| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Peijun Tian, Renying Zou, Linhong Song, Xu Zhang, Bin Jiang, Gang Wang, Yuan-Kun Lee, Jianxin Zhao, Hao Zhang, Wei Che. Ingestion of Bifidobacterium longum subspecies infantis strain CCFM687 regulated emotional behavior and the central BDNF pathway in chronic stress-induced depressive mice through reshaping the gut microbiota. Food & function. vol 10. issue 11. 2020-04-16. PMID:31687714. |
infantis strain ccfm687 could significantly enhance the biosynthesis of 5-hydroxytryptamine (5-htp) in vitro in rin14b cells through up-regulation of the tph1 gene expression. |
2020-04-16 |
2023-08-13 |
mouse |
| Minxuan Cai, Liangliang Zhou, Jun Liao, Qiaoling Huang, Zhenjiang Xia, Jing Shan. IFN-γ inhibits 5-HT-induced melanin biosynthesis via downregulation of 5-HT receptors in vivo/in vitro. Journal of pharmacological sciences. vol 141. issue 1. 2020-03-11. PMID:31519333. |
in addition, we found that ifn-γ decreased serum serotonin levels as well as the cutaneous expression of tryptophan hydroxylase 1 (tph1), 5-ht1a receptor (5-ht1ar) and 5-ht1b receptor (5-ht1br) in c57bl/6 mice. |
2020-03-11 |
2023-08-13 |
mouse |
| Erik Höglund, Øyvind Øverli, Svante Winber. Tryptophan Metabolic Pathways and Brain Serotonergic Activity: A Comparative Review. Frontiers in endocrinology. vol 10. 2020-02-25. PMID:31024440. |
in the periphery as well as in brain areas expressing tph1, 5-ht synthesis is probably not restricted by trp availability. |
2020-02-25 |
2023-08-13 |
Not clear |
| Yun Han Kwon, Huaqing Wang, Emmanuel Denou, Jean-Eric Ghia, Laura Rossi, Michelle E Fontes, Steve P Bernier, Md Sharif Shajib, Suhrid Banskota, Stephen M Collins, Michael G Surette, Waliul I Kha. Modulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis. Cellular and molecular gastroenterology and hepatology. vol 7. issue 4. 2020-01-17. PMID:30716420. |
serotonin (5-hydroxytryptamine [5-ht]) is synthesized mainly within enterochromaffin (ec) cells in the gut, and tryptophan hydroxylase 1 (tph1) is the rate-limiting enzyme for 5-ht synthesis in ec cells. |
2020-01-17 |
2023-08-13 |
Not clear |
| Ana Coelho, Raquel Oliveira, Helena Cavaleiro, Celia Duarte Cruz, Francisco Cru. Evidence for an urethro-vesical crosstalk mediated by serotonin. Neurourology and urodynamics. vol 37. issue 8. 2019-10-21. PMID:29664149. |
to study the contribution of urethral serotonin for the urethro-vesical crosstalk methods: urethane-anesthetized female rats and tph1 |
2019-10-21 |
2023-08-13 |
rat |
| Samantha R Weaver, Hannah P Fricke, Cynthia Xie, Robert J Aiello, Julia F Charles, Laura L Hernande. Peripartum dietary supplementation of a small-molecule inhibitor of tryptophan hydroxylase 1 compromises infant, but not maternal, bone. American journal of physiology. Endocrinology and metabolism. vol 315. issue 6. 2019-08-26. PMID:30351987. |
we hypothesized that inhibiting nonneuronal serotonin activity by feeding a small-molecule inhibitor of the rate-limiting enzyme in serotonin synthesis [tryptophan hydroxylase 1 (tph1)] would preserve maternal bone postweaning without affecting neonatal bone. |
2019-08-26 |
2023-08-13 |
Not clear |
| Alexander D Vincent, Xuan-Yu Wang, Sean P Parsons, Waliul I Khan, Jan D Huizing. Abnormal absorptive colonic motor activity in germ-free mice is rectified by butyrate, an effect possibly mediated by mucosal serotonin. American journal of physiology. Gastrointestinal and liver physiology. vol 315. issue 5. 2019-08-16. PMID:30095295. |
