| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Gary C Mouradian, Madeline Kilby, Santiago Alvarez, Kara Kaplan, Matthew R Hodge. Mortality and ventilatory effects of central serotonin deficiency during postnatal development depend on age but not sex. Physiological reports. vol 9. issue 13. 2021-11-10. PMID:34228894. |
infants that succumb to sudden infant death syndrome (sids) have reduced brainstem 5-ht levels and tryptophan hydroxylase 2 (tph2). |
2021-11-10 |
2023-08-13 |
rat |
| Luoyang Ding, Shane K Maloney, Mengzhi Wang, Jennifer Rodger, Lianmin Chen, Dominique Blach. Association between temperament related traits and single nucleotide polymorphisms in the serotonin and oxytocin systems in Merino sheep. Genes, brain, and behavior. vol 20. issue 3. 2021-11-09. PMID:33161622. |
variations like single nucleotide polymorphisms (snps) in the genes for tryptophan 5-hydroxylase (tph2), the serotonin transporter (slc6a4), the serotonin receptor (htr2a), and the oxytocin receptor (oxtr) are associated with behavioral phenotype in humans. |
2021-11-09 |
2023-08-13 |
Not clear |
| Chunyan Yao, Zhiyuan Wang, Huiyong Jiang, Ren Yan, Qianfei Huang, Yin Wang, Hui Xie, Ying Zou, Ying Yu, Longxian L. Ganoderma lucidum promotes sleep through a gut microbiota-dependent and serotonin-involved pathway in mice. Scientific reports. vol 11. issue 1. 2021-11-08. PMID:34211003. |
glaa administration increased the levels of the sleep-promoting neurotransmitter 5-hydroxytryptamine and the tph2, iptr3 and gng13 transcripts in the sleep-regulating serotonergic synapse pathway in the hypothalamus during this process. |
2021-11-08 |
2023-08-13 |
mouse |
| Chen Li, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun L. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31980728. |
here we show that adiponectin receptor 1 (adipor1) is expressed in the dorsal raphe nucleus (drn) and colocalized with tryptophan hydroxylase 2 (tph2), a marker of serotonin (5-ht) neurons. |
2021-11-02 |
2023-08-13 |
mouse |
| Chen Li, Fantao Meng, Jacob C Garza, Jing Liu, Yun Lei, Sergei A Kirov, Ming Guo, Xin-Yun L. Modulation of depression-related behaviors by adiponectin AdipoR1 receptors in 5-HT neurons. Molecular psychiatry. vol 26. issue 8. 2021-11-02. PMID:31980728. |
the expression levels of tph2 were downregulated with a concurrent reduction of 5-ht-immunoreactivity in the drn and its two major projection regions, the hippocampus and medial prefrontal cortex (mpfc), in male but not female mice lacking adipor1 in 5-ht neurons. |
2021-11-02 |
2023-08-13 |
mouse |
| Manuel A Giannoni-Guzmán, Anna Kamitakahara, Valerie Magalong, Pat Levitt, Douglas G McMaho. Circadian photoperiod alters TREK-1 channel function and expression in dorsal raphe serotonergic neurons via melatonin receptor 1 signaling. Journal of pineal research. vol 70. issue 2. 2021-11-01. PMID:33210730. |
we found that long photoperiod significantly reduced levels of kcnk2 in serotonin neurons co-expressing tph2, and pet-1. |
2021-11-01 |
2023-08-13 |
mouse |
| Weam Fageera, Sarojini M Sengupta, Marie-Ève Fortier, Natalie Grizenko, Svetlana Babienco, Aurelie Labbe, Ridha Joobe. Sex-dependent complex association of TPH2 with multiple dimensions of ADHD. Progress in neuro-psychopharmacology & biological psychiatry. vol 110. 2021-11-01. PMID:33677046. |
tryptophan hydroxylase 2 (tph2) is a key enzyme in the biosynthesis of serotonin in the brain. |
