| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| b' Pascal Amireault, Sarah Hatia, Elisa Bayard, Florence Bernex, Corinne Collet, Jacques Callebert, Jean-Marie Launay, Olivier Hermine, Elke Schneider, Jacques Mallet, Michel Dy, Francine C\\xc3\\xb4t\\xc3\\xa. Ineffective erythropoiesis with reduced red blood cell survival in serotonin-deficient mice. Proceedings of the National Academy of Sciences of the United States of America. vol 108. issue 32. 2011-10-18. PMID:21788492.' |
availability of 5-ht depends on the expression of the enzyme tryptophan hydroxylase (tph), and the recent discovery of a dual system for 5-ht synthesis in the brain (tph2) and periphery (tph1) has renewed interest in studying the potential functions played by 5-ht in nonnervous tissues. |
2011-10-18 |
2023-08-12 |
mouse |
| Thibault Renoir, Michelle S Zajac, Xin Du, Terence Y Pang, Leah Leang, Caroline Chevarin, Laurence Lanfumey, Anthony J Hanna. Sexually dimorphic serotonergic dysfunction in a mouse model of Huntington's disease and depression. PloS one. vol 6. issue 7. 2011-10-13. PMID:21760962. |
while tissue levels of serotonin were reduced in both male and female hd mice, we found that serotonin concentration and hydroxylase-2 (tph2) mrna levels were higher in the hippocampus of males compared to female animals. |
2011-10-13 |
2023-08-12 |
mouse |
| Zhishan Li, Alcmène Chalazonitis, Yung-Yu Huang, J John Mann, Kara Gross Margolis, Qi Melissa Yang, Dolly O Kim, Francine Côté, Jacques Mallet, Michael D Gersho. Essential roles of enteric neuronal serotonin in gastrointestinal motility and the development/survival of enteric dopaminergic neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. vol 31. issue 24. 2011-08-22. PMID:21677183. |
5-ht biosynthesis depends on tryptophan hydroxylase 1 (tph1) in ec cells and on tph2 in neurons; therefore, mice lacking tph1 and/or tph2 distinguish ec-derived from neuronal 5-ht. |
2011-08-22 |
2023-08-12 |
mouse |
| Elisabeth M Dykens, Elizabeth Roof, Douglas Bittel, Merlin G Butle. TPH2 G/T polymorphism is associated with hyperphagia, IQ, and internalizing problems in Prader-Willi syndrome. Journal of child psychology and psychiatry, and allied disciplines. vol 52. issue 5. 2011-08-18. PMID:21418060. |
as aberrant serotonergic functioning is strongly implicated in pws, we examined associations between the pws phenotype and polymorphisms in tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in the biosynthesis of serotonin in the brain. |
2011-08-18 |
2023-08-12 |
Not clear |
| Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Din. Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21246047. |
after administration of tamoxifen, the level of 5-ht in the brain of lmx1b icko mice was reduced to 60% of that in control mice, and the expression of tryptophan hydroxylase 2 (tph2), serotonin transporter (sert) and vesicular monoamine transporter 2 (vmat2) was greatly down-regulated. |
2011-08-02 |
2023-08-12 |
mouse |
| Ning-Ning Song, Jian-Bo Xiu, Ying Huang, Jia-Yin Chen, Lei Zhang, Lise Gutknecht, Klaus Peter Lesch, He Li, Yu-Qiang Din. Adult raphe-specific deletion of Lmx1b leads to central serotonin deficiency. PloS one. vol 6. issue 1. 2011-08-02. PMID:21246047. |
our results reveal that lmx1b is required for the biosynthesis of 5-ht in adult mouse brain, and it may be involved in maintaining normal functions of central 5-htergic neurons by regulating the expression of tph2, sert and vmat2. |
2011-08-02 |
2023-08-12 |
mouse |
| Chen Zhang, Zezhi Li, Yang Shao, Bin Xie, Yasong Du, Yiru Fang, Shunying Y. Association study of tryptophan hydroxylase-2 gene in schizophrenia and its clinical features in Chinese Han population. Journal of molecular neuroscience : MN. vol 43. issue 3. 2011-07-21. PMID:20938755. |
