| Publication |
Sentence |
Publish Date |
Extraction Date |
Species |
| Yunting Xie, Chong Wang, Di Zhao, Chao Wang, Chunbao L. Dietary Proteins Regulate Serotonin Biosynthesis and Catabolism by Specific Gut Microbes. Journal of agricultural and food chemistry. vol 68. issue 21. 2021-01-07. PMID:32363863. |
however, the soy protein diet increased the number of enterochromaffin cells and tph1 mrna level but decreased the maoa mrna level and the serotonin content. |
2021-01-07 |
2023-08-13 |
mouse |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
5-ht synthesis is catalyzed by tryptophan hydroxylase (tph) which exists as two distinct isoforms; tph1 and tph2, which are responsible for peripheral and central 5-ht, respectively. |
2020-12-17 |
2023-08-13 |
Not clear |
| Nibal Betari, Kristoffer Sahlholm, Xavier Morató, Héctor Godoy-Marín, Olga Jáuregui, Knut Teigen, Francisco Ciruela, Jan Haavi. Inhibition of Tryptophan Hydroxylases and Monoamine Oxidase-A by the Proton Pump Inhibitor, Omeprazole- Frontiers in pharmacology. vol 11. 2020-12-17. PMID:33324221. |
the s-enantiomer of omeprazole, esomeprazole, has recently also been described as an inhibitor of monoamine oxidase-a (mao-a), the main enzyme responsible for 5-ht degradation, albeit with lower potency compared to the effect on tph1 and tph2. |
2020-12-17 |
2023-08-13 |
Not clear |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
there are two independent serotonin systems in the body characterized by two isoforms of tph, tph1 and tph2. |
2020-12-10 |
2023-08-13 |
mouse |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
while tph2 synthesizes serotonin in the brain, tph1 is expressed in the gut and in other peripheral tissues and supplies platelets in the circulation with serotonin. |
2020-12-10 |
2023-08-13 |
mouse |
| Michael Bade. Inhibition of serotonin synthesis: A novel therapeutic paradigm. Pharmacology & therapeutics. vol 205. 2020-12-10. PMID:31629717. |
tph1 deficient mice were shown to be protected from diverse diseases including hemostatic, inflammatory, fibrotic, gastrointestinal, and metabolic disorders and therefore serotonin synthesis inhibition emerged as a reasonable therapeutic paradigm. |
2020-12-10 |
2023-08-13 |
mouse |
| Bojan Mirkovic, Claudine Laurent, Marc-Antoine Podlipski, Thierry Frebourg, David Cohen, Priscille Gerardi. Genetic Association Studies of Suicidal Behavior: A Review of the Past 10 Years, Progress, Limitations, and Future Directions. Frontiers in psychiatry. vol 7. 2020-10-01. PMID:27721799. |
numerous meta-analyses of case-control studies have shown significant associations of sb with variants in the serotonin transporter gene (5-htt or slc6a4) and the tryptophan hydroxylase 1 gene (tph1), but others report contradictory results. |
2020-10-01 |
2023-08-13 |
Not clear |
| Walter J Lukiw, Evgeny I Rogae. Genetics of Aggression in Alzheimer's Disease (AD). Frontiers in aging neuroscience. vol 9. 2020-10-01. PMID:28443016. |
interestingly, (i) the expression of three of these six genes (comt, dbh, nos1) are highly variable; (ii) three of these six genes (comt, dbh, tph1) are involved in da or serotonin metabolism, biosynthesis and/or neurotransmission; and (iii) five of these six genes (ar, bdnf, comt, dbh, nos1) have been implicated in the development, onset and/or propagation of schizophrenia. |
2020-10-01 |
2023-08-13 |
human |
| Emmi Naskali, Katja Dettmer, Peter J Oefner, Pedro A B Pereira, Kai Krohn, Petri Auvinen, Annamari Ranki, Nicolas Kluge. Serotonin and tryptophan metabolites, autoantibodies and gut microbiome in APECED. Endocrine connections. vol 8. issue 1. 2020-10-01. PMID:30608907. |
