| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Robert Brommage, Jeff Liu, Deon Doree, Wangsheng Yu, David R Powell, Qi Melissa Yan. Adult Tph2 knockout mice without brain serotonin have moderately elevated spine trabecular bone but moderately low cortical bone thickness. BoneKEy reports. vol 4. 2015-08-03. PMID:26229596. |
disruption of serotonin synthesis in neurons and the periphery by knockout (ko) of mouse genes for tryptophan hydroxylases (peripheral tph1 and neuronal tph2) has been claimed to decrease (tph2 ko) and increase (tph1 ko) bone mass. |
2015-08-03 |
2023-08-13 |
mouse |
| Jimena Laporta, Kimberly P Keil, Samantha R Weaver, Callyssa M Cronick, Austin P Prichard, Thomas D Crenshaw, Galen W Heyne, Chad M Vezina, Robert J Lipinski, Laura L Hernande. Serotonin regulates calcium homeostasis in lactation by epigenetic activation of hedgehog signaling. Molecular endocrinology (Baltimore, Md.). vol 28. issue 11. 2015-07-07. PMID:25192038. |
here, using a mouse model, we found that genetic inactivation of tryptophan hydroxylase 1 (tph1), which catalyzes the rate-limiting step in peripheral 5-ht synthesis, reduced circulating and mammary pthrp expression, osteoclast activity, and maternal circulating calcium concentrations during the transition from pregnancy to lactation. |
2015-07-07 |
2023-08-13 |
mouse |
| Christopher S Reigstad, Charles E Salmonson, John F Rainey, Joseph H Szurszewski, David R Linden, Justin L Sonnenburg, Gianrico Farrugia, Purna C Kashya. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550456. |
microbiota from hm and conventionally raised (cr) mice significantly increased colonic mrnas tph1 [(tryptophan hydroxylase) 1, rate limiting for mucosal 5-ht synthesis; p < 0.01] and chromogranin a (neuroendocrine secretion; p < 0.01), with no effect on monoamine oxidase a (serotonin catabolism), serotonin receptor 5-ht4, or mouse serotonin transporter. |
2015-06-22 |
2023-08-13 |
mouse |
| Christopher S Reigstad, Charles E Salmonson, John F Rainey, Joseph H Szurszewski, David R Linden, Justin L Sonnenburg, Gianrico Farrugia, Purna C Kashya. Gut microbes promote colonic serotonin production through an effect of short-chain fatty acids on enterochromaffin cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. vol 29. issue 4. 2015-06-22. PMID:25550456. |
hm and cr mice also had increased colonic tph1 protein (p < 0.05) and 5-ht concentrations (gf, 17 ± 3 ng/mg; hm, 25 ± 2 ng/mg; and cr, 35 ± 3 ng/mg; p < 0.05). |
2015-06-22 |
2023-08-13 |
mouse |
| Christian E Oberkofler, Perparim Limani, Jae-Hwi Jang, Andreas Rickenbacher, Kuno Lehmann, Dimitri A Raptis, Udo Ungethuem, Yinghua Tian, Kamile Grabliauskaite, Rok Humar, Rolf Graf, Bostjan Humar, Pierre-Alain Clavie. Systemic protection through remote ischemic preconditioning is spread by platelet-dependent signaling in mice. Hepatology (Baltimore, Md.). vol 60. issue 4. 2015-05-11. PMID:24700614. |
the roles of platelets, peripheral serotonin, and circulating vascular endothelial growth factor (vegf) were studied in thrombocytopenic mice, tph1(-) (/) (-) mice, and through neutralizing antibodies, respectively. |
2015-05-11 |
2023-08-13 |
mouse |
| Justin D Crane, Rengasamy Palanivel, Emilio P Mottillo, Adam L Bujak, Huaqing Wang, Rebecca J Ford, Andrew Collins, Regje M Blümer, Morgan D Fullerton, Julian M Yabut, Janice J Kim, Jean-Eric Ghia, Shereen M Hamza, Katherine M Morrison, Jonathan D Schertzer, Jason R B Dyck, Waliul I Khan, Gregory R Steinber. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature medicine. vol 21. issue 2. 2015-04-09. PMID:25485911. |
serotonin (5-hydroxytryptamine, 5-ht) is a highly conserved biogenic amine that resides in non-neuronal and neuronal tissues that are specifically regulated via tryptophan hydroxylase 1 (tph1) and tph2, respectively. |
2015-04-09 |
2023-08-13 |
mouse |
