| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Shuyue Cheng, Zemeng Zhu, Haonan Li, Wei Wang, Zhijun Jiang, Fang Pan, Dexiang Liu, Roger C M Ho, Cyrus S H H. Rifaximin ameliorates depression-like behaviour in chronic unpredictable mild stress rats by regulating intestinal microbiota and hippocampal tryptophan metabolism. Journal of affective disorders. 2023-02-26. PMID:36842645. |
indoleamine-2, 3-dioxygenase-1 (ido1) and tryptophan hydroxylase 2 (tph2) are the key rate-limiting enzymes in trp metabolism and play an important role in kyn and 5-ht metabolism. |
2023-02-26 |
2023-08-14 |
rat |
| Cheng-Ting Xie, Mei-Ling Tan, Ying-Wen Li, Qi-Liang Chen, Yan-Jun Shen, Zhi-Hao Li. Chronic exposure to environmentally relevant concentrations of carbamazepine interferes with anxiety response of adult female zebrafish through GABA /5-HT pathway and HPI axis. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP. 2023-02-13. PMID:36781090. |
despite the upregulation of tph2 was consistent with increased 5-ht level in the brain, significantly downregulated htr1aa and htr1b may indicate attenuated 5-ht potency. |
2023-02-13 |
2023-08-14 |
zebrafish |
| Xia-Jing Zhang, Zhi-Bin Xiao, Jun-Xiang Gu, Kun Chen, Jian Wang, Sheng-Long Xu, Ke-Ke Xing, Tao Che. Investigating the molecular mechanisms of delirium-like neuropsychiatric disorder induced by electromagnetic pulse based on bioinformatics analysis. Molecular brain. vol 16. issue 1. 2023-02-08. PMID:36750928. |
lncrna aabr07042999.1 and mrna tph2, slc6a4, dbh and th were upregulated, and the contents of serotonin, dopamine and norepinephrine were increased in both pfc and hip after emp exposure. |
2023-02-08 |
2023-08-14 |
rat |
| P D Komleva, E Yu Bazhenova, N V Khotskin, E A Kulikova, A V Kuliko. C1473G Polymorphism in Tph2 Gene Affects Activation of Serotonin Metabolism in Mouse Brain 24 h after LPS Administration. Bulletin of experimental biology and medicine. 2023-01-04. PMID:36600037. |
c1473g polymorphism in tph2 gene affects activation of serotonin metabolism in mouse brain 24 h after lps administration. |
2023-01-04 |
2023-08-14 |
mouse |
| P D Komleva, E Yu Bazhenova, N V Khotskin, E A Kulikova, A V Kuliko. C1473G Polymorphism in Tph2 Gene Affects Activation of Serotonin Metabolism in Mouse Brain 24 h after LPS Administration. Bulletin of experimental biology and medicine. 2023-01-04. PMID:36600037. |
we studied the effect of the c1473g polymorphism in the tph2 gene that reduces the activity of the tryptophan hydroxylase 2 in the brain on the severity of changes in motor activity (23 h after intraperitoneal administration of 0.8 mg/kg lps or saline) and on the level of serotonin (5-ht) and its metabolite 5-hydroxyindoleacetic acid (5-hiaa) in the endings of 5-ht neurons in the cortex, hippocampus, and striatum (24 h after administration) of mature male mice of congenic lines b6-1473cc (high activity) and b6-1473gg (low activity). |
2023-01-04 |
2023-08-14 |
mouse |
| Michael D Gersho. The Shaggy Dog Story of Enteric Signaling: Serotonin, a Molecular Megillah. Advances in experimental medicine and biology. vol 1383. 2022-12-31. PMID:36587168. |
the smaller enteric 5-ht store is biosynthetically dependent upon tph2 and is located within a small subset of myenteric neurons. |
2022-12-31 |
2023-08-14 |
dog |
| Richard L Spinieli, Jennifer Cornelius-Green, Kevin J Cumming. A serotonin-deficient rat model of neurogenic hypertension: influence of sex and sympathetic vascular tone. Journal of neurophysiology. vol 128. issue 5. 2022-10-28. PMID:36169206. |