hence, serum 5-ht, tph1 and aadc aabs should be determined in apeced patients presenting with gi symptoms. |
2020-10-01 |
2023-08-13 |
Not clear |
| Margaret Mandy R MacLea. The serotonin hypothesis in pulmonary hypertension revisited: targets for novel therapies (2017 Grover Conference Series). Pulmonary circulation. vol 8. issue 2. 2020-09-30. PMID:29468941. |
pulmonary endothelial serotonin synthesis via tryptophan hydroxlase 1 (tph1) is increased in patients with pah and serotonin can act in a paracrine fashion on underlying pulmonary arterial smooth muscle cells (pasmcs), in humans, serotonin can enter pasmcs via the serotonin transporter (sert) or activate the 5-ht1b receptor; 5-ht1b activation and sert activity cooperate to induce pasmc contraction and proliferation via activation of downstream proliferative and contractile signaling pathways. |
2020-09-30 |
2023-08-13 |
Not clear |
| Lulu Wang, Xiangcheng Fan, Jichun Han, Minxuan Cai, Xiaozhong Wang, Yan Wang, Jing Shan. Gut-Derived Serotonin Contributes to the Progression of Non-Alcoholic Steatohepatitis Frontiers in pharmacology. vol 11. 2020-09-28. PMID:32477107. |
the absence of 5-ht, through the pharmaceutical blockade of tph1 (lp533401) and dietary control (trp-free diet), suppressed hepatic lipid load and the expression of inflammatory factors ( |
2020-09-28 |
2023-08-13 |
rat |
| Michael A Morse, Eric Liu, Vijay N Joish, Lynn Huynh, Mu Cheng, Mei Sheng Duh, Kiernan Seth, Pablo Lapuerta, David C Met. Antiproliferative Effects of Telotristat Ethyl in Patients with Neuroendocrine Tumors: The TELEACE Real-World Chart Review Study. Cancer management and research. vol 12. 2020-09-28. PMID:32801896. |
neuroendocrine tumors (nets) associated with carcinoid syndrome (cs) overproduce serotonin, mediated by tryptophan hydroxylase-1 (tph1). |
2020-09-28 |
2023-08-13 |
Not clear |
| Yu-Yao Zou, Xiao-Yu Wu, Lan Shu, Pei-Lin Ji, Hua-Shan Gong, Wei-Fang Ron. [Perinatal antibiotics exposure causes increase in serum 5-hydroxytryptamine level as well as changes in behavior and gastrointestinal motility in the male offspring in mice]. Sheng li xue bao : [Acta physiologica Sinica]. vol 72. issue 3. 2020-09-24. PMID:32572427. |
serum 5-ht levels were detected with elisa, and potassium/sodium hyperpolarization activated cyclic nucleotide-gated channel 2 (hcn2) and tryptophan hydroxylase 1 (tph1) expression levels in colon epithelium of offspring were detected by western blot and rt-qpcr. |
2020-09-24 |
2023-08-13 |
mouse |
| Li Tong, Li-Bin Wu, Nan Li, Hong-Liang Cheng, Rong-Lin Cai, Hao-Ran Ch. [Moxibustion relieves abdominal hypersensitivity and diarrhea by regulating colonic 5-hydroxytryptamine signaling pathway in rats with diarrhea type irritable bowel syndrome]. Zhen ci yan jiu = Acupuncture research. vol 45. issue 7. 2020-09-16. PMID:32705826. |
to observe the effect of moxibustion on visceral pain, diarrhea, colonic 5-hydroxytryptamine (5-ht) content, and expression of tryptophan hydroxylase 1 (tph1), serotonin reup take transporter (sert) and 5-hydroxytryptamine receptor 3 (5-ht3r) in colon tissue of rats with diarrhea irritable bowel syndrome (ibs-d), so as to reveal its underlying mechanisms in treating ibs-d. |
2020-09-16 |
2023-08-13 |
rat |
| Peijun Tian, Gang Wang, Jianxin Zhao, Hao Zhang, Wei Che. Bifidobacterium with the role of 5-hydroxytryptophan synthesis regulation alleviates the symptom of depression and related microbiota dysbiosis. The Journal of nutritional biochemistry. vol 66. 2020-09-09. PMID:30743155. |
