| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Benjamin D Sachs, Ramona M Rodriguiz, William B Siesser, Alexander Kenan, Elizabeth L Royer, Jacob P R Jacobsen, William C Wetsel, Marc G Caro. The effects of brain serotonin deficiency on behavioural disinhibition and anxiety-like behaviour following mild early life stress. The international journal of neuropsychopharmacology. vol 16. issue 9. 2014-04-01. PMID:23672796. |
here, we examined the effects of early life maternal separation (ms) stress on anxiety-like behaviour and behavioural disinhibition, a type of impulsivity-like behaviour, in wild-type (wt) and tryptophan hydroxylase 2 (tph2) knock-in (tph2ki) mice, which exhibit ~60-80% reductions in the levels of brain 5-ht due to a r439h mutation in tph2. |
2014-04-01 |
2023-08-12 |
mouse |
| Chieh-Hsin Lin, Yu-Lun Tseng, Chieh-Liang Huang, Yue-Cune Chang, Guochuan E Tsai, Hsien-Yuan Lan. Synergistic effects of COMT and TPH2 on social cognition. Psychiatry. vol 76. issue 3. 2014-03-10. PMID:23965265. |
this study investigates whether social cognition varies with genetic variations of comt and tryptophan hydroxylase-2 (tph2), which modulate dopamine and serotonin neurotransmissions respectively, and thereby emotion regulation. |
2014-03-10 |
2023-08-12 |
human |
| Asem Surindro Singh, Rashmi Chandra, Subhrangshu Guhathakurta, Swagata Sinha, Anindita Chatterjee, Shabina Ahmed, Saurabh Ghosh, Usha Rajamm. Genetic association and gene-gene interaction analyses suggest likely involvement of ITGB3 and TPH2 with autism spectrum disorder (ASD) in the Indian population. Progress in neuro-psychopharmacology & biological psychiatry. vol 45. 2014-02-26. PMID:23628433. |
therefore, in the present study we investigate the association of tph2, the rate limiting enzyme in 5-ht biosynthesis and itgb3, a serotonin quantitative trait locus with asd in the indian population. |
2014-02-26 |
2023-08-12 |
Not clear |
| Tomaž Zupanc, Peter Pregelj, Alja Videtič Pask. Tryptophan hydroxylase 2 (TPH 2) single nucleotide polymorphisms, suicide, and alcohol-related suicide. Psychiatria Danubina. vol 25 Suppl 2. 2014-02-25. PMID:23995203. |
studies investigating suicide, alcohol-related suicide and the rate limiting enzyme of serotonin synthesis, tryptophan hydroxylase 2 (tph2), remain to date rather limited. |
2014-02-25 |
2023-08-12 |
Not clear |
| Lukasz Piszczek, Kevin Schlax, Anna Wyrzykowska, Agnieszka Piszczek, Enrica Audero, Cornelius Thilo Gros. Serotonin 1A auto-receptors are not sufficient to modulate anxiety in mice. The European journal of neuroscience. vol 38. issue 4. 2014-02-19. PMID:23701504. |
transgenic mice expressing htr1a under the control of the tryptophan hydroxylase 2 (tph2) promoter showed restored htr1a-mediated serotonin negative feedback and hypothermia, but anxiety behavior indistinguishable from that of knockout mice. |
2014-02-19 |
2023-08-12 |
mouse |
| Christinna V Jørgensen, Jacob P Jacobsen, Marc G Caron, Anders B Klein, Gitte M Knudsen, Jens D Mikkelse. Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice. Neuroscience letters. vol 555. 2014-01-31. PMID:24055299. |
transgenic mice with a knock-in (ki) of a tryptophan hydroxylase 2 (tph2) r439h mutation, analogous to the tph2 r441h single-nucleotide polymorphism originally identified in a late life depression cohort, have markedly reduced levels of 5-hydroxytryptamine (5-ht). |
2014-01-31 |
2023-08-12 |
mouse |