tryptophan hydroxylase 2 (tph2), a newly identified isoform of tryptophan hydroxylase (the rate limiting enzyme in the biosynthesis of serotonin), regulates the brain-specific serotonin synthesis. |
2011-07-21 |
2023-08-12 |
human |
| Nurgul Carkaci-Salli, Ugur Salli, Kara L Kuntz-Melcavage, Michael M Pennock, Hande Ozgen, Izel Tekin, Willard M Freeman, Kent E Vran. TPH2 in the ventral tegmental area of the male rat brain. Brain research bulletin. vol 84. issue 6. 2011-07-18. PMID:21272616. |
tph2 is the genetic isoform of tph that catalyzes the rate-limiting step in serotonin biosynthesis within the central nervous system. |
2011-07-18 |
2023-08-12 |
rat |
| Laurent Nexon, Dominique Sage, Paul Pévet, Sylvie Raiso. Glucocorticoid-mediated nycthemeral and photoperiodic regulation of tph2 expression. The European journal of neuroscience. vol 33. issue 7. 2011-07-18. PMID:21299657. |
in the syrian hamster dorsal and median raphé nuclei, the tryptophan hydroxylase 2 gene (tph2), which codes the rate-limiting enzyme of serotonin synthesis, displays daily variations in its expression in animals entrained to a long but not to a short photoperiod. |
2011-07-18 |
2023-08-12 |
Not clear |
| Prisila Dulcy Charles, Ganesh Ambigapathy, Pitchairaj Geraldine, Mohammad Abdulkadar Akbarsha, Koilmani Emmanuvel Raja. Bacopa monniera leaf extract up-regulates tryptophan hydroxylase (TPH2) and serotonin transporter (SERT) expression: implications in memory formation. Journal of ethnopharmacology. vol 134. issue 1. 2011-07-14. PMID:21129470. |
bacopa monniera leaf extract up-regulates tryptophan hydroxylase (tph2) and serotonin transporter (sert) expression: implications in memory formation. |
2011-07-14 |
2023-08-12 |
rat |
| Massimo Cocchi, Lucio Tonello, Fabio Gabrielli, Massimo Pregnolat. Depression, osteoporosis, serotonin and cell membrane viscosity between biology and philosophical anthropology. Annals of general psychiatry. vol 10. 2011-07-14. PMID:21450092. |
moreover, it is believed that the hereditary or acquired involvement of tryptophan hydroxylase 2 (tph2) or 5-hydroxytryptamine transporter (5-htt) is responsible for the reduced concentration of serotonin in the central nervous system, causing depression and affective disorders. |
2011-07-14 |
2023-08-12 |
human |
| A V Kulikov, M A Tikhonova, E A Kulikova, T M Khomenko, D V Korchagina, K P Volcho, H F Salachutdinov, N K Popov. [Effect of new potential psychotropic drug, 8-(trifluoromethyl)-1,2,3,4,5-benzopentathiepin-6-amine hydrochloride, on the expression of serotonin-related genes in mouse brain]. Molekuliarnaia biologiia. vol 45. issue 2. 2011-07-08. PMID:21634115. |
the expression of genes encoding 1) the key enzyme of serotonin synthesis, tryptophan hydroxylase 2 (tph2), 2) main enzyme of serotonin degradation, monoamine oxydase a (maoa), 3) 5-ht transporter (sert) and 4) 5-ht(1a) receptor was studied using quantitative rt-pcr. |
2011-07-08 |
2023-08-12 |
mouse |
| K Raghuveer, C C Sudhakumari, B Senthilkumaran, H Kagawa, A Dutta-Gupta, Y Nagaham. Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation. General and comparative endocrinology. vol 171. issue 1. 2011-07-05. PMID:21156177. |
differential expression of tph2 was observed at mrna and protein levels in the poa-hyp and oct regions of male and female brains during development that further correlate with the 5-hydroxytryptophan (5-htp) and 5-ht levels measured using hplc method in these regions of male and female brains. |
2011-07-05 |
2023-08-12 |
Not clear |
