| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Z C Flood, D L J Engel, C C Simon, K R Negherbon, L J Murphy, W Tamavimok, G M Anderson, S Janušoni. Brain growth trajectories in mouse strains with central and peripheral serotonin differences: relevance to autism models. Neuroscience. vol 210. 2012-09-21. PMID:22450231. |
in addition, it has a lower 5-ht synthesis rate in the central nervous system due to a single-nucleotide polymorphism in the tryptophan hydroxylase 2 (tph2) gene. |
2012-09-21 |
2023-08-12 |
mouse |
| Nina C Donner, Philip L Johnson, Stephanie D Fitz, Karen E Kellen, Anantha Shekhar, Christopher A Lowr. Elevated tph2 mRNA expression in a rat model of chronic anxiety. Depression and anxiety. vol 29. issue 4. 2012-08-30. PMID:22511363. |
allelic variations in tph2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-ht) biosynthesis, may be genetic predictors of panic disorder and panic responses to panicogenic challenges in healthy volunteers. |
2012-08-30 |
2023-08-12 |
human |
| V S Naumenko, A S Tsybko, D V Bazovkina, N K Popov. [Implication of 5-HT2A receptors in the genetic mechanisms of the brain 5-HT system autoregulation]. Molekuliarnaia biologiia. vol 46. issue 3. 2012-08-29. PMID:22888631. |
at the same time, the increase in the expression of the gene encoding key enzyme of 5-ht synthesis, tryptophan hydroxylase 2 (tph2), the increase in tph2 activity and 5-ht levels and decreased expression of serotonin transporter (5-htt) gene was found in the midbrain of doi-treated mice. |
2012-08-29 |
2023-08-12 |
mouse |
| Sean D Kristjansson, Arpana Agrawal, Christina N Lessov-Schlaggar, Pamela A F Madden, M Lynne Cooper, Kathleen K Bucholz, Kenneth J Sher, Michael T Lynskey, Andrew C Heat. The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers. Alcoholism, clinical and experimental research. vol 36. issue 1. 2012-08-24. PMID:21797889. |
this study investigated whether drinking motives mediate the associations between alcohol consumption and 2 single-nucleotide polymorphisms (snps) from genes involved in serotonin (tph2; rs1386496) and dopamine synthesis (ddc; rs3779084). |
2012-08-24 |
2023-08-12 |
Not clear |
| Mariana Angoa-Pérez, Michael J Kane, Denise I Briggs, Catherine E Sykes, Mrudang M Shah, Dina M Francescutti, David R Rosenberg, David M Thomas, Donald M Kuh. Genetic depletion of brain 5HT reveals a common molecular pathway mediating compulsivity and impulsivity. Journal of neurochemistry. vol 121. issue 6. 2012-08-14. PMID:22443164. |
mice lacking tph2 (and brain 5ht) show intense compulsive and impulsive behaviors to include extreme aggression. |
2012-08-14 |
2023-08-12 |
mouse |
| Galina T Shishkina, Tatyana S Kalinina, Inna V Berezova, Nikolay N Dygal. Stress-induced activation of the brainstem Bcl-xL gene expression in rats treated with fluoxetine: correlations with serotonin metabolism and depressive-like behavior. Neuropharmacology. vol 62. issue 1. 2012-08-13. PMID:21740920. |
we also found that the levels of mrnas for tryptophan hydroxylase-2 (tph2) and 5-ht transporter (5-htt) were significantly down-regulated following prolonged treatment with fluoxetine, but were not affected by stress. |
2012-08-13 |
2023-08-12 |
rat |
| Nina C Donner, Christian D Montoya, Jodi L Lukkes, Christopher A Lowr. Chronic non-invasive corticosterone administration abolishes the diurnal pattern of tph2 expression. Psychoneuroendocrinology. vol 37. issue 5. 2012-07-27. PMID:21924839. |
we describe here a non-invasive rat model for hypercortisolism, as observed in major depression, and its effects on physiology, behavior, and the expression of tph2, the gene encoding tryptophan hydroxylase 2, the rate-limiting enzyme for brain serotonin (5-hydroxytryptamine; 5-ht) synthesis. |
2012-07-27 |
2023-08-12 |
rat |
| Guo-Lin Chen, Gregory M Mille. Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22241550. |
tryptophan hydroxylase (tph) is the rate-limiting enzyme in 5-ht biosynthesis, and the recent identification of a second, neuron-specific tph isoform (tph2) opened up a new area of research. |
2012-05-22 |
2023-08-12 |
monkey |
| Guo-Lin Chen, Gregory M Mille. Advances in tryptophan hydroxylase-2 gene expression regulation: new insights into serotonin-stress interaction and clinical implications. American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics. vol 159B. issue 2. 2012-05-22. PMID:22241550. |
particularly, based on findings on rhesus monkey tph2 genetics and other relevant literature, we propose that: (i) upon activation of adrenal cortisol secretion, the cortisol surge induces tph2 expression and de novo 5-ht synthesis; (ii) the induced 5-ht in turn inhibits cortisol secretion by modulating the adrenal sensitivity to acth via the suprachiasmatic nuclei (scn)-sns-adrenal system, such that it contributes to the feedback inhibition of cortisol production; (iii) basal tph2 expression or 5-ht synthesis, as well as early-life experience, influence basal cortisol primarily via the hormonal hpa axis; and (iv) 5'- and 3'-regulatory polymorphisms of tph2 may differentially influence the stress response, presumably due to their differential roles in gene expression regulation. |
2012-05-22 |
2023-08-12 |
monkey |