| D Pérez-Cáceres, A Ciudad-Roberts, M T Rodrigo, D Pubill, A Camins, J Camarasa, E Escubedo, M Pallà. Depression-like behavior is dependent on age in male SAMP8 mice. Biogerontology. vol 14. issue 2. 2014-01-30. PMID:23559311. |
we also applied the dexamethasone suppression test (dst) and studied changes in the dopamine and serotonin (5-ht) uptake systems, the 5-ht2a/2c receptor density in the cortex, and levels of tph2. |
2014-01-30 |
2023-08-12 |
mouse |
| Richard Musil, Peter Zill, Florian Seemüller, Brigitta Bondy, Sebastian Meyer, Ilja Spellmann, Wolfram Bender, Mazda Adli, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Wolfgang Maier, Marcella Rietschel, Dan Rujescu, Rebecca Schennach, Hans-Jürgen Möller, Michael Riede. Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:23063133. |
common polymorphisms involved in the tryptophan hydroxylase 1 (tph1) and 2 (tph2), serotonin transporter, monoamine oxidase a (maoa) and brain-derived neurotrophic factor (bdnf) were investigated in a naturalistic inpatient study of the german research network on depression. |
2014-01-23 |
2023-08-12 |
Not clear |
| Sergi Mas, Maria Teresa Plana, Josefina Castro-Fornieles, Patricia Gassó, Amalia Lafuente, Elena Moreno, Esteban Martinez, Montserrat Milà, Luisa Lazar. Common genetic background in anorexia nervosa and obsessive compulsive disorder: preliminary results from an association study. Journal of psychiatric research. vol 47. issue 6. 2014-01-21. PMID:23337130. |
the interaction observed between the associated polymorphisms, could indicate that there is a biological interaction between the serotonin (tph2 and slc18a1) and glutamate (gria3) pathways and the factors related to neurogenesis (cdh9, olig2 and ntrk3) for the explanation of etiopathophysiology in both diseases. |
2014-01-21 |
2023-08-12 |
Not clear |
| Shingo Matsuda, Daisuke Matsuzawa, Daisuke Ishii, Haruna Tomizawa, Junko Sajiki, Eiji Shimiz. Perinatal exposure to bisphenol A enhances contextual fear memory and affects the serotoninergic system in juvenile female mice. Hormones and behavior. vol 63. issue 5. 2014-01-17. PMID:23567477. |
furthermore, bpa induced increases in the expression levels of tph2, slc6a4, and maoa mrna in the hippocampus of juvenile females, indicating that bpa induces hyper 5-ht turnover in the hippocampus. |
2014-01-17 |
2023-08-12 |
mouse |
| Ryoko Hiroi, Robert J Hand. Estrogen receptor-β regulates human tryptophan hydroxylase-2 through an estrogen response element in the 5' untranslated region. Journal of neurochemistry. vol 127. issue 4. 2014-01-06. PMID:24033289. |
in the dorsal raphe nucleus, 17β-estradiol (e2) increases the expression of the brain-specific, rate-limiting enzyme for serotonin biosynthesis, tryptophan hydroxylase-2 (tph2). |
2014-01-06 |
2023-08-12 |
human |
| Sebastiaan Engelborghs, Kristel Sleegers, Stefan Van der Mussele, Nathalie Le Bastard, Nathalie Brouwers, Christine Van Broeckhoven, Peter Paul De Dey. Brain-specific tryptophan hydroxylase, TPH2, and 5-HTTLPR are associated with frontal lobe symptoms in Alzheimer's disease. Journal of Alzheimer's disease : JAD. vol 35. issue 1. 2013-12-27. PMID:23334703. |
a prospective, longitudinal study was set up to investigate possible genetic associations of behavioral and psychological signs and symptoms of dementia (bpsd) in alzheimer's disease (ad) with two candidate genes in the serotonergic neurotransmitter pathway: serotonin transporter (slc6a4) and brain-specific tryptophan hydroxylase (tph2). |
2013-12-27 |
2023-08-12 |
Not clear |
