| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Jodi L Lukkes, Kevin J Norman, Shirisha Meda, Susan L Anderse. Sex differences in the ontogeny of CRF receptors during adolescent development in the dorsal raphe nucleus and ventral tegmental area. Synapse (New York, N.Y.). vol 70. issue 3. 2016-10-17. PMID:26696011. |
the serotonin and catecholamine enzymes in the dr and vta, tryptophan hydroxylase 2 (tph2) and tyrosine hydroxylase, respectively, were also analyzed for maturational differences. |
2016-10-17 |
2023-08-13 |
rat |
| Christina M Ragan, Kaitlyn M Harding, Joseph S Lonstei. Associations among within-litter differences in early mothering received and later emotional behaviors, mothering, and cortical tryptophan hydroxylase-2 expression in female laboratory rats. Hormones and behavior. vol 77. 2016-09-15. PMID:26219576. |
medial prefrontal cortex expression of tryptophan hydroxylase-2 (tph2; enzyme necessary for serotonin synthesis) was negatively associated with early maternal licking received. |
2016-09-15 |
2023-08-13 |
rat |
| Alexander V Kulikov, Nina K Popov. Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives? Reviews in the neurosciences. vol 26. issue 6. 2016-09-09. PMID:26167977. |
tryptophan hydroxylase 2 (tph2) is the key and rate-limiting enzyme in 5-ht synthesis in the brain. |
2016-09-09 |
2023-08-13 |
human |
| Alexander V Kulikov, Nina K Popov. Tryptophan hydroxylase 2 in seasonal affective disorder: underestimated perspectives? Reviews in the neurosciences. vol 26. issue 6. 2016-09-09. PMID:26167977. |
the main conclusions of this review are as follows: (i) the brain 5-ht deficiency contributes to the mechanism underlying sad, (ii) tph2 is involved in the regulation of some kinds of genetically defined affective disorders and (iii) the activation of 5-ht synthesis with exogenous l-tryptophan alone or in combination with light therapy could be effective in sad treatment. |
2016-09-09 |
2023-08-13 |
human |
| Rani K Vasudeva, Alexander R Hobby, Lynn G Kirb. Ethanol consumption in the Sprague-Dawley rat increases sensitivity of the dorsal raphe nucleus to 5,7-dihydroxytryptamine. Behavioural brain research. vol 295. 2016-09-05. PMID:26073764. |
quantification of 5-ht depletion in the dorsal raphe nucleus (drn) using tryptophan hydroxylase-2 (tph2) immunohistochemistry resulted in a 76% decrease in staining with 5,7-dht treatment. |
2016-09-05 |
2023-08-13 |
rat |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
cellular resilience: 5-ht neurons in tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-ht. |
2016-08-26 |
2023-08-13 |
mouse |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
we report that the active properties of dorsal raphe nucleus (drn) 5-ht neurons in vivo (firing rate magnitude and variability; the presence of spike doublets) and in vitro (firing in response to depolarizing current pulses; action potential shape) as well as the resting membrane potential remained essentially unchanged across tph2 genotypes. |
2016-08-26 |
2023-08-13 |
mouse |
| Alberto Montalbano, Jonas Waider, Mario Barbieri, Ozan Baytas, Klaus-Peter Lesch, Renato Corradetti, Boris Mlina. Cellular resilience: 5-HT neurons in Tph2(-/-) mice retain normal firing behavior despite the lack of brain 5-HT. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 25. issue 11. 2016-08-26. PMID:26409296. |
this difference may at least in part be a consequence of slightly bigger size of the drn 5-ht neurons in tph2(-/-) mice (approximately 10%, p<0.0001). |
2016-08-26 |
2023-08-13 |
mouse |
| Michael M Havranek, Matthias Vonmoos, Christian P Müller, Jessica R Büetiger, Eve Tasiudi, Lea M Hulka, Katrin H Preller, Rainald Mössner, Edna Grünblatt, Erich Seifritz, Boris B Quedno. Serotonin Transporter and Tryptophan Hydroxylase Gene Variations Mediate Working Memory Deficits of Cocaine Users. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 13. 2016-08-25. PMID:26013962. |
several significant gene × environment interactions between 5-ht genotypes and cocaine use on wm emerged: in cocaine users, the long/long (5-httlpr), 9+10/9+10 (vntr in2) and c/c (tph2 rs1386497) genotypes were risk alleles for wm impairments, whereas in healthy controls these polymorphisms were associated with improved wm performance. |
2016-08-25 |
2023-08-13 |
human |
