| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
we demonstrated that the cre-mediated excision of the third exon of tph2 gene results in the production of a tph2null allele in which we observed the near-complete loss of brain serotonin, as well as the growth defects and perinatal lethality observed in serotonin conventional knockouts. |
2016-05-13 |
2023-08-13 |
mouse |
| D L A Van den Hove, N K Leibold, E Strackx, M Martinez-Claros, K P Lesch, H W M Steinbusch, K R J Schruers, J Prickaert. Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 4. 2016-05-06. PMID:24139910. |
at the neurochemical level, both ps and cms induced various sex-specific alterations in serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) immunoreactivity in the dorsal raphe nucleus, hippocampus and prefrontal cortex with, in line with the behavioral observations, more profound effects in male offspring. |
2016-05-06 |
2023-08-12 |
rat |
| D L A Van den Hove, N K Leibold, E Strackx, M Martinez-Claros, K P Lesch, H W M Steinbusch, K R J Schruers, J Prickaert. Prenatal stress and subsequent exposure to chronic mild stress in rats; interdependent effects on emotional behavior and the serotonergic system. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 24. issue 4. 2016-05-06. PMID:24139910. |
in conclusion, these findings show that prenatal maternal stress in sprague-dawley rats induces various anxiety- and depression-related behavioral and neuroendocrine changes, as well as alterations in central 5-ht and tph2 function, predominantly in male offspring. |
2016-05-06 |
2023-08-12 |
rat |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
we previously showed that tryptophan hydroxylase 2 (tph2) and serotonin reuptake transporter (sert) mrnas are increased by the androgens, testosterone (t) and dihydrotestosterone (dht) in serotonin neurons of male macaques. |
2016-05-05 |
2023-08-13 |
monkey |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
double-label of raphe neurons for each receptor plus tph2 determined whether the receptors were localized in serotonin neurons. |
2016-05-05 |
2023-08-13 |
monkey |
| Cynthia L Bethea, Kenny Phu, Yelena Belikova, Sarah C Bethe. Localization and regulation of reproductive steroid receptors in the raphe serotonin system of male macaques. Journal of chemical neuroanatomy. vol 66-67. 2016-05-05. PMID:25908331. |
however, approximately 40% of dorsal raphe serotonin neurons contained erα or erβ⋅ in conclusion, the stimulatory effect of androgens on tph2 and sert mrna expression is mediated indirectly by neighboring neurons contain ar. |
2016-05-05 |
2023-08-13 |
monkey |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
coordinated serotonin (5-ht) synthesis and reuptake depends on coexpression of tph2, aadc (ddc), and sert (slc6a4) in brain 5-ht neurons. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
our previous studies showed that pet-1 is a critical transcription factor in a regulatory program that controls coexpression of tph2, aadc, and sert in 5-ht neurons. |
2016-04-19 |
2023-08-13 |
Not clear |
| Steven C Wyler, Lauren J Donovan, Mia Yeager, Evan Deneri. Pet-1 Controls Tetrahydrobiopterin Pathway and Slc22a3 Transporter Genes in Serotonin Neurons. ACS chemical neuroscience. vol 6. issue 7. 2016-04-19. PMID:25642596. |
thus, pet-1 coordinates expression of all rate-limiting enzymatic (tph2, gch1) and post-translational regulatory (gchfr) steps that determine the level of mammalian brain 5-ht synthesis. |
2016-04-19 |
2023-08-13 |
Not clear |
| Francis Lemay, François Y Doré, Jean-Martin Beaulie. Increased ethanol consumption despite taste aversion in mice with a human tryptophan hydroxylase 2 loss of function mutation. Neuroscience letters. vol 609. 2016-04-15. PMID:26497913. |
polymorphisms in the gene encoding the brain serotonin synthesis enzyme tph2 have been identified in mental illnesses, with co-morbidity of substance use disorder. |
2016-04-15 |
2023-08-13 |
mouse |
| Karina Villalba, Jessy G Dévieux, Rhonda Rosenberg, Jean Lud Cade. Serotonin-Related Gene Polymorphisms and Asymptomatic Neurocognitive Impairment in HIV-Infected Alcohol Abusers. Genetics research international. vol 2016. 2016-04-12. PMID:27069689. |