| K Raghuveer, C C Sudhakumari, B Senthilkumaran, H Kagawa, A Dutta-Gupta, Y Nagaham. Gender differences in tryptophan hydroxylase-2 mRNA, serotonin, and 5-hydroxytryptophan levels in the brain of catfish, Clarias gariepinus, during sex differentiation. General and comparative endocrinology. vol 171. issue 1. 2011-07-05. PMID:21156177. |
changes in tph2 mrna expression, 5-htp, and 5-ht levels in the poa-hyp+oct region of brains of methyltestosterone and para-chlorophenylalanine treated fishes during development further endorse our results. |
2011-07-05 |
2023-08-12 |
Not clear |
| Catherina E M van Beijsterveldt, Christel M Middeldorp, Margarita C T Slof-Op't Landt, Meike Bartels, Jouke-Jan Hottenga, H Eka D Suchiman, P Eline Slagboom, Dorret I Boomsm. Influence of candidate genes on attention problems in children: a longitudinal study. Behavior genetics. vol 41. issue 1. 2011-06-28. PMID:21049304. |
this study investigated the effect of 26 single nucleotide polymorphisms (snps) in genes encoding for serotonin receptors 2a (htr2a), catechol-o-methyltransferase (comt), tryptophane hydroxylase type 2 (tph2), and brain derived neurotrophic factor (bdnf). |
2011-06-28 |
2023-08-12 |
Not clear |
| Jonas Waider, Naozumi Araragi, Lise Gutknecht, Klaus-Peter Lesc. Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective. Psychoneuroendocrinology. vol 36. issue 3. 2011-06-21. PMID:21257271. |
based on genetic variation, there is accumulating evidence that altered function of tryptophan hydroxylase-2 (tph2), the enzyme critical for synthesis of serotonin (5-ht) in the brain, plays a role in anxiety-, aggression- and depression-related personality traits and in the pathogenesis of disorders featuring deficits in cognitive control and emotion regulation. |
2011-06-21 |
2023-08-12 |
mouse |
| Jonas Waider, Naozumi Araragi, Lise Gutknecht, Klaus-Peter Lesc. Tryptophan hydroxylase-2 (TPH2) in disorders of cognitive control and emotion regulation: a perspective. Psychoneuroendocrinology. vol 36. issue 3. 2011-06-21. PMID:21257271. |
mouse models in conjunction with cognitive neuroscience approaches in humans are providing unexpected results and it may well be that future research on tph2 will provide an entirely new view of 5-ht in brain development and function related to neuropsychiatric disorders. |
2011-06-21 |
2023-08-12 |
mouse |
| S Jun, R Kohen, K C Cain, M E Jarrett, M M Heitkempe. Associations of tryptophan hydroxylase gene polymorphisms with irritable bowel syndrome. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21073637. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms: tph1 and tph2. |
2011-05-31 |
2023-08-12 |
Not clear |
| M Camiller. LX-1031, a tryptophan 5-hydroxylase inhibitor, and its potential in chronic diarrhea associated with increased serotonin. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society. vol 23. issue 3. 2011-05-31. PMID:21159063. |
lx-1031 appears promising for chronic diarrhea associated with increased 5-ht expression including ibs-d. optimal doses, efficacy and safety in ibs clinical trials need to be fully elucidated; low systemic exposure, selectivity for tph1 over tph2, and lack of effect on brain 5-ht in several species suggest that lx-1031 is unlikely to cause affective disorders. |
2011-05-31 |
2023-08-12 |
human |
| Yan Liu, Yun'ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen, Yi Ra. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. vol 472. issue 7341. 2011-05-31. PMID:21441904. |
a role for 5-ht was demonstrated by the phenotype of mice lacking tryptophan hydroxylase 2 (tph2), which is required for the first step of 5-ht synthesis in the brain. |
2011-05-31 |
2023-08-12 |
mouse |