| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
adult tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. |
2015-08-03 |
2023-08-13 |
mouse |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
disruption of serotonin synthesis in neurons and the periphery by knockout (ko) of mouse genes for tryptophan hydroxylases (peripheral tph1 and neuronal tph2) has been claimed to decrease (tph2 ko) and increase (tph1 ko) bone mass. |
2015-08-03 |
2023-08-13 |
mouse |
| Shiqing Chen, Xiaoye Huang, Tao Yu, Xin Li, Yanfei Cao, Xingwang Li, Fei Xu, Fengping Yang, Forrest Fabian Jesse, Mingqing Xu, Weidong Li, Lin He, Guang H. Association study of TPH2 polymorphisms and bipolar disorder in the Han Chinese population. Progress in neuro-psychopharmacology & biological psychiatry. vol 56. 2015-07-31. PMID:25152196. |
tryptophan hydroxylase isoform-2 (tph2), which controls the synthesis of serotonin in the brain, has been suggested as a candidate gene for bdp. |
2015-07-31 |
2023-08-13 |
Not clear |
| Sandra Van der Auwera, Deborah Janowitz, Andrea Schulz, Georg Homuth, Matthias Nauck, Henry Völzke, Matthias Rose, Henriette Meyer zu Schwabedissen, Harald Jürgen Freyberger, Hans Jörgen Grab. Interaction among childhood trauma and functional polymorphisms in the serotonin pathway moderate the risk of depressive disorders. European archives of psychiatry and clinical neuroscience. vol 264 Suppl 1. 2015-06-08. PMID:25214390. |
as a rate-limiting enzyme of serotonin synthesis in the brain, tryptophan hydroxylase 2 (tph2) represents a plausible candidate gene. |
2015-06-08 |
2023-08-13 |
human |
| M Angoa-Pérez, M J Kane, C E Sykes, S A Perrine, M W Church, D M Kuh. Brain serotonin determines maternal behavior and offspring survival. Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:25077934. |
to evaluate the contribution of serotonin to maternal care, we used mice with a null mutation in the gene for tryptophan hydroxylase-2 (tph2), which results in a genetic depletion of brain serotonin, and tested them in a wide range of maternal behavior paradigms. |
2015-05-22 |
2023-08-13 |
mouse |
| M Angoa-Pérez, M J Kane, C E Sykes, S A Perrine, M W Church, D M Kuh. Brain serotonin determines maternal behavior and offspring survival. Genes, brain, and behavior. vol 13. issue 7. 2015-05-22. PMID:25077934. |
these findings illustrate a profound influence of brain serotonin on virtually all elements of maternal behavior and establish that tph2(-/-) pups can engender maladaptive mothering in dams of both genotypes. |
2015-05-22 |
2023-08-13 |
mouse |
| Peiyan Wong, Ying Sze, Laura Jane Gray, Cecilia Chin Roei Chang, Shiwei Cai, Xiaodong Zhan. Early life environmental and pharmacological stressors result in persistent dysregulations of the serotonergic system. Frontiers in behavioral neuroscience. vol 9. 2015-05-12. PMID:25964750. |
we showed that chronic mild stress applied in adulthood did not affect the behaviors and serotonin levels of wt and tph2 knock-in (ki) mice. |
2015-05-12 |
2023-08-13 |
mouse |
| Helene Bach, Victoria Arango, Suham A Kassir, Tea Tsaava, Andrew J Dwork, J John Mann, Mark D Underwoo. Alcoholics have more tryptophan hydroxylase 2 mRNA and protein in the dorsal and median raphe nuclei. Alcoholism, clinical and experimental research. vol 38. issue 7. 2015-04-14. PMID:24942188. |
chronic alcohol use depletes brain serotonin (5-hydroxytryptamine [5-ht]), yet we previously found more tryptophan hydroxylase 2 (tph2), the rate-limiting biosynthetic enzyme for 5-ht, in the dorsal raphe nucleus (drn) of alcoholics. |
2015-04-14 |
2023-08-13 |
Not clear |
| Justin D Crane, Rengasamy Palanivel, Emilio P Mottillo, Adam L Bujak, Huaqing Wang, Rebecca J Ford, Andrew Collins, Regje M Blümer, Morgan D Fullerton, Julian M Yabut, Janice J Kim, Jean-Eric Ghia, Shereen M Hamza, Katherine M Morrison, Jonathan D Schertzer, Jason R B Dyck, Waliul I Khan, Gregory R Steinber. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature medicine. vol 21. issue 2. 2015-04-09. PMID:25485911. |
serotonin (5-hydroxytryptamine, 5-ht) is a highly conserved biogenic amine that resides in non-neuronal and neuronal tissues that are specifically regulated via tryptophan hydroxylase 1 (tph1) and tph2, respectively. |
