| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Armen K Goenjian, Julia N Bailey, David P Walling, Alan M Steinberg, Devon Schmidt, Uma Dandekar, Ernest P Nobl. Association of TPH1, TPH2, and 5HTTLPR with PTSD and depressive symptoms. Journal of affective disorders. vol 140. issue 3. 2013-01-31. PMID:22483952. |
to examine the potential contribution of the serotonin hydroxylase (tph1 and tph2) genes, and the serotonin transporter promoter polymorphism (5httlpr) to the unique and pleiotropic risk of ptsd symptoms and depressive symptoms. |
2013-01-31 |
2023-08-12 |
Not clear |
| Mariana P Torrente, Alan J Gelenberg, Kent E Vran. Boosting serotonin in the brain: is it time to revamp the treatment of depression? Journal of psychopharmacology (Oxford, England). vol 26. issue 5. 2013-01-21. PMID:22158544. |
a recently discovered isoform, tph2, is responsible for serotonin biosynthesis in the brain. |
2013-01-21 |
2023-08-12 |
Not clear |
| Peter A Fasching, Florian Faschingbauer, Tamme W Goecke, Anne Engel, Lothar Häberle, Anna Seifert, Franziska Voigt, Manuela Amann, Dirk Rebhan, Pascal Burger, Johannes Kornhuber, Arif B Ekici, Matthias W Beckmann, Elisabeth B Binde. Genetic variants in the tryptophan hydroxylase 2 gene (TPH2) and depression during and after pregnancy. Journal of psychiatric research. vol 46. issue 9. 2013-01-09. PMID:22721547. |
the aim of this study was to investigate whether genetic polymorphisms in the tph2 gene, the gene product of which is the rate-limiting enzyme in the biosynthesis of serotonin in the central nervous system, are associated with depressive symptoms in pregnancy and the postpartum period. |
2013-01-09 |
2023-08-12 |
Not clear |
| Denis A Nikishin, Stanislav V Kremnyov, Victoria V Konduktorova, Yuri B Shmukle. Expression of serotonergic system components during early Xenopus embryogenesis. The International journal of developmental biology. vol 56. issue 5. 2012-12-14. PMID:22811272. |
transcripts encoding the serotonin receptors htr2c and htr7, as well as the vesicular monoamine transporter vmat2, the serotonin transporter (sert) and the serotonin synthesis enzymes tryptophan hydroxylase (tph2) and aromatic amino acid decarboxylase (aaad) were found to be expressed during the cleavage division stages, whereas the degradation enzyme monoamine oxidase a (maoa) was absent. |
2012-12-14 |
2023-08-12 |
xenopus_laevis |
| Klaus-Peter Lesch, Naozumi Araragi, Jonas Waider, Daniel van den Hove, Lise Gutknech. Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826343. |
with the exception of brain-specific tryptophan hydroxylase-2 (tph2), which generates serotonin (5-ht) in raphe neurons, the contribution of gene variation to aggression-related behaviour in genetically modified mouse models has been previously appraised (lesch 2005 novartis found symp. |
2012-12-06 |
2023-08-12 |
mouse |
| Klaus-Peter Lesch, Naozumi Araragi, Jonas Waider, Daniel van den Hove, Lise Gutknech. Targeting brain serotonin synthesis: insights into neurodevelopmental disorders with long-term outcomes related to negative emotionality, aggression and antisocial behaviour. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826343. |
mouse models in conjunction with approaches focusing on tph2 variants in humans provide unexpected views of 5-ht's role in brain development and in disorders related to negative emotionality, aggression and antisocial behaviour. |
2012-12-06 |
2023-08-12 |
mouse |
| Jacob P R Jacobsen, Ivan O Medvedev, Marc G Caro. The 5-HT deficiency theory of depression: perspectives from a naturalistic 5-HT deficiency model, the tryptophan hydroxylase 2Arg439His knockin mouse. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. vol 367. issue 1601. 2012-12-06. PMID:22826344. |
in this review, we will critically assess the evidence for 5-ht deficiency in depression and the possible role of polymorphisms in the tph2 gene as a causal factor in 5-ht deficiency, the latter investigated from a clinical as well as preclinical angle. |
2012-12-06 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (tph2) loss-of-function mice. |
2012-11-13 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
we employed a naturalistic model of 5-ht deficiency, the tryptophan hydroxylase 2 (tph2) r439h knockin mouse, to address this question. |
2012-11-13 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
