| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
however, the tph2 increase in hfd-offspring did not alter hippocampal serotonin levels quantified through elisa. |
2021-08-11 |
2023-08-13 |
mouse |
| Luana Olegário da Silva, Raquel da Silva Aragão, Manuella da Luz Duarte Barros, Kelli Nogueira Ferraz-Pereira, Isabeli Lins Pinheiro, Lígia Cristina Monteiro Galind. Maternal exposure to high-fat diet modifies anxiety-like/depression-like behaviors and compounds of Serotonergic System in offspring: A preclinical systematic review. International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience. vol 81. issue 5. 2021-08-06. PMID:33788300. |
maternal consumption of hfd was found to be associated with an inconsistent pattern of the expression of tph2 as well as reduced the immunoreactivity of 5-ht in the prefrontal cortex and increased 5-ht1a receptor expression in the dorsal raphe of offspring. |
2021-08-06 |
2023-08-13 |
Not clear |
| Eeva-Leena Kataja, Jukka M Leppänen, Katri Kantojärvi, Juho Pelto, Tuomo Häikiö, Riikka Korja, Saara Nolvi, Hasse Karlsson, Tiina Paunio, Linnea Karlsso. The role of TPH2 variant rs4570625 in shaping infant attention to social signals. Infant behavior & development. vol 60. 2021-06-07. PMID:32711172. |
tph2, the rate-limiting enzyme in the synthesis of serotonin, has been connected to several psychiatric outcomes. |
2021-06-07 |
2023-08-13 |
Not clear |
| Ling Shen, Hai-Bo Qiu, Hui-Hong Xu, Kai Wei, Liang Zhao, Cheng-Cheng Zhu, Cheng-Jian Li, Zhi-Jie L. Nicotine withdrawal induces hyperalgesia via downregulation of descending serotonergic pathway in the nucleus raphe magnus. Neuropharmacology. vol 189. 2021-06-04. PMID:33722649. |
these rats showed less tryptophan hydroxylase 2 (tph2) positive neurons and reduced tph2 expression in the nucleus raphe magnus (nrm), and thus resulted in decreased 5-hydroxytryptamine (5-ht) levels in cerebrospinal fluid. |
2021-06-04 |
2023-08-13 |
rat |
| Gilciane Ceolin, Giulia Pipolo Rodrigues Mano, Natália Schmitt Hames, Luciana da Conceição Antunes, Elisa Brietzke, Débora Kurrle Rieger, Júlia Dubois Moreir. Vitamin D, Depressive Symptoms, and Covid-19 Pandemic. Frontiers in neuroscience. vol 15. 2021-06-01. PMID:34054418. |
the signaling of 1,25-dihydroxyvitamin d3, the active form of vitamin d, through vitamin d receptor (vdr) induces the expression of the gene of tryptophan hydroxylase 2 (tph2), influences the expression of serotonin reuptake transporter (sert) as well as the levels of monoamine oxidase-a (mao-a), the enzyme responsible for serotonin catabolism. |
2021-06-01 |
2023-08-13 |
Not clear |
| Jiawei Li, Ting Dong, Tharushi P Keerthisinghe, Hao Chen, Ming Li, Wenqing Chu, Jingfeng Yang, Zongfu Hu, Shane Allen Snyder, Wu Dong, Mingliang Fan. Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish. Journal of hazardous materials. vol 399. 2021-05-14. PMID:32485476. |
for the serotonin (5-ht) synthesis, the expression of tryptophan hydroxylase (tph2) was 41 % and 9.3 % of the control group for 1 and 100 μg/l otc exposed groups; respectively. |
2021-05-14 |
2023-08-13 |
zebrafish |
| Hailan Liu, Chunmei Wang, Meng Yu, Yongjie Yang, Yang He, Hesong Liu, Chen Liang, Longlong Tu, Nan Zhang, Lina Wang, Julia Wang, Feng Liu, Fang Hu, Yong X. TPH2 in the Dorsal Raphe Nuclei Regulates Energy Balance in a Sex-Dependent Manner. Endocrinology. vol 162. issue 1. 2021-05-14. PMID:33034617. |