motility was then assessed in tryptophan hydroxylase-1 (tph1) knockout (ko) mice, devoid of mucosal 5-ht, with phosphate buffer, butyrate, or propionate intraluminal perfusion. |
2019-08-16 |
2023-08-13 |
mouse |
| Emanuel Carvalho-Dias, Alice Miranda, Olga Martinho, Paulo Mota, Ângela Costa, Cristina Nogueira-Silva, Rute S Moura, Natalia Alenina, Michael Bader, Riccardo Autorino, Estêvão Lima, Jorge Correia-Pint. Serotonin regulates prostate growth through androgen receptor modulation. Scientific reports. vol 7. issue 1. 2019-07-23. PMID:29133842. |
since peripheral 5-ht production is specifically regulated by tryptophan hydroxylase 1(tph1), we showed that tph1 knockout mice present higher prostate mass and up-regulation of ar when compared to wild-type, whereas 5-ht treatment restored the prostate weight and ar levels. |
2019-07-23 |
2023-08-13 |
human |
| V M Pokrovskii, Yu V Kashina, O V Kiek, O V Gumerova, V Yu Gorbunova, V G Abushkevich, A G Penzhoyan, N V Zabolotskik. Association of Regulatory and Adaptive Status in Humans with Serotonergic Transmitter System Gene Polymorphism. Bulletin of experimental biology and medicine. vol 166. issue 4. 2019-07-15. PMID:30783842. |
we performed molecular-genetic analysis of polymorphic variants of the main gene of serotonin biosynthesis, tryptophan hydroxylase tph1 (a218c polymorphism) and tph2 (g703t polymorphism), and serotonin receptors (htr2c and htr2a genes). |
2019-07-15 |
2023-08-13 |
human |
| Qiangqiang He, Ji Ma, Praveen Kumar Kalavagunta, Liangliang Zhou, Junyi Zhu, Jing Dong, Owais Ahmad, Yuzhi Du, Lixin Wei, Jing Shan. HgS Inhibits Oxidative Stress Caused by Hypoxia through Regulation of 5-HT Metabolism Pathway. International journal of molecular sciences. vol 20. issue 6. 2019-07-10. PMID:30889910. |
administration of exogenous 5-ht exacerbated this effect, whereas the inhibition of tph1, lp533401 alleviated the oxidative stress. |
2019-07-10 |
2023-08-13 |
zebrafish |
| Zhenjiang Xia, Yan Xu, Jichun Han, Qiangqiang He, Jinjin Dong, Xiaoyan Zou, Yuzhi DU, Jing Shang, Lixin We. [Metabolic analysis of serotonin system in serum and gastric tissues of ovalbumin-induced allergic mice]. Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology. vol 34. issue 4. 2019-07-08. PMID:29973322. |
the mrna levels of tryptophan hydroxylase-1 (tph1), indolamine-2, 3-dioxygenase 1 (ido1), monoamine oxidase a (mao-a), 5-hydroxytryptamine 1a receptor (htr1a), 5-hydroxytryptamine 3 receptor (htr3), 5-hydroxytryptamine 4 receptor (htr4) and serotonin reuptake transporter (sert) were determined by real-time quantitative pcr. |
2019-07-08 |
2023-08-13 |
mouse |
| b' Guillemette Fouquet, Tereza Coman, Olivier Hermine, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin, hematopoiesis and stem cells. Pharmacological research. vol 140. 2019-05-13. PMID:30107202.' |
since the generation of tryptophan hydroxylase (tph1 and tph2) knockout mice, unsuspected roles have been identified for serotonin synthesized outside the brain. |
2019-05-13 |
2023-08-13 |
mouse |
| b' Guillemette Fouquet, Tereza Coman, Olivier Hermine, Francine C\\xc3\\xb4t\\xc3\\xa. Serotonin, hematopoiesis and stem cells. Pharmacological research. vol 140. 2019-05-13. PMID:30107202.' |
moreover, the murine model deficient in peripheral serotonin (tph1 |
2019-05-13 |
2023-08-13 |
mouse |
