| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Hideo Nakagawa, Takashi Ueda, Saya Ito, Takumi Shiraishi, Hidefumi Taniguchi, Naruhiro Kayukawa, Hiroyuki Nakanishi, So Ushijima, Motohiro Kanazawa, Terukazu Nakamura, Yoshio Naya, Fumiya Hongo, Kazumi Kamoi, Koji Okihara, Osamu Ukimur. Androgen suppresses testicular cancer cell growth in vitro and in vivo. Oncotarget. vol 7. issue 23. 2018-01-12. PMID:27144435. |
activation of androgen/ar signaling in se cells reduced the expression of tph1 in se cells, followed by the reduction of serotonin secretion in cell culture supernatant. |
2018-01-12 |
2023-08-13 |
Not clear |
| Kasper D Tidemand, Günther H Peters, Pernille Harris, Eva Stensgaard, Hans E M Christense. Isoform-Specific Substrate Inhibition Mechanism of Human Tryptophan Hydroxylase. Biochemistry. vol 56. issue 46. 2017-12-19. PMID:29035515. |
tph1 catalyzes the initial step in the synthesis of serotonin in the peripheral tissues, while tph2 catalyzes this step in the brain. |
2017-12-19 |
2023-08-13 |
human |
| Carlos Acosta-Andrade, Ana Lambertos, José L Urdiales, Francisca Sánchez-Jiménez, Rafael Peñafiel, Ignacio Fajard. A novel role for antizyme inhibitor 2 as a regulator of serotonin and histamine biosynthesis and content in mouse mast cells. Amino acids. vol 48. issue 10. 2017-12-07. PMID:27084713. |
accordingly, tryptophan hydroxylase-1 (tph1; the key enzyme for serotonin biosynthesis) mrna expression and protein levels were reduced, whereas histidine decarboxylase (the enzyme responsible for histamine biosynthesis) enzymatic activity was increased. |
2017-12-07 |
2023-08-13 |
mouse |
| Kara Gross Margolis, Jennifer Vittorio, Maria Talavera, Karen Gluck, Zhishan Li, Alina Iuga, Korey Stevanovic, Virginia Saurman, Narek Israelyan, Martha G Welch, Michael D Gersho. Enteric serotonin and oxytocin: endogenous regulation of severity in a murine model of necrotizing enterocolitis. American journal of physiology. Gastrointestinal and liver physiology. vol 313. issue 5. 2017-11-20. PMID:28774871. |
in contrast, genetic deletion of tryptophan hydroxylase 1 (tph1), which is responsible for 5-ht biosynthesis in enterochromaffin (ec) cells of the intestinal mucosa, and tph inhibition with lp-920540 both decrease the severity of experimental nec in the small intestine and liver. |
2017-11-20 |
2023-08-13 |
mouse |
| b' Jelena Karanovi\\xc4\\x87, Maja Ivkovi\\xc4\\x87, Vladimir M Jovanovi\\xc4\\x87, Maja Pantovi\\xc4\\x87, Nata\\xc5\\xa1a Pavlovi\\xc4\\x87-Jankovi\\xc4\\x87, Aleksandar Damjanovi\\xc4\\x87, Goran Braju\\xc5\\xa1kovi\\xc4\\x87, Stanka Romac, Du\\xc5\\xa1anka Savi\\xc4\\x87-Pavi\\xc4\\x87evi\\xc4\\x8. Tryptophan Hydroxylase 1 Variant rs1800532 is Associated with Suicide Attempt in Serbian Psychiatric Patients but does not Moderate the Effect of Recent Stressful Life Events. Suicide & life-threatening behavior. vol 46. issue 6. 2017-10-03. PMID:27037949.' |
tryptophan hydroxylase 1 (tph1) gene, coding for serotonin synthesizing enzyme, and recent stressful life events (sles) have been commonly associated with suicidal behavior. |
2017-10-03 |
2023-08-13 |
Not clear |
| Coedy Hadden, Tariq Fahmi, Anthonya Cooper, Alena V Savenka, Vladimir V Lupashin, Drucilla J Roberts, Luc Maroteaux, Sylvie Hauguel-de Mouzon, Fusun Kili. Serotonin transporter protects the placental cells against apoptosis in caspase 3-independent pathway. Journal of cellular physiology. vol 232. issue 12. 2017-10-02. PMID:28109119. |
using placentas dissected from 18d gestational sert-knock out (ko), peripheral 5-ht (tph1)-ko, and wild-type (wt) mice, we explored the role of 5-ht and sert in placental functions in detail. |
2017-10-02 |
2023-08-13 |
mouse |
| Laetitia Laurent, Kathy Deroy, Joey St-Pierre, Francine Côté, J Thomas Sanderson, Cathy Vaillancour. Human placenta expresses both peripheral and neuronal isoform of tryptophan hydroxylase. Biochimie. vol 140. 2017-09-15. PMID:28751217. |