| Cynthia L Bethea, Kenny Phu, Arubala P Reddy, Judy L Camero. The effect of short-term stress on serotonin gene expression in high and low resilient macaques. Progress in neuro-psychopharmacology & biological psychiatry. vol 44. 2013-12-18. PMID:23357537. |
tryptophan hydroxylase 2 (tph2), the serotonin reuptake transporter (sert), and the 5ht1a autoreceptor mrnas expression were determined at 4 morphological levels of the dorsal raphe nucleus with in situ hybridization (ish) using digoxigenin-incorporated riboprobes. |
2013-12-18 |
2023-08-12 |
monkey |
| Of Khabour, Bh Amarneh, Ea Bani Hani, Im Lataife. Associations Between Variations in TPH1 , TPH2 and SLC6A4 Genes and Postpartum Depression: A Study in the Jordanian Population. Balkan journal of medical genetics : BJMG. vol 16. issue 1. 2013-11-22. PMID:24265583. |
in this study, we investigated the association between tryptophan hydroxylase-1 (tph1 ) (218a>c), tryptophan hydroxylase-2 ( tph2 ) (1463g>a) and serotonin carrier family 6, member 4 (slc6a4) [long (l) vs. short (s)] gene polymorphisms with post-partum depression (ppd) in women from jordan. |
2013-11-22 |
2023-08-12 |
Not clear |
| Naozumi Araragi, Klaus-Peter Lesc. Serotonin (5-HT) in the regulation of depression-related emotionality: insight from 5-HT transporter and tryptophan hydroxylase-2 knockout mouse models. Current drug targets. vol 14. issue 5. 2013-10-29. PMID:23547810. |
moreover, the recent advent of knockout (ko) mice for tryptophan hydroxylase 2 (tph2 ko), which lacks the rate-limiting enzyme for 5-ht synthesis in the brain, has further provided insight to the brain serotonergic system and its role in emotion dysregulation. |
2013-10-29 |
2023-08-12 |
mouse |
| William B Siesser, Benjamin D Sachs, Amy J Ramsey, Tatyana D Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G Caron, Raul R Gainetdino. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336047. |
chronic ssri treatment exacerbates serotonin deficiency in humanized tph2 mutant mice. |
2013-07-02 |
2023-08-12 |
mouse |
| William B Siesser, Benjamin D Sachs, Amy J Ramsey, Tatyana D Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G Caron, Raul R Gainetdino. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336047. |
a rare mutation in tryptophan hydroxylase 2 (tph2), the rate limiting enzyme for 5-ht synthesis, was identified in several patients with major depression, and knock-in mice expressing the analogous mutation (r439h tph2 ki) show 80% reduction in 5-ht synthesis and tissue levels. |
2013-07-02 |
2023-08-12 |
mouse |
| William B Siesser, Benjamin D Sachs, Amy J Ramsey, Tatyana D Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G Caron, Raul R Gainetdino. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336047. |
chronic treatment with ssris (fluoxetine and paroxetine) resulted in a dramatic further depletion of 5-ht tissue levels in r439h tph2 ki mice (down to 1-3% of wild type levels) while having little effects in wild-type controls. |
2013-07-02 |
2023-08-12 |
mouse |
| William B Siesser, Benjamin D Sachs, Amy J Ramsey, Tatyana D Sotnikova, Jean-Martin Beaulieu, Xiaodong Zhang, Marc G Caron, Raul R Gainetdino. Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. ACS chemical neuroscience. vol 4. issue 1. 2013-07-02. PMID:23336047. |
these data demonstrate that chronic ssri treatment could further exacerbate the 5-ht deficiency in tph2 mutation carriers, and this can be prevented by 5-htp supplementation. |
2013-07-02 |
2023-08-12 |
mouse |