single nucleotide polymorphisms in the slc6a4, tph2, and galm genes may affect the activity of serotonin and increase the risk of hand. |
2016-04-12 |
2023-08-13 |
Not clear |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
increased anxiety-related behavior was associated with significant decreases in tryptophan hydroxylase 2 (tph2) expression and activity, and subsequent reductions in tissue levels of 5-ht, its metabolite 5-hydroxyindoleacetic acid (5-hiaa), and norepinephrine in the raphe nuclei. |
2016-03-29 |
2023-08-13 |
mouse |
| Tillmann Weber, Miriam A Vogt, Sarah E Gartside, Stefan M Berger, Rafael Lujan, Thorsten Lau, Elke Herrmann, Rolf Sprengel, Dusan Bartsch, Peter Gas. Adult AMPA GLUA1 receptor subunit loss in 5-HT neurons results in a specific anxiety-phenotype with evidence for dysregulation of 5-HT neuronal activity. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. vol 40. issue 6. 2016-03-29. PMID:25547714. |
however, tph2 expression and activity as well as monoamine levels were unchanged in the projection areas of 5-ht neurons. |
2016-03-29 |
2023-08-13 |
mouse |
| Yuqi Zhang, Zaohuo Chang, Jionghua Chen, Yang Ling, Xiaowei Liu, Zhang Feng, Caixia Chen, Minghua Xia, Xingfu Zhao, Wang Ying, Xu Qing, Guilin Li, Changsong Zhan. Methylation of the tryptophan hydroxylase‑2 gene is associated with mRNA expression in patients with major depression with suicide attempts. Molecular medicine reports. vol 12. issue 2. 2016-03-01. PMID:25955598. |
tryptophan hydroxylase-2 (tph2) contributes to alterations in the function of neuronal serotonin (5-ht), which are associated with various psychopathologies, including major depressive disorder (mdd) or suicidal behavior. |
2016-03-01 |
2023-08-13 |
Not clear |
| Andras David Nagy, Ayaka Iwamoto, Misato Kawai, Ryosei Goda, Haruka Matsuo, Tsuyoshi Otsuka, Mao Nagasawa, Mitsuhiro Furuse, Shinobu Yasu. Melatonin adjusts the expression pattern of clock genes in the suprachiasmatic nucleus and induces antidepressant-like effect in a mouse model of seasonal affective disorder. Chronobiology international. vol 32. issue 4. 2016-02-16. PMID:25515595. |
melatonin treatments altered the expression of genes of serotonergic neurotransmission in the dorsal raphe (tph2, sert, vmat2 and 5ht1a) and serotonin contents in the amygdala. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-ht restoration and role of striatal noradrenaline release. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
variants of tryptophan hydroxylase-2 (tph2), the gene encoding enzyme responsible for the synthesis of brain serotonin (5-ht), have been associated with neuropsychiatric disorders, substance abuse and addiction. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
the role of endogenous 5-ht in enhancing the effect of amphetamine was confirmed showing that treatment with the 5-ht precursor 5-hydroxytryptophan (10 mg/kg) restored tissue and extracellular levels of brain 5-ht and the effects of amphetamine on striatal na release and motor activity in tph2(-/-) mice. |
2016-02-16 |
2023-08-13 |
mouse |
| Mirjana Carli, Chrysaugi Kostoula, Giuseppina Sacchetti, Pierangela Mainolfi, Alessia Anastasia, Claudia Villani, Roberto William Invernizz. Tph2 gene deletion enhances amphetamine-induced hypermotility: effect of 5-HT restoration and role of striatal noradrenaline release. Journal of neurochemistry. vol 135. issue 4. 2016-02-16. PMID:26259827. |
here, we show that deletion of tph2, the gene responsible for brain 5-ht synthesis, enhances the motor effect of amphetamine in mice through the inhibition of striatal na release. |
2016-02-16 |
2023-08-13 |
mouse |
| Lise Gutknecht, Sandy Popp, Jonas Waider, Frank M J Sommerlandt, Corinna Göppner, Antonia Post, Andreas Reif, Daniel van den Hove, Tatyana Strekalova, Angelika Schmitt, Maria B N Colaςo, Claudia Sommer, Rupert Palme, Klaus-Peter Lesc. Interaction of brain 5-HT synthesis deficiency, chronic stress and sex differentially impact emotional behavior in Tph2 knockout mice. Psychopharmacology. vol 232. issue 14. 2016-01-19. PMID:25716307. |
interaction of brain 5-ht synthesis deficiency, chronic stress and sex differentially impact emotional behavior in tph2 knockout mice. |
2016-01-19 |
2023-08-13 |
mouse |