| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| S R Weaver, C M Cronick, A P Prichard, J Laporta, N J Benevenga, L L Hernande. Use of the RatLoft decreases pup mortality in lactating mice. Laboratory animals. vol 50. issue 5. 2017-04-26. PMID:26568578. |
this environmental enrichment may be particularly beneficial to tph1(-/-) dams that, in addition to decreased infanticide, had increased serotonin concentrations, possibly indicating enhanced well-being. |
2017-04-26 |
2023-08-13 |
mouse |
| Kanu Megha, Pravin S Deshmukh, Alok K Ravi, Ashok K Tripathi, Mahesh P Abegaonkar, Basu D Banerje. Effect of Low-Intensity Microwave Radiation on Monoamine Neurotransmitters and Their Key Regulating Enzymes in Rat Brain. Cell biochemistry and biophysics. vol 73. issue 1. 2017-01-18. PMID:25672490. |
tyrosine hydroxylase (th) (for da, ne and e) and tryptophan hydroxylase (tph1 and tph2) (for serotonin) was also estimated. |
2017-01-18 |
2023-08-13 |
human |
| Jihua Fu, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu H. Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884719. |
lts with hyperglucocorticoidemia induced hepatic 5-ht synthetic increase with tryptophan hydroxylase 1 (tph1) up-regulation, and 5-ht2 receptor (5-ht2r, including 5-ht2a, 2b receptor) up-regulation in liver and visceral adipose, as well as hepatic mtor activation with triglycerides and vldl overproduction with steatosis, and visceral adipose lipolytic increase with high blood free fatty acids (ffas) level. |
2016-12-13 |
2023-08-13 |
rat |
| Jihua Fu, Shaoxin Ma, Xin Li, Shanshan An, Tao Li, Keke Guo, Min Lin, Wei Qu, Shanshan Wang, Xinyue Dong, Xiaoyu Han, Ting Fu, Xinping Huang, Tianying Wang, Siyu H. Long-term Stress with Hyperglucocorticoidemia-induced Hepatic Steatosis with VLDL Overproduction Is Dependent on both 5-HT2 Receptor and 5-HT Synthesis in Liver. International journal of biological sciences. vol 12. issue 2. 2016-12-13. PMID:26884719. |
in hepg2 cells dexamethasone or palmitate-induced mtor activation with triglycerides and vldl overproduction were accompanied by up-regulations of 5-ht synthesis and 5-ht2r, which were significantly abolished by gene silencing tph1 or 5-ht2r and were almost fully abolished by co-silencing of both, especially on vldl overproduction. |
2016-12-13 |
2023-08-13 |
rat |
| Daniel R Goldberg, Stéphane De Lombaert, Robert Aiello, Patricia Bourassa, Nicole Barucci, Qing Zhang, Vishwas Paralkar, James Valentine, William Zavadosk. Discovery of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorganic & medicinal chemistry letters. vol 26. issue 4. 2016-10-05. PMID:26821821. |
we disclose herein the discovery of a new class of tph1 inhibitors that significantly lower peripherally 5-ht. |
2016-10-05 |
2023-08-13 |
Not clear |
| b' Yasmine Chabbi-Achengli, Tereza Coman, Corinne Collet, Jacques Callebert, Michelangelo Corcelli, Hil\\xc3\\xa8ne Lin, Rachel Rignault, Michel Dy, Marie-Christine de Vernejoul, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption. The American journal of pathology. vol 186. issue 4. 2016-09-06. PMID:26968113.' |
we studied serotonin's involvement during collagen-induced arthritis in wild-type and tph1(-/-) mice, which have markedly reduced peripheral serotonin levels. |
2016-09-06 |
2023-08-13 |
mouse |