moreover, it is not known if the two tryptophan hydroxylase isoforms (tph1 and tph2), the rate-limiting enzymes in serotonin biosynthesis, are expressed in placenta. |
2017-09-15 |
2023-08-13 |
mouse |
| Stefanie Gross, Diana C Garofalo, Dina A Balderes, Teresa L Mastracci, José M Dias, Thomas Perlmann, Johan Ericson, Lori Susse. The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development (Cambridge, England). vol 143. issue 14. 2017-09-05. PMID:27287799. |
lmx1a-deficient mice have reduced expression of tph1, the rate-limiting enzyme for serotonin biosynthesis. |
2017-09-05 |
2023-08-13 |
mouse |
| Stefanie Gross, Diana C Garofalo, Dina A Balderes, Teresa L Mastracci, José M Dias, Thomas Perlmann, Johan Ericson, Lori Susse. The novel enterochromaffin marker Lmx1a regulates serotonin biosynthesis in enteroendocrine cell lineages downstream of Nkx2.2. Development (Cambridge, England). vol 143. issue 14. 2017-09-05. PMID:27287799. |
these data clarify the function of nkx2.2 in the specification and homeostatic maintenance of enteroendocrine populations, and identify lmx1a as a novel enterochromaffin cell marker that is also essential for the production of the serotonin biosynthetic enzyme tph1. |
2017-09-05 |
2023-08-13 |
mouse |
| Onur Beden, Ender Senol, Sevcan Atay, Handan Ak, Ayse Ender Altintoprak, Guclu Selahattin Kiyan, Buket Petin, Utku Yaman, Hikmet Hakan Aydi. TPH1 A218 allele is associated with suicidal behavior in Turkish population. Legal medicine (Tokyo, Japan). vol 21. 2017-08-31. PMID:27497328. |
the first and rate-limiting step in the synthesis of serotonin is catalyzed by tryptophan hydroxylase (tph) which is encoded by tph1 and thp2 genes. |
2017-08-31 |
2023-08-13 |
Not clear |
| Anna L Xavier, Romain Fontaine, Solal Bloch, Pierre Affaticati, Arnim Jenett, Michaël Demarque, Philippe Vernier, Kei Yamamot. Comparative analysis of monoaminergic cerebrospinal fluid-contacting cells in Osteichthyes (bony vertebrates). The Journal of comparative neurology. vol 525. issue 9. 2017-08-25. PMID:28295297. |
furthermore, we found that many csf-c cells coexpress th2 and tph1 and contain both da and 5-ht, a dual neurotransmitter phenotype hitherto undescribed in the brain of any vertebrate. |
2017-08-25 |
2023-08-13 |
chicken |
| Daniel R Goldberg, Stéphane De Lombaert, Robert Aiello, Patricia Bourassa, Nicole Barucci, Qing Zhang, Vishwas Paralkar, Adam J Stein, Jim Valentine, William Zavadosk. Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorganic & medicinal chemistry letters. vol 26. issue 12. 2017-07-20. PMID:27146606. |
given that tryptophan hydroxylase 1 (tph1) is the rate limiting enzyme in the biosynthesis off serotonin, it represents an attractive target to regulate peripheral serotonin. |
2017-07-20 |
2023-08-13 |
Not clear |
| Daniel R Goldberg, Stéphane De Lombaert, Robert Aiello, Patricia Bourassa, Nicole Barucci, Qing Zhang, Vishwas Paralkar, Adam J Stein, Jim Valentine, William Zavadosk. Discovery of acyl guanidine tryptophan hydroxylase-1 inhibitors. Bioorganic & medicinal chemistry letters. vol 26. issue 12. 2017-07-20. PMID:27146606. |
through our work, we found that compounds of this nature provide highly potent tph1 inhibitors with favorable physicochemical properties that were effective in reducing murine intestinal 5-ht in vivo. |
2017-07-20 |
2023-08-13 |
Not clear |
| Daniel R Goldberg, Stéphane De Lombaert, Robert Aiello, Patricia Bourassa, Nicole Barucci, Qing Zhang, Vishwas Paralkar, Adam J Stein, Melissa Holt, Jim Valentine, William Zavadosk. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorganic & medicinal chemistry letters. vol 27. issue 3. 2017-07-04. PMID:28041831. |
in particular, 15b (kar5585), the prodrug of the potent tph1 inhibitor 15a (kar5417), showed robust reduction of intestinal serotonin (5-ht) levels in mice. |
2017-07-04 |
2023-08-13 |
mouse |