abstractcentral 5-hydroxytryptamine (5-ht), which is primarily synthesized by tryptophan hydroxylase 2 (tph2) in the dorsal raphe nuclei (drn), plays a pivotal role in the regulation of food intake and body weight. |
2021-05-14 |
2023-08-13 |
mouse |
| Madhusmita P Sahu, Yago Pazos-Boubeta, Anna Steinzeig, Katja Kaurinkoski, Michela Palmisano, Olgierd Borowecki, Timo Petteri Piepponen, Eero Castré. Depletion of TrkB Receptors From Adult Serotonergic Neurons Increases Brain Serotonin Levels, Enhances Energy Metabolism and Impairs Learning and Memory. Frontiers in molecular neuroscience. vol 14. 2021-05-04. PMID:33935645. |
the transgenic mice show increased 5-ht and tph2 levels with abnormal behavioral phenotype. |
2021-05-04 |
2023-08-13 |
mouse |
| Shuhua Lai, Liangpan Shi, Zhixian Jiang, Zhihang Li. Glycyrrhizin treatment ameliorates post-traumatic stress disorder-like behaviours and restores circadian oscillation of intracranial serotonin. Clinical and experimental pharmacology & physiology. vol 47. issue 1. 2021-05-03. PMID:31494960. |
in addition, glycyrrhizin treatment restored the circadian rhythm changes of serotonin and tph2. |
2021-05-03 |
2023-08-13 |
human |
| Sarah Bonk, Johannes Hertel, Helena U Zacharias, Jan Terock, Deborah Janowitz, Georg Homuth, Matthias Nauck, Henry Völzke, Henriette Meyer Zu Schwabedissen, Sandra Van der Auwera, Hans Jörgen Grab. Vitamin D moderates the interaction between 5-HTTLPR and childhood abuse in depressive disorders. Scientific reports. vol 10. issue 1. 2021-04-27. PMID:33372187. |
vitamin d has been shown to stimulate the expression of the tryptophan hydroxylase 2 (tph2) gene, which is the rate-limiting enzyme for serotonin production in the brain. |
2021-04-27 |
2023-08-13 |
Not clear |
| Anna Gorlova, Gabriela Ortega, Jonas Waider, Natalia Bazhenova, Ekaterina Veniaminova, Andrey Proshin, Allan V Kalueff, Daniel C Anthony, Klaus-Peter Lesch, Tatyana Strekalov. Stress-induced aggression in heterozygous TPH2 mutant mice is associated with alterations in serotonin turnover and expression of 5-HT6 and AMPA subunit 2A receptors. Journal of affective disorders. vol 272. 2021-02-15. PMID:32553388. |
stress-induced aggression in heterozygous tph2 mutant mice is associated with alterations in serotonin turnover and expression of 5-ht6 and ampa subunit 2a receptors. |
2021-02-15 |
2023-08-13 |
mouse |
| Tian Shen, Xingyu Li, Lei Chen, Zimu Chen, Tingting Tan, Tiantian Hua, Bingwei Chen, Yonggui Yuan, Zhijun Zhang, Liz Kuney, Zhi X. The relationship of tryptophan hydroxylase-2 methylation to early-life stress and its impact on short-term antidepressant treatment response. Journal of affective disorders. vol 276. 2021-02-15. PMID:32738671. |
the gene tryptophan hydroxylase 2 (tph2) encodes the associated rate-limiting enzyme in the biosynthesis 5-ht (serotonin). |
2021-02-15 |
2023-08-13 |
Not clear |
| Shunpei Moriya, Akira Yamashita, Daiki Masukawa, Yuki Kambe, Junichi Sakaguchi, Honami Setoyama, Akihiro Yamanaka, Tomoyuki Kuwak. Involvement of supralemniscal nucleus (B9) 5-HT neuronal system in nociceptive processing: a fiber photometry study. Molecular brain. vol 13. issue 1. 2021-02-12. PMID:32005128. |
we introduced the g-camp6 in b9 5-ht neurons using transgenic mice carrying a tetracycline-controlled transactivator transgene (tta) under the control of a tryptophan hydroxylase-2 (tph2) promoter and site-specific injection of adeno associated virus (aav-teto(3g)-g-camp6). |