2021-11-01 |
2023-08-13 |
Not clear |
| Lu Xiao, Junyan Yan, Ting Yang, Jiang Zhu, Tingyu Li, Hong Wei, Jie Che. Fecal Microbiome Transplantation from Children with Autism Spectrum Disorder Modulates Tryptophan and Serotonergic Synapse Metabolism and Induces Altered Behaviors in Germ-Free Mice. mSystems. vol 6. issue 2. 2021-10-28. PMID:33824200. |
western blotting detected the protein expression levels of tryptophan hydroxylase 1 (tph1), serotonin transporter (sert), and serotonin 1a receptor (5-ht1ar) in the colon and tph2, sert, and 5-ht1ar in the prefrontal cortex of mice. |
2021-10-28 |
2023-08-13 |
mouse |
| Chao-Jin Xu, Peng-Zhang, Ting-Li Dai, Xue-Yuan Niu, Jun-Ling Wang, Ming-Shun Jin, Min-Lia. Evaluation of blood-brain barrier permeability in tryptophan hydroxylase 2-knockout mice. Experimental and therapeutic medicine. vol 8. issue 5. 2021-10-21. PMID:25289042. |
tryptophan hydroxylase 2 (tph2) is a unique genetic enzyme isoform that catalyzes the rate-limiting step in the biosynthesis of 5-ht in the cns; however, its role in the permeability changes of the bbb remains unclear. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
tryptophan hydroxylase type 2 (tph2) is the rate-limiting enzyme for serotonin (5-ht) biosynthesis in the brain. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
dysfunctional tph2 alters 5-ht biosynthesis, leading to a deficiency of 5-ht, which could have repercussions on human behavior. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
therefore, the tph2 gene could be an ideal target for analyzing the effects of a 5-ht deficiency on brain function. |
2021-10-21 |
2023-08-13 |
mouse |
| Emiliano Tesoro-Cruz, Leticia Manuel-Apolinar, Norma Oviedo, Sandra Orozco-Suárez, Minerva Crespo Ramírez, Vilma Carolina Bekker-Méndez, M Magdalena Aguirre-García, Sandra Angélica Rojas-Osornio, Vladimir Paredes-Cervantes, Miguel Pérez de la Mor. Increase of 5-HT levels is induced both in mouse brain and HEK-293 cells following their exposure to a non-viral tryptophan hydroxylase construct. Translational psychiatry. vol 11. issue 1. 2021-10-21. PMID:34625528. |
further research will be needed on the possible application of this treatment for psychiatric diseases involving a tph2 dysfunction or serotonin deficiency. |
2021-10-21 |
2023-08-13 |
mouse |
| Anna Haduch, Renata Pukło, Natalia Alenina, Agnieszka Nikiforuk, Piotr Popik, Michael Bader, Władysława A Danie. The effect of ageing and cerebral serotonin deficit on the activity of cytochrome P450 2D (CYP2D) in the brain and liver of male rats. Neurochemistry international. vol 141. 2021-10-18. PMID:33091481. |
kinetics of 5-methoxytryptamine o-demethylation to serotonin was studied and the cyp2d activity was measured in brain and liver microsomes of dark agouti wild type (wt) rats (mature 3.5-month-old and senescent 21-month-old rats) and in tryptophan hydroxylase 2 (tph2)-deficient senescent rats. |
2021-10-18 |
2023-08-13 |
rat |
| Ming-Fen Ho, Cheng Zhang, Lingxin Zhang, Lixuan Wei, Ying Zhou, Irene Moon, Jennifer R Geske, Doo-Sup Choi, Joanna Biernacka, Mark Frye, Zhexing Wen, Victor M Karpyak, Hu Li, Richard Weinshilbou. TSPAN5 influences serotonin and kynurenine: pharmacogenomic mechanisms related to alcohol use disorder and acamprosate treatment response. Molecular psychiatry. vol 26. issue 7. 2021-10-15. PMID:32753686. |
