| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Ning-Ning Song, Qiong Zhang, Ying Huang, Ling Chen, Yu-Qiang Ding, Lei Zhan. Enhanced dendritic morphogenesis of adult hippocampal newborn neurons in central 5-HT-deficient mice. Stem cell research. vol 19. 2017-11-22. PMID:28012347. |
here, we address this question using two central 5-ht-deficient mouse models, tph2 conditional knockout mice (cko) losing central 5-ht from embryonic stage, and pet1-cre;rosa26-dtr (diphtheria toxin receptor) mice lacking central 5-ht neurons exclusively in adulthood. |
2017-11-22 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Daria V Bazovkina, Elizabeth A Kulikova, Dariya V Fursenko, Nikita V Khotskin, Daria V Lichman, Alexander V Kuliko. C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress. Neuroscience letters. vol 640. 2017-10-24. PMID:28069454. |
tryptophan hydroxylase-2 (tph2) is the key enzyme of serotonin (5-ht) synthesis in the brain. |
2017-10-24 |
2023-08-13 |
mouse |
| Ekaterina Y Bazhenova, Daria V Bazovkina, Elizabeth A Kulikova, Dariya V Fursenko, Nikita V Khotskin, Daria V Lichman, Alexander V Kuliko. C1473G polymorphism in mouse tryptophan hydroxylase-2 gene in the regulation of the reaction to emotional stress. Neuroscience letters. vol 640. 2017-10-24. PMID:28069454. |
the effect of interaction between c1473g polymorphism and 30min restriction stress on the behavior in the open field test, c-fos gene expression and 5-ht metabolism in the brain in adult male of b6-1473c and b6-1473g congenic mouse lines with high and low tph2 activity was investigated. |
2017-10-24 |
2023-08-13 |
mouse |
| Pei-Tan Hsueh, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Ya-Lei Chen, Jong-Kang Li. Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide. PloS one. vol 12. issue 6. 2017-09-18. PMID:28650979. |
the mrna expression levels of tph2 (5-ht synthesizing enzyme) and slc6a4 (5-ht transporter) were down-regulated in both adolescent (5 weeks of age) and adult (8 weeks of age) brains. |
2017-09-18 |
2023-08-13 |
mouse |
| Pei-Tan Hsueh, Hsuan-Han Wang, Chiu-Lin Liu, Wei-Fen Ni, Ya-Lei Chen, Jong-Kang Li. Expression of cerebral serotonin related to anxiety-like behaviors in C57BL/6 offspring induced by repeated subcutaneous prenatal exposure to low-dose lipopolysaccharide. PloS one. vol 12. issue 6. 2017-09-18. PMID:28650979. |
we concluded that maternal immune activation induced by exposure to a low dose of lps decreased cerebral 5-ht levels in parallel to the down-regulation of the tph2 and slc6a4 genes and in conjunction with anxiety-like behaviors in offspring. |
2017-09-18 |
2023-08-13 |
mouse |
| Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancour. Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase. Biochimie. vol 140. 2017-09-15. PMID:28751217. |
moreover, it is not known if the two tryptophan hydroxylase isoforms (tph1 and tph2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. |
2017-09-15 |
2023-08-13 |
mouse |
| Meredith Sorenson Whitney, Ashley M Shemery, Alexandra M Yaw, Lauren J Donovan, J David Glass, Evan S Deneri. Adult Brain Serotonin Deficiency Causes Hyperactivity, Circadian Disruption, and Elimination of Siestas. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 36. issue 38. 2017-08-17. PMID:27656022. |
here, we have developed a genetic approach that reproducibly achieves near-complete elimination of 5-ht synthesis from the adult ascending 5-ht system by stereotaxic injection of an adeno-associated virus expressing cre recombinase (aav-cre) into the midbrain/pons of mice carrying a loxp-conditional tryptophan hydroxylase 2 (tph2) allele. |
2017-08-17 |
2023-08-13 |
mouse |
| Honghai Zhang, Haiting Zhao, Xiaoxuan Yang, Qingsheng Xue, Joseph F Cotten, Hua-Jun Fen. 5-Hydroxytryptophan, a precursor for serotonin synthesis, reduces seizure-induced respiratory arrest. Epilepsia. vol 57. issue 8. 2017-06-20. PMID:27302625. |
the tryptophan hydroxylase-2 (tph2) enzyme converts l-tryptophan to 5-hydroxytryptophan (5-htp), a precursor for central nervous system (cns) serotonin (5-ht) synthesis; and dba/1 mice have a polymorphism that decreases tph2 activity. |
2017-06-20 |
2023-08-13 |
mouse |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:26975194. |
serotonin and the brain's rich club-association between molecular genetic variation on the tph2 gene and the structural connectome. |
2017-04-28 |
2023-08-13 |
Not clear |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:26975194. |
tryptophane hydroxylase 2 (tph2) is a rate-limiting enzyme in the biosynthesis of serotonin and is known to inhibit, in addition to its role as a trans-synaptic messenger, axonal and dendritic growth. |
2017-04-28 |
2023-08-13 |
Not clear |
| Sebastian Markett, Marcel A de Reus, Martin Reuter, Christian Montag, Bernd Weber, Jan-Christoph Schoene-Bake, Martijn P van den Heuve. Serotonin and the Brain's Rich Club-Association Between Molecular Genetic Variation on the TPH2 Gene and the Structural Connectome. Cerebral cortex (New York, N.Y. : 1991). vol 27. issue 3. 2017-04-28. PMID:26975194. |