2021-02-12 |
2023-08-13 |
mouse |
| Nina C Donner, Sofia M Davies, Stephanie D Fitz, Drake M Kienzle, Anantha Shekhar, Christopher A Lowr. Crh receptor priming in the bed nucleus of the stria terminalis (BNST) induces tph2 gene expression in the dorsomedial dorsal raphe nucleus and chronic anxiety. Progress in neuro-psychopharmacology & biological psychiatry. vol 96. 2021-01-04. PMID:31415826. |
since the bnst projects heavily to the dorsal raphe nucleus (dr), the main source of brain serotonin, we here tested the hypothesis that such repeated, anxiety-inducing activation of crh receptors in the bnst alters the expression of serotonergic genes in the dr, including tph2, the gene encoding the rate-limiting enzyme for brain serotonin synthesis, and slc6a4, the gene encoding the serotonin transporter (sert). |
2021-01-04 |
2023-08-13 |
rat |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
5-ht synthesis is catalyzed by tryptophan hydroxylase (tph) which exists as two distinct isoforms; tph1 and tph2, which are responsible for peripheral and central 5-ht, respectively. |
2020-12-17 |
2023-08-13 |
Not clear |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
the s-enantiomer of omeprazole, esomeprazole, has recently also been described as an inhibitor of monoamine oxidase-a (mao-a), the main enzyme responsible for 5-ht degradation, albeit with lower potency compared to the effect on tph1 and tph2. |
2020-12-17 |
2023-08-13 |
Not clear |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
there are two independent serotonin systems in the body characterized by two isoforms of tph, tph1 and tph2. |
2020-12-10 |
2023-08-13 |
mouse |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
while tph2 synthesizes serotonin in the brain, tph1 is expressed in the gut and in other peripheral tissues and supplies platelets in the circulation with serotonin. |
2020-12-10 |
2023-08-13 |
mouse |
| Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Kanoko Onaru, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Yoshiaki Tabuchi, Collins Nimako, Mayumi Ishizuka, Yoshinori Ikenaka, Nobuhiko Hosh. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. The Journal of veterinary medical science. vol 82. issue 3. 2020-11-16. PMID:31983702. |
in addition, serotonin (5-ht) and tryptophan hydroxylase 2 (tph2) of the dorsal raphe nuclei (drn) and median raphe nuclei (mrn) and tyrosine hydroxylase (th) of the ventral tegmental area and substantia nigra (sn) were evaluated immunohistochemically. |
2020-11-16 |
2023-08-13 |
mouse |
| Tadashi Takada, Naoki Yoneda, Tetsushi Hirano, Kanoko Onaru, Youhei Mantani, Toshifumi Yokoyama, Hiroshi Kitagawa, Yoshiaki Tabuchi, Collins Nimako, Mayumi Ishizuka, Yoshinori Ikenaka, Nobuhiko Hosh. Combined exposure to dinotefuran and chronic mild stress counteracts the change of the emotional and monoaminergic neuronal activity induced by either exposure singly despite corticosterone elevation in mice. The Journal of veterinary medical science. vol 82. issue 3. 2020-11-16. PMID:31983702. |
a noel dose of din or cums alone increased of the total distance in oft, decreased or increased the immobility time in tst or fst, respectively, and increased the positive intensity of 5-ht and tph2 in the drn/mrn, and th in the sn. |
2020-11-16 |
2023-08-13 |
mouse |