| Rui Weng, Sensen Shen, Yonglu Tian, Casey Burton, Xinyuan Xu, Yi Liu, Cuilan Chang, Yu Bai, Huwei Li. Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific reports. vol 5. 2016-08-10. PMID:26154191. |
serotonin deficiency was achieved through pharmacological inhibition of tryptophan hydroxylase (tph) using p-chlorophenylalanine (pcpa) or genetic knockout of the neuronal specific tph2 isoform. |
2016-08-10 |
2023-08-13 |
mouse |
| Rui Weng, Sensen Shen, Yonglu Tian, Casey Burton, Xinyuan Xu, Yi Liu, Cuilan Chang, Yu Bai, Huwei Li. Metabolomics Approach Reveals Integrated Metabolic Network Associated with Serotonin Deficiency. Scientific reports. vol 5. 2016-08-10. PMID:26154191. |
this dual approach improved specificity for the serotonin deficiency-associated biomarkers while minimizing nonspecific effects of pcpa treatment or tph2 knockout (tph2-/-). |
2016-08-10 |
2023-08-13 |
mouse |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
in this study, the effects of verbascoside on treadmill exercise endurance, 5-hydroxytryptamine (5-ht) concentrations, the second isoforms of tryptophan hydroxylase (tph2) and serotonergic type 1b inhibitory autoreceptors (5-ht1b) protein expression in the caudate putamen of exercised rats were investigated. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
we found that verbascoside could prolong the time to exhaustion in treadmill exercise and suppress the exercise-induced increase of 5-ht synthesis and tph2 protein expression, and prevent the exercise-induced decrease of 5-ht1b protein expression in the caudate putamen. |
2016-08-04 |
2023-08-13 |
rat |
| Meiju Zhu, Hongzhu Zhu, Ninghua Tan, Hui Wang, Hongbiao Chu, Chonglin Zhan. Central anti-fatigue activity of verbascoside. Neuroscience letters. vol 616. 2016-08-04. PMID:26827721. |
the mechanism of verbascoside' s anti-fatigue activity might be related to the inhibition of the exercise-induced synthesis of 5-ht and tph2 expression, and to the increase of the 5-ht1b expression in the caudate putamen of exercised rats. |
2016-08-04 |
2023-08-13 |
rat |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
we showed in isolated islets and min6 cells that gcs decreased expression and activity of the two key enzymes of serotonin synthesis, tryptophan hydroxylase 1 (tph1) and 2 (tph2), leading to reduced serotonin contents. |
2016-07-18 |
2023-08-13 |
mouse |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
finally, islets from mice deleted for the gr in the pancreas displayed an increased expression of tph1 and tph2 and a strong increased serotonin content per islet. |
2016-07-18 |
2023-08-13 |
mouse |
| Isabelle E Bauer, David P Graham, Jair C Soares, David A Nielse. Serotonergic gene variation in substance use pharmacotherapy: a systematic review. Pharmacogenomics. vol 16. issue 11. 2016-06-29. PMID:26265436. |
current evidence suggests that genetic variability of the serotonergic biosynthesis enzyme tryptophan hydroxylase 2 (tph2) and the serotonin transporter (slc6a4) genes mediates the efficacy of several addiction treatments, such as ondansetron and disulfiram, and the antidepressants bupropion, nortriptyline and sertraline. |
2016-06-29 |
2023-08-13 |
Not clear |
| Qiang Shen, Meijun Teo, Eyal Winter, Einav Hart, Soo H Chew, Richard P Ebstei. To Cheat or Not To Cheat: Tryptophan Hydroxylase 2 SNP Variants Contribute to Dishonest Behavior. Frontiers in behavioral neuroscience. vol 10. 2016-05-20. PMID:27199691. |
the results of this exploratory study provide provisional evidence that snp variants across the tryptophan hydroxylase 2 (tph2) gene, that encodes the rate-limiting enzyme in the biosynthesis of brain serotonin, contribute to individual differences in deceptive behavior. |
2016-05-20 |
2023-08-13 |
Not clear |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
generation of a tph2 conditional knockout mouse line for time- and tissue-specific depletion of brain serotonin. |
2016-05-13 |
2023-08-13 |
mouse |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
serotonin synthesis is a 2-step process, the first step of which is mediated by the rate-limiting activity of tph enzymes, belonging to the family of aromatic amino acid hydroxylases and existing in two isoforms, tph1 and tph2, responsible for the production of peripheral and brain serotonin, respectively. |
2016-05-13 |
2023-08-13 |
mouse |