the tph2 t-variant has been associated with reduced mrna expression and reduced serotonin levels, which may particularly influence the development of macroscale anatomical connectivity. |
2017-04-28 |
2023-08-13 |
Not clear |
| David Coyle, Justin M Murphy, Brian Doyle, Anne Marie O'Donnell, John Gillick, Prem Pur. Altered tryptophan hydroxylase 2 expression in enteric serotonergic nerves in Hirschsprung's-associated enterocolitis. World journal of gastroenterology. vol 22. issue 19. 2017-04-10. PMID:27217698. |
to determine if expression of colonic tryptophan hydroxylase-2 (tph2), a surrogate marker of neuronal 5-hydroxytryptamine, is altered in hirschsprung's-associated enterocolitis. |
2017-04-10 |
2023-08-13 |
Not clear |
| Yan Fei, Xin Wang, Songsong Chen, Qiangqiang Zhou, Chao Zhang, Ying Li, Lihong Sun, Licai Zhan. Role of the RVM in Descending Pain Regulation Originating from the Cerebrospinal Fluid-Contacting Nucleus. Neurochemical research. vol 41. issue 7. 2017-03-03. PMID:26961890. |
a significant downregulation of 5-ht-labeled neurons and tryptophan hydroxylase 2 (tph2) as the marker of 5-ht cells in the rvm, and 5-ht expression in spinal dorsal horn in both normal and chronic constriction injury (cci) rats after i.c.v. |
2017-03-03 |
2023-08-13 |
rat |
| Kanu Megha, Pravin S Deshmukh, Alok K Ravi, Ashok K Tripathi, Mahesh P Abegaonkar, Basu D Banerje. Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain. Cell biochemistry and biophysics. vol 73. issue 1. 2017-01-18. PMID:25672490. |
tyrosine hydroxylase (th) (for da, ne and e) and tryptophan hydroxylase (tph1 and tph2) (for serotonin) was also estimated. |
2017-01-18 |
2023-08-13 |
human |
| Kaitlyn M Harding, Joseph S Lonstei. Extensive juvenile "babysitting" facilitates later adult maternal responsiveness, decreases anxiety, and increases dorsal raphe tryptophan hydroxylase-2 expression in female laboratory rats. Developmental psychobiology. vol 58. issue 4. 2017-01-17. PMID:26806471. |
we examined the effect of chronic exposure to pups during post-weaning juvenile life (days 22-36) on adult maternal responsiveness, anxiety-related behaviors, and dorsal raphe tryptophan hydroxylase-2 (tph2) and serotonin transporter (sert) levels in nulliparous rats. |
2017-01-17 |
2023-08-13 |
rat |
| Golo Kronenberg, Valentina Mosienko, Karen Gertz, Natalia Alenina, Rainer Hellweg, Friederike Klempi. Increased brain-derived neurotrophic factor (BDNF) protein concentrations in mice lacking brain serotonin. European archives of psychiatry and clinical neuroscience. vol 266. issue 3. 2016-12-21. PMID:26100147. |
using a highly sensitive enzyme-linked immunosorbent assay, we studied bdnf concentrations in hippocampus and cortex of two mouse models of altered serotonin signaling: tryptophan hydroxylase (tph)2-deficient (tph2 (-/-)) mice lacking brain serotonin and serotonin transporter (sert)-deficient (sert(-/-)) mice lacking serotonin re-uptake. |
2016-12-21 |
2023-08-13 |
mouse |
| Jin Gao, Mingrui Jia, Dongdong Qiao, Huimin Qiu, Jeremy Sokolove, Jingxuan Zhang, Zhenglun Pa. TPH2 gene polymorphisms and bipolar disorder: A meta-analysis. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 171B. issue 2. 2016-12-13. PMID:26365518. |
tryptophan hydroxylase-2 (tph2) is an important rate-limiting enzyme in the synthetic pathway for brain serotonin and has been suggested to play a role in bd. |
2016-12-13 |
2023-08-13 |
Not clear |
| R Hiroi, D L Carbone, D G Zuloaga, H A Bimonte-Nelson, R J Hand. Sex-dependent programming effects of prenatal glucocorticoid treatment on the developing serotonin system and stress-related behaviors in adulthood. Neuroscience. vol 320. 2016-12-13. PMID:26844389. |
tph2 is the rate-limiting enzyme for serotonin (5-ht) synthesis and has been implicated in the etiology of human affective disorders. |
2016-12-13 |
2023-08-13 |
human |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
anxiety and affective disorders are often associated with hypercortisolism and dysfunctional serotonergic systems, including increased expression of tph2, the gene encoding the rate-limiting enzyme of neuronal serotonin synthesis. |
2016-10-19 |
2023-08-13 |
rat |
| Nina C Donner, Philip H Siebler, Danté T Johnson, Marcos D Villarreal, Sofia Mani, Allison J Matti, Christopher A Lowr. Serotonergic systems in the balance: CRHR1 and CRHR2 differentially control stress-induced serotonin synthesis. Psychoneuroendocrinology. vol 63. 2016-10-19. PMID:26454419. |
crhr2 blockade prevented stress-induced increases of tph2 activity within the drd/drc, while blockade of crhr1 potentiated stress-induced tph2 activity in the entire dr. stress-induced tph2 activity in the drd/drc furthermore predicted tph2 activity in the amygdala and in the caudal pontine reticular nucleus (pnc), while serotonin synthesis in the pnc was strongly correlated with the maximum startle response. |
2016-10-19 |
2023-08-13 |
rat |