| b' Yasmine Chabbi-Achengli, Tereza Coman, Corinne Collet, Jacques Callebert, Michelangelo Corcelli, Hil\\xc3\\xa8ne Lin, Rachel Rignault, Michel Dy, Marie-Christine de Vernejoul, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin Is Involved in Autoimmune Arthritis through Th17 Immunity and Bone Resorption. The American journal of pathology. vol 186. issue 4. 2016-09-06. PMID:26968113.' |
ex vivo serotonin and agonists of the 5-ht2a and 5-ht2b receptors restored il-17 secretion from splenocytes and th17 cell differentiation in tph1(-/-) mice. |
2016-09-06 |
2023-08-13 |
mouse |
| Anthony C Ruocco, Achala H Rodrigo, Dean Carcone, Shelley McMain, Grace Jacobs, James L Kenned. Tryptophan hydroxylase 1 gene polymorphisms alter prefrontal cortex activation during response inhibition. Neuropsychology. vol 30. issue 1. 2016-08-15. PMID:26710093. |
the tryptophan hydroxylase 1 gene (tph1) catalyzes the formation of 5-hydroxytryptophan, a precursor to the neurotransmitter serotonin. |
2016-08-15 |
2023-08-13 |
Not clear |
| Igor Erjavec, Tatjana Bordukalo-Niksic, Jelena Brkljacic, Danka Grcevic, Gordana Mokrovic, Maja Kesic, Dunja Rogic, William Zavadoski, Vishwas M Paralkar, Lovorka Grgurevic, Vladimir Trkulja, Lipa Cicin-Sain, Slobodan Vukicevi. Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats. PloS one. vol 11. issue 2. 2016-07-21. PMID:26907598. |
reduced peripheral serotonin (5ht) in mice lacking tryptophan hydroxylase (tph1), the rate limiting enzyme for 5ht synthesis, was reported to be anabolic to the skeleton. |
2016-07-21 |
2023-08-13 |
mouse |
| Igor Erjavec, Tatjana Bordukalo-Niksic, Jelena Brkljacic, Danka Grcevic, Gordana Mokrovic, Maja Kesic, Dunja Rogic, William Zavadoski, Vishwas M Paralkar, Lovorka Grgurevic, Vladimir Trkulja, Lipa Cicin-Sain, Slobodan Vukicevi. Constitutively Elevated Blood Serotonin Is Associated with Bone Loss and Type 2 Diabetes in Rats. PloS one. vol 11. issue 2. 2016-07-21. PMID:26907598. |
in vitro, insulin and 5ht synergistically up-regulated osteoblast differentiation isolated from high-5ht rats, whereas tph1 inhibition decreased the number of bone marrow-derived osteoclasts. |
2016-07-21 |
2023-08-13 |
mouse |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
we showed in isolated islets and min6 cells that gcs decreased expression and activity of the two key enzymes of serotonin synthesis, tryptophan hydroxylase 1 (tph1) and 2 (tph2), leading to reduced serotonin contents. |
2016-07-18 |
2023-08-13 |
mouse |
| Moina Hasni Ebou, Amrit Singh-Estivalet, Jean-Marie Launay, Jacques Callebert, François Tronche, Pascal Ferré, Jean-François Gautier, Ghislaine Guillemain, Bernadette Bréant, Bertrand Blondeau, Jean-Pierre Rivelin. Glucocorticoids Inhibit Basal and Hormone-Induced Serotonin Synthesis in Pancreatic Beta Cells. PloS one. vol 11. issue 2. 2016-07-18. PMID:26901633. |
finally, islets from mice deleted for the gr in the pancreas displayed an increased expression of tph1 and tph2 and a strong increased serotonin content per islet. |
2016-07-18 |
2023-08-13 |
mouse |
| Toshihisa Maeda, Yasushi Miura, Koji Fukuda, Shinya Hayashi, Masahiro Kurosak. Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26238767. |
decoy receptor 3 (dcr3) is expressed in rheumatoid arthritis fibroblast‑like synoviocytes (ra‑fls) and downregulates the expression of tryptophan hydroxylase 1 (tph1), which is the rate‑limiting enzyme in serotonin synthesis. |
2016-06-27 |
2023-08-13 |
Not clear |
| Toshihisa Maeda, Yasushi Miura, Koji Fukuda, Shinya Hayashi, Masahiro Kurosak. Decoy receptor 3 regulates the expression of tryptophan hydroxylase 1 in rheumatoid synovial fibroblasts. Molecular medicine reports. vol 12. issue 4. 2016-06-27. PMID:26238767. |