| Ronadip R Banerjee, Holly A Cyphert, Emily M Walker, Harini Chakravarthy, Heshan Peiris, Xueying Gu, Yinghua Liu, Elizabeth Conrad, Lisa Goodrich, Roland W Stein, Seung K Ki. Gestational Diabetes Mellitus From Inactivation of Prolactin Receptor and MafB in Islet β-Cells. Diabetes. vol 65. issue 8. 2017-06-05. PMID:27217483. |
targeted prlr loss in maternal β-cells in vivo impaired expression of the transcription factor foxm1, both g1/s and g2/m cyclins, tryptophan hydroxylase 1 (tph1), and islet serotonin production, for which synthesis requires tph1. |
2017-06-05 |
2023-08-13 |
Not clear |
| Robert J Aiello, Patricia-Ann Bourassa, Qing Zhang, Jeffrey Dubins, Daniel R Goldberg, Stéphane De Lombaert, Marc Humbert, Christophe Guignabert, Maria A Cavasin, Timothy A McKinsey, Vishwas Paralka. Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension. The Journal of pharmacology and experimental therapeutics. vol 360. issue 2. 2017-05-16. PMID:27927914. |
here, we investigated the chronic effects of pharmacological inhibition of tryptophan hydroxylase 1 (tph1), the rate-limiting enzyme in peripheral 5-ht biosynthesis, in two preclinical models of pulmonary hypertension (ph), the monocrotaline (mct) rat and the semaxanib (sugen, medinoah, suzhou, china)-hypoxia rat. |
2017-05-16 |
2023-08-13 |
rat |
| Robert J Aiello, Patricia-Ann Bourassa, Qing Zhang, Jeffrey Dubins, Daniel R Goldberg, Stéphane De Lombaert, Marc Humbert, Christophe Guignabert, Maria A Cavasin, Timothy A McKinsey, Vishwas Paralka. Tryptophan hydroxylase 1 Inhibition Impacts Pulmonary Vascular Remodeling in Two Rat Models of Pulmonary Hypertension. The Journal of pharmacology and experimental therapeutics. vol 360. issue 2. 2017-05-16. PMID:27927914. |
in both ph models, ethyl (s)-8-(2-amino-6-((r)-1-(5-chloro-[1,1'-biphenyl]-2-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate and ethyl (s)-8-(2-amino-6-((r)-1-(3',4'-dimethyl-3-(3-methyl-1 h-pyrazol-1-yl)-[1,1'-biphenyl]-4-yl)-2,2,2-trifluoroethoxy)pyrimidin-4-yl)-2,8-diazaspiro[4.5]decane-3-carboxylate, novel orally active tph1 inhibitors with nanomolar in vitro potency, decreased serum, gut, and lung 5-ht levels in a dose-dependent manner and significantly reduced pulmonary arterial pressure, and pulmonary vessel wall thickness and occlusion in male rats. |
2017-05-16 |
2023-08-13 |
rat |
| Takeshi Tsuruta, Shinichi Saito, Yosuke Osaki, Akihiro Hamada, Ayako Aoki-Yoshida, Kei Sonoyam. Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium. Biochemical and biophysical research communications. vol 474. issue 1. 2017-05-08. PMID:27105910. |
reverse transcription-polymerase chain reaction (rt-pcr) analysis showed that small intestinal and colonic organoids express mrnas encoding tryptophan hydroxylase-1 (tph1) (the rate-limiting enzyme of 5-ht synthesis), serotonin reuptake transporter (sert), 5-ht receptor (htr)2a, htr2b, and htr4. |
2017-05-08 |
2023-08-13 |
Not clear |
| Takeshi Tsuruta, Shinichi Saito, Yosuke Osaki, Akihiro Hamada, Ayako Aoki-Yoshida, Kei Sonoyam. Organoids as an ex vivo model for studying the serotonin system in the murine small intestine and colon epithelium. Biochemical and biophysical research communications. vol 474. issue 1. 2017-05-08. PMID:27105910. |
although the 5-ht concentration and levels of chromogranin a (cga) (an enteroendocrine cell marker), tph1, and htr4 mrnas were significantly higher in the colonic mucosa than the small intestinal mucosa, they were the same in small intestinal and colonic organoids. |
2017-05-08 |
2023-08-13 |
Not clear |
| S R Weaver, C M Cronick, A P Prichard, J Laporta, N J Benevenga, L L Hernande. Use of the RatLoft decreases pup mortality in lactating mice. Laboratory animals. vol 50. issue 5. 2017-04-26. PMID:26568578. |
the purpose of this study was to examine the effect of access to an environmental enrichment device called the ratloft on milk yield, circulating serotonin, and pup mortality using both wild-type mice and mice genetically deficient in tryptophan hydroxylase 1 (tph1(-/-); the rate-limiting enzyme in the non-neuronal serotonin synthesis pathway). |
2017-04-26 |
2023-08-13 |
mouse |