| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yan Liu, Yun'ai Jiang, Yunxia Si, Ji-Young Kim, Zhou-Feng Chen, Yi Ra. Molecular regulation of sexual preference revealed by genetic studies of 5-HT in the brains of male mice. Nature. vol 472. issue 7341. 2011-05-31. PMID:21441904. |
thirty-five minutes after the injection of the intermediate 5-hydroxytryptophan (5-htp), which circumvented tph2 to restore 5-ht to the wild-type level, adult tph2 knockout mice also preferred females over males. |
2011-05-31 |
2023-08-12 |
mouse |
| Jasminka Stefulj, Gordana Mokrovic, Dubravka Hranilovic, Tatjana Bordukalo-Niksic, Mirko Bakula, Milovan Kubat, Branimir Jerne. Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide. Psychiatry research. vol 186. issue 2-3. 2011-05-12. PMID:20869124. |
the association between suicide and g-703t polymorphism of the tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of croatian origin. |
2011-05-12 |
2023-08-12 |
human |
| Caroline A Browne, Gerard Clarke, Timothy G Dinan, John F Crya. Differential stress-induced alterations in tryptophan hydroxylase activity and serotonin turnover in two inbred mouse strains. Neuropharmacology. vol 60. issue 4. 2011-05-12. PMID:21130784. |
the balb/c strain is stress-sensitive, highly anxious and possess a single nucleotide polymorphism in their tryptophan hydroxylase (tph) 2 gene (tph2), resulting in reduced levels of central serotonin compared to c57bl/6j mice, which harbour the wild-type allele. |
2011-05-12 |
2023-08-12 |
mouse |
| Kirsten X Jacobsen, Margaret Czesak, Mariam Deria, Brice Le François, Paul R Alber. Region-specific regulation of 5-HT1A receptor expression by Pet-1-dependent mechanisms in vivo. Journal of neurochemistry. vol 116. issue 6. 2011-04-15. PMID:21182526. |
in the raphe nuclei of pet-1-/- mice tryptophan hydroxylase 2 (tph2) rna, and 5-ht and tph immunostaining were greatly reduced, indicating a deficit in 5-ht production. |
2011-04-15 |
2023-08-12 |
mouse |
| Alexander Jung, Andreas Huge, Gregor Kuhlenbäumer, Steffi Kempt, Tanja Seehafer, Stefan Evers, Klaus Berger, Martin Marzinia. Genetic TPH2 variants and the susceptibility for migraine: association of a TPH2 haplotype with migraine without aura. Journal of neural transmission (Vienna, Austria : 1996). vol 117. issue 11. 2011-03-21. PMID:20740293. |
the tph2 isoform is responsible for the cerebral serotonin biosynthesis. |
2011-03-21 |
2023-08-12 |
Not clear |
| Alessia Omenetti, Liu Yang, Raul R Gainetdinov, Cynthia D Guy, Steve S Choi, Wei Chen, Marc G Caron, Anna Mae Dieh. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 2. 2011-03-15. PMID:21071507. |
results in the cell culture models confirm that cholangiocytes have serotonin receptors and demonstrate for the first time that these cells express tph2 and produce serotonin, which autoinhibits their growth but stimulates mf production of tgf-β(1). |
2011-03-15 |
2023-08-12 |
mouse |
| Alessia Omenetti, Liu Yang, Raul R Gainetdinov, Cynthia D Guy, Steve S Choi, Wei Chen, Marc G Caron, Anna Mae Dieh. Paracrine modulation of cholangiocyte serotonin synthesis orchestrates biliary remodeling in adults. American journal of physiology. Gastrointestinal and liver physiology. vol 300. issue 2. 2011-03-15. PMID:21071507. |
studies of tph2ki mice confirm that tph2-mediated production of serotonin plays an important role in remodeling damaged bile ducts because mice with decreased tph2 function have reduced biliary serotonin levels and exhibit excessive cholangiocyte proliferation, accumulation of aberrant ductules and liver progenitors, and increased liver fibrosis after bile duct ligation. |
2011-03-15 |
2023-08-12 |
mouse |
| Donald M Kuhn, Catherine E Sykes, Timothy J Geddes, Karen L Eskow Jaunarajs, Christopher Bisho. Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of neurochemistry. vol 116. issue 3. 2011-02-17. PMID:21105877. |
therefore, the oxidative processes that prevail in pd could cause tph2 misfolding and modify serotonin neuronal function much as is seen in dopamine neurons. |
2011-02-17 |
2023-08-12 |
Not clear |
| Donald M Kuhn, Catherine E Sykes, Timothy J Geddes, Karen L Eskow Jaunarajs, Christopher Bisho. Tryptophan hydroxylase 2 aggregates through disulfide cross-linking upon oxidation: possible link to serotonin deficits and non-motor symptoms in Parkinson's disease. Journal of neurochemistry. vol 116. issue 3. 2011-02-17. PMID:21105877. |