previously we showed that a loss of central nervous system (cns) 5-hydroxytryptamine (5-ht) (tryptophan hydroxylase 2 knockout; tph2 |
2022-10-28 |
2023-11-08 |
rat |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
the shh ligand activates two main transcriptional factors known as foxa2 and nkx2.2, which again activates another transcriptional factor, gata (gata2 and gata3), in post mitotic precursor cells of serotonergic neurons-following increased expression of pet-1 and lmx1b after gata regulates the expression of many serotonergic enzymes such as tph2, sert, vmat, slc6a4, htr1a, htr1b (serotonin receptor enzymes), and mao that regulate and control the release of serotonin and maintain their neuronal identity after their maturation. |
2022-10-22 |
2023-08-14 |
Not clear |
| Ria Gupta, Sidharth Mehan, Swesha Chhabra, Aditi Giri, Kajal Sherawa. Role of Sonic Hedgehog Signaling Activation in the Prevention of Neurological Abnormalities Associated with Obsessive-Compulsive Disorder. Neurotoxicity research. 2022-10-22. PMID:36272053. |
abbreviation: foxa2: forkhead box; gata: globin transcription factor; lmx1b: lim homeobox transcription factor 1 beta; tph2: tryptophan hydroxylase 2; htr1a: serotonin receptor 1a; htr1b: serotonin receptor 1b; sert: serotonin transporter; vmat: vesicular monoamine transporter; mao: monoamine oxidase. |
2022-10-22 |
2023-08-14 |
Not clear |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
both 5-ht and tryptophan hydroxylase-2 (tph2) were mainly present in the limbic systems of the cerebrum, such as the glomerular layer of the olfactory bulb, nucleus accumbens, cingulate, fimbria of the hippocampus, mediodorsal thalamic nucleus, habenular nucleus, ventromedial hypothalamus nucleus, lateral hypothalamus area, dorsal raphe nucleus and piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
tph2 and 5-ht were expressed in cell bodies in the dorsal raphe nucleus and piriform cortex, while in other regions they were distributed as filaments and clump shapes in axons. |
2022-10-20 |
2023-08-14 |
mouse |
| Pei He, Binjun He, Shu Li, Wen Chai, Wei Rao, Yu Zhu, Wenzhi Chen, Ping Zhang, Xiong Zhang, Haili Pan, Renshi X. Distribution Features and Potential Effects of Serotonin in the Cerebrum of SOD1 G93A Transgenic Mice. eNeuro. 2022-10-20. PMID:36265904. |
double immunofluorescence staining showed that tph2, mammalian achaete-scute homolog-1 and 5-ht were mainly expressed in neurons but rarely in microglia or astrocytes in the piriform cortex. |
2022-10-20 |
2023-08-14 |
mouse |
| Na Luo, Ioanna Mosialou, Mattia Capulli, Brygida Bisikirska, Chyuan-Sheng Lin, Yung-Yu Huang, Peter Timothy Shyu, X Edward Guo, Aris Economides, J John Mann, Stavroula Kousten. A neuronal action of sirtuin 1 suppresses bone mass in young and aging mice. The Journal of clinical investigation. 2022-10-04. PMID:36194488. |
sirt1 did so by increasing expression of monoamine oxidase a (mao-a), a sirt1 target that reduces brain serotonin levels by inducing its catabolism, and by suppressing tph2 expression and serotonin synthesis in the brainstem. |
2022-10-04 |
2023-08-14 |
mouse |
| Ping Tian, Wei Zhang, Kai-Yan Li, Hong-Wei Li, Kai Ma, De-En Ha. [Effect of Rehmanniae Radix on depression-like behavior and hippocampal monoamine neurotransmitters of chronic unpredictable mild stress model rats]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica. vol 47. issue 17. 2022-09-27. PMID:36164876. |
western blot was used to detect the protein expressions of tryptophan hydroxylase 2(tph2), serotonin transporter(sert), and monoamine oxidase a(mao-a) in the hippocampus of rats. |