infantis e41 and bifidobacterium breve m2cf22m7, which improved the expression of tph1 and secretion of 5-hydroxytryptophan (5-htp) in rin14b cells, significantly reduced depressive behaviors of mice in the forced swim test, sucrose preference test and step-down test, as well as increased the level of 5-hydroxytryptamine and brain-derived neurotrophic factor concentration in brain. |
2020-09-09 |
2023-08-13 |
mouse |
| Susann Matthes, Valentina Mosienko, Elena Popova, Marion Rivalan, Michael Bader, Natalia Alenin. Targeted Manipulation of Brain Serotonin: RNAi-Mediated Knockdown of Tryptophan Hydroxylase 2 in Rats. ACS chemical neuroscience. vol 10. issue 7. 2020-06-11. PMID:30977636. |
tph1, predominantly expressed in the gastrointestinal tract and pineal gland, mediates 5-ht biosynthesis in non-neuronal tissues, while tph2, mainly found in the raphe nuclei of the brain stem, is accountable for the production of 5-ht in the brain. |
2020-06-11 |
2023-08-13 |
rat |
| Qing Pang, Hao Jin, Xiquan Ke, Zhongran Man, Yong Wang, Yi Tan, Zheng Lu, Huichun Li. The Role of Serotonin in Concanavalin A-Induced Liver Injury in Mice. Oxidative medicine and cellular longevity. vol 2020. 2020-06-03. PMID:31998441. |
another group of tph1 knockout ali mice was supplied with 5-hydroxytryptophan (5-htp) in advance to recover serotonin. |
2020-06-03 |
2023-08-13 |
mouse |
| Andre R Brunoni, Angel Carracedo, Olalla M Amigo, Ana L Pellicer, Leda Talib, Andre F Carvalho, Paulo A Lotufo, Isabela M Benseñor, Wagner Gattaz, Carolina Capp. Association of BDNF, HTR2A, TPH1, SLC6A4, and COMT polymorphisms with tDCS and escitalopram efficacy: ancillary analysis of a double-blind, placebo-controlled trial. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999). vol 42. issue 2. 2020-05-26. PMID:31721892. |
we investigated whether single nucleotide polymorphisms (snps) associated with neuroplasticity and activity of monoamine neurotransmitters, such as the brain-derived neurotrophic factor (bdnf, rs6265), the serotonin transporter (slc6a4, rs25531), the tryptophan hydroxylase 1 (tph1, rs1800532), the 5-hydroxytryptamine receptor 2a (htr2a, rs6311, rs6313, rs7997012), and the catechol-o-methyltransferase (comt, rs4680) genes, are associated with efficacy of transcranial direct current stimulation (tdcs) in major depression. |
2020-05-26 |
2023-08-13 |
Not clear |
| Julian M Yabut, Eric M Desjardins, Eric J Chan, Emily A Day, Julie M Leroux, Bo Wang, Elizabeth D Crane, Wesley Wong, Katherine M Morrison, Justin D Crane, Waliul I Khan, Gregory R Steinber. Genetic deletion of mast cell serotonin synthesis prevents the development of obesity and insulin resistance. Nature communications. vol 11. issue 1. 2020-04-24. PMID:31974364. |
herein, we report that the exposure of mice to thermoneutrality promotes the infiltration of white adipose tissue with mast cells that are highly enriched with tryptophan hydroxylase 1 (tph1), the rate limiting enzyme regulating peripheral serotonin synthesis. |
2020-04-24 |
2023-08-13 |
mouse |
| Asami Hagiwara, Yoshiyasu Nakamura, Rumi Nishimoto, Satoko Ueno, Yohei Miyag. Induction of tryptophan hydroxylase in the liver of s.c. tumor model of prostate cancer. Cancer science. vol 111. issue 4. 2020-04-22. PMID:31997472. |
furthermore, tryptophan hydroxylase-1 (tph1), an enzyme that catalyzes the reaction of trp to serotonin, was significantly increased in liver and spleen of at-2 engrafted rats. |
2020-04-22 |
2023-08-13 |
rat |