the propensity of tph2 to misfold upon oxidation of its cysteine residues is responsible for its catalytic lability and may be related to loss of serotonin neuronal function in pd and the emergence of non-motor (psychiatric) symptoms. |
2011-02-17 |
2023-08-12 |
Not clear |
| C M Middeldorp, M C T Slof-Op 't Landt, S E Medland, C E M van Beijsterveldt, M Bartels, G Willemsen, J-J Hottenga, E J C de Geus, H E D Suchiman, C V Dolan, M C Neale, P E Slagboom, D I Boomsm. Anxiety and depression in children and adults: influence of serotonergic and neurotrophic genes? Genes, brain, and behavior. vol 9. issue 7. 2011-02-08. PMID:20633049. |
this study investigated the effect of 45 single nucleotide polymorphisms (snps) in genes encoding for serotonin receptors 1a, 1d, 2a, catechol-o-methyltransferase (comt), tryptophane hydroxylase type 2 (tph2), brain derived neurotrophic factor (bdnf), plexina2 and regulators of g-protein-coupled signaling (rgs) 2, 4, 16. |
2011-02-08 |
2023-08-12 |
human |
| Nina K Popova, Alexander V Kuliko. Targeting tryptophan hydroxylase 2 in affective disorder. Expert opinion on therapeutic targets. vol 14. issue 11. 2011-02-07. PMID:20874521. |
the key and rate limiting enzyme of 5-ht synthesis is tryptophan hydroxylase 2 (tph2). |
2011-02-07 |
2023-08-12 |
Not clear |
| M A Tikhonova, E L Alperina, T G Tolstikova, D V Bazovkina, V Y Di, G V Idova, A V Kulikov, N K Popov. Effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1A and 2A serotonin receptors and the tph2 and SERT genes. Neuroscience and behavioral physiology. vol 40. issue 5. 2011-01-28. PMID:20464512. |
effects of chronic fluoxetine treatment on catalepsy and the immune response in mice with a genetic predisposition to freezing reactions: the roles of types 1a and 2a serotonin receptors and the tph2 and sert genes. |
2011-01-28 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
brain-specific conditional and time-specific inducible tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
we therefore studied different animal models featuring reduced tph2 expression to investigate the consequences of impaired brain 5-ht synthesis on neuronal development. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
raphe neurons of a brain-specific constitutive tph2 ko were completely devoid of tph2-positive neurons and, consequently, 5-ht in the brain, and also displayed no compensatory up-regulation of tph1 expression. |
2010-12-22 |
2023-08-12 |
mouse |
| Claudia Kriegebaum, Ning-Ning Song, Lise Gutknecht, Ying Huang, Angelika Schmitt, Andreas Reif, Yu-Qiang Ding, Klaus-Peter Lesc. Brain-specific conditional and time-specific inducible Tph2 knockout mice possess normal serotonergic gene expression in the absence of serotonin during adult life. Neurochemistry international. vol 57. issue 5. 2010-12-22. PMID:20599453. |
these findings confirm the specificity of tph2 in brain 5-ht synthesis across the lifespan, yet also suggest that neither developmental nor adult 5-ht synthesis is required for the expression of genes specific for serotonergic signalling. |
2010-12-22 |
2023-08-12 |
mouse |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
the aim of this work was to investigat the role of protein gp130 in the regulation of expression of genes, coding the key enzyme of serotonin synthesis--tryptophan hydroxylase 2 (tph2), 5-ht-transporter, 5-ht(1a)- and 5-ht(2a)-receptors of serotonin. |
2010-12-17 |
2023-08-12 |
mouse |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
decreased expression of 5-ht(1a) - 5-ht(2a)-receptor genes in hippocampus midbrain and tph2 gene in midbrain in akr.cba-d13mit76 mice compared with akr mice were shown. |
2010-12-17 |
2023-08-12 |
mouse |
| A V Kulikov, V S Naumenko, A S Tsybko, N A Siniakova, D V Bazovkina, N K Popov. [The role of the glycoprotein gp130 in serotonin mediator system in mouse brain]. Molekuliarnaia biologiia. vol 44. issue 5. 2010-12-17. PMID:21090245. |
the results indicate: 1) the participation of gp130 in the regulation of tph2, 5-ht(1a)- and 5-ht(2a)-receptor genes and 2) association of this protein in the genetically determined sensitivity to lps. |
2010-12-17 |
2023-08-12 |
mouse |
| William B Siesser, Xiaodong Zhang, Jacob P R Jacobsen, Tatyana D Sotnikova, Raul R Gainetdinov, Marc G Caro. Tryptophan hydroxylase 2 genotype determines brain serotonin synthesis but not tissue content in C57Bl/6 and BALB/c congenic mice. Neuroscience letters. vol 481. issue 1. 2010-11-08. PMID:20600620. |
tryptophan hydroxylase 2 (tph2) catalyzes the rate-limiting step in the synthesis of brain serotonin (5-ht). |
2010-11-08 |
2023-08-12 |
mouse |