| Justin D Crane, Rengasamy Palanivel, Emilio P Mottillo, Adam L Bujak, Huaqing Wang, Rebecca J Ford, Andrew Collins, Regje M Blümer, Morgan D Fullerton, Julian M Yabut, Janice J Kim, Jean-Eric Ghia, Shereen M Hamza, Katherine M Morrison, Jonathan D Schertzer, Jason R B Dyck, Waliul I Khan, Gregory R Steinber. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nature medicine. vol 21. issue 2. 2015-04-09. PMID:25485911. |
recent findings suggest that increased peripheral serotonin and polymorphisms in tph1 are associated with obesity; however, whether this is directly related to reduced bat thermogenesis and obesity is not known. |
2015-04-09 |
2023-08-13 |
mouse |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
gsis was impaired in islets isolated from hfd-fed htr3a ko and tph1 βko mice, and 5-ht treatment improved insulin secretion from tph1 βko islets but not from htr3a ko islets. |
2015-03-24 |
2023-08-13 |
mouse |
| Kyuho Kim, Chang-Myung Oh, Mica Ohara-Imaizumi, Sangkyu Park, Jun Namkung, Vijay K Yadav, Natalia A Tamarina, Michael W Roe, Louis H Philipson, Gerard Karsenty, Shinya Nagamatsu, Michael S German, Hail Ki. Functional role of serotonin in insulin secretion in a diet-induced insulin-resistant state. Endocrinology. vol 156. issue 2. 2015-03-24. PMID:25426873. |
tph1 and htr3a gene expression in pancreatic islets was not affected by an hfd, and immunostaining could not detect 5-ht in pancreatic islets from mice fed an hfd. |
2015-03-24 |
2023-08-13 |
mouse |
| Yong-Gu Kim, Hun-Soo Chang, Eun-Soo Won, Byung-Joo Ham, Min-Soo Le. Serotonin-related polymorphisms in TPH1 and HTR5A genes are not associated with escitalopram treatment response in Korean patients with major depression. Neuropsychobiology. vol 69. issue 4. 2015-02-23. PMID:24903772. |
the tryptophan hydroxylase-1 (tph1) gene and serotonin 5a receptor (htr5a) gene are known to be involved in serotonin biosynthesis and signal transduction, respectively. |
2015-02-23 |
2023-08-13 |
Not clear |
| Takuya Yokoyama, Yamaguchi-Yamada Misuzu, Yoshio Yamamot. Immunohistochemical localization of tryptophan hydroxylase and serotonin transporter in the carotid body of the rat. Histochemistry and cell biology. vol 140. issue 2. 2014-11-24. PMID:23266900. |
in the present study, we investigated mrna expression and immunohistochemical localization of the 5-ht synthetic enzyme isoforms, tryptophan hydroxylase 1 (tph1) and tph2, and the 5-ht plasma membrane transport protein, 5-ht transporter (sert), in the cb of the rat. |
2014-11-24 |
2023-08-12 |
rat |
| b' Pascal Amireault, Elisa Bayard, Jean-Marie Launay, David Sibon, Caroline Le Van Kim, Yves Colin, Michel Dy, Olivier Hermine, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin is a key factor for mouse red blood cell survival. PloS one. vol 8. issue 12. 2014-10-21. PMID:24358245.' |
targeted disruption in mice of the tph1 gene results in very low levels of circulating 5-ht. |
2014-10-21 |
2023-08-12 |
mouse |
| Abdelkareem A Ahmed, Wenqiang Ma, Yingdong Ni, Qin Zhou, Ruqian Zha. Embryonic exposure to corticosterone modifies aggressive behavior through alterations of the hypothalamic pituitary adrenal axis and the serotonergic system in the chicken. Hormones and behavior. vol 65. issue 2. 2014-10-20. PMID:24333411. |
high dose cort exposure significantly increased platelet serotonin (5-ht) uptake, decreased whole blood 5-ht concentration (p<0.05), downregulated hypothalamic tryptophan hydroxylase 1 (tph1) mrna and upregulated 5-ht receptor 1a (5-htr1a) and monoamine oxidase a (mao-a) mrna, but not monoamine oxidase b (mao-b). |
2014-10-20 |
2023-08-12 |
chicken |
| Dante J Heredia, Michael D Gershon, Sang Don Koh, Robert D Corrigan, Takanubu Okamoto, Terence K Smit. Important role of mucosal serotonin in colonic propulsion and peristaltic reflexes: in vitro analyses in mice lacking tryptophan hydroxylase 1. The Journal of physiology. vol 591. issue 23. 2014-08-21. PMID:24127620. |
