| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Wei-Yang Xiao, Ying-Wen Li, Qi-Liang Chen, Zhi-Hao Li. Tributyltin impaired reproductive success in female zebrafish through disrupting oogenesis, reproductive behaviors and serotonin synthesis. Aquatic toxicology (Amsterdam, Netherlands). vol 200. 2018-07-25. PMID:29775928. |
in addition, tbt significantly suppressed the expressions of serotonin-related genes, such as tph2 (encoding serotonin synthase), pet1 (marker of serotonin neuron) and kiss 1 (the modulator of serotonin synthesis), suggesting that tbt might disrupt the non-reproductive behaviors of zebrafish. |
2018-07-25 |
2023-08-13 |
zebrafish |
| J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell, M R Arnold, B Aboagye, A Schmitt-Böhrer, C A Lowry, H C Pape, K P Lesc. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Translational psychiatry. vol 7. issue 10. 2018-06-14. PMID:28972592. |
here we investigate the influence of constitutively deficient 5-ht synthesis on stressor-related anxiety-like behaviors using tryptophan hydroxylase 2 (tph2) mutant mice. |
2018-06-14 |
2023-08-13 |
mouse |
| J Waider, S Popp, M D Lange, R Kern, J F Kolter, J Kobler, N C Donner, K R Lowe, J H Malzbender, C J Brazell, M R Arnold, B Aboagye, A Schmitt-Böhrer, C A Lowry, H C Pape, K P Lesc. Genetically driven brain serotonin deficiency facilitates panic-like escape behavior in mice. Translational psychiatry. vol 7. issue 10. 2018-06-14. PMID:28972592. |
our findings indicate that constitutive tph2 inactivation and consequential lack of 5-ht synthesis in tph2 null mutant mice (tph2 |
2018-06-14 |
2023-08-13 |
mouse |
| Feng Wang, Mingliang Fang, David E Hinton, Melissa Chernick, Shenglan Jia, Yingdan Zhang, Lingtian Xie, Wenjing Dong, Wu Don. Increased coiling frequency linked to apoptosis in the brain and altered thyroid signaling in zebrafish embryos (Danio rerio) exposed to the PBDE metabolite 6-OH-BDE-47. Chemosphere. vol 198. 2018-05-29. PMID:29421749. |
moreover, exposure to 100 nm 6-oh-bde-47 significantly reduced the number of hypothalamic 5-hydroxytryptamine (5-ht, serotonin)-immunoreactive (5-ht-ir) neurons and the mrna expression of tryptophan hydroxylase 2 (tph2). |
2018-05-29 |
2023-08-13 |
zebrafish |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
the interaction between sert and the key enzyme of 5-ht synthesis in the brain, tryptophan hydroxylase 2 (tph2), is essential to maintain the brain 5-ht level. |
2018-04-27 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
the polymorphism did not affect the levels of 5-ht, its metabolite, 5-hydroxyindoleacetic acid (5-hiaa) and tph2 gene mrna in the brain. |
2018-04-27 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Nadezhda A Sinyakova, Elizabeth A Kulikova, Irina A Kazarinova, Daria V Bazovkina, Raul R Gainetdinov, Alexander V Kuliko. No effect of C1473G polymorphism in the tryptophan hydroxylase 2 gene on the response of the brain serotonin system to chronic fluoxetine treatment in mice. Neuroscience letters. vol 653. 2018-04-27. PMID:28579486. |
fluoxetine significantly attenuated 5-ht levels in the cortex and striatum, 5-hiaa concentrations in the cortex, hippocampus, striatum and midbrain, and tph2 gene expression in the midbrain. |
2018-04-27 |
2023-08-13 |
mouse |
| D A Nikishin, N M Alyoshina, Y B Shmukle. Synthesis and Membrane Transport of Serotonin in the Developing Ovarian Follicle of Mouse. Doklady. Biochemistry and biophysics. vol 478. issue 1. 2018-04-09. PMID:29536299. |
using rt-pcr, we showed the presence of tph1 mrna in follicular cells and tph2 mrna in oocytes isolated from primary multilayer ovarian follicles of mouse and the absence of ddc expression, which indicates that serotonin cannot be synthesized in a developing ovarian follicle. |
2018-04-09 |
2023-08-13 |
mouse |
| Maurizio Pompili, Giovanna Gentile, Catia Scassellati, Cristian Bonvicini, Marco Innamorati, Denise Erbuto, Franco Montebovi, Giuseppe Ducci, Alberto Forte, Eleonora De Pisa, Stefano Ferracuti, Gianluca Serafini, Vincenzo De Luca, Mario Amore, Maurizio Simmaco, Paolo Girard. Genetic association analysis of serotonin and signal transduction pathways in suicide attempters from an Italian sample of psychiatric patients. Neuroscience letters. vol 656. 2018-04-05. PMID:28716530. |
we aimed to investigate functional polymorphisms in eight genes (serotonin transporter, slc6a4; receptors, 5htr1a, 1b, 5htr2a; tryptophan hydroxylase, tph1, tph2; monoamine oxidase, maoa and g protein subunit beta 3, gnb3) to investigate their predictive value for suicide. |
2018-04-05 |
2023-08-13 |
Not clear |
| Patricia Gassó, Natalia Rodríguez, Daniel Boloc, Ana Blázquez, Teresa Torres, Ana Gortat, Maria Teresa Plana, Amalia Lafuente, Sergi Mas, Joan Albert Arnaiz, Luisa Lázar. Association of regulatory TPH2 polymorphisms with higher reduction in depressive symptoms in children and adolescents treated with fluoxetine. Progress in neuro-psychopharmacology & biological psychiatry. vol 77. 2018-03-05. PMID:28456685. |