these results suggested that synovial serotonin may be involved in the pathogenesis of ra, and that tph1 and dcr3 may be potential therapeutic targets for the treatment of ra. |
2016-06-27 |
2023-08-13 |
Not clear |
| Jimena Laporta, Francisco Peñagaricano, Laura L Hernande. Transcriptomic Analysis of the Mouse Mammary Gland Reveals New Insights for the Role of Serotonin in Lactation. PloS one. vol 10. issue 10. 2016-06-27. PMID:26470019. |
the rate limiting enzyme in the synthesis of non-neuronal serotonin is tryptophan-hydroxylase (tph1). |
2016-06-27 |
2023-08-13 |
mouse |
| Jimena Laporta, Francisco Peñagaricano, Laura L Hernande. Transcriptomic Analysis of the Mouse Mammary Gland Reveals New Insights for the Role of Serotonin in Lactation. PloS one. vol 10. issue 10. 2016-06-27. PMID:26470019. |
therefore, we used tph1 deficient dams (ko; serotonin deficient, n = 4) and compared them to wild-type (wt; n = 4) and rescue (rc; ko + 100 mg/kg 5-hydroxytryptophan injected daily, n = 4) dams. |
2016-06-27 |
2023-08-13 |
mouse |
| S Blazevic, I Erjavec, M Brizic, S Vukicevic, D Hranilovi. Molecular background and physiological consequences of altered peripheral serotonin homeostasis in adult rats perinatally treated with tranylcypromine. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society. vol 66. issue 4. 2016-06-07. PMID:26348077. |
our results: a) show that perinatal exposure to tranylcypromine leads to long-lasting compensatory decrease in tph1 expression in the peripheral compartment, accompanied with alterations in bone remodeling and hematopoiesis, b) suggest that peripheral and central 5ht compartment use different strategies to compensate for 5-ht imbalances of the same cause, and c) indicate dominant role of peripheral over central 5-ht in the regulation of bone maintenance, as well as possible negative in vivo influence of peripheral 5-ht on leukocyte development and/or sustainment. |
2016-06-07 |
2023-08-13 |
rat |
| Hao Zhong, Wei Huang, Gu He, Cheng Peng, Fengbo Wu, Liang Ouyan. Molecular dynamics simulation of tryptophan hydroxylase-1: binding modes and free energy analysis to phenylalanine derivative inhibitors. International journal of molecular sciences. vol 14. issue 5. 2016-05-26. PMID:23665899. |
tryptophan hydroxylase-1 (tph1) is a key enzyme of serotonin synthesis. |
2016-05-26 |
2023-08-12 |
Not clear |
| Kannan Baskar, Swastika Sur, Vithyalakshmi Selvaraj, Devendra K Agrawa. Functional constituents of a local serotonergic system, intrinsic to the human coronary artery smooth muscle cells. Molecular biology reports. vol 42. issue 8. 2016-05-23. PMID:25861735. |
our aim was to examine the presence of functional tryptophan hydroxylase-1 (tph1) and serotonin transporter (sert) in hcasmcs. |
2016-05-23 |
2023-08-13 |
human |
| Barbara Pelosi, Marta Pratelli, Sara Migliarini, Giulia Pacini, Massimo Pasqualett. Generation of a Tph2 Conditional Knockout Mouse Line for Time- and Tissue-Specific Depletion of Brain Serotonin. PloS one. vol 10. issue 8. 2016-05-13. PMID:26291320. |
serotonin synthesis is a 2-step process, the first step of which is mediated by the rate-limiting activity of tph enzymes, belonging to the family of aromatic amino acid hydroxylases and existing in two isoforms, tph1 and tph2, responsible for the production of peripheral and brain serotonin, respectively. |
2016-05-13 |
2023-08-13 |
mouse |