2022-09-27 |
2023-08-14 |
rat |
| Bernardo Lopez-Torres, Irma Ares, Marta Martínez, Jorge-Enrique Maximiliano, María-Rosa Martínez-Larrañaga, Arturo Anadón, María-Aránzazu Martíne. Neurotoxicity induced by the pyrethroid lambda-cyhalothrin: Alterations in monoaminergic systems and dopaminergic and serotoninergic pathways in the rat brain. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2022-09-20. PMID:36126889. |
this research study also showed in hippocampus and prefrontal cortex, that lambda-cyhalothrin modified the mrna levels of da transporter gene (dat1 up-regulation), 5-ht transporter gene (sert down-regulation), da receptor genes (drd1and drd2 down-regulation), 5-ht receptor genes (5-ht1a and 5-ht2a down-regulation/up-regulation), da synthesis gene (th down-regulation), 5-ht synthesis gene (tph2 down-regulation), da and 5-ht degradation genes (maoa and maob up-regulation). |
2022-09-20 |
2023-08-14 |
rat |
| Giulia Braccagni, Simona Scheggi, Marco Bortolat. Elevated levels of serotonin 5-HT European archives of psychiatry and clinical neuroscience. 2022-09-12. PMID:36094569. |
tissues were processed for immunoblotting analyses on eight key serotonergic targets: tryptophan hydroxylase 2 (tph2), the rate-limiting enzyme of brain serotonin synthesis; serotonin transporter (sert), the primary carrier for serotonin uptake; monoamine oxidase a (maoa), the primary enzyme for serotonin catabolism; and five serotonin receptors previously shown to influence social behavior: 5-ht |
2022-09-12 |
2023-08-14 |
human |
| Kongfu Zhu, Chao Liu, Yuanzhu Gao, Jianping Lu, Daping Wang, Huawei Zhan. Cryo-EM Structure and Activator Screening of Human Tryptophan Hydroxylase 2. Frontiers in pharmacology. vol 13. 2022-09-01. PMID:36046836. |
human tryptophan hydroxylase 2 (tph2) is the rate-limiting enzyme in the synthesis of serotonin. |
2022-09-01 |
2023-08-14 |
human |
| Yini Zhou, Tonglaga Li, Shangzi Zhou, Han Xu, Xiaoyu Yin, Hao Chen, Xuan Ni, Meirong Bai, Wuliji Ao, Jingfeng Yang, R G Ahmed, Xuefu Zhang, Shuyin Bao, Jianhua Yu, Kevin W H Kwok, Wu Don. Pseudoephedrine hydrochloride causes hyperactivity in zebrafish via modulation of the serotonin pathway. Metabolic brain disease. 2022-07-30. PMID:35907131. |
pse also elevated the expression of serotonin (5-ht)-related genes 5-htr1ab and tph2 and dopamine-related gene dbh. |
2022-07-30 |
2023-08-14 |
zebrafish |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
we studied changes in the behavior, content of 5-ht and its major metabolite 5-hydroxyindoleacetic acid (5-hiaa), and the expression of genes encoding the key enzymes of 5-ht metabolism, tryptophan hydroxylases tph1a, tph1b, tph2, monoamine oxidase (mao), 5-ht transporter, and 5-ht1a and 5-ht2a receptors in the brain of zebrafish reared for 60 days under short (04:20 h) compared to those reared at normal (12:12 h) photoperiod. |
2022-07-17 |
2023-08-14 |
zebrafish |
| I E Sorokin, V S Evsyukova, A V Kuliko. Effect of Short Photoperiod on the Behavior and Brain Serotonin System in Zebrafish Danio rerio. Bulletin of experimental biology and medicine. 2022-07-17. PMID:35844021. |
exposure to short photoperiod decreased locomotor activity in the novel tank diving test, increased the level 5-hiaa, and reduced the level of mao gene mrna, but did not affect the level of 5-ht and expression of tph1a, tph1b, tph2, slc6a4a (transporter), htr1aa, and htr2aa (receptors) genes. |
2022-07-17 |
2023-08-14 |
zebrafish |