tph2 is one of the most important serotonergic candidate genes in selective serotonin reuptake inhibitors (ssris) pharmacogenetic studies. |
2018-03-05 |
2023-08-13 |
human |
| Helene Bach, Victoria Arango, Suham A Kassir, Andrew J Dwork, J John Mann, Mark D Underwoo. Cigarette Smoking and Tryptophan Hydroxylase 2 mRNA in the Dorsal Raphe Nucleus in Suicides. Archives of suicide research : official journal of the International Academy for Suicide Research. vol 20. issue 3. 2018-01-24. PMID:26954509. |
tryptophan hydroxylase (tph2) synthesizes serotonin and is over-expressed in suicides. |
2018-01-24 |
2023-08-13 |
Not clear |
| Margus Maksimov, Mariliis Vaht, Carolina Murd, Jaanus Harro, Talis Bachman. Variants of TPH2 interact with fast visual processing as assessed by metacontrast. Neuroreport. vol 28. issue 2. 2018-01-10. PMID:27926628. |
in a sample of normal human individuals, we studied the effects of a single nucleotide polymorphism (rs4570625) in the gene that encodes the rate-limiting enzyme in serotonin synthesis, tph2, on metacontrast masking. |
2018-01-10 |
2023-08-13 |
human |
| Satoshi Ansai, Hiroshi Hosokawa, Shingo Maegawa, Kiyoshi Naruse, Youhei Washio, Kenji Sato, Masato Kinoshit. Deficiency of Serotonin in Raphe Neurons and Altered Behavioral Responses in Tryptophan Hydroxylase 2-Knockout Medaka (Oryzias latipes). Zebrafish. vol 14. issue 6. 2018-01-05. PMID:28933662. |
here, we established a medaka (oryzias latipes) strain with targeted disruption of tryptophan hydroxylase 2 (tph2) gene that is involved in the 5-ht synthesis in the raphe nuclei. |
2018-01-05 |
2023-08-13 |
Not clear |
| Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikso. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27189957. |
here, we evaluated whether our recent finding of elevated neural serotonin synthesis rate in patients with social anxiety disorder could be reproduced in a separate cohort, and whether allelic variation in the tryptophan hydroxylase-2 (tph2) g-703t polymorphism relates to differences in serotonin synthesis assessed with positron emission tomography. |
2017-12-28 |
2023-08-13 |
Not clear |
| Tomas Furmark, Ina Marteinsdottir, Andreas Frick, Kerstin Heurling, Maria Tillfors, Lieuwe Appel, Gunnar Antoni, Per Hartvig, Håkan Fischer, Bengt Långström, Elias Eriksson, Mats Fredrikso. Serotonin synthesis rate and the tryptophan hydroxylase-2: G-703T polymorphism in social anxiety disorder. Journal of psychopharmacology (Oxford, England). vol 30. issue 10. 2017-12-28. PMID:27189957. |
in patients, the serotonin synthesis rate in the amygdala and anterior cingulate cortex was significantly elevated in tph2 t carriers in comparison with gg homozygotes. |
2017-12-28 |
2023-08-13 |
Not clear |
| Kasper D Tidemand, Günther H Peters, Pernille Harris, Eva Stensgaard, Hans E M Christense. Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase. Biochemistry. vol 56. issue 46. 2017-12-19. PMID:29035515. |
tph1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while tph2 catalyzes this step in the brain. |
2017-12-19 |
2023-08-13 |
human |
| Kara Kaplan, Ashley E Echert, Ben Massat, Madeleine M Puissant, Oleg Palygin, Aron M Geurts, Matthew R Hodge. Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 9. 2017-12-14. PMID:26869713. |
chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult tph2 knockout rats. |
2017-12-14 |
2023-08-13 |
mouse |
| Kara Kaplan, Ashley E Echert, Ben Massat, Madeleine M Puissant, Oleg Palygin, Aron M Geurts, Matthew R Hodge. Chronic central serotonin depletion attenuates ventilation and body temperature in young but not adult Tph2 knockout rats. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 9. 2017-12-14. PMID:26869713. |
herein, we generated a mutant rat model with constitutive central nervous system (cns) 5-ht depletion by mutation of the tryptophan hydroxylase 2 (tph2) gene in dark agouti (da(tph2-/-)) rats. |
2017-12-14 |
2023-08-13 |
mouse |
| Scott A Givan, Kevin J Cumming. Intermittent severe hypoxia induces plasticity within serotonergic and catecholaminergic neurons in the neonatal rat ventrolateral medulla. Journal of applied physiology (Bethesda, Md. : 1985). vol 120. issue 11. 2017-12-14. PMID:26968026. |
in both groups the expression of the 5-ht transporter and tph2 was increased following ish. |
2017-12-14 |
2023-08-13 |
rat |
| S Neufang, A Akhrif, C G Herrmann, C Drepper, G A Homola, J Nowak, J Waider, A G Schmitt, K-P Lesch, M Romano. Serotonergic modulation of 'waiting impulsivity' is mediated by the impulsivity phenotype in humans. Translational psychiatry. vol 6. issue 11. 2017-12-04. PMID:27824354. |
subjects were genotyped for the tryptophan hydroxylase-2 (tph2; g-703t; rs4570625) variant, an enzyme specific for brain serotonin synthesis. |
2017-12-04 |
2023-08-13 |
human |