2015-04-09 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced tph2 activity. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
polymorphisms in the tph2 gene coding for the serotonin synthesizing enzyme in the brain are considered as risk factors associated with depression and anxiety in humans. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
however, whether a certain variation in the tph2 gene leads to decreased brain serotonin production and development of psychological abnormalities remains unresolved. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
progressive reduction in tph2 activity had no effect on emotional behavior, and only slightly affected brain serotonin levels. |
2015-03-30 |
2023-08-13 |
mouse |
| Valentina Mosienko, Susann Matthes, Natalie Hirth, Daniel Beis, Michael Flinders, Michael Bader, Anita C Hansson, Natalia Alenin. Adaptive changes in serotonin metabolism preserve normal behavior in mice with reduced TPH2 activity. Neuropharmacology. vol 85. 2015-03-30. PMID:24863038. |
however, serotonin degradation rate was drastically decreased in mice with reduced tph2 activity, thereby compensating for the lowered rate of serotonin production in these mice. |
2015-03-30 |
2023-08-13 |
mouse |
| J W Lunden, L G Kirb. Opiate exposure and withdrawal dynamically regulate mRNA expression in the serotonergic dorsal raphe nucleus. Neuroscience. vol 254. 2015-02-23. PMID:24055683. |
gene expression for brain-derived neurotrophic factor (bdnf), tyrosine kinase receptor b (trkb), corticotrophin releasing-factor (crf)-r1, crf-r2, alpha 1 subunit of the gabaa receptor (gabaa-α1), μ-opioid receptor (mor), 5-ht1a receptor, tryptophan hydroxylase2 (tph2) and the 5-ht transporter was then measured using quantitative real-time polymerase chain reaction at multiple time-points across the model of morphine exposure, withdrawal and post withdrawal stress. |
2015-02-23 |
2023-08-12 |
rat |
| Aki Takahashi, Isabel M Quadros, Rosa M M de Almeida, Klaus A Micze. Behavioral and pharmacogenetics of aggressive behavior. Current topics in behavioral neurosciences. vol 12. 2015-01-20. PMID:22297576. |
studies of aggression in genetically modified mice identified several molecules that affect the 5-ht system directly (e.g., tph2, 5-ht1b, 5-ht transporter, pet1, maoa) or indirectly[e.g., bdnf, neuronal nitric oxide (nnos), acamkii, neuropeptide y].the future agenda delineates specific receptor subpopulations for gaba, glutamate and neuropeptides as they modulate the canonical aminergic neurotransmitters in brainstem, limbic and cortical regions with the ultimate outcome of attenuating or escalating aggressive behavior. |
2015-01-20 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
gaba concentration and gabaergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in tph2 knockout mice. |
2014-12-17 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
while tryptophan hydroxylase-2 (tph2) null mutant (tph2(-/-)) mice are completely deficient in brain serotonin (5-ht) synthesis, the formation of serotonergic neurons and pathfinding of their projections are not impaired. |
2014-12-17 |
2023-08-12 |
mouse |
| Jonas Waider, Florian Proft, Georg Langlhofer, Esther Asan, Klaus-Peter Lesch, Lise Gutknech. GABA concentration and GABAergic neuron populations in limbic areas are differentially altered by brain serotonin deficiency in Tph2 knockout mice. Histochemistry and cell biology. vol 139. issue 2. 2014-12-17. PMID:23052836. |
to assess the influence of 5-ht deficiency on γ-amino butyric acid (gaba) systems, we carried out measurements of gaba concentrations in limbic brain regions of adult male wildtype (wt), heterozygous (tph2(+/-)) and tph2(-/-) mice. |
2014-12-17 |
2023-08-12 |
mouse |
| Thomas Del'Guidice, Francis Lemay, Morgane Lemasson, Jean Levasseur-Moreau, Stella Manta, Adeline Etievant, Guy Escoffier, François Y Doré, François S Roman, Jean-Martin Beaulie. Stimulation of 5-HT2C receptors improves cognitive deficits induced by human tryptophan hydroxylase 2 loss of function mutation. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 39. issue 5. 2014-12-01. PMID:24196946. |
polymorphisms in the gene encoding the serotonin synthesis enzyme tph2 have been identified in mental illnesses, including bipolar disorder, major depression, autism, schizophrenia, and adhd. |
2014-12-01 |
2023-08-12 |
mouse |