ethanol treatment resulted in decreased 5-ht concentrations in human induced pluripotent stem cell (ipsc)-derived neuron culture media, and the downregulation of gene expression of tspan5, ddc, maoa, maob, tph1, and tph2 in those cells. |
2021-10-15 |
2023-08-13 |
human |
| Aude Muzerelle, Mariano Soiza-Reilly, Cornelia Hainer, Pierre-Louis Ruet, Klaus-Peter Lesch, Michael Bader, Natalia Alenina, Sophie Scotto-Lomassese, Patricia Gaspa. Dorsal raphe serotonin neurotransmission is required for the expression of nursing behavior and for pup survival. Scientific reports. vol 11. issue 1. 2021-10-14. PMID:33727585. |
this nursing defect is due to acute rather constitutive 5-ht depletion, as it is reproduced by adult knockdown of tph2 in the dorsal raphe nucleus in mothers with a prior normal maternal experience. |
2021-10-14 |
2023-08-13 |
mouse |
| Congcong Liu, Lei Xu, Jialin Li, Feng Zhou, Xi Yang, Xiaoxiao Zheng, Meina Fu, Keshuang Li, Cornelia Sindermann, Christian Montag, Yina Ma, Dirk Scheele, Richard P Ebstein, Shuxia Yao, Keith M Kendrick, Benjamin Becke. Serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a TPH2 imaging genetics approach. Psychological medicine. vol 51. issue 14. 2021-10-12. PMID:32981537. |
serotonin and early life stress interact to shape brain architecture and anxious avoidant behavior - a tph2 imaging genetics approach. |
2021-10-12 |
2023-08-13 |
Not clear |
| Tatyana Strekalova, Evgeniy Svirin, Jonas Waider, Anna Gorlova, Raymond Cespuglio, Allan Kalueff, Igor Pomytkin, Angelika G Schmitt-Boehrer, Klaus-Peter Lesch, Daniel C Anthon. Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene. Progress in neuro-psychopharmacology & biological psychiatry. vol 108. 2021-09-02. PMID:33127424. |
increased impulsivity, excessive aggression, and other behavioural characteristics are associated with variants within the tryptophan hydroxylase-2 (tph2) gene, a key enzyme in brain serotonin synthesis. |
2021-09-02 |
2023-08-13 |
mouse |
| Tatyana Strekalova, Evgeniy Svirin, Jonas Waider, Anna Gorlova, Raymond Cespuglio, Allan Kalueff, Igor Pomytkin, Angelika G Schmitt-Boehrer, Klaus-Peter Lesch, Daniel C Anthon. Altered behaviour, dopamine and norepinephrine regulation in stressed mice heterozygous in TPH2 gene. Progress in neuro-psychopharmacology & biological psychiatry. vol 108. 2021-09-02. PMID:33127424. |
recently, we showed excessive aggression and altered serotonin brain metabolism in heterozygous tph2-deficient male mice (tph2 |
2021-09-02 |
2023-08-13 |
mouse |
| Clarissa Tavares Dias, Haidar Tafner Curi, Tanyara Baliani Payolla, Simone Ferreira Lemes, Isadora Carolina Betim Pavan, Marcio Alberto Torsoni, Fernando Moreira Simabuco, Rafael Herling Lambertucci, Cristiano Mendes da Silv. Maternal high-fat diet stimulates proinflammatory pathway and increases the expression of Tryptophan Hydroxylase 2 (TPH2) and brain-derived neurotrophic factor (BDNF) in adolescent mice hippocampus. Neurochemistry international. vol 139. 2021-08-11. PMID:32652271. |
this study aims to evaluate maternal hfd effects, during pregnancy and lactation, upon dams/mice offspring nutritional status, protein and gene expression of inflammatory pathway (jnk, pjnk and tnf-α), serotonin system molecules (tryptophan hydroxylase 2 (tph2), key-enzyme of serotonin synthesis, serotonin transporter (sert); 5-ht1a serotonergic receptor (5-ht1a)) and brain derived neurotrophic factor (bdnf) on recently weaned mice offspring hippocampus. |
2021-08-11 |
2023-08-13 |
mouse |