| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
exposure to short photoperiod decreased locomotor activity in the novel tank diving test, increased the level 5-hiaa, and reduced the level of mao gene mrna, but did not affect the level of 5-ht and expression of tph1a, tph1b, tph2, slc6a4a (transporter), htr1aa, and htr2aa (receptors) genes. |
2022-07-17 |
2023-08-14 |
zebrafish |
| Yongxiang Li, Shuqing Zhu, Kailai Xie, Xiajie Feng, Lvshuang Chen, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Canjun Zhu, Ping Gao, Qingyan Jiang, Lina Wan. TLR4 in Tph2 neurons modulates anxiety-related behaviors in a sex-dependent manner. Neuropharmacology. 2022-07-05. PMID:35787402. |
tph2 is a rate-limiting enzyme for 5-ht biosynthesis that is expressed at high levels in the drn, which includes the main 5-ht projection to the hippocampus and prefrontal cortex and regulates anxiety disorder. |
2022-07-05 |
2023-08-14 |
mouse |
| Yongxiang Li, Shuqing Zhu, Kailai Xie, Xiajie Feng, Lvshuang Chen, Xin Wu, Zhonghua Sun, Gang Shu, Songbo Wang, Canjun Zhu, Ping Gao, Qingyan Jiang, Lina Wan. TLR4 in Tph2 neurons modulates anxiety-related behaviors in a sex-dependent manner. Neuropharmacology. 2022-07-05. PMID:35787402. |
the underlying mechanisms seem to involve alterations in the excitability of tph2 neurons and key components of 5-ht transmission, including synthesis, reuptake, and transmission. |
2022-07-05 |
2023-08-14 |
mouse |
| Giulia Sbrini, Sabrina I Hanswijk, Paola Brivio, Anthonieke Middelman, Michael Bader, Fabio Fumagalli, Natalia Alenina, Judith R Homberg, Francesca Calabres. Peripheral Serotonin Deficiency Affects Anxiety-like Behavior and the Molecular Response to an Acute Challenge in Rats. International journal of molecular sciences. vol 23. issue 9. 2022-05-14. PMID:35563331. |
while the tph2 isoform is responsible for the production of serotonin in the brain, tph1 is expressed in peripheral organs. |
2022-05-14 |
2023-08-13 |
rat |
| Pingping Zhu, Tiankun Lu, Zhenzhen Chen, Benyu Liu, Dongdong Fan, Chong Li, Jiayi Wu, Luyun He, Xiaoxiao Zhu, Ying Du, Yong Tian, Zusen Fa. 5-hydroxytryptamine produced by enteric serotonergic neurons initiates colorectal cancer stem cell self-renewal and tumorigenesis. Neuron. 2022-05-13. PMID:35550066. |
mechanistically, colorectal cancer (crc)-enriched microbiota metabolite isovalerate suppresses the enrichment of the nurd complex onto tph2 promoter to initiate tph2 expression, leading to 5-ht production. |
2022-05-13 |
2023-08-13 |
mouse |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
additionally, tph1's impact on serotonin synthesis production throughout the body will be discussed with regards to its involvement in neuropsychiatric disorders similar to tph2. |
2022-05-13 |
2023-08-13 |
Not clear |
| Kuljeet Kaur, Alexis Redfairn-Ogunyemi, Kehinde Awe, Lanie Gardne. Interactions of TPH2 and TPH1 in Biosynthesis Pathways. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36 Suppl 1. 2022-05-13. PMID:35552315. |
tph1 shows a greater affinity for tryptophan, an amino acid used in the production of serotonin, and has a stronger enzymatic activity than tph2 for a developing brain stem. |
2022-05-13 |
2023-08-13 |
Not clear |
| Huawei Li, Peng Wang, Yunping Zhou, Fei Zhao, Xue Gao, Chunfeng Wu, Tianxia Wu, Liping Jiang, Dianliang Zhan. Correlation between intestinal microbiotal imbalance and 5-HT metabolism, immune inflammation in chronic unpredictable mild stress male rats. Genes, brain, and behavior. 2022-05-10. PMID:35535862. |
the concentrations of 5-ht and tph2 in the prefrontal and hippocampal tissues were lower, while ido1 was higher. |
2022-05-10 |
2023-08-13 |
rat |
| Diana Marie Battaglia, Maria D Sanchez-Pino, Charles D Nichols, Timothy P Foste. Herpes Simplex Virus-1 Induced Serotonin-Associated Metabolic Pathways Correlate With Severity of Virus- and Inflammation-Associated Ocular Disease. Frontiers in microbiology. vol 13. 2022-04-08. PMID:35391733. |
intriguingly, tryptophan hydroxylase 2 (tph2), the neuronal specific rate-limiting enzyme for serotonin synthesis, was the most significantly upregulated gene by hsv in an amino acid metabolism pcr array. |
2022-04-08 |
2023-08-13 |
Not clear |
| Tingting Tan, Zhi Xu, Chenjie Gao, Tian Shen, Lei Li, Zimu Chen, Lei Chen, Min Xu, Bingwei Chen, Jiacheng Liu, Zhijun Zhang, Yonggui Yua. Influence and interaction of resting state functional magnetic resonance and tryptophan hydroxylase-2 methylation on short-term antidepressant drug response. BMC psychiatry. vol 22. issue 1. 2022-03-26. PMID:35337298. |
5-ht biosynthesis is regulated by the rate-limiting enzyme tryptophan hydroxylase-2 (tph2). |
2022-03-26 |
2023-08-13 |
Not clear |