| Qi Wu, Michael S Clark, Richard D Palmite. Deciphering a neuronal circuit that mediates appetite. Nature. vol 483. issue 7391. 2012-05-08. PMID:22419158. |
blockade of serotonin (5-ht(3)) receptor signalling in the nts by either the chronic administration of ondansetron or the genetic inactivation of tph2 in caudal serotonergic neurons that project to the nts protects against starvation when agrp neurons are ablated. |
2012-05-08 |
2023-08-12 |
mouse |
| Melinda Bence, Julia Koller, Maria Sasvari-Szekely, Gergely Keszle. Transcriptional modulation of monoaminergic neurotransmission genes by the histone deacetylase inhibitor trichostatin A in neuroblastoma cells. Journal of neural transmission (Vienna, Austria : 1996). vol 119. issue 1. 2012-05-07. PMID:21785940. |
to this end, short-term parallel cultures of sk-nf-i neuroblastoma cells were treated with tsa either alone or in combination with hypoxia, and mrna levels of dopamine receptor d3 (drd3) and d4 (drd4), dopamine transporter (dat), dopamine hydroxylase (dbh), dopamine receptor regulating factor (drrf), catechol-o-methyltransferase (comt), serotonin receptor 1a (htr1a), monoamino oxidase a (mao-a), serotonin transporter (slc6a4) and tryptophan hydroxylase 2 (tph2) were determined by quantitative pcr. |
2012-05-07 |
2023-08-12 |
human |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
previously we reported a deficiency of serotonin (5-ht) and its key biosynthetic enzyme, tryptophan hydroxylase (tph2), in sids infants in the medullary 5-ht system that modulates homeostatic responses during sleep. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
yet, the underlying basis of the tph2 and 5-ht deficiency is unknown. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
in this study, we tested the hypothesis that proteomics would uncover previously unrecognized abnormal levels of proteins related to tph2 and 5-ht regulation in sids cases compared with controls, which could provide novel insight into the basis of their deficiency. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
we first performed a discovery proteomic analysis of the gigantocellularis of the medullary 5-ht system in the same data set with deficiencies of tph2 and 5-ht levels. |
2012-05-01 |
2023-08-12 |
Not clear |
| Kevin G Broadbelt, Keith D Rivera, David S Paterson, Jhodie R Duncan, Felicia L Trachtenberg, Joao A Paulo, Martha D Stapels, Natalia S Borenstein, Richard A Belliveau, Elisabeth A Haas, Christina Stanley, Henry F Krous, Hanno Steen, Hannah C Kinne. Brainstem deficiency of the 14-3-3 regulator of serotonin synthesis: a proteomics analysis in the sudden infant death syndrome. Molecular & cellular proteomics : MCP. vol 11. issue 1. 2012-05-01. PMID:21976671. |
abnormalities in 5-ht and tph2 levels and 5-ht(1a) receptor binding were associated with the 14-3-3 deficits in the same sids cases. |
2012-05-01 |
2023-08-12 |
Not clear |
| Margaret Czesak, Brice Le François, Anne M Millar, Mariam Deria, Mireille Daigle, Jane E Visvader, Hymie Anisman, Paul R Alber. Increased serotonin-1A (5-HT1A) autoreceptor expression and reduced raphe serotonin levels in deformed epidermal autoregulatory factor-1 (Deaf-1) gene knock-out mice. The Journal of biological chemistry. vol 287. issue 9. 2012-04-25. PMID:22232550. |
in the dorsal raphe, deaf-1 knock-out mice displayed increased 5-ht1a mrna, protein, and 5-ht1a-positive cell counts but reduced 5-ht levels, whereas other serotonergic markers, such as tryptophan hydroxylase (tph)- or 5-ht-positive cells and tph2 rna levels, were unchanged. |
2012-04-25 |
2023-08-12 |
mouse |
| X Zhang, P J Nicholls, G Laje, T D Sotnikova, R R Gainetdinov, P R Albert, G Rajkowska, C A Stockmeier, M C Speer, D C Steffens, M C Austin, F J McMahon, K R R Krishnan, M A Garcia-Blanco, M G Caro. A functional alternative splicing mutation in human tryptophan hydroxylase-2. Molecular psychiatry. vol 16. issue 12. 2012-03-27. PMID:20856248. |
the tryptophan hydroxylase-2 (tph2) gene is the rate-limiting enzyme in brain 5-ht synthesis, and thus is an ideal candidate gene for understanding the role of dysregulation of brain serotonergic homeostasis. |
2012-03-27 |
2023-08-12 |
human |
| X Zhang, P J Nicholls, G Laje, T D Sotnikova, R R Gainetdinov, P R Albert, G Rajkowska, C A Stockmeier, M C Speer, D C Steffens, M C Austin, F J McMahon, K R R Krishnan, M A Garcia-Blanco, M G Caro. A functional alternative splicing mutation in human tryptophan hydroxylase-2. Molecular psychiatry. vol 16. issue 12. 2012-03-27. PMID:20856248. |
tph2-tr, which lacks tph2 enzyme activity, dominant-negatively affects full-length tph2 function, causing reduced 5-ht production. |
2012-03-27 |
2023-08-12 |
human |
| Michael L Huynh, Elena Rivkin, Ryan Mui, Sabine P Corde. A tryptophan hydroxlyase 1 reporter that directs Cre recombinase extinguishable placental alkaline phosphatase expression in serotonergic (5-HT) neurons and peripheral tissues. Genesis (New York, N.Y. : 2000). vol 49. issue 11. 2012-02-24. PMID:21438125. |
while, in tph1-lox-plap mice, most plap-expressing neurons are monoaminergic, plap was expressed in only 5-10% of neurons expressing the predominant neuronal 5-ht biosynthetic enzyme tph2, serotonin transporter (sert) or aromatic amino acid decarboxylase (aadc). |
2012-02-24 |
2023-08-12 |
mouse |