we report that tph2 knockin mice have reduced basal and stimulated levels of extracellular 5-ht (5-ht(ext)). |
2012-11-13 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
moreover, 5-ht(1a) receptor agonist-induced hypothermia is blunted and frontal cortex 5-ht(2a) receptors are increased in the tph2 knockin mice. |
2012-11-13 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
further, 5-ht(2a) receptor function is enhanced in the tph2 knockin mice. |
2012-11-13 |
2023-08-12 |
mouse |
| J P R Jacobsen, W B Siesser, B D Sachs, S Peterson, M J Cools, V Setola, J H A Folgering, G Flik, M G Caro. Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. Molecular psychiatry. vol 17. issue 7. 2012-11-13. PMID:21537332. |
in contrast, 5-ht(1a) receptor levels and g-protein coupling is normal in tph2 knockin mice, indicating that the blunted hypothermic response relates directly to the low 5-ht(ext). |
2012-11-13 |
2023-08-12 |
mouse |
| A V Kulikov, D V Osipova, V S Naumenko, E Terenina, P Mormède, N K Popov. A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561036. |
previously, it was shown that intensity of mouse intermale aggression was positively associated with activity of the key enzyme of 5-ht synthesis - tryptophan hydroxylase 2 (tph2) in mouse brain. |
2012-11-05 |
2023-08-12 |
mouse |
| A V Kulikov, D V Osipova, V S Naumenko, E Terenina, P Mormède, N K Popov. A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561036. |
the aim of the present study was to investigate the effect of pharmacological activation or inhibition of 5-ht synthesis in the brain on intermale aggression in two mouse strains differing in the tph2 activity: c57bl/6j (b6, high tph2 activity, high aggressiveness) and cc57br/mv (br, low tph2 activity, low aggressiveness). |
2012-11-05 |
2023-08-12 |
mouse |
| A V Kulikov, D V Osipova, V S Naumenko, E Terenina, P Mormède, N K Popov. A pharmacological evidence of positive association between mouse intermale aggression and brain serotonin metabolism. Behavioural brain research. vol 233. issue 1. 2012-11-05. PMID:22561036. |
and vice versa, administration of tph2 inhibitor p-chlorophenylalanine (pcpa) (300 mg/kg, i.p., for 3 consecutive days) to b6 mice dramatically reduced the 5-ht and 5-hiaa contents in brain structures and attenuated the frequency and the duration of aggressive attacks. |
2012-11-05 |
2023-08-12 |
mouse |
| Jin Gao, Zhenglun Pan, Zhian Jiao, Feng Li, Guoqing Zhao, Qianqian Wei, Fang Pan, Evangelos Evangelo. TPH2 gene polymorphisms and major depression--a meta-analysis. PloS one. vol 7. issue 5. 2012-10-22. PMID:22693556. |
tryptophan hydroxylase-2 (tph2) is the rate-limiting enzyme in the synthetic pathway for brain serotonin and is considered key factor for maintaining normal serotonin transmission in the central neuron system (cns). |
2012-10-22 |
2023-08-12 |
Not clear |
| Hyo Youl Moon, Se Hyun Kim, Yong Ryoul Yang, Parkyong Song, Hyun Sook Yu, Hong Geun Park, Onyou Hwang, Whaseon Lee-Kwon, Jeong Kon Seo, Daehee Hwang, Jang Hyun Choi, Richard Bucala, Sung Ho Ryu, Yong Sik Kim, Pann-Ghill Su. Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 32. 2012-10-15. PMID:22826223. |
this increment of tph2 was accompanied by increases in the levels of total serotonin in vitro. |
2012-10-15 |
2023-08-12 |
mouse |
| Hyo Youl Moon, Se Hyun Kim, Yong Ryoul Yang, Parkyong Song, Hyun Sook Yu, Hong Geun Park, Onyou Hwang, Whaseon Lee-Kwon, Jeong Kon Seo, Daehee Hwang, Jang Hyun Choi, Richard Bucala, Sung Ho Ryu, Yong Sik Kim, Pann-Ghill Su. Macrophage migration inhibitory factor mediates the antidepressant actions of voluntary exercise. Proceedings of the National Academy of Sciences of the United States of America. vol 109. issue 32. 2012-10-15. PMID:22826223. |
moreover, the mif receptor cd74 and the erk1/2 pathway mediate the mif-induced tph2 and bdnf gene expression as well as serotonin content. |
2012-10-15 |
2023-08-12 |
mouse |
| Rebecca S Henkhaus, Douglas C Bittel, Merlin G Butle. TPH2 polymorphisms and expression in Prader-Willi syndrome subjects with differing genetic subtypes. Journal of neurodevelopmental disorders. vol 2. issue 3. 2012-10-02. PMID:22127900. |
we investigated the tryptophan hydroxylase gene (tph2), the rate-limiting enzyme in the production of brain serotonin, by analyzing three different tph2 gene polymorphisms, transcript expression, and correlation with pws genetic subtype. |
2012-10-02 |
2023-08-12 |
human |