| Rosanna Caputo, Vincent-Joseph Poirel, Etienne Challet, Johanna H Meijer, Sylvie Raiso. Bimodal serotonin synthesis in the diurnal rodent, Arvicanthis ansorgei. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 36. issue 4. 2022-03-16. PMID:35294080. |
using in situ hybridization, we characterized the anatomical extension of the raphe nuclei and we investigated 24 h mrna levels of the serotonin rate-limiting enzyme, tryptophan hydroxylase 2 (tph2). |
2022-03-16 |
2023-08-13 |
Not clear |
| Rachel A Walker, Rebecca L Suthard, Taylor N Perison, Nora M Sheehan, Caitlin C Dwyer, Jillian K Lee, Eghosa K Enabulele, Madelyn H Ray, Michael A McDannal. Dorsal raphe 5-HT neurons utilize, but do not generate, negative aversive prediction errors. eNeuro. 2022-01-26. PMID:35078807. |
5-ht, synthesized via tryptophan hydroxylase 2 (tph2), is a widely functioning neuromodulator implicated in fear learning. |
2022-01-26 |
2023-08-13 |
rat |
| Anna Haduch, Przemysław J Danek, Wojciech Kuban, Renata Pukło, Natalia Alenina, Joanna Gołębiowska, Piotr Popik, Michael Bader, Władysława A Danie. Cytochrome P450 2D (CYP2D) enzyme dysfunction associated with aging and serotonin deficiency in the brain and liver of female Dark Agouti rats. Neurochemistry international. vol 152. 2021-12-11. PMID:34780807. |
in summary, the aging process and tph2 deficit affect the cyp2d activity and protein level in female rats, which may have a negative impact on the compensatory capacity of cyp2d in the synthesis of serotonin and dopamine in cerebral structures involved in cognitive and emotional functions. |
2021-12-11 |
2023-08-13 |
rat |
| Valentina S Evsiukova, Daria Bazovkina, Ekaterina Bazhenova, Elizabeth A Kulikova, Alexander V Kuliko. Tryptophan Hydroxylase 2 Deficiency Modifies the Effects of Fluoxetine and Pargyline on the Behavior, 5-HT- and BDNF-Systems in the Brain of Zebrafish ( International journal of molecular sciences. vol 22. issue 23. 2021-12-10. PMID:34884655. |
tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in 5-ht synthesis in the brain. |
2021-12-10 |
2023-08-13 |
zebrafish |
| Kento Igarashi, Toshiko Kuchiiwa, Satoshi Kuchiiwa, Haruki Iwai, Kazuo Tomita, Tomoaki Sat. Kamishoyosan (a Japanese traditional herbal formula), which effectively reduces the aggressive biting behavior of male and female mice, and potential regulation through increase of Tph1, Tph2, and Esr2 mRNA levels. Brain research. vol 1768. 2021-12-09. PMID:34260963. |
furthermore, gene expression of tryptophan hydroxylase (tph) 1 and tph2 were increased and 5-ht immunofluorescence was slightly increased in the dorsal raphe nucleus (drn) of isolation-reared mice administered with kss. |
2021-12-09 |
2023-08-13 |
mouse |
| Tianle Zhu, Pan Gao, Jingjing Gao, Xi Liu, Hui Jiang, Xiansheng Zhan. The upregulation of tryptophan hydroxylase-2 expression is important for premature ejaculation treatment with the selective serotonin reuptake inhibitor. Andrology. 2021-12-07. PMID:34874128. |
although there was some evidence to suggest that the serotonergic system in the brain played an important role in premature ejaculation (pe), tryptophan hydroxylase-2 (tph2) is considered to be the key enzyme for the synthesis of 5-hydroxytryptamine (5-ht) and few studies have reported that brain tph2 is involved in the regulation of ejaculation. |
2021-12-07 |
2023-08-13 |
Not clear |
| B Aboagye, T Weber, H L Merdian, D Bartsch, K P Lesch, J Waide. Serotonin deficiency induced after brain maturation rescues consequences of early life adversity. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686115. |
tamoxifen (tam)-induced cre/loxp-mediated inactivation of the tryptophan hydroxylase-2 gene (tph2) was used to investigate the effects of provoked 5-ht deficiency in adult mice (tph2 icko) previously subjected to maternal separation (ms). |
2021-11-22 |
2023-08-13 |
mouse |
| B Aboagye, T Weber, H L Merdian, D Bartsch, K P Lesch, J Waide. Serotonin deficiency induced after brain maturation rescues consequences of early life adversity. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686115. |
the impact of tph2 icko in interaction with ms stress (tph2 icko × ms) on physiological parameters, emotional behavior and expression of 5-ht system-related marker genes were assessed. |
2021-11-22 |
2023-08-13 |
mouse |
| B Aboagye, T Weber, H L Merdian, D Bartsch, K P Lesch, J Waide. Serotonin deficiency induced after brain maturation rescues consequences of early life adversity. Scientific reports. vol 11. issue 1. 2021-11-22. PMID:33686115. |
tph2 icko mice displayed a significant reduction in 5-ht immunoreactive cells and 5-ht concentrations in the rostral raphe region within four weeks following tam treatment. |
2021-11-22 |
2023-08-13 |
mouse |