| Hanjie Yu, Dan Lv, Mengxin Shen, Yanhua Zhang, Dongsheng Zhou, Zhongming Chen, Chuang Wan. BDNF mediates the protective effects of scopolamine in reserpine-induced depression-like behaviors via up-regulation of 5-HTT and TPH1. Psychiatry research. vol 271. 2019-04-15. PMID:30529315. |
in addition, the reserpine-induced decreases in serotonin transporter (5-htt), brain-derived neurotrophic factor (bdnf) and tryptophan hydroxylase 1 (tph1) in mouse hippocampus and prefrontal cortex (pfc) were significantly reversed by scopolamine. |
2019-04-15 |
2023-08-13 |
mouse |
| Claudia Schoenichen, Christoph Bode, Daniel Duerschmie. Role of platelet serotonin in innate immune cell recruitment. Frontiers in bioscience (Landmark edition). vol 24. 2019-04-01. PMID:30468670. |
peripheral serotonin is synthesized by the enzyme tryptophan hydroxylase (tph), which exists in two different isoforms: tph2 being responsible for serotonin synthesis in neurons and tph1 for generation of serotonin in peripheral organs. |
2019-04-01 |
2023-08-13 |
Not clear |
| Hailong Shi, Yaya Cui, Yifei Qi. Discovery and characterization of a novel tryptophan hydroxylase 1 inhibitor as a prodrug. Chemical biology & drug design. vol 91. issue 1. 2019-02-20. PMID:28719094. |
two distinct tryptophan hydroxylases (tph), tph1 and tph2, are the rate-limiting enzymes in the 5-ht biosynthesis process. |
2019-02-20 |
2023-08-13 |
rat |
| F Jiménez-Trejo, I Coronado-Mares, M Boeta, I González-Santoyo, R Vigueras-Villaseñor, C Arriaga-Canon, L A Herrera, M Tapia-Rodrígue. Identification of serotoninergic system components in stallion sperm. Histology and histopathology. vol 33. issue 9. 2019-01-10. PMID:29658099. |
therefore, using both immunofluorescence and western blot techniques, we searched for and found some serotonin markers such as 5-ht, 5-ht1b, 5-ht2a, 5-ht₃ receptors, both tph1 and maoa enzymes, and serotonin transporter (5-htt) in stallion sperm. |
2019-01-10 |
2023-08-13 |
Not clear |
| Cassidy Delaney, Laurie Sherlock, Susan Fisher, Joanne Maltzahn, Clyde Wright, Eva Nozik-Grayc. Serotonin 2A receptor inhibition protects against the development of pulmonary hypertension and pulmonary vascular remodeling in neonatal mice. American journal of physiology. Lung cellular and molecular physiology. vol 314. issue 5. 2019-01-09. PMID:29345193. |
following treatment with bleomycin, pulmonary expression of the rate-limiting enzyme of 5-ht synthesis, tryptophan hydroxylase-1 (tph1), was significantly increased. |
2019-01-09 |
2023-08-13 |
mouse |
| Harvey J Kliman, Sarah B Quaratella, Alessandra C Setaro, Erin C Siegman, Zarrin T Subha, Reshef Tal, Kristin M Milano, Theodore L Stec. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. vol 159. issue 4. 2018-11-27. PMID:29381782. |
we used immunocytochemistry to gauge 5-ht, its biosynthetic enzyme tryptophan hydroxylase 1 (tph1); an importer (serotonin transporter, 5-htt/sert/slc6a); other transporters [p-glycoprotein 1 (p-gp/abcb1), oct3/slc22a3, and gap junction connexin-43]; and the 5-ht degradative enzyme monoamine oxidase a (maoa) in sections of placentas. |
2018-11-27 |
2023-08-13 |
mouse |
| Harvey J Kliman, Sarah B Quaratella, Alessandra C Setaro, Erin C Siegman, Zarrin T Subha, Reshef Tal, Kristin M Milano, Theodore L Stec. Pathway of Maternal Serotonin to the Human Embryo and Fetus. Endocrinology. vol 159. issue 4. 2018-11-27. PMID:29381782. |
in humans, 5-ht was faintly stained only in first-trimester trophoblasts, whereas tph1 was not seen at any stage. |
2018-11-27 |
2023-08-13 |
mouse |