to do so, we analysed the mechanisms underlying faecal pellet propulsion in isolated colons of mice lacking tryptophan hydroxylase 1 (tph1(-/-) mice), which is the rate-limiting enzyme in the biosynthesis of mucosal but not neuronal 5-ht. |
2014-08-21 |
2023-08-12 |
mouse |
| Sang-Eun Jun, Ruth Kohen, Kevin C Cain, Monica E Jarrett, Margaret M Heitkempe. TPH gene polymorphisms are associated with disease perception and quality of life in women with irritable bowel syndrome. Biological research for nursing. vol 16. issue 1. 2014-07-30. PMID:23172723. |
tph is the rate-limiting enzyme in the biosynthesis of serotonin and has two isoforms, tph1 and tph2. |
2014-07-30 |
2023-08-12 |
human |
| Marta Sadkowski, Brittany Dennis, Robert C Clayden, Wala Elsheikh, Sumathy Rangarajan, Jane Dejesus, Zainab Samaa. The role of the serotonergic system in suicidal behavior. Neuropsychiatric disease and treatment. vol 9. 2014-06-24. PMID:24235834. |
these genes - tph1, tph2, slc6a4, slc18a2, htr1a, htr1b, htr2a, ddc, maoa, and maob - encode proteins that are vital to serotonergic function: tryptophan hydroxylase; the serotonin transporter 5-htt; the vesicular transporter vmat2; the htr1a, htr1b, and htr2a receptors; the l-amino acid decarboxylase; and the monoamine oxidases. |
2014-06-24 |
2023-08-12 |
Not clear |
| François Reichardt, Charlotte Baudry, Lisa Gruber, Gemma Mazzuoli, Raphaël Moriez, Christian Scherling, Patrick Kollmann, Hannelore Daniel, Sigrid Kisling, Dirk Haller, Michel Neunlist, Michael Scheman. Properties of myenteric neurones and mucosal functions in the distal colon of diet-induced obese mice. The Journal of physiology. vol 591. issue 20. 2014-06-20. PMID:23940384. |
this was associated with increased tissue acetylcholine and 5-hydroxytryptamine (5-ht) content, and increased expression of tph1 and tph2. |
2014-06-20 |
2023-08-12 |
mouse |
| Niki Antypa, Alessandro Serretti, Dan Rujesc. Serotonergic genes and suicide: a systematic review. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 10. 2014-04-24. PMID:23742855. |
in this paper, we review evidence from studies examining the association between various serotonergic genes (tryptophan hydroxylase genes: tph1; tph2, serotonin transporter gene: 5-httlpr in slc6a4, serotonin receptor genes: htr1a, htr2a, htr1b, htr2c and monoamine oxidase a gene: maoa) and suicidal behavior. |
2014-04-24 |
2023-08-12 |
Not clear |
| Raffaella Calati, Florence Gressier, Martina Balestri, Alessandro Serrett. Genetic modulation of borderline personality disorder: systematic review and meta-analysis. Journal of psychiatric research. vol 47. issue 10. 2014-04-04. PMID:23810197. |
meta-analyses were performed for three serotonergic polymorphisms: two common polymorphisms of the serotonin transporter gene (slc6a4), the promoter insertion/deletion (5-httlpr) and the intron 2 vntr (stin2 vntr), and the rs1800532 (a218c) polymorphism of the tryptophan hydroxylase 1 gene (tph1), all showing no association. |
2014-04-04 |
2023-08-12 |
Not clear |
| Richard Musil, Peter Zill, Florian Seemüller, Brigitta Bondy, Sebastian Meyer, Ilja Spellmann, Wolfram Bender, Mazda Adli, Isabella Heuser, Robert Fisher, Wolfgang Gaebel, Wolfgang Maier, Marcella Rietschel, Dan Rujescu, Rebecca Schennach, Hans-Jürgen Möller, Michael Riede. Genetics of emergent suicidality during antidepressive treatment--data from a naturalistic study on a large sample of inpatients with a major depressive episode. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. vol 23. issue 7. 2014-01-23. PMID:23063133. |
common polymorphisms involved in the tryptophan hydroxylase 1 (tph1) and 2 (tph2), serotonin transporter, monoamine oxidase a (maoa) and brain-derived neurotrophic factor (bdnf) were investigated in a naturalistic inpatient study of the german research network on depression. |
2014-01-23 |
2023-08-12 |
Not clear |