M Flinders, M Bader, M Wöhr, N Alenin. Brain serotonin deficiency leads to social communication deficits in mice. Biology letters. vol 11. issue 3. 2015-11-10. PMID:25808003. |
we challenged this hypothesis in mice with a brain-specific serotonin depletion caused by a tryptophan hydroxylase 2 (tph2) deficiency. |
2015-11-10 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
tryptophan hydroxylase 2 (tph2) is the initial and rate-limiting enzyme in the biosynthetic pathway of 5ht in the cns, and losses in its catalytic activity lead to reductions in 5ht production and release. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
mice lacking the gene for tph2 are genetically depleted of brain 5ht and were tested for a depression-like behavioral phenotype using a battery of valid tests for affective-like disorders in animals. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
the behavioral phenotype of the tph2(-/-) mouse questions the role of 5ht in depression. |
2015-11-02 |
2023-08-13 |
mouse |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Nieves Herrera-Mundo, Catherine E Sykes, Dina M Francescutti, Donald M Kuh. Mice genetically depleted of brain serotonin do not display a depression-like behavioral phenotype. ACS chemical neuroscience. vol 5. issue 10. 2015-11-02. PMID:25089765. |
furthermore, the tph2(-/-) mouse may serve as a useful model in the search for new medications that have therapeutic targets for depression that are outside of the 5ht neuronal system. |
2015-11-02 |
2023-08-13 |
mouse |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
this study reports the expression of serotonin-related genes: tryptophan hydroxylase 2 (tph2), serotonin reuptake transporter (sert) and the serotonin 1a autoreceptor (5ht1a) using digoxigenin-ish and image analysis. |
2015-10-15 |
2023-08-13 |
monkey |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
comparatively, t- and dht + atd-treated groups had elevated tph2 and sert gene expression, but the dht + atd group had markedly suppressed serotonin axon density relative to the t-treated group. |
2015-10-15 |
2023-08-13 |
monkey |
| C L Bethea, K Coleman, K Phu, A P Reddy, A Ph. Relationships between androgens, serotonin gene expression and innervation in male macaques. Neuroscience. vol 274. 2015-10-15. PMID:24909896. |
this suggested that androgen activity increased tph2 and sert gene expression but, aromatase activity, and neural production of estradiol (e), may subserve axonal serotonin and determination of the compartment acted upon by fenfluramine. |
2015-10-15 |
2023-08-13 |
monkey |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
the effects of acorus tatarinowii schott on 5-ht concentrations, tph2 and 5-ht1b expression in the dorsal raphe of exercised rats. |
2015-09-25 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Guangzhi Zeng, Zhigang Zeng, Hongbiao Chu, Hui Wang, Zhi Xia, Renle W. The effects of Acorus tatarinowii Schott on 5-HT concentrations, TPH2 and 5-HT1B expression in the dorsal raphe of exercised rats. Journal of ethnopharmacology. vol 158 Pt A. 2015-09-25. PMID:25456438. |
in this study, the effects of acorus tatarinowii schott on treadmill running endurance, 5-ht concentrations, tph2, 5-ht1b expression in the dorsal raphe of exercised rats were investigated. |
2015-09-25 |
2023-08-13 |
rat |
| Nozomi Asaoka, Kazuki Nagayasu, Naoya Nishitani, Mayumi Yamashiro, Hisashi Shirakawa, Takayuki Nakagawa, Shuji Kanek. Inhibition of histone deacetylases enhances the function of serotoninergic neurons in organotypic raphe slice cultures. Neuroscience letters. vol 593. 2015-09-08. PMID:25796177. |
sustained treatment with tsa (1μm) for 2 or 4 days significantly increased the 5-ht tissue content and tryptophan hydroxylase 2 (tph2) expression, which were accompanied by hyper-acetylation of histone h3 in the promoter region of the tph2 gene. |
2015-09-08 |
2023-08-13 |
Not clear |
| Darya V Bazovkina, Daria V Lichman, Alexander V Kuliko. The C1473G polymorphism in the Tryptophan hydroxylase-2 gene: involvement in ethanol-related behavior in mice. Neuroscience letters. vol 589. 2015-08-27. PMID:25603476. |
tryptophan hydroxylase-2 (tph2) is the rate limiting enzyme of serotonin synthesis in the brain. |
2015-08-27 |
2023-08-13 |
mouse |
| Kelli Lehto, Mariliis Vaht, Jarek Mäestu, Toomas Veidebaum, Jaanus Harr. Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample. Progress in neuro-psychopharmacology & biological psychiatry. vol 57. 2015-08-13. PMID:25455586. |
the tryptophan hydroxylase-2 gene (tph2) is coding for the key enzyme of serotonin (5-ht) synthesis in the brain and has been associated with a number of psychiatric conditions. |
2015-08-13 |
2023-08-13 |
human |
| Kelli Lehto, Mariliis Vaht, Jarek Mäestu, Toomas Veidebaum, Jaanus Harr. Effect of tryptophan hydroxylase-2 gene polymorphism G-703 T on personality in a population representative sample. Progress in neuro-psychopharmacology & biological psychiatry. vol 57. 2015-08-13. PMID:25455586. |
we have examined the association of the tph2 g-703t polymorphism with ffm personality traits, and the possible modulation by the functional variation in the serotonin transporter gene (5-httlpr) in a large longitudinal population representative sample. |
2015-08-13